日本衛生学雑誌
Online ISSN : 1882-6482
Print ISSN : 0021-5082
ISSN-L : 0021-5082
26 巻, 3 号
選択された号の論文の9件中1~9を表示しています
  • 主成分分析による解析
    白崎 和夫, 伊藤 志真子, 根岸 龍雄, 秋山 房雄
    1971 年 26 巻 3 号 p. 281-284
    発行日: 1971/08/28
    公開日: 2009/02/17
    ジャーナル フリー
    PMI (Proportional Mortality Indicator) is the percentage of deaths at a certain age and over to total deaths, and this age is usually fixed to that of 50 years old. Through the procedure of principal component analysis, the authors investigated the age for PMI in regions with various scales of population.
    Results obtained were as follows:
    1) Judging from the eigen values in the primary and secondary principal component, linear regressions were considerable clear.
    2) The age of 40 or 45 years was most adequate for the age mentioned above.
    3) The values of linear combination in the primary principal component of PMI calculated by dividing lines for every 5th year were valid for the evaluation of health in the middle or large regions but not in the small regions in comparison to another health indicators.
  • 福田 勝洋, 三宅 浩次, 岡田 晃
    1971 年 26 巻 3 号 p. 285-290
    発行日: 1971/08/28
    公開日: 2009/02/17
    ジャーナル フリー
    ラットを種々の濃度の水銀蒸気に間けつ的に暴露し, 一定期間後の組織別水銀量を測定した先の実験成績1)をもとに, 水銀の組織間移行 pattern を数学モデルで simulate し, 組織別水銀量の推移を数式的に表現することを目的として本研究を行なった。先の実験で, 水銀暴露終了後の組織別水銀量は対数値でほぼ直線的に減少し, その速度の差から11組織は肺, 脳, 腎およびその他の組織の4群に大別できたので, この各群をそれぞれ1つの compartment とみなし, はじめに各 compartment の水銀量の推移を simulate した。水銀の組織間移行速度は, その時の組織水銀量に比例3),4)し, 4 compartment 相互間に水銀の授受があるものとみなして連立微分方程式を立てた。数学モデルによる計算値が実験値と満足な一致を示すか否かは, アナログ計算機ALS-2000を用いて検討した。いくつかのモデルについて試行錯誤的に検討したが, 水銀は屎尿の他, 肺からも体外へ排泄されることを組込んだモデルが最もよく実験値に一致し, その時の各 compartment の水銀の移行速度定数が推定できた。次に, 水銀の移行速度定数は水銀暴露・非暴露期間で等しく, また, 吸気から肺への移行速度定数を1.0とみなして, 先の実験での2つの暴露様式, 6.0mg/m3×1hr. (HS), と1.0mg/m3×6hrs. (LL) による compartment 別水銀量の推移を同じ数学モデルを用いて, ALS-2000およびCLOAP-2000により計算した。暴露4週目の実測値と計算値は満足な一致を示し, (濃度×時間) の値が等しくても水銀蒸気暴露による組織水銀量はHS群とLL群とで異なることも simulate された。先の実験で水銀量は肺でHS群の方がLL群より, またその他の組織ではLL群の方がHS群より多くなる理由として, 水銀の移行速度定数が (肺→他の組織) に比して (吸気→肺) の場合の方が大きいことが推測されたが, 本数学モデルによる simulation の結果からもそのことが推測された。
  • 入鹿山 且朗, 桑原 駿介
    1971 年 26 巻 3 号 p. 291-297
    発行日: 1971/08/28
    公開日: 2009/03/31
    ジャーナル フリー
    Methyl mercury chloride administered subcutaneously to hens transferred to their eggs and the major part of mercury in eggs existed as methyl mercury complex with the protein of the egg white. Egg white powder obtained by treatment with ether and acetone was dissolved in water. The protein containing methyl mercury in the solution was salted out by adding 30-60% of ammonium sulphate. The protein which was salted out was again dissolved in water by dialysis, and the protein solution was fractionated in tubes of a fraction collector through Sephadex G 100. Protein in the solution of each tube was fractionated by electrophoresis through a cellulose acetate membrane. The albumin fraction contained mercury.
    The same protein solution was fractionated by Disk-electrophoresis apparatus using polyacrylamide gel (pH 9.4), and protein and mercury in each tude were quantitatively determined. Solution of the tubes in which contents of protein and mercury were high was lyophilized. The lyophilized protein powder which was dissolved in veronal buffer solution containing 0.1M natrium chloride was analyzed by an ultracentrifuger (rotor speed 60, 000rpm). The calculated sedimentation constant (S20, w) was 3.44× 10-13m/sec (dyne/g) (≈3.4S) as V was taken for 0.748.
  • 吉田 昌男, 川名 林治
    1971 年 26 巻 3 号 p. 298-303
    発行日: 1971/08/28
    公開日: 2009/02/17
    ジャーナル フリー
    Bacteriological observations of the throats of 1, 015 persons were carried out. In this study 370 hospitalized patients (in and outpatients) were tested. They had not been treated using wide-spectrum-antibiotics. The remaining 645 persons were employed as control groups, 78 healthy employees in the medical hospital, (physicians, nurses and etc.) and 567 healthy convicts in The Morioka National Prison.
    The gram negative bacilli (except Hemophilus) which grow under an aerobic condition, Staphylococcus and Candida were investigated, in reference to the detection rates and resistance to antibiotics and furthermore to the phage-typing of Staphylococcus.
