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Volume 22 (1967 - 196･･･
- Issue 6 Pages 581-
- Issue 5 Pages 521-
- Issue 4 Pages 469-
- Issue 3 Pages 405-
- Issue 2 Pages 323-
Volume 22, Issue 3
Displaying 1-8 of 8 articles from this issue
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II. On the serum mineral levels with special reference to the calcium contentsFumio Yamada1967 Volume 22 Issue 3 Pages 405-415
Published: August 30, 1967
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThe present paper deals with the survey of the serum levels of total calcium, dialyzable calcium and serum total base. The results were determined after examining 1821 inhabitants over 40 years of age of both sexes in the inland farm and the coastal fishing villages where the mortalities from cerebrovascular lesions were high and low, respectively.
The conclusion is as follows;
(1) Serum total calcium level estimated using Yanagisawa's photometric procedure was higher in the fishing villages through the entire age group at the significant level of p<0.001.
(2) Inversely to the total calcium, the serum dialyzable calcium level was significantly higher in the farm villages.
(3) Serum total base level measured with the ion-exchange resin method of Bonting modified by Uchida, showed significantly higher values in the farm villages.
(4) Significant positive correlation was seen only between the serum total calcium and dialyzable calcium levels of the farm villagers.View full abstractDownload PDF (1422K) -
Report IX Transition of the Pollution of Minamata Bay and its NeighbourhoodKatsuro Irukayama, Sadao Ushikusa, Shizuko Tajima, Hiroshi Nakamura, S ...1967 Volume 22 Issue 3 Pages 416-423
Published: August 30, 1967
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESS1) No new cases of Minamata disease have been found since 1961. However it was considered that a slight amount of the organomercury compound as the causative agent of the disease had been discharged from Minamata Factory until May, 1966, notwithstanding the completion of the waste treatment of the factory in January, 1961. In June, 1966, the system of waste treatment wsa revised. Then, the mercury content in the fish from the bay abruptly decreased.
2) Methylmercury chloride was extracted as crystalline solids from the waste water discharged from the rectifying column of acetaldehyde plant, and a considerable amount of chloride appeared in in the same waste water.View full abstractDownload PDF (976K) -
1967 Volume 22 Issue 3 Pages 423
Published: 1967
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSDownload PDF (78K) -
I. Distribution of Radioiodine in Maternal and Fetal Tissues of MiceHideki Ikeda1967 Volume 22 Issue 3 Pages 424-432
Published: August 30, 1967
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThe increasing possibilities of radioiodine exposure from various sources, i.e. fallout from nuclear weapon tests, accidental release from nuclear energy institutions or the wide spread use of radioiodine in the medical field, emphasize a need to develop the prophylactic measures for radioiodine contamination of humans especially newborn infants, pregnant mothers and fetus.
As a part of the study, a preliminary experment was carried out on the distribution of I-131 in maternal and fetal tissues at the various intervals following oral or intratracheal administration of I-131 into pregnant mice of 18 days of gestation.
1. Thyroidal I-131 content of both mother and fetus reached a peak value at about 24 hours after the administration.
2. The concentration of I-131 in whole fetus reached a maxmum at 2 hours following the administration, while the concentration in maternal body decreased continously.
3. The fetal I-131 concentration was found to be higher than the maternal concentration during the period of observation from 1 hour to 48 hours after the administration, and in the ratio of fetus-to-mother a maximum value of about 3 was obtained at 2 hours after the administration.
4. Among the various tissues of mother, placenta, uterus and mammary glands seemed to concentrate I-131 and the highest values were observed at 2 hours after the administration.
5. Significant differences of the distribution of I-131 was not observed between the oral and the tracheal routes of administration in pregnant mice, while in rats, the I-131 retention for intratracheal administration was found to be higher than the level for ingestion.
6. The 24 hour thyroidal uptake and whole body retention of I-131 in pregnant and fetal mice was observed to be the highest in summer and the lowest in autumn.View full abstractDownload PDF (3686K) -
II. Effects of Stable Iodide on the Distribution of I-131 in Pregnant and Fetal MiceHideki Ikeda1967 Volume 22 Issue 3 Pages 433-441
Published: August 30, 1967
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSEffects of single oral dose of stable iodide (NaI) on the distribution of I-131 were investigated in pregnant and fetal mice 18 days of gestation, following the administration of I-131 by the oral and the intratracheal routes.
1. Radioiodine uptake by the maternal and fetal thyroids has been demonstrated to be inhibited by the oral administration of NaI with minimum retention at 1 hour before I-131 administration.
