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Volume 28 (1973 - 197･･･
- Issue 6 Pages 499-
- Issue 5 Pages 443-
- Issue 4 Pages 381-
- Issue 3 Pages 315-
- Issue 2 Pages 237-
Volume 28, Issue 6
Displaying 1-10 of 10 articles from this issue
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Kozo Ishiguro, Kyoko Hara, Takao Watanabe, Isamu Kaneko, Eiji Takahash ...1974 Volume 28 Issue 6 Pages 499-504
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSSince among females in the farm area of Northeast Japan, anemia is a common finding, 339 women aged 40 to 49 in a farm village in Miyagi Prefecture were examined for; blood specific gravity (SG), hemoglobin content (Hb), hematocrit value (Ht), serum iron concentration and serum protein compsition.
In 98 anemic subjects, having the lower level in one or more of the SG, the Hb and the Ht, the Hb showed a positive correlation with the serum albumin level and a negative correlation with the serum globulin level.
Furthermore, the serum iron concentration showed a positive correlation with SG, Hb, Ht and serum albumin (P<0.01), and a negative correlation with serum β-globulin (P<0.01).
These relationships were not found in women without anemia.View full abstractDownload PDF (726K) -
Hiroyuki Morita, Masayoshi Ohmichi, Shigeo Koike1974 Volume 28 Issue 6 Pages 505-510
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSRadioisotopic kinetic studies of plasma triglyceride transport have been performed in rabbits treated with tetrachlorobiphenyls and compared with data obtained from untreated or olive oil-treated rabbits. Administration of tetrachlorobiphenyls provoked a rise of plasma triglyceride and an elevation of plasma triglyceride production rate but tended to lower the fractional turnover rate. The relationship of turnover rate to plasma concentration of triglyceride suggests that the increase of plasma triglyceride concentration observed in tetrachlorobiphenyl-treated rabbits can be accounted for by an increased production in some of cases, but in other cases glyceridemia is due primarily to a removal defect.View full abstractDownload PDF (686K) -
Chieko Sugawara, Naoki Sugawara1974 Volume 28 Issue 6 Pages 511-516
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThere are some reports on the effect of cadmium on calcium metabolism, especially in relation to damage of the renal tobules. We hypothesized that the disturbance of calcium in cadmium intoxication is the result of damage not only of the kidney but also of the intestines. To test this speculation, we fed rats with 10ppm (Cd-10ppm group) or 50ppm (Cd-50ppm group) of cadmium for 287 days.
(1) The calcium and phosphorus absorption rate was decreased to some extent in the Cd-10ppm group. In the Cd-50ppm group, it was significantly decreased starting at the beginning of cadmium feeding.
(2) In the Cd-50ppm group, blood in the feces was most prominent at the beginning of cadmium feeding, and by the 12th day, it had disappeared. After prolonged feeding of cadmium, stool blood increased again. In the Cd-10ppm group, there was no significant melena.
(3) Paraffin sections of the duodenum were stained with hematoxyin-eosin. On the 5th day of 50ppm cadmium feeding, eosinophilic cell infiltration of the submcosa layer and erosion were found, but on the 21th day, no significant abnormality was seen. In the Cd-10ppm group, no abnormality was found.
These observations indicate that the intestinal damage caused by cadmium leads to disorders of calcium metabolism. Further investigation is required to clarify the mechanism of cadmium toxicity in relation to calcium absorption.View full abstractDownload PDF (3019K) -
Kotaro Yamamura, Hirotsugu Miyake, Naoki Sugawara, Akira Okada, Masaya ...1974 Volume 28 Issue 6 Pages 517-521
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSEight males (aged 22-27) with normal ears were exposured to (1) steady state noise (broad band noise, 90dB). (2) impact noise with the frequency of one time per two seconds (peak value 105dB with about 25msec B-duration and peak value 120dB with 25msec and about 100msec B-duration), and (3) a combination of steady state noise and impact noise.
(1) Impact noise alone with a peak value of 105dB produced no significant TTS growth for steady state noise or combined noise above both.
(2) TTS growth of combined noise with impact noise (peak value 120dB, B-duration about 25msec) and steady state noise were larger than that of steady state noise alone, and the difference was statistically significant.
