巻号一覧
40 巻, 4 号
選択された号の論文の6件中1～6を表示しています
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御輿 久美子1985 年 40 巻 4 号 p. 745-755
発行日: 1985/10/30
公開日: 2009/02/17
ジャーナル フリーWistar male rats (21 days-old at the start) were administered drinking water containing 0 (control), 1, 2.5 or 5ppm of cadmium respectively, for 25 weeks. All four groups were given a normal diet MF (ORIENTAL YEAST Co., LTD.). After the administration of cadmium, the femurs and the humeri were dissected out and used for mechanical strength tests. Ultimate strength, elasticity and fracture strain were measured under compressive, bending and torsional loadings. A hematological test, determination of Alp activity, NPN, BUN, calcium, phosphorus and iron levels in the serum, calcium, phosphorus and cadmium determinations in the tibia and cadmium determinations of the liver and kidney cortex were also done.
There was no decrease in bone strength nor any anemia in the 1 and 2.5ppm groups.
In the 5ppm group, the ultimate strength of the compressive, bending and torsional loadings decreased compared with the control group. There was a decrease in serum iron, but anemia was not observed. A slight decrease in serum Alp activity, NPN, BUN and calcium levels were also observed. The calcium and phosphorus levels in the tibia did not vary in the 5ppm group. Cadmium concentrations were 136.0±26.0ng/g dry weight of the epi- and meta-physes of tibia, 69.3±17.8ng/g dry weight of the diaphysis of tibia, 10.01±2.43μg/g dry weight of the liver and 30.23±4.52μg/g dry weight of the kidney cortex in the 5ppm group.抄録全体を表示PDF形式でダウンロード (1382K) -
牧野 茂徳, 大森 正英, 青山 政史, 宮田 昭吾1985 年 40 巻 4 号 p. 756-762
発行日: 1985/10/30
公開日: 2009/02/17
ジャーナル フリーThe purpose of the present study was to investigate the annual changes of coefficient variations of live birth weight and proportion of live birth weight from 1969 to 1981 in Japan, to clarify annual changes in the distribution of live birth weight. These analyses were done using vital statistics compiled by the Japanese government.
The coefficient variations of live birth weight have declined annually from 1969 to 1976 and then increased slightly in the following years.
The proportion of newborns with live birth weight less than 1.0kg decreased from 1969 to 1974 and then increased somewhat in the following years.
The proportion of newborns with live birth weight less than 1.5kg, less than 2.0kg and less than 2.5kg decreased from 1969 to 1976 and then increased somewhat in the following years. Conversely, the proportion of newborns with live birth weight more than 4.0kg increased from 1969 to 1976 and decreased in the years following.
The coefficient variations of live birth weight were affected by the proportion of low birth weight infants.抄録全体を表示PDF形式でダウンロード (860K) -
長期飼育によるリポおよびアポ蛋白の変動小川 博, 福島 晋一, 笹川 祐成1985 年 40 巻 4 号 p. 763-773
発行日: 1985/10/30
公開日: 2009/02/17
ジャーナル フリーIn our previous paper, we reported that long-term feeding of high-fat and-cholesterol diet (HFC diet) suppressed the development of severe hypertension and reduced the incidence of stroke in stroke-prone spontaneously hypertensive rats (SHRSP). Very little is known, however, about the role of lipo-and apoproteins in relation to the reduction of strokes in SHRSP, although it is evident that long-term feeding of the HFC diet drastically changes the distribution of lipo-and apoproteins. Thus, it is useful for elucidation of the mechanism to investigate the changes in lipo-and apoproteins induced by long-term feeding of the HFC diet. In this paper, we examined the changes of lipo-and apoproteins by long-term (6 months) feeding of HFC diet to SHRSP (HFC-SHRSP) and Kyo: Wistar rats (HFC-WKY). SHRSP (C-SHRSP) and WKY (C-WKY) fed normal diets were used as controls.
The concentrations of total cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL)-cholesterol in C-SHRSP increased with age during the experimental period, while those of C-WKY were almost constant. Heparin-Sepharose affinity chromatography suggested that the increase of HDL-cholesterol in C-SHRSP was probably due to an age-related increase of HDL rich in apo A-I (apo A-I HDL).
In HFC-WKY, a decrease of HDL accompanied by a rapid increase of serum TC were observed after about 1 month on the HFC diet, then HDL increased to the same level or higher with prolonged feeding of the HFC diet in comparison with that of C-WKY. The increase of HDL seemed to be due to the increase of HDL rich in apo E (apo E HDL) including HDLc. β-lipoprotein also increased gradually with prolonged feeding.
In HFC-SHRSP, the development of severe hypertension was partially suppressed and the incidence of stroke was reduced in comparison with C-SHRSP as reported previously. But, there was no increase of HDL as was seen in HFC-WKY, which was associated with the low content of both apo E HDL and apo A-I HDL. Moreover, the production of HDLc was much less than that in HFC-WKY. On the other hand, there was a remarkable increase of β-lipoprotein associated with a large increase of apo B.
