巻号一覧
28 巻, 5 号
選択された号の論文の7件中1～7を表示しています
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松下 敏夫, 有松 徳樹, 三角 順一, 冨尾 利江, 上田 忠子, 上田 厚1973 年 28 巻 5 号 p. 443-449
発行日: 1973/12/28
公開日: 2009/02/17
ジャーナル フリーSeventy-five adolescent sniffers of organic solvents were investigated to obtain epidemiological and clinical data.
There was no correlation between sniffing and personal or family madical history, but some relation to family circumstances.
The motivation for sniffing seemed to be related at first to pressure by friends or to curiosity, and later to seeking pleasure or relief from discomfort and anxiety.
There was a positive correlation between frequency of sniffing and various abnormal clinical findings, such as specific gravity of whole blood, red blood cell count, appearance of Mommsen's toxic granules in neutrophiles and neurological symptoms.抄録全体を表示PDF形式でダウンロード (958K) -
倉恒 匡徳, 吉村 健清, 徳留 信寛, 河内 清司, 松坂 淳一, 西住 昌裕, 森 勢伊1973 年 28 巻 5 号 p. 450-455
発行日: 1973/12/28
公開日: 2009/02/17
ジャーナル フリーThe medical records of patients with tuberculosis hospitalized in 1966 and 1967 were investigated retrospectively for the incidence of SMON and the intake of chinoform and other drugs during the same calendar years. Those who were given chinoform for the treatment of abdominal symptoms such as pain and diarrhea lasting for at least a day showed a significantly higher incidence of SMON than those who had similar abdminal symptoms but were treated with other drugs. When the comparison was restricted to those who had had the abdominal symptoms for at least a week, a similar higher incidence of SMON was noted for those treated with chinoform than for those treated with other drugs, but the difference was not statistically significant. It was also demonstrated that five SMON patients whom we observed had been given larger amounts of chinoform than those who had been given chinoform but did not develop SMON. It was remarkable that one patient who had been given more than 200g of chinoform from January to October, 1966, did not develop SMON. None of the 12 drugs used for the treatment of tuberculosis seemed to be associated with the disease.抄録全体を表示PDF形式でダウンロード (838K) -
大山 佳代子, 森田 博行, 長谷川 武志, 小池 重夫1973 年 28 巻 5 号 p. 456-462
発行日: 1973/12/28
公開日: 2009/02/17
ジャーナル フリー体重1kg当り25mgの塩化コバルトを空腹状態のオス家兎に毎日1回3日間注射して肝, 心の脂質ならびに糖質代謝の中間生成物に及ぼす影響を観察した。
塩化コバルト注射によって血糖は顕著に上昇し, 心では空腹によって低下したブドウ糖は増加した。肝では塩化コバルトによる血糖上昇に伴ってブドウ糖は顕著に上昇し, 空腹によって減少したG-6-P, F-6-Pの含有量は増加した。
塩化コバルトによって血漿のトリグリセライド (TG) は空腹群に比べて約4倍増加したが心のTGは増加の傾向を示し, 肝のTGも正常摂食群に比べて増加したが空腹群に比べて有意差はなかった。塩化コバルト注射によって, 空腹状態で上昇した血漿FFAは減少したが正常摂食群に比べると増加していた。
上昇した血漿FFAは肝でエステル化されてTGの合成に消費されたが残りは Ketone 体合成に使われ, コバルト注射群と空腹群との血中のβ-Hydroxybutyrate 量の上昇は同じ程度であった。抄録全体を表示PDF形式でダウンロード (848K) -
佐渡 一郎1973 年 28 巻 5 号 p. 463-476
発行日: 1973/12/28
公開日: 2009/02/17
ジャーナル フリーIn an investigation of the synergistic toxicity of officially permitted preservative food additives, the acute toxicity test and six-months breeding test were used.
Part 1. (Acute toxicity test)
(1) Ten preservatives were chosen from the officially permitted list: (sodium dehydroacetate, sorbic acid, benzoic acid, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, salicylic acid, sodium propionate, furylfuramide…2%, furylfuramide…pure). Mixtures of two additives each were administered orally to dd mice.
(2) Mixtures were made in two ways: eqaul amounts of each ingredient and eqaul LD50 doses of each.
(3) In order to evaluate the synergistic toxicity of the mixtures, the theoretical LD50 values of the mixtures were caliculated.
(4) The toxicity of the mixtures was found not to exceed the theoretical values; i.e., it was not synergistic.
Part 2. (Six-months breeding test)
(1) From the preservatives listed in part 1, furylfuramide…2% (F), sorbic acid (S) and ethyl p-hydroxybenzoate (E) were chosen and administered as single doses and in pairs to SD-JCL rats for 25 weeks.
(2) The amounts administered corresponded to about 1/5, 1/10 and 1/50 of the LD50. The percentages of preservatives in the diet were: (F) 4.0%, 2.0%, 0.4%; (S) 3.0%, 1.5%, 0.3%; (E) 2.0%, 1.0%, 0.2%.
(3) Experimental results.
1) During the experimental period, no significant difference was noted in the general appearence, behavior, food consumption, mortality or mean survival times between the experimental and control groups.
2) The weight gain was normal except for a slight delay in the F4%-E2% group.
3) The red blood cell count hemoglobin, hematocrit and white blood cell count were not affected.
4) The results of biochemical serum tests were as follows: the males in groups F4%, F4%-S3%, F2%-S1.5%, and the females in groups F4%, F2%-S1.5%, F0.4%-S0.3%, F4%-E2% and F2%-E1% showed significantly higher total protein and total cholesterol than the control group.
5) The F4% and F4%-E2% groups tended to have enlarged livers and kidneys, and F4%-S3%, F2%-S1.5% and F2%-E1% groups tended to have enlarged livers only.
6) Pathological examinations showed no abnormal findings either macroscopically or microscopically.
(4) These experiments showed no significant synergistic toxicity in mixtures of the above-mentioned food preservatives.抄録全体を表示PDF形式でダウンロード (9021K) -
I. 明暗交替リズム, 食餌摂取および運動と肝温菊池 正一, 千葉 百子, 吉田 淳1973 年 28 巻 5 号 p. 477-487
発行日: 1973/12/28
公開日: 2009/02/17
ジャーナル フリーA copper-constantan thermocouple was implanted in the livers of male Wistar rats, weighing 150-300g, and the liver temperature was measured for 3-4 weeks in unanaesthetized, relatively unrestrained rats.
Under lighting conditions of LD 12:12, liver temperature was high in the dark period and low in the light period. The temperature curves were of three types, and each rat did not necessarily have the same type of curve during the experimental period.
When the light-dark cycle was reversed, the circadian rhythm of liver temperature adjusted to the new lighting regimen in 5-7 days, during which time each period of the rhythm was prololonged.
It was observed that a temporary rise of liver temperature occurred at feeding time, when the latter was restricted to a few hours. After the controlled feeding time was maintained for several days, the liver temperature began to rise just before feeding time even during a fast of 48 hours.
Variations of liver temperature, on the whole, corresponded to the activity of the animal, but the coincidence was not quite complete when the temperature and the activity were observed more frequently. Moreover, after a phase shift in the light-dark cycle the liver temperature no longer paralleled physical activity.
It was concluded that feeding, activity and the light-dark cycle per se were not direct causes of the circadian rhythm of liver temperature; the rhythm must be endogeneous, the light-dark cycle being a Zeitgeber.抄録全体を表示PDF形式でダウンロード (4442K) -
岩田 弘敏, 小谷 諒夫1973 年 28 巻 5 号 p. 488-491
発行日: 1973/12/28
公開日: 2009/02/17
ジャーナル フリーIn vibration disease there is damage to the peripheral circulation. This paper describes basic experiments which will hopefully lead to a method of determining accurately the degree of injury.
The peak amplitude in the plethysmogram and the skin temperature of the finger were recorded as indices of the dynamics of the peripheral circulation.
The relationship between the skin temperature and the peak amplitude of the plethysmogram at various room temperatures (14.7-25.9°C) was studied after exposure to water (30°, 20°, 10° and 5°C).
The subjects were 39 females between 18 and 38 years of age.
1. The correlation between the skin temperature and the peak amplitude of the plethysmogram was statistically high, except after exposure to 5°C water. The two measurements appeared to reflect the same circulation dynamics.
2. The correlation between either the skin temperature or the peak amplitude of the plethysmogram and the room temperature was statistically high when there was no exposure to water and 10 minutes after exposure to 5°C water. Consequently it is obvious that circulation dynamics are influenced by room temperature.
3. Significant differences of skin temperature occurred when the room temperature was above or below 23°C. Therefore, skin temperatures must be recorded at room temperatures between 20°C and 23°C, when we want to evaluate circulation dynamics with the use of skin temperature, especially when we evaluate the rate of recovery of skin temperature after exposure to water.
4. The ratios of skin temperatures during and after water exposure to that with no exposure were not significantly different at room temperatures between 15° and 25°C. Thus, the ratios of skin temperatures during and after water exposure at these room temperatures to that with no exposure may well be a valuable index of the health of the peripheral circulation.抄録全体を表示PDF形式でダウンロード (549K) -
田中 慶一, 末田 香里1973 年 28 巻 5 号 p. 492-496
発行日: 1973/12/28
公開日: 2009/02/17
ジャーナル フリーカドミウムの体内挙動を検討する目的で肝臓, 腎臓および小腸粘膜の各上清成分とカドミウムの結合を正常ラットおよびカドミウム投与ラットについて検討した。
一群4匹の正常ラットおよび50, 100, あるいは200ppmのカドミウムを含む水を30日間摂取させたラットにそれぞれ109Cd溶液 (5μCi/1.37μg/体重100g) を皮下注射した。24時間後に肝臓, 腎臓および小腸粘膜をとり出し, 各ホモジネートから105,000×g上清分画を得た。各上清分画について SephadexG-75カラムによるゲル濾過を行ない, 溶出液中のカドミウム濃度, radioactivity および254mμにおける吸光度を測定したところ次の結果を得た。
1) ラット肝臓, 腎臓および小腸粘膜の上清分画中にはいずれも分子量5万以上のカドミウム結合成分(fr-1)と分子量約1万のカドミウム結合成分 (fr-2) が存在している。
2) 50, 100あるいは200ppmのカドミウム溶液を投与したラットにおいては, 特に肝臓と腎臓中のfr-2と結合した型でカドミウムが蓄積された。
3) 小腸粘膜上清中のカドミウム結合能はカドミウム投与量が増加しても著明に増大せず, 100および200ppm投与群では遊離カドミウムが検出された。
4) カドミウムの体内蓄積の多少にかかわらず, 新しく体内に浸入したカドミウムは大部分が肝臓のfr-2と結合した。
5) 肝臓, 腎臓および小腸粘膜上清中のカドミウム結合成分は蛋白質であると考えられる。抄録全体を表示PDF形式でダウンロード (544K)
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