(3) In the case of third impact noise (peak value 120dB, B-duration 100msec), the effect to hearing loss was showed in following order, impact noise alone, combined both, steady state noise.View full abstractDownload PDF (2186K) -
Masahisa Shimada, Kiyohisa Kurimoto, Masahito Watanabe, Yasuhisa Yoshi ...1974 Volume 28 Issue 6 Pages 522-529
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThe effect of cyanide hypoxia on the metabolism of free amino acids in mouse brains was studied by testing the radioactive metabolites of injected [U-14C] glucose. Free amino acids in mouse brains were separated by a fraction collecter, and analysed by gas-liquid chromatography. 14C concentrations of free amino acids were estimated separately for each region of the brain with a scintilation spectrometer. Macroautoradiographs were analyzed with a microdensitometer and radioac tive concentrations for each region of the brain were computed.
In hypoxic brains, each free amino acid showed a decrease of 14C uptake and especially in the neo-cerebral cortex and caudate nucleus where the activity of cytochrome oxidase is always high in normal mice. However, in the thalamus, hypothalamus and medulla oblongata, it was only slightly below normal. This indicates that these regions are most resistant to cyanide poisoning. In the cerebellum, the decrease of 14C uptake by each amino acid was between that in the neo-cerebral cortex and in the medulla oblongata.
These results of chemical analysis are closely comparable to those obtaind by macroautoradiography. Low radioactive concentrations on the autoradiographs were noted in the neo-cerebral cortex, and relatively high concentrations in the thalamus, hypothalamus and medulla oblongata after cyanide poisoning.View full abstractDownload PDF (3950K) -
Kunio Owada, Heizo Tanaka, Yutaka Ueda, Chigusa Date, Hiroko Tsue, Hir ...1974 Volume 28 Issue 6 Pages 530-542
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSBlood samples were collected from 197 healthy men and 378 women after an overnight fast. Serum total cholesterol was measured by the Zak-Henly method and serum triglyceride by the modified Fletcher method.
1. Both serum total cholesterol values and serum triglyceride values showed nearly a log-normal distribution curve by sex and age.
2. The median and the lower and upper normal limits (α=0.05) of serum total cholesterol were calculated theoretically and the values for men and women were: 20-29 age group, median for men 150.4mg/dl (lower and upper limits 105.4mg/dl-214.5mg/dl), for women 136.5 (103.3-180.2); 30-39 age group, men 162.1 (115.1-228.4), women 146.4 (96.4-222.3); 40-49 age group, men 163.7 (106.8-250.9), women 172.2 (113.7-260.6); 50-59 age group, men 174.6 (116.8-261.1), women 178.9 (123.4-259.4); 60-69 age group, men 159.0 (111.0-227.7), women 184.8 (152.2-224.4); over 70 age group, men 172.2 (130.5-227.2), women 174.5 (124.6-244.3).
3. The median and the lower and upper normal limits (α=0.05) of serum triglyceride were calculated theoretically and the values for men and women were: 20-29 age group, median for men 66.7 mg/dl (lower and upper limits 19.3mg/dl-231.8mg/dl), for woman 58.4 (23.5-145.3); 30-39 age group, men 74.4 (39.5-140.1), women 67.9 (28.4-162.3); 40-49 age group, men 85.2 (24.1-300.9), women 72.7 (31.7-166.3); 50-59 age group, men 81.1 (30.1-218.6), women 88.1 (36.2-215.0); 60-69 age group, men 78.2 (37.3-164.0), women 102.9 (38.5-274.2); over 70 age group, men 66.6 (15.6-283.3), women 98.2 (39.6-243.5).
4. The serum total cholesterol level increased with age, showing a peak in the sixth decade in men, and in the seventh in women. The cholesterol level of women was significantly higher than that of men in the seventh decade.
5. The serum triglyceride level increased with age, showing a peak in the fifth decade in men, and in the seventh in women. The triglyceride level of women was significantly higher than that of men in those over 60.View full abstractDownload PDF (1328K) -
Koei Minagawa, Yukio Takizawa, Hiroshi Sakai, Itaru Sasagawa1974 Volume 28 Issue 6 Pages 543-547
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSThe authors have been able to establish a new analytical method of measuring polychlorinated terphenyl compounds (PCT) and have applied it to quantitative determinations in the human body.