    Detection rates of the gram negative bacilli and of Staphylococcus were found to be the lowest in the throats of patients. The isolated strains on patient, however, resisted more to multiple antibiotics than those isolated in the throats of the healthy convicts. The throats of healthy hospital employees and those of patients showed similar tendencies. The numbers of gram negative bacilli in the throats of the patients were more numerous than those of the 2 healthy groups.
    It was epidemiologically significant that Escherichia and Pseudmonas aeruginosa were found in the throats of all groups.
    Bacteriological investigations of the throat indicated a greater significance than that of the nose, one of the reasons being that gram negative bacilli were not detected in the nasal cavity but in the throat.
  • 伊藤 耕三
    1971 年 26 巻 3 号 p. 304-314
    発行日: 1971/08/28
    公開日: 2009/02/17
    ジャーナル フリー
    Nitrogen dioxide is one of the main atmospheric pollutants in many communities. It is emitted in large quantities in the exhaust of automotive engines and is formed when atmospheric nitrogen and oxygen are heated to a high temperature in a flame.
    Experiments were made to ascertain possible synergistic effects of nitrogen dioxide and influenza virus infection in mice. Young female dd strain mice weighing 15 to 17g were challenged with mouse-adapted type A influenza virus, strain PR 8, two hours after acute and intermittent exposure to 10ppm nitrogen dioxide for two hours daily for one, three and five days. Female I.C.R. strain mice weighing 22 to 25g were also challenged with type A influenza virus after continuous exposure to 0.5 to 1.0ppm nitrogen dioxide for 39 days.
    Results were as follows;
    1) Acute and intermittent exposure to 10ppm nitrogen dioxide for two hours daily for five days significantly increased the susceptibility of mice to influenza virus infection as demonstrated by enhanced mortality.
    2) Extent of interstitial pneumonia was higher in the mice challenged with influenza virus after chronic and continuous exposure and acute and intermittent exposure to nitrogen dioxide than in the infected controls.
    3) Adenomatous proliferations of bronchial and bronchiolar epithelium were marked in the mice challenged with influenza virus after continuous exposure to low levels of nitrogen dioxide.
  • 大和田 国夫, 阪本 州弘, 田中 平三
    1971 年 26 巻 3 号 p. 315-320
    発行日: 1971/08/28
    公開日: 2009/02/17
    ジャーナル フリー
    The sex ratio and birth order between siblings of parents and their children were surveyed on 4, 700 families of students who were attending 6 public junior high schools in the suburbs of a large city.
    Results obtained are as follows:
    (1) The sex ratios in the siblings of parents and their children were 103 and 97 respectively.
    (2) The mean number of the siblings of the children was 2.7 and that of parents was as high as 5.1.
    (3) When siblings were two in number, cases where both siblings were males appeared more frequently among the children than the parents, and vice versa in the case where both were females. This phenomenon appears to be characteristic of recent Japan.
    (4) When siblings were more than four, the birth order among males and females corresponded to the theory of“random walk”in case of the parents, but not so in the case of children.
    These results seem to imply that recent changes in socio-economic status as well as propagation of family planning have bearing on sex ratio and birth order.
  • 山村 晃太郎, 岡田 晃
    1971 年 26 巻 3 号 p. 321-324
    発行日: 1971/08/28
    公開日: 2009/02/17
    ジャーナル フリー
    Authors studied the masking of speech (One-Syllable 100 Word List) by white noise. The following conclusions were reached:
    The curves of Speech Articulation Score shift to the right with increased intensity of masking noise. Davis' Social Adequacy Index (S.A.I.) derived from the curves of Speech Articulation Score revealed a sharp descent when the level of the sound pressure of noise increased.
  • ロールシャッハテストによる
    桑原 治雄
    1971 年 26 巻 3 号 p. 325-336
    発行日: 1971/08/28
    公開日: 2009/02/17
    ジャーナル フリー
    The Rorschach Test was administered to 165 persons all over 65.
    Results are as follows:
    Subjects were composed of three groups A, B and D.
    Group A was characterized by a marked increase of the Rorschach signs of Personal reference and Idea perseveration;
    Group B by a marked increase in the Rorschach signs of Fine details (tendency to be meticulous about minor parts of the blot on the Rorschach card) and Ambiguities in the blot choice;
    Group D by a tendency to say something in accordance with a Rorschach response but actually paying little attention to the blot on the cards (nonsensical response). This group belongs to a latent dementia senilis.
    General characteristics of the test: to be meticulous about minor details as well as a lack of usual content and form in response.
    Rorschach responses in relation to mental function of the aged: Memory decreases with old age and compensation is made by: (a) making excessive use of personal experiences when responding to the Rorschach cards (b) being meticulous about minor details of the blots. Considerable decrease in mental function makes use of compensation impossible and a nonsensical response is given.
  • 上野 陽里
    1971 年 26 巻 3 号 p. 337-343
    発行日: 1971/08/28
    公開日: 2009/02/17
    ジャーナル フリー
    The concept of a permissible dose is one appearing at a contactpoint of natural and social sciences. The permissible dose in radiation protection was adopted as a model in the present paper, reason being to analyze the concept historically and to realize and understand the process of development, as this concept has been discussed extensively in radiation protection. It is emphasized here that not only somatic but also genetic changes are included in biological responses where permissible doses are concerned. The permissible dose is being considered separately for the individual and for workmen in shops where they may contact agents concerned with the permissible dose. A decision has been reached utilizing ecological knowledge including mechanisms of dilution and concentration on a global scale. In general, the permissible dose has been estimated conceptually pivoting on the balance of benefit and injury for humans. It is extremely necessary to know for whom it is beneficial and for whom it is injurious. When discussing a permissible dose, medical staff should arrive at decisions from purely medical and biological viewpoints rather than from the viewpoint of balance.
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