巻号一覧
33 巻, 3 号
選択された号の論文の9件中1～9を表示しています
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田口 徹也, 鈴木 庄亮1978 年 33 巻 3 号 p. 467-473
発行日: 1978/08/30
公開日: 2009/02/17
ジャーナル フリー飲水とともにCd (100ppm) を1, 3, 6, 9, 32, 96日間継続投与したラットの小腸粘膜を剥ぎとり, その上清分画をゲルろ過し (G-75 Sephadex), 次の結果を得た。
1) Cd経口投与により, 小腸管壁中にとり込まれたCdの大部分 (2/3) は, その粘膜にとり込まれたものであり, 粘膜内ではその2/3が細胞質中に分布していた。
2) 剥ぎとった小腸粘膜上清分画を Sephadex G-75のカラムに添加すると, Cd投与1日群ですでに, elution factor 2.2 (分子量約8,700) の位置にCd peak がみられた。
3) 肝臓および小腸粘膜の上清分画中のCdは同じ結合状態を示したが, 両Cd結合蛋白質誘導産生に log period の存在することより, 小腸粘膜上皮細胞内においてもCd結合蛋白質が誘導産生されることが示唆された。
4) 小腸粘膜上皮細胞中に存在するCdの大部分は分子量約8,700の蛋白質と結合した状態で存在しており, 他の形体ではほとんどCdが存在しないことより, このCd結合蛋白質がCdの吸収に重要な役割をはたしていることが示唆された。抄録全体を表示PDF形式でダウンロード (901K) -
清水 英佑, 林 和夫, 竹村 望1978 年 33 巻 3 号 p. 474-485
発行日: 1978/08/30
公開日: 2009/02/17
ジャーナル フリーHydrazine and its derivatives are widely used in industrial, agricultural and medical fields, but they also exist in nature, for example, in the mushroom or tobacco and tobacco smoke. Therefore, it is important to investigate the mutagenic and carcinogenic effects of hydrazine derivatives.
The microbial mutagenicity of 26 hydrazine compounds were tested with Salmonella typhimurium TA98, TA100 and TA1537 in the presence or absence of S-9 Mix. Eighteen of these 26 compounds were already found to be carcinogenic, but the carcinogenicity of 8 of these compounds are yet unknown.
1) Five carcinogenic compounds, such as 2-hydroxyethylhydrazine, butylhydrazine oxalate, phenylhydrazine HCl, beta-phenylethylhydrazine sulfate and p-tolylhydrazine HCl, were found to be mutagenic to TA100 with and without S-9 Mix, and 2 of these compounds, hydrazine hydrate and hydrazine sulfate, were mutagenic to TA100 only in the presence of S-9 Mix.
2) 2, 4-Dinitrophenylhydrazine and p, p'-oxybisbenzendisulfonylhydrazide, the carcinogenicity of which is unknown, were mutagenic to TA100 with and without S-9 Mix.
3) Phenylhydrazine HCl, p-tolylhydrazine HCl and 2, 4-dinitrophenylhydrazine were mutagenic to TA1537 with and without S-9 Mix.