The selected materials were human fat from the omentum major and mother's milk. PCT was detected in most samples Sy gas chromatography and confirmed by mass spectroscopy coupled with gas chromatography.
The amount of PCT present in human fat was 0.37±0.88ppm on fat basis and was approximately one third the level of PCB. In mother's milk the amount of PCT was 0.012±0.05ppm on fat basis, but the level of PCT was negligible (1/60 that of PCB).View full abstractDownload PDF (562K) -
Masuhiro Nakamura1974 Volume 28 Issue 6 Pages 548-573
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSRecently there has been much interest in an accurate evaluation of the consequences of induced abortion in Jappan which has a history of more than twenty years of legal abortion.
Most of the reports have been concerned mainly with clinical complications during the first 4-6 weeks after treatment or hospital based surveys only of women who had induced abortions.
The author describes a feasible method of determining the prevalence of induced abortion, its relation to the outcome of pregnancy and the characteristics of women who use it.
Questionnaires were sent to 2, 825 women and 650 women were interviewed in a cross-sectional survey representing all women aged 20-44 residing in Kochi Prefectre.
(1) Fewer induced abortions were reported by intervied than by self-administrated recall questionnaires.
(2) There were some difficulties in obtaining information from doctors.
(3) About half of the married women had had one or more induced abortions and the prevalence in each geographic area was almost the same.
(4) Women who had had abortions were not significantly different from those who had not in regard to subsequent pregnancies.
(5) Induced abortion was often resorted to because of inability to use contraceptive methods effectively.View full abstractDownload PDF (2688K) -
1st Report; Relationship between Mercury Levels in Fish and Mercury Contamination of River.Sumie Yamanaka, Kiichi Ueda1974 Volume 28 Issue 6 Pages 574-581
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESSIn the nation-wide survey of mercury levels in river fish conducted by the Ministry of Health and Welfare (later by the Environment Agency) since 1968, the authors have collaborated with the project by analysis of samples in several districts.
Unusually high levels of mercury around 1ppm were found in fish from the Jinzu River and Oyabe R. (Toyama), Muka R. and Shokotsu R. (Hokkaido), Hono R. (Nara), in addition to the notorious Minamata Bay and Agano R. where human poisoning has been reported.
1. In the Jinzu R., the extraordinary feature was the detection of ethylmercury in fish far above the level of methylmercury. Investigation of the source of pollution finally implicated a pharmaceutical factory synthesizing an antiseptic “Thimerosal” (Sodium ethylmercury thiosalicylate) which was discharging ethyl- and inorganic mercury into the river.
2. In the Muka R. (and also Hono R. and Shokotsu R.) which starts from and runs through mercury mine areas, the major component of mercury in fish was methylmercury, supporting the hypothesis of natural conversion of mercury, reported by Swedish researchers.
3. The variation of mercury levels in fish was large in the areas of industrial pollution by organic mercury (in the Jinzu R.), but small where natural contamination was caused by geological factors (in the Muka R.)
4. The correlation between mercury levels and fish size (fish age) was positive in case of natural contamination over a wide area, but insignificant in areas of localized industrial pollution.View full abstractDownload PDF (886K) -
2nd Report; Metabolisms of Mercury Compounds in Fish-with Special Reference to Labeled Mercury CompoundsSumie Yamanaka, Kiichi Ueda, Tamao Yoshida1974 Volume 28 Issue 6 Pages 582-587
Published: February 28, 1974
Released on J-STAGE: February 17, 2009
JOURNAL FREE ACCESS1. In fish with high mercury levels, methylmercury represented about 60% of total mercury content. In fish with low levels, it was around 20%.
2. The mercury level in fish paralleled the size of the fish.
3. Almost no labeled inorganic mercury was absorbed from the intestines after 24hrs., while labeled methylmercury was more quickly absorbed, and was distributed abundantly in muscles and brain.
4. The pattern of distribution of methylmercury in fish was almost the same as that in mammals.
5. The biological half lives of labeled mercury compounds were determined by the whole body counting method in trout, carp and catfish.
There was little difference among species of fish.
6. The biological half life of methylmercury in fish was about 200 days in water at 16°C., which was considerably longer than that in mammals.
The possible contribution of the longer biological half life in fish to the accumulation of methylmercury is discussed.View full abstractDownload PDF (2354K)
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