日本衛生学雑誌
Online ISSN : 1882-6482
Print ISSN : 0021-5082
ISSN-L : 0021-5082
31 巻, 3 号
選択された号の論文の8件中1~8を表示しています
  • 倉山 令子, 中村 功, 滝沢 行雄
    1976 年 31 巻 3 号 p. 393-398
    発行日: 1976/08/31
    公開日: 2009/02/17
    ジャーナル フリー
    This is a report of the dynamic aspects of the selective accumulation of mercury binding protein in the kidney and liver from mice injected with HgCl2. Mercury present in the kideny and liver was bound to the low (M.W. about 10, 000) and high molecular weight fractions of supernatant on Sephadex G-75.
    At the start after dosing, a large amount of mercury in the kidney was bound to the high molecular weight protein, while mercury in the liver bound almost bisectionally to the both low and high molecular weight proteins. Mercury of the low molecular weight fractions of the kidney and liver increased gradually with time.
    In the mice repeatedly exposed, amount of mercury in the kidney increased in the low molecular weight fraction, but the distribution of mercury binding protein of the liver remained almost unchanged.
  • 森 忠繁, 大本 美彌子, 石見 敦子, 大羽 和子, 明石 信爾
    1976 年 31 巻 3 号 p. 399-403
    発行日: 1976/08/31
    公開日: 2009/02/17
    ジャーナル フリー
    It is well known that water colours and poster colours are made of inorganic pigments that then contain metals such as Cr, Pb, Fe, Co, Cd, Hg etc.. Recently, promoting the culture of sentiments, children practice painting with their fingers using water colours and poster colours, that is called the finger-painting. It is possible that inorganic metals contained in water colours and poster colours are potentially hazardous to children who practice painting in a private school. Each of four colours of red, blue, yellow and green of water colours and poster colours was analyzed for Cr, Pb, Fe, Co, Cd and Hg. And urinary Pb and Cd were determined on twenty five children, ages 4 to 11 of a private school of the painting and five control children ages 3 to 11. The following results were obtained.
    1) On the whole, water colours and poster colours contained a large quantity of Fe and Pb next to Fe. Especially yellow-2 of water colours contained a large quantity of Pb and showed 1, 012.5μg/g. The dissolved lead was found in water colours that were in lead tubes.
    2) The average of urinary Pb of tested children was 6.07±6.67μg/l(n=15), and that of control children 2.20±2.59μg/l(n=5). There were not significant difference at levels of 5% between the mean of subjects and that of the control.
    3) The average of urinary Cd of subjects was 0.68±0.94μg/l(n=25), and that of the control 0±0μg/l(n=5). There were not significant difference at levels of 5% between the mean of subjects and that of the control.
    4) The coefficient of correlation between experimental length in years and urinary Pb was 0.98, its regression line being yPb=3.18x+2.17(±2.92) as yPb for urinary Pb and x for experimental length in years.
    5) The coefficient of correlation between experimental length in years and urinary Cd showed 0.91, its regression line being yCd=0.23x+0.11(±0.25) as yCd for urinary Cd and x for experimental length in years.
    6) The coefficient of correlation between ages and urinary Pb was 0.10, and that between ages and urinary Cd was 0.72. Urinary Cd was apt to increase in proportion to ages.
