Using
in vitro hybridization method, polymorphism of thyroxine-binding prealbumin (TBPA) in primate species was investigated. Tetrameric TBPA was observed only in Catarrhini species, but was not observed in Platyrrhini species or Prosimii species. TBPA polymorphism was widely present in Cercopithecoid species. Frequency of
PAF was generally high in Cercopithecoids. In Hominoid species including Hylobatidae and Hominidae, gene constitution which controlled TBPA was fixed as
PAF/PAF. These results suggest that TBPA protein appeared in the process of evolution of primates.
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