These changes suggest that different pathways of lipoprotein metabolism (presumably β-pathway of VLDL) might be accelerated and maintained by hypertension in HFC-SHRSP. Therefore, it seems to be reasonable that this accelerated atherogenic condition, contrary to our expectation, would attenuate severe hypertension and protect cerebral arteries from necrosis, which may result in the reduction of strokes.抄録全体を表示PDF形式でダウンロード (4712K) -
吉村 武, 三好 保, 今木 雅英, 田村 隆教1985 年 40 巻 4 号 p. 774-780
発行日: 1985/10/30
公開日: 2009/02/17
ジャーナル フリーThe purpose of this study is to make clear a comprehensive relationship between activity and fraction ratio of serum γ-GTP and serum vitamin C. Futhermore, the effects of large doses of vitamin C on activity and fraction ratio of serum γ-GTP were examined.
1) In an epidemiological study, no significant correlation was found between serum total γ-GTP activity and serum vitamin C in healthy young volunteers (178 men and 39 women excluding habitual users of alcohol).
However, high inverse correlations were found between fraction ratio of γ-GTP (1) and serum vitamin C in young men and women. For men, the correlation between fraction ratio of γ-GTP (1) and serum vitamin C conformed to Y=-0.06X+4.29 (N=178 r=-0.582 p<0.01), while that between fraction ratio of γ-GTP (1) and serum vitamin C conformed to Y=-0.06X+4.30 (N=39 r=-0.433 p<0.01) in women.
2) In a laboratory study, we administered vitamin C at a dose of 1g/day for 10 days and then at a dose of 10g/day for 10 days to six subjects, but found no significant difference between serum total γ-GTP activity before and after treatment. However, fraction ratio of γ-GTP (1) levels of all subjects tended to decrease during the administration of large doses of vitamin C.抄録全体を表示PDF形式でダウンロード (759K) -
ケース・コントロール・スタディー長橋 捷, 山崎 信行, 大井 玄, 甲斐 一郎, 鈴木 久乃, 早川 和雄, 長廻 紘, 木村 健1985 年 40 巻 4 号 p. 781-788
発行日: 1985/10/30
公開日: 2009/02/17
ジャーナル フリーTo see the role of dietary fiber (DF) in the pathogenesis of diverticular disease of the colon, we conducted a case control study at two urban (T and W) and one rural (J) hospitals. Fiftyone subjects with colonic diverticulosis (aged 62.3±8.8 years) were compared with 64 control subjects (60.5±7.4 years), regarding daily consumption of nutrients.
The study group consumed significantly less DF than the control group (14.0±4.0g/day, 16.4±5.6g/day respectively, p<0.05) at the urban hospitals. The same tendency was also noted at the rural hospital, but there was no statistically significant difference. The difference in DF intake between study and control groups was derived mainly from DF in vegetables.
Our findings support the hypothesis that DF acts as a protective factor in the formation of colonic diverticulosis.抄録全体を表示PDF形式でダウンロード (972K) -
逢坂 文夫, 春日 斉, 杉田 稔, 松木 秀明, 三宅 健1985 年 40 巻 4 号 p. 789-795
発行日: 1985/10/30
公開日: 2009/02/17
ジャーナル フリーA survey of respiratory symptoms and housing environment using ATS-DLD questionnaire (published by the Environment Agency of Japan) and measurement of Mite IgE value in serum according to the RAST method were carried out from June to July, 1984 among elementary school children (766) in Suginami Ward, Tokyo. The relationship between allergic status or housing environment (family smoking habits) of the children and the proportion of their Mite IgE positivity (grade 2 or higher) was studied. The following results were obtained.
1. The proportion of positive Mite IgE was significantly higher for those with heavy-smoking mothers than for those with no smokers in the family, with smokers except for the mothers or with light-smoking mothers.
2. Among the subjects with allergic history, the proportion of positive Mite IgE was high regardless of the smoking of the mother. Among those without allergic history, on the other hand, the proportion of positive Mite IgE was significantly higher for the subjects with smoking mothers than for those with non-smoking mothers.
3. Among the inhabitants of wooden houses or aluminumsashed houses, which are comparatively well ventilated, no difference was observed in the proportion of positive Mite IgE regardless of the smoking of the mother. Among the inhabitants of reinforced concrete or steel-frame buildings, which are poorly ventilated, the proportion of positive Mite IgE was significantly higher for those with smoking mothers than for those with non-smoking mothers.
4. Animals inside the house and the smoking of the mother: no remarkable difference was observed in the proportion of positive Mite IgE among the subjects without an animal inside the houses and non-smoking mothers, those without an animal inside the houses and smoking mothers, those with animals inside the houses and non-smoking mothers and those with animals inside the houses and smoking mothers.
5. Comparison of the proportion of positive Mite IgE for the use of a carpet and the smoking of the mother: without a carpet+a non-smoking mother<without a carpet+a smoking mother<with a carpet+a non-smoking mother<with a carpet+a smoking mother. The proportion of positive Mite IgE was significantly higher for the users of carpets, regardless of the smoking of the mother, than for those without a carpet and with non-smoking mothers.
The above results indicate that the proportion of positive Mite IgE for children can be increased by smoking in the family (especially smoking by the mother). This is effective especially for those who live in poorly ventilated buildings with carpets.抄録全体を表示PDF形式でダウンロード (834K)
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