  • 日本の気候下に於ける一般市民日本人と白人の血清の基礎代謝の季節変動
    陳 澄雄
    1976 年 31 巻 3 号 p. 404-416
    発行日: 1976/08/31
    公開日: 2009/02/17
    ジャーナル フリー
    日本人には基礎代謝の季節変動がみとめられているが,白人ではこれがみられないとの説もある。当教室の吉田は日本の気候下における白人と日本人の基礎代謝季節変動について,佐世保に駐留する海上自衛隊員と米海軍海兵隊員を対象として比較実験を行ない,両対象群ともその基礎代謝に季節変動のある事を確認し,既に当誌に発表した。
    しかしこれは集団生活で,戸外活動の激しい軍隊という特殊な条件下での場合であったので,今回我々は長崎に在住し食生活,生活様式の点で日本の市民に近いと考えられる白人を対象として,この点を追求する実験を行なった。白人被験者は長崎に在住する教員,神父であって,その日本在留期間は3年以上の5名と1年未満の5名計10名だった。そして対象群の日本人群は長崎出身の当教室員や医学部学生計10名だった。実験期間は1972年7月より1年間に亘り行なった。
    本実験の成績から以下の事が結論される。
    1) 西日本(長崎市)の気候下では白人にも,その基礎代謝に季節変動がある。両群とも外気温,室温と極めて強い相関性を示し,共に冬高夏低一峰性を呈した。
    2) 日本滞在期間の短い(1年未満)白人では長い者(3年以上)に比べて,その基礎代謝の向寒期の上昇がより速かで大きい傾向があり,気候への反応が激しい事がうかがわれる。
    3) 呼吸商は年間平均日本人0.816,白人0.826で両群に差はない。また白人でも日本滞在期間の長い者の呼吸商は短い者のそれより高い傾向がある。これは日本に移住した白人被験者達の食生活が,なかでも脂肪摂取において日本人とほとんど相異のないことを示唆している。
  • 日本に居住する一般職種の日本人と白人の血清蛋白結合ヨードの季節変動
    槌本 六良
    1976 年 31 巻 3 号 p. 417-432
    発行日: 1976/08/31
    公開日: 2009/02/17
    ジャーナル フリー
    長崎市に在住する一般職業人の白人10名と日本人(教室員)10名について,1972年6月から1973年7月まで毎月1回血清蛋白結合ヨードの測定をした。その結果は次の如くであった。
    1) 長崎市の気候下でも,白人の血清PBI濃度に日本人と同様な夏低冬高の一峰性の季節変動を確認した。白人の冬の血清PBI濃度は日本人のそれより有意に高かった。これは冬の白人の居住室温がたまたま4°C低かったためと考察した。
    2) 白人のあいだでも,日本気候下に滞在した年数の違いで,その血清PBI濃度の季節変動の様相が異なった。つまり滞在年数の1年未満群は3年以上群に比べて気候の激変季の秋と春に血清PBIの変化が激しい傾向であった。これは両白人群の日本気候下での順応程度の違いによったものと考察した。
    3) 血清PBI変動率とBMR変動率との間に周知の有意な正相関性を確認した。その回帰係数は白人に有意に大きかった。またPBIとBMRとの関係における両値の逐月推移で白人,日本人ともに,夏から冬に向けてPBIがBMRに先行上昇し,冬から夏に向けてはPBIが先行低下し,PBIとBMRの増減に時相のずれを観察した。
    4) 血清PBI濃度と環境温度との関係においては,日本人,白人ともに有意な高い負の相関性を認め,環境温度でも居住室温の方が外気温よりも相関性が高い傾向にあった。またこの関係について,年間を向寒期と向暖期の2期に分けて見ると,環境室温が同じでもPBI濃度は向寒期に高い傾向であった。
    5) 血液水分にも季節気候にともなう変動が,白人にも日本人同様に認められた。
  • 日本の気候下に於ける一般市民日本人と白人の血清の遊離脂肪酸の季節変動
    阿賀 倶子
    1976 年 31 巻 3 号 p. 433-444
    発行日: 1976/08/31
    公開日: 2009/02/17
    ジャーナル フリー
    先に陳・槌本が報告したBMRと血清PBIに関する研究と併行して,同じ日本の気候に曝露される日本人10名と,白人10名の被検者について,血清遊離脂肪酸(FFA)濃度を1972年6月から毎月1回1年間にわたりItaya-Ui変法を用いて測定した。
    (1) 血清FFA値の年間平均値には日本人と白人の間に差がなかった。これは教室の山口の米軍人と日本自衛隊員と比べて前者が有意に高かったという報告とは異なる結果である。そして白人のFFA値は1, 2月の厳冬期に日本人に比べて低く,かつこの季に大きく低下する動きを示し,その年間変動率(49.6%)は日本人(25.2%)よりも有意に大きかった。この点も山口の結果とは逆であった。また白人でも日本に移住して間もない者の寒期の低下は著しかった。
    (2) FFA値とBMR値とは,日本人では有意の正相関を呈したのに対し,白人では負の相関傾向を示した。両計測値を各個人の平均に対する各月の変動率でみると白人の負の相関係数は有意であった。また季節別にみると,夏期のFFA値とBMR値との関係は日本人,白人とも正相関の傾向にとどまるが,冬期には日本人は正相関傾向を示すのに反して白人では有意の負の相関を示した。
    山口は冬の居住気温が日本人で10°Cも低かった事が主因となって,日本人の方がより強く寒冷に順応されたものと解しているが,(1), (2)の結果を綜合すると,本研究では逆に白人被験者の方が強く寒冷に順応したものと解される。したがってFFA値の水準や季節変動には人種的な差はなく,その寒冷期の居住環境が大きく関与すると推論された。血清PBI値とFFA値とは両群とも負の相関傾向を呈した。血清FFA値と基礎代謝の呼吸商(RQ)の間に年間を通じて有意ではないが負の相関傾向がみられた。
  • I まぐろ投与猫に於ける生体試料中水銀濃度と末梢血リンパ球異常染色体発現とのDose-Response Relationship
    白水 美智子, 賀来 俊輔, 下條 信弘, 佐野 憲一, 山口 誠哉
    1976 年 31 巻 3 号 p. 445-452
    発行日: 1976/08/31
    公開日: 2009/02/17
    ジャーナル フリー
    A positive correlation between the amount of mercury contaminated tuna intake and the amount of mercury in the human scalp hair has been observed in both the epidemiological and the experimental studies, and also the evidence showed the positive dose-response relationship between the amount of intake of methyl mercury incorporated in mercury contaminated fishes and the concentration of mercury in blood samples. However, other problem for health effects of long-term tuna diet has not been obvious.