4) Phenylhydrazine HCl and p-tolylhydrazine HCl were mutagenic to TA98 with S-9 Mix, while 2, 4-dinitrophenylhydrazine showed mutagenic activity to TA98 with and without S-9 Mix.抄録全体を表示PDF形式でダウンロード (2175K) -
永松 国助, 城戸 靖雅, 浦久保 五郎, 会田 喜崇, 池田 康和, 鈴木 康雄1978 年 33 巻 3 号 p. 486-496
発行日: 1978/08/30
公開日: 2009/02/17
ジャーナル フリーモルモットを用いて113Sn-トリフェニルスズアセテート(113Sn-TPTA) の経皮吸収を検討した。投与1日後および2日後に投与量の3.04%および7.97%が経皮的に吸収され, 16.3%および12.4%が塗布部位に残留していた。
113Sn-TPTAを皮下投与すると, 注射部位からの吸収は緩徐に進み, 吸収された放射能の多量が肝, 腎, 脳中に分布した。生体に残留する放射能は9.4日の半減期で減衰し, 一方投与量の83%が20日間に糞中に排泄された。
113SnCl4を皮下注射すると骨, 腎に最高の放射能濃度が認められ, 脳への移行は認められなかった。注射部位からの吸収, 排泄は極めておそく, その主排泄経路は尿であった。生物学的半減期は26.5日であった。
113Sn-TPTAの皮下注射後, 糞中に113Sn-トリフェニルスズ, 113Sn-ジフェニルスズ, 113Sn-モノフェニルスズを同定した。抄録全体を表示PDF形式でダウンロード (1623K) -
その代謝および吸収と排泄について佐藤 稔1978 年 33 巻 3 号 p. 497-505
発行日: 1978/08/30
公開日: 2009/02/17
ジャーナル フリーThe male rabbits were exposed to 20ppm of acrylonitrile for 8 hours a day, once a week for 8 continuous weeks, during which the daily amounts of free acrylonitrile and thiocyanate excreted in urine were measured. The activity in the acrylonitrile metabolism was also determined as the amounts of cyanide and thiocyanate formed after the addition of acrylonitrile in the extirpated liver homogenate of those rabbits.
In another experiment, to investigate the distribution in the tissues and the excretion of the substance, 14C-acrylonitrile was administered once to rabbits subcutaneously, and 14C radioactivities were determined by liquid scintillation counting.
1) The excreted amount of free acrylonitrile in urine increased at every exposure from the 1st to the 3rd time, and after the 4th an equilibrium state was reached by the exposure of 20ppm of acrylonitrile once a week, repeatedly.
2) The excreted amount of thiocyanate in urine increased about sixfold in the 1st acrylonitrile exposure, then decreased a little the 2nd time, and thereafter reached an equilibrium state.
3) The activity in the acrylonitrile metabolism of the liver (measured as mentioned above) was lowered during the 1st, 2nd and 3rd exposures.
4) The amount of thiocyanate accumulation in the liver also decreased during the 1st, 2nd and 3rd exposures.
5) Experiment of subcutanious 14C-acrylonitrile injection revealed that an insoluble acrylonitrile complex, inseparable by boiling with acid, remained within the blood and tissues even 48 hours after the administration.
Most of the acrylonitrile was metabolised to some soluble substances (most of them was thiocyanate), and consequently about 90% of injected acrylonitrile was excreted in urine as such metabolites.
6) From the above results, it is considered that part of acrylonitrile absorbed in the body is combined strongly with the tissues by the cyanoethylation and this combined complex brings about inhibition of enzyme activity, etc., lowering the metabolism of acrylonitrile.抄録全体を表示PDF形式でダウンロード (1419K) -
吉村 健清, 廣畑 富雄1978 年 33 巻 3 号 p. 506-511
発行日: 1978/08/30
公開日: 2009/02/17
ジャーナル フリーIn order to determine the availability of medical records for epidemiological study, questionnaires were sent to all the medical and surgical wards of hospitals in Kyushu, Japan in 1968. Questions included items on storage and retrieval systems of medical records, and description of information available for epidemiological study.
Eleven hundred and twenty-two questionnaires out of 1, 321 were returned and analyzed. Three hundred and forty-two (30.5%) of medical and surgical wards have kept their medical records for 10 years or more. Only 120 (10.7%) had medical record librarians. Almost none of the hospitals had adopted the unit file system. Five hundred and twenty one (46.4%) wards out of 1, 122 had some kind of indices. Name indices and discharge date indices were common in the wards where the indices were compiled.
Information for follow-up was recorded routinely on the medical records, i. e., 271 (24.2%) wards for permanent address, 354 (31.6%) wards for address of family or relatives. However, medical findings of x-ray, E. C. G., etc., were well described on the records.
In summary, it would not be easy to obtain information from medical records preserved in hospitals for epidemiological study, because of short-term custody of medical records, lack of suitable management systems for medical records, incompleteness of retrieval systems and lack of follow-up information. Recently it is well recognized by workers in medical areas, however, that management of medical records should be improved, not only for medical research but also for hospital management. Therefore, in the near future, the information from medical records could be fully utilized.抄録全体を表示PDF形式でダウンロード (1241K) -
三好 保, 棚田 成紀, 坊木 佳人1978 年 33 巻 3 号 p. 512-520
発行日: 1978/08/30
公開日: 2009/02/17
ジャーナル フリーThe static adsorption of methyl disulfide on twenty kinds of adsorbents was investigated by a gravimetric method in order to obtain some fundamental information on deodorization of methyl disulfide gas. The adsorption of activated carbon No. 4 with the highest adsorptive capacity was expressed by Dubinin-Astakhov's equation (n=2). It may be concluded that the amount of methyl disulfide adsorbed and the rate of adsorption depend mainly on micropore volume (r<15Å) rather than on other properties such as pH, pKa, basic amount, and surface area. Regarding good application of Dubinin-Astakhov's equation to adsorption isotherm on activated carbon No. 4, its heat of adsorption (14∼21kcal/mol), and its amount chemisorbed (4∼5%), it seemed likely that methyl disulfide was held by physical adsorption in its micropores.抄録全体を表示PDF形式でダウンロード (1925K) -
第1報 ピーク値が高い場合山村 晃太郎, 高橋 清久1978 年 33 巻 3 号 p. 521-527
発行日: 1978/08/30
公開日: 2009/02/17
ジャーナル フリーAudiometrically normal, male students (8-9 persons) were exposed to several intermittent and steady-state noises (90 minutes), then TTS growth and saliva cortisol levels were measured.
The results were;
1) There was no significant difference between the TTS induced by intermittent noises (On Fractions 5% and 10%) and that induced by steady-state noises whose sound levels were 3 or 7dB (A) lower than the equal energy noises.
2) The TTS induced by intermittent noises of On Fraction 25% was midway between that induced by steady-state noise at the same level as that of the equal energy noise, and TTS induced by steady-state noise whose level was 4dB (A) lower than that of equal energy noise.
3) The TTS induced by intermittent noise of On Fraction 50% was neary the level of that induced by steady-state noise whose level was the same as that of equal energy noise.
4) Sixty or ninety minutes after the onset of noise exposure, the saliva cortisol levels were lower than pre-exposure levels of the hormon for most of the experimental groups.
5) Thirty minutes after the onset of noise exposure, the saliva cortisol levels rose under exprimental conditions in which the sounds levels were 80 and 84dB (A), but under other experimental conditions the saliva cortisol levels decresed.抄録全体を表示PDF形式でダウンロード (1297K) -
稲益 建夫, 石西 伸, 児玉 泰1978 年 33 巻 3 号 p. 528-537
発行日: 1978/08/30
公開日: 2009/02/17
ジャーナル フリーHealth examination was carried out on subjects (2 males and 5 females) who used arsenic containing hot water from the geothermal power station in Kyushu, Japan. They used the hot water only to take a bath over 4 years. The arsenic concentration measured by the atomic absorption method after generating AsH3 was 3.53μg/ml in the hot water. Waste water from the bath drained into a brook at the backyard and arsenic concentration in the brook were 0.54, 0.03 and 0.01μg/ml at the points of 0, 200 and 600m from the outlet, respectively.
A special health examination was carried out on the following items: 1) Physical examination by doctors (dermatologist and general physician) 2) blood examination 3) urine analysis 4) biochemical and enzymological serum examination by SMA-12 5) determination of arsenic in urine and hair.
Arsenic concentration in urine measured 3 times per day for each subject ranged from 58 to 178μg/l and it was within normal range, Arsenic concentration in hair was higher than normal range: the highest was 5.2μg/g, and for 5 of 7 subjects it was over 1μg/g. The result was suspected to be responsible for exogenous contamination such as washing of hair by hot water containing arsenic. There were no particular findings related to the arsenic poisoning.
It must be emphasized that special attention should be paid to prevent the environmental popllution and health hazard caused by the hot water from geothermal power stations.抄録全体を表示PDF形式でダウンロード (2129K) -
辻 達彦1978 年 33 巻 3 号 p. 538-568
発行日: 1978/08/30
公開日: 2009/02/17
ジャーナル フリーPDF形式でダウンロード (7617K)
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