Hormodendrum Pedrosoi was cultivated from a deeply infiltrated, partly papillary ulcer having developed in a 71 years-old man who lives in Saitama Prefecture near Tokyo on the back of the left hand. The ulcer first occured at the site of a long standing small verrucose tumor after it was accidentally contused and has resisted antiseptic local treatment for four years. In addition to the successful isolation of the fungus species aforementioned from the skin lesion, the histological examination revealed small brownish-colored spores lying in the cytoplasma of polynuclear giant cells found scattered in the granulomatous cell infiltrate in the dermis. Clinically there is nothing suggesting systemic infection outside of the skin lesion. Prompt healing was attained after the administration of pottasium iodide both orally and topically. The case belongs to the in Japan so much not necessarily rare incidence of chromomycosis, that hitherto there are some 15 case reports, in the greater part of which the infection with Hormodendrum Pedrosoi or other species of so-called Chromoblastomycetes were confirmed. The patient is a stone dealer and it is said that at the time of onset of the disease he engaged by himself in stone cutting. Whether the disease is related on the one hand to this, on the other geographically to the place of residence of the patient is not determined.

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In the last 3 years 10 cases of sporotrichosis were observed, 9 cases healing from the Tokyo Metropolis and 1 case from the Saitama Prefecture neighboring on the Tokyo Metropolis. The disease is now no more rare incidence in Japan, especially in the Tokyo district. In 3 of 10 cases the infection should have followed the preexisting injury. In 7 cases the upper extremity was involved, 2 cases presenting so-called lymphangial form of the disease. In 3 cases the ear, upper lip or nose was a site of the lesions. Sporotrichin reaction was positive in 9 cases having been diseased 3 weeks to 3 years and negative in 1 case 2 months after the onset of the disease. In all 10 cases administration of potassium iodide, orally and in addition topically as an ointment, led to a prompt healing, Sporotrichum Schenckii was cultivated from all these 10 cases. Histologically, in 3 cases spores were found in giant cells and in 2 cases asteroid bodies in the following cell agglomerations. In 4 cases, in the granulomatous tissue round circumscribed cell proliferation consisting mainly of polynuclear leucocytes and lymphocytes was found. Scattered in the granulomatous cell infiltrate, the cell agglomerations are well-defined and sometimes encircled by rings made of spindle-shaped cells resembling endothels of blