Recently, various organochlorine pesticides have been quantitatively used in agricultural fields. In Japan, pesticides, particularly BHC isomers have consequently been discovered not only in farm produce but in the human body and human milk as well. A public hazard problem has been created herein.
The present study was undertaken in order to examine accumulation of BHC (α-, β-, γ- and δ-) isomers in rat bodies and excretion into urine following oral administrations.
Decomposition and isomerization of relative isomers in the tissues were discussed and determination of isomers in the blood, liver, kidneys and urine was carried out by means of gas chromatography.
Conclusions are as follows;
1. The level of the accumulation of BHC isomers in a rat body is β>>α>γ>δ. This difference of accumulation could depend on the chemical stability of isomers in the tissues.
2. BHC isomers not changed in rat tissues are excreted into the urine. Level of the quantity of excreted isomers for the period of a month is in the order of α>γ>>δ>β and, as to the length of their excretive period, β>α>γ>δ.
3. β-isomer is accumulated in a rat body when α-, γ- and δ-isomers are administrated. It can be presumed that isomers are isomerized to β-isomer in the tissues.
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