巻号一覧
19 巻, 5 号
選択された号の論文の7件中1～7を表示しています
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特にアメリカ鉤虫感染期仔虫及び脱繊維素血液で処理せるズビニ鉤虫仔虫を以ってせる人体経胃感染実験について安戸 一皓1964 年 19 巻 5 号 p. 285-309
発行日: 1964/12/10
公開日: 2009/02/17
ジャーナル フリーNumerous Necator americanus larvae were orally given to five volunteers with the gastric tube and one of them succeded in the infection. The recovering rate of the worms was 0.08%. The volunteer aquired infection, however, was free of symptoms. No increase of the eosinophil count was noted. An attempt to induce asthematic condition in them remained to be unsuccessful.
A. duodenale larvae were orally administered in one human subject. The rate recoverd of the worms was 50%. The volunteer complained slight respiratory and gastrointestinal distresses. The complaints disappeared approximately 2 months after the onset of the symptoms. During the clinical course, the eosinophil count had gradually increased two or three weeks after the infection, reaching up to 26%. Hookworm egg and the larvae of A. duodenale were found on 87 days.
The auther studied the intestine invading activity of N. americanus and A. duodenale larvae. The invading activity of N. americanus larvae into the rabbit intestine was less than that of A. duodenale larvae.抄録全体を表示PDF形式でダウンロード (3128K) -
III) 分画精製した皮内反応抗原について武井 一利, 沢田 利貞, 米山 邦彦, 片峰 大助, 吉村 税, 山本 久1964 年 19 巻 5 号 p. 310-317
発行日: 1964/12/10
公開日: 2009/02/17
ジャーナル フリーSawada et al. (1962) reported that the antigen TCA obtained from adult worms (Dirofilaria immities) by the treatment of phosphate buffer, centrifugation and trichlor acetic acid produced noticeable reactions on the filariasis patients who were demonstrating microfilariae in their blood. The further fractionation and purification of this antigen to study the substance reponsible for the skin reaction and to obtain the more reliable antigen with high sentitivity and specificity was attempted.
The fraction FS obtained by the similar treatment to Sawada et al. was used as parent material. By the gel-filtration on sephadex G-100 column chromatography of antigen FS, antigen FS1 which produced noticeable reactions on the filariasis patients was obtained.
The highly reactive antigen FS1 was separated into 6 fractions FSC1, FSC2, FSC3, FSC4, FSC5 and FSC6 by CM cellulose chromatography. The 6 antigens were tested at the 1γ (protein component) level on patients infected with Wuchreria bancrofti. Antigen FSC4, containing 1, 500γ of protein and 40γ of carbohydrate per ml, was most active. Then the further fractionation of antigen FSC4 by DEAE sephadex A50 column chromatography was conducted to yield 4 antigens FSCD1, FSCD2, FSCD3 and FSCD4. The 4 antigens were tested at the 0.05γ (protein component) level on the filariasis patients. Antigen FSCD1 produced the most noticeable skin reaction on the patients.
The elimination of protein components from antigen FSCD1 was attempted with nagarse and pronase to obtain antigens FSCDN and FSCDP. Each of the 2 antigens was tested on the proved patients with filariasis, but the reaction produced by the injection of each antigen was lesser than that produced by antigen FSCD1.
It may be said that the substance responsible for the skin reaction seems to be protein, although the further studies are required.抄録全体を表示PDF形式でダウンロード (859K) -
竹村 望, 山村 行夫, 中島 ちせ, 福田 美和子, 秋山 俊1964 年 19 巻 5 号 p. 318-321
発行日: 1964/12/10
公開日: 2009/02/17
ジャーナル フリーIt is said that the food dye, Yellow AB or Yellow OB, contains often the impurity of the original dyestuff intermediate, namely β-naphthylamine which is potent carcinogen. These industrial food dyes manufactured in our country were examined and it was found that all the food dyes, yellow AB and Yellow OB, examined contained a small amount of β-naphthylamine.
The main aromatic amines as the metabolits in the urine of experimental animals fed with these food dyes were aniline or o-toludine and its derivatives.
It is desirable to cease the use of such food dye as Yellow AB or Yellow OB which contains carcinogenic intermediate even if its amount is a very little.抄録全体を表示PDF形式でダウンロード (402K) -
中村 健一1964 年 19 巻 5 号 p. 322-333
発行日: 1964/12/10
公開日: 2009/02/17
ジャーナル フリーMake use of pneumotachograph and airflow interruption technique, the pulmonary air-way resistance in 25 healthy male volunteers was measured to compare the consecutive responses followed by (1) 5 minute inhalation of NaCl aerosols (0.95μ and 0.22μ of count median diameter), (2) irritant gases (SO2 and NO2), (3) mixture of the NaCl aerosols and the irritant gases. Each inhalation was made after completion of recovery from the preceding effect.
For 10 subjects (group I) the large size aerosols and SO2 of 9-60ppm were inhaled, for 8 subjects (group II) the small size aerosols and NO2 of 3-23ppm, and for 7 subjects (group III) the large aerosols and NO2 of 6-40ppm, respectively. To the combination of the small size NaCl and SO2, result of the previous study done by Toyama and the author was referred.
Results are as follows; (1) no or slight change of air-way resistance were observed by NaCl aerosol inhalation, (2) the dose-response relationship between air-way resistance change and the concentration of inhaled gas was clear in the exposure to sulfur dioxide but not to nitrogen dioxide, (3) synergistic increase of a air-way resistance was observed in group I and III, especially in group I, but it was not remarkable in group II. The difference of synergistic response among each group is concerned with the penetrability of gas and aerosols into respiratory tracts, the retentive rate of aerosols, and the air-way size of respiratory tracts which mainly participate in the change of airway resistance.
It is concluded that the mixture of NO2 and smll size aerosols (group II) are considered to be the most penetrative into the alveoli where the constriction participated to the air-way resistance change may be minimal.
On the other hand, the mixture of large size aerosols (CMD=ca. 1μ) and SO2 (group I) are the most retentive in respiratory tracts, especially in lower parts (respiratory bronchioles or alveolar ducts) which mainly participate in the air-way resistance change.抄録全体を表示PDF形式でダウンロード (1411K) -
1964 年 19 巻 5 号 p. e1a
発行日: 1964年
公開日: 2009/02/17
ジャーナル フリーPDF形式でダウンロード (58K) -
1964 年 19 巻 5 号 p. e1b
発行日: 1964年
公開日: 2009/02/17
ジャーナル フリーPDF形式でダウンロード (58K) -
1964 年 19 巻 5 号 p. e1c
発行日: 1964年
公開日: 2009/02/17
ジャーナル フリーPDF形式でダウンロード (58K)
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