    In order to determine the health effects of long-term tuna diet, the cats fed with tuna meat in this experiment for more than two years have been observed for the accumulation of mercury in vaious organs and related health effects including the numerical aberration of lymphocyte chromosome.
    The experimental cats were divided into two groups according to the mercury levels in the tuna. The first group were given tuna of mercury level 0.665ppm, and the second group were given tuna of mercury level 0.995ppm.
    A comparison was made on the concentration of mercury in the biological specimens between control and experimental groups, and the mercury levels in the experimental groups were obviously higher than those in the control group. Also, the cats in the second group showed more frequent and significant symptoms than those of the first group.
    The percentage frequences of the numerical aberration of lymphocyte chromosome in the control group, the first group and the second group were 3.62, 29.3 and 62.5%, respectively. The difference in each group was statistically significant.
  • 山口 正義, 山本 丈夫
    1976 年 31 巻 3 号 p. 453-456
    発行日: 1976/08/31
    公開日: 2009/02/17
    ジャーナル フリー
    The effect of tin on gastric secretion in rats was examined. The volume, acidity, and total acidity of gastric contents showed a remarkable reduction in rats administered orally with tin (3.0mg/100g body weight) during 3 days. Also, acidity and total acidity of gastric contents in rats that had fasted for 24 hours significantly decreased 6 hours after a single oral administration of tin (3.0mg/100g). An oral administration of tin to rats that had fasted for 24 hours diminished the acidity and total acidity of gastric contents with the three dose (1.5, 3.0 or 5.0mg of Sn/100g) of tin employed, while did not alter the volume. On the other hand, the volume, acidity, and total acidity of gastric contents in rats that had fasted for 24 hours significantly reduced 1 hour after a single intraperitoneal injection of tin (3.0mg/100g), while it had no effect after 6 hours of fasting. The present study indicates that tin inhibits gastric secretion of rats.
  • 第一報 旧土呂久鉱山従業員及び住民の健康被害
    太田 武夫, 柳楽 翼, 五島 正規, 小河 孝則, 畝 博, 大橋 邦和
    1976 年 31 巻 3 号 p. 457-464
    発行日: 1976/08/31
    公開日: 2009/02/17
    ジャーナル フリー
    There was an old mine in the Toroku district in Miyazaki Prefecture, where the yields were arsenic, lead, tin, zinc etc. Arsenic ore had been mined and refined until 1962.
    The miners suffered from verious diseases caused by occupational hazards, because they were assumed to have worked under very poor and deleterious conditions. The residents living in the vicinity of the mine likewise suffered through the ecological cycle caused by the environmental contamination: water pollution, contamination of crops and other products.
    After mass examination provided by the Prefectural Government in 1974, the National Government recognized the district officially as “polluted district by arsenic” and the forty-eight persons who had air and worked or lived there as “the patients with chronic arsenic poisoning”.
    Many residents have, however, protested against this Governmental conclusion as insufficient, because the poisoning was diagnosed simplly from the limited symptoms such as nasal perforation, skin eruption and pigmentation, and several other severe symptoms were excluded.
    The authors performed an epidemiological survey including medical examination of 104 persons, 37 males and 67 females, in October 1974. The residents of the area near the Toroku district were examined and used as controls.
    The results were as follows:
    1) Many persons among the residents of the district had complaints such as headache, general fatigue, sleeplessness, emaciation, disturbance of vision, conjunctival hyperemia, epihora, nasal hypersecretion, huskiness, cough, sputum, wheeze, palpitation, abdominal pain, low back pain, stiffness on their shoulders, myalgia in their upper limb and so on. Arsenic eruption and hypoesthesia of their extremities were also observed.
    2) The authors suggested that health hazards mentioned above were not caused only by arsenic but also by sulfer oxide and other metals such as lead, zinc and tin.
    3) The authors pointed out that the measures by the central and local governments were not sufficient to provide medical and health care for the sufferers in that district.
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