We reported a case of progressive sensorineural hearing impairment and dysphagia induced as late complications of radiotherapy for nasopharyngeal cancer.
The patient was a 64-year-old male who had received radiotherapy for nasopharyngeal cancer at the age of 37. Twelve years after the radiotherapy, he complained of gradually progressive bilateral hearing impairment and dysphagia.
The structures of the oral cavity, pharyngeal cavity, and larynx were found to be atrophic. The hypoglossal nerve on the right side was also affected. Electromyographic examination of the genioglossus muscle on the right side showed a pattern of myokymic discharges. Chronic radio-dermatitic change was observed around the upper neck and the submandibular regions.
Pure tone audiometry revealed bilateral sensorineural hearing impairment particularly for higher frequencies. Maximum speech recognition scores were worse than the results of the audiometry indicated, and there were no auditory brainstem responses. DP-OAE response was not disturbed, however. These results indicated that the sensorineural hearing impairment originated mainly from disturbance of the fibers of the auditory nerves. Administrations of Prednisolone, PGE
1and Warfarin were unable to stop the bilateral hearing impairment and dysphagia from progressing.
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