2. The administered NaI appeared to have a greater inhibitory effect for the thyroidal I-131 uptake of fetus than for the pregnant mother. When NaI was administered to the pregnant mother 6 hours after the administration of I-131, the thyroidal I-131 uptake of fetus was suppressed to a level of less than a half of the control value, while the I-131 uptake by the maternal thyroid suppressed slightly.
3. Extrathyroidal retention of I-131 in pregnant mice was not significantly influenced by the treatment of NaI, but the I-131 retention in fetal extrathyroidal tissues tended to exceed that in the untreated control fetus.
4. The NaI treatment for the intratracheal administration of I-131 appeared to be more effective than for the ingestion of I-131.
5. The concentration of I-131 in mammary glands of pregnant mother decreased by the administration of NaI, while the I-131 concentration in placenta and uterus were reduced with the treatment of NaI.View full abstractDownload PDF (1331K) -
III. Effects of Potassium Thiocyanate and Combined Use with Stable Iodide on the Distribution of I-131 in Pregnant and Fetal MiceHideki Ikeda1967 Volume 22 Issue 3 Pages 442-450
Published: August 30, 1967
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSIn the previous reports, it was demonstrated that the extrathyroidal I-131 retention appeared to be higher than that of untreated control fetus, although the I-131 uptake by the fetal thyroids was suppressed markedly by the administration of NaI. The present study was directed to reduce I-131 retention in fetal body especially in extrathyroidal tissues by the treatment with KSCN or the combination of KSCN and NaI.
1. Placental transfer of radioiodine appeared to be inhibited by the administration of KSCN to the pregnant mice of 18 days of gestation.
2. The administered KSCN appeared to have a greater inhibitory effect for the I-131 uptake by the fetal thyroids than for the pregnant mother, but less effective than NaI.
3. Extrathyroidal retention of I-131 in both mother and fetus was reduced by the administration of KSCN and the combination of KSCN and NaI appeared to have a greater protective effect than KSCN alone.
4. The concentration of I-131 in mammary glands, placenta and uterus of pregnant mother decreased by the administration of KSCN and the combined use of KSCN and NaI was more effective.View full abstractDownload PDF (1357K) -
Shigeo Koike, Michiko Komaya, Kenji Ikoma, Eiko Horiuchi, Tadataka Nag ...1967 Volume 22 Issue 3 Pages 451-459
Published: August 30, 1967
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThe serum lipids and lipoproteins of 215 men and women over 20 years of age in Tokyo and its suburbs were investigated. The serum cholesterol and triglyceride levels in healthy subjects were below Western countries figures. In healthy men, age trends were observed only in the serum cholesterol content. In male and female hypertensives as well as subjects suffering from ischemic heart disease, every lipid component and lipoprotein showed a higher value as compared with that of normal persons. The serum triglyceride levels were elevated significantly in hypertensives but not significantly in subjects with ischemic heart disease compared with those of a normal control group. Total serum cholesterol, beta-lipoprotein lipids and cholesterol revealed significantly higher values in male hypertensives as well as the patients with ischemic heart disease from 40 to 59 years in comparison with a normal control in a comparable age group. There were no significant differences in the serum lipids and lipoprotein levels among the subjects at any stage of developing hypertension.View full abstractDownload PDF (1129K) -
Quartz and talc particles in lung preparations of newborns, infants and school childrenTadashige Mori1967 Volume 22 Issue 3 Pages 460-464
Published: August 30, 1967
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSIn daily living, a great quantity of sand, mineral dusts and talc powders containing α-quartz or talc particles is inhaled. To recognize the effects of such mineral dusts, lung preparations of newborns, infants and school children were examined with a polarizing microscope.
Findings are as follows on the quartz and talc examinations:
1) Many particles of quartz and talc derived from baby powder are found in lung preparations of infants and school children.
2) Amount of quartz particles in the lung tissue (Q) is shown as the function of the living age (M: months).
Q=18√M+38 (SQ=±28.66)
Thus, quartz deposited in the lung tissue increases in proportion to a square root of living age with a large variance resulting from the enviromental situations of subjects.
3) Amount of talc particles in the lung tissue (T) is also given as the function of the living age (M).
T=2.5√M+38 (ST=±14.89)
In other words, talc particles deposit in the lung tissue very slowly, and show a small variance. Those talc particles are seemingly derived from inhalation of the baby powder.
4) All dusts deposited in the lung tissue are below 20μ in size and mostly are ranging between 3 and 5μ.
5) No remarkable tissue changes are found at foci of deposition of mineral dusts.View full abstractDownload PDF (3440K)
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