Background: Olfactory neuroblastoma (ONB) is rare, and there is no clear consensus regarding the treatment of cervical lymph node metastasis. In this study, we investigated cervical lymph node metastasis in ONB.
Methods: Of 59 ONB patients treated at our hospital between September 1996 and April 2022, 17 were treated for cervical lymph node metastasis (6 Kadish stage D patients with cervical lymph node metastasis at the time of initial treatment and 11 Kadish stage C and below patients with late cervical lymph node metastasis after initial treatment). The clinical study was conducted on 17 subjects.
Results: Of the 6 Kadish stage D patients, 3 (50%) underwent neck dissection and 3 (50%) irradiation, and no death due to lymph node metastasis was observed in Kadish stage D patients. Among Kadish stage C and below patients with late cervical metastases, 9 (81.8%) underwent neck dissection, and the remaining 2 patients underwent radiation therapy. There were no deaths due to cervical lymph node metastases.
One case was observed in which more than 20 years had elapsed between the initial treatment and the manifestation of cervical lymph node metastasis. The primary tumor control rate was 72.7% (8/11), which was better in the Kadish stage C and below group than in the Kadish stage D group.
Conclusion: There were no deaths due to cervical lymph node metastases in patients with both initial and subsequent disease. Cervical lymph node involvement should be considered in patients with cervical lymph node involvement, and treatment should be considered in the cervical region if possible, based on the patient’s general condition and other factors, including involvement of the cervical region.
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