巻号一覧
31 巻, 6 号
選択された号の論文の9件中1～9を表示しています
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河合 正計, 丸田 英夫, 上田 喜一, 東条 憲一1977 年 31 巻 6 号 p. 637-643
発行日: 1977/02/28
公開日: 2009/02/17
ジャーナル フリーThis study was designed to evaluate the teratogenetic and reproductive effects of Di-isopropyl naphthalene or Di-arylethane isomer which are being used as substitutes for PCB in the dye stuff solvent in noncarbon paper. The compounds were administered to pregnant mice during six days from the 7th through the 12th day orally by a stomach tube at the dose levels of 192mg/kg and 19.2mg/kg of Di-isopropyl naphthalene and 198mg/kg and 19.8mg/kg of Di-arylethane isomer. And pregnant mice in the second mating period were not treated.
Fetuses form both mating period were removed by cesarean section at the end of the gestation period. Offsprings of both generations were maintained for 42 day safter birth.No effects attributable to the administration of both compounds were observed in parental body weight, survival rates, pregnancy and reproduction data, and in newborn growth data.
Datas obtained from fetuses removed by cesarean section did not reveal any findings which would indicate that both compounds are fetal toxic or teratogenetic when administered to pregnant mice.抄録全体を表示PDF形式でダウンロード (927K) -
児玉 博和, 河村 典久, 太田 秀夫1977 年 31 巻 6 号 p. 644-651
発行日: 1977/02/28
公開日: 2009/02/17
ジャーナル フリーA simple and rapid method for the determination of PCB in human milk and blood using and Improved Essencial Oil Distillator has been developed. The analytical procedure is as follows: 5.0g of sample was put into a boiling flask and then 5ml of 5N-KOH solution and 50ml of refined water were added. The Improved Essencial Oil Distillator was connected with the above flask and distilled for 1hr or 2hrs. After distillation, the n-heptane layer was collected in a small test tube, then 0.1g of activated Florisil was added, stirred for 10sec. and used for gaschromatographic analysis.
Organochlorinated pesticide residues, which inhibited PCB analysis, were treated with alkaline degradation and Florisil adsorption, but PCB decreased only about 5% by this procedure. The recovery rates of PCB added to human milk and blood were 87-93% and 88-105%, res pectively. The comparison of the standard method with this method showed a good result. The merits of this distillation method were low cost, easy procedure in a short time and a good repeatability.抄録全体を表示PDF形式でダウンロード (903K) -
とくに悪性新生物について清水 忠彦1977 年 31 巻 6 号 p. 652-656
発行日: 1977/02/28
公開日: 2009/02/17
ジャーナル フリーThe automobile traffic in Osaka City, Japan, is extremely heavy in recent years. According to an estimate by the administrative organization in 1970, the hydrocarbon output by automobiles in Osaka City (205.6km2) reached 49, 786 tons per year. Therefore, there is a risk of automobile drivers being severely contaminated with air pollutants. A statistical study was therefore made of the cause of deaths of automobile drivers residing in Osaka City during the period of 1963-1967, and also in 1970. Selected as controls were people engaged in other occupations in the same city during the period of 1965-1967. The followings were found by the study.
1) Of a total of 353 deaths, excluding those from accidents, poisoning and suicide, malignant neoplasms accounted for 33.4%, while the neoplasms accounted for 28.3% of the deaths of the control subjects.
2) The classification of the rates of deaths according to the sites of malignant neoplasms disclosed that the death rate from malignant neoplasms of the lymphatic and hematopoietic systems of automobile drivers was 1.6 times as high as that in the control group, and the death rate from lung and liver cancers in automobile drivers was 1.5 times as high as the counterparts in the control.
3) The classification by age disclosed that malignant neoplasms of the lymphatic and hematopoietic systems accounted for a high rate in those under thirty, lung cancer for a high rate in the 40's, and liver cancer also for a high rate in the 40's and the 50's, as compared with their counterparts in the control: thus, there was a tendency for the predilected site to vary according to age group.
4) The classification by the type of occupation showed that the death rate from malignant neoplasms was high in truck drivers and taxi drivers.
5) The noticeable death cause besides malignant tumors was liver disease, the death rate from which was 1.3 times as high as that in the control group.
6) These results emphasize the need for a more intensive research on the etiological factors.抄録全体を表示PDF形式でダウンロード (637K) -
中島 克行, 山西 哲郎1977 年 31 巻 6 号 p. 657-661
発行日: 1977/02/28
公開日: 2009/02/17
ジャーナル フリーThe effect of mouth breathing was studied for the protective method against noxious gas exposure, especially at the sudden accidents with no protective tools.
Ventilatory functions of 22 healthy male volunteers, aged 18 to 36, were examined. The studies were made in normal, nasal and mouth breathing with the bicycle ergometer method.
Oxygen uptake and heart rate per minutes was not significantly different among three different breathings. But respiratory frequency and ventilation volume in mouth breathing showed higher values than those in nasal breathing. This resulted the ventilatory equivalent higher in mouth breathing compared to that in nasal breathing (p<0.05).
The result indicated that the respiratory function in normal or nasal breathing was more efficient among the volunteers than that in mouth breathing alone. This shared the same results with those of mice and rats studied under noxius gas exposure. Possible mechanisms and the application for men were discussed.抄録全体を表示PDF形式でダウンロード (705K) -
阿部 純子1977 年 31 巻 6 号 p. 662-678
発行日: 1977/02/28
公開日: 2009/02/17
ジャーナル フリーPlasma samples of Yusho patients and ordinary persons were analyzed for polychlorinated biphenyls (PCB). The extraction and cleanup of the plasma were performed basically with the method which Jensen had reported with some modifications.
PCB were detected in all of the 762 plasma samples. PCB concentrations in plasma of Yusho patients ranged from 3 to 47ppb in Fukuoka, from 2 to 57ppb in Goto, and those of ordinary persons ranged from 2 to 9ppb in Fukuoka, from 2 to 30ppb in Goto. The mean levels of the patients (9.3ppb in Fukuoka, 14.4ppb in Goto) were higher than those of ordinary persons (4.2ppb in Fukuoka, 8.8ppb in Goto). The majority of Yusho patients showed a peculiar peak pattern in gas chromatogram of plasma PCB, and the PCB concentrations were at high levels in most cases. But PCB in plasma of 15% of the patients were not different from those of ordinary persons both in concentration and in peak pattern. Regional difference and sex difference in PCB concentrations were found. Several ordinary persons with high levels of PCB, over the mean level for patients, were found in Goto. In addition, the peak patterns of PCB in Goto residents were a little different from those in Fukuoka. The children under 15 years old had lower levels of PCB than the older people. Residue levels in plasma seemed not to have varied significantly from 1972 to 1975.
The investigation suggests that PCB still remains in Yusho patients eight years later since the accident, but regarding the concentration, some ordinary persons would have the same degree of PCB in their plasma as patients at present. The following reasons are assumed for the peculiar peak pattern to patients.
1) KC-400 were deformed by heating before were administered.
2) Patients administered a great deal of PCB.
3) Metabolic rates of indivisual PCB compornents are different.抄録全体を表示PDF形式でダウンロード (2373K) -
永田 久紀, 水上 戴子, 有賀 みさか, 石榑 清司, 林 正1977 年 31 巻 6 号 p. 679-686
発行日: 1977/02/28
公開日: 2009/02/17
ジャーナル フリーOn each group of boys or girls in every school year of primary schools and junior high schools in Kyoto city, the joint distribution of height and weight was investigated based on the data in April 1976, and the distribution was compared with that in 1966.
The arithmetical means and standard deviations of height and weight, the correlation coefficient between height and weight, and the regression coefficient of weight on height were calculated (Table 1). Besides, the median, 10th and 90th percentiles of weight distribution in every group of height (1cm in width) were calculated to note the characteristics of the joint distribution more clearly (Fig. 1, Fig. 2, Table 2).
In every group of boys or girls in every school year, the arithmetical means of height and weight, and the standard deviation of weigth in 1976 were greater than those in 1966. But the differences between 1976 and 1966 were negligible as for the correlation between height and weight, and the regression coefficient of weight on height.
For boys in the school year from the second to sixth in the primary school, and for girls in the school year from the third to sixth in the primary school and in the first school year of the junior high school, the median, 10th and 90th percentiles of weight corresponding to the same height were almost the same in 1976 and in 1966, for every group of height.
For boys in the first school year of the primary school and for girls in the first and second school year of the primary school and in the third school year of the junior high school, 90th percentile of weight corresponding to the same height was greater in 1976 for relatively tall children. For boys in every school year of the junior high school, 90th percentile of weight corresponding to the same height was greater in 1976 for every group of height. However, for these groups of school children, the median and 10th percentile of weight corresponding to the same height were almost the same in both years.
For girls in the second grade school year of the junior high school, the median and 90th percentile of weight corresponding to the same height were greater in 1976 for relatively short children. The difference of the form of the joint distribution between 1976 and 1966 seemed to suggest the acceleration of growth since 1966.抄録全体を表示PDF形式でダウンロード (1015K) -
浅野 恭代, 吉本 佐雅子, 勝野 真吾, 阪本 州弘1977 年 31 巻 6 号 p. 687-692
発行日: 1977/02/28
公開日: 2009/02/17
ジャーナル フリーAn analysis was done on the trend of relationship of deaths from tuberclosis with deaths from cerebrovascular, neoplasm and heart disease separately in the period of 1902-1973 in Japan by using the ecologic model for competition with each other.
The results obtained were as follows:
1) There was a close relationship between the decreasing trend of deaths from tuberclosis and the increasing trend of deaths from neoplasm, cerebrovascular, and heart disease separately.
2) The trend of the relationship between deaths from neoplasm and from cerebrovascular disease is gradually increasing to the equilibrium point and it seems that it will decrease after that point.
3) On cross-sectional observation in the period of 1935-1955, the prefecture that had the higher rate of death from tuberclosis had a tendency to have the lower rate of death from cerebrovascular disease and neoplasm.
4) In 1973, it seemed that the prefecture that had the higher rate of death from cerebrovascular disease was also had the higher rate of death from neoplasm.抄録全体を表示PDF形式でダウンロード (631K) -
(2) 高温環境のマウス抗体産生能に及ぼす影響藤田 紘一郎, 月舘 説子, 片山 誠, 菊池 正一1977 年 31 巻 6 号 p. 693-702
発行日: 1977/02/28
公開日: 2009/02/17
ジャーナル フリー近時,冷暖房設備の発達普及と共に急激な温熱環境条件の変化に暴露される機会が増大している。
一方,暑熱に対する体温調節の中枢が存在する視床下部前部の破壊がラットにおいて顕著な抗体産生抑制効果を示すことが知られている。我々は前回の低温環境の実験にひきつづいて,高温環境が視床下部刺激を介して抗体産生に如何なる影響を及ぼすかを調べた。
実験動物としてdd系雄性マウス(体重15 to 17g)を1群10∼12匹として使用し,25°C RH 60%の人工気候室(照明07:00∼19:00の明暗12時間交替)及び湿度,明暗とも同条件の33°C, 35°C, 36.5°C,及び38°Cの人工気候室を使用した。羊赤血球浮遊液(SRC)を腹腔内注射するてとによって抗原刺激とし,免疫反応は脾プラック形成細胞(PFC)の数及び血中抗体について血球凝集反応(HA),血球溶血反応(HR)の測定を抗原刺激後3∼26日間経時的に行ない,次のような結果を得た。
1. 33°Cあるいは35°Cに3週間馴化したマウスは,25°C馴化マウスに比して,抗体産生能に殆んど差異は認められなかった。しかし体重減少の著しい36.5°C馴化マウスはPFC, HA, HRとも免疫反応の全経過を通じて明らかな低下が認められた。
2. 25°C馴化マウスを抗原刺激直後,より高温の環境へ移動した場合の免疫反応もマウスを移動した環境温度の高低により異なる結果を得た。すなわち,33°Cの環境温度にマウスを移動させた場合には,25°C継続群に比し,反応の初期では抗体産生能が増強された。PFCの数は後期において逆に低下が早く,反応全体が前方にずれる傾向がみられた。しかし,35°C, 36.5°C, 38°Cなどの35°C以上の環境温度に移動させた場合には,マウスの抗体産生能は免疫反応の全経過を通じて一様に抑制された。
以上,1. 2.の結果より,マウスの体重増加が遅延する程度の高温度環境では,その温度に馴化した場合も,あるいは抗原刺激後,その環境に移動させた場合も抗体産生が全般的に抑制されるてとが判明した。
3. 高温に馴化したマウスを抗原刺激と共に25°Cに移動させた場合の免疫反応は明確な一定の傾向がみられなかった。すなわち,33°Cから25°Cに移動したマウスのHA, HRは33°C継続群に比べ低下する傾向がみられたが,36.5°Cからの移動群のPFCは36.5°C継続群に比べ促進する傾向がみられた。
4. 免疫反応に最も影響を与えるような環境温度の変化が,25°C及び33°C馴化マウスを用いて調べられた。25°Cから33°Cの変化に際しては,環境温度を変化させた後3日目に抗原刺激を与えるてと,また33°Cから25°Cの移動の場合には移動後1日目に抗原刺激を与えるてとがそれぞれ最も影響が顕著になるてとが観察された。
5. 25°C馴化マウスを抗原刺激後,36.5°Cあるいは8°Cに午前,午後各1時間ずつ暴露したマウスの抗体産生はいずれも25°C継続群に比べ,はっきりとした差は得られなかった。抄録全体を表示PDF形式でダウンロード (1174K) -
特にCase-control-studyによる大気汚染,職業因子,喫煙についての分析江崎 廣次, 張 正博1977 年 31 巻 6 号 p. 703-710
発行日: 1977/02/28
公開日: 2009/02/17
ジャーナル フリー大牟田市を中心に,肺癌死亡の統計的観察ならびに肺癌死亡者およびそれと1:1の割合でmatchさせたcontrolをとり,case-control-studyを245組について実施し,次の結果を得た。
1. 大牟田市は全国平均,近接市郡の久留米市,大川市および三潴郡にくらべて肺癌死亡が有意に多い。
2. 大気汚染を考慮した居住歴と肺癌死亡との間に,有意の関係を認め得なかった。
3. 喫煙との関係では,肺癌死亡者に男女とも多量喫煙のものが有意に多かった。
4. 肺癌死亡者に多い職種は,コークス製造作業,製錬作業および自動車運転手などであった。
以上のことから,大牟田市肺癌死亡の多い原因が有害職種によることが明らかになったが,さらにこれら有害職種の退職者についての追跡調査を試みたいと思う。抄録全体を表示PDF形式でダウンロード (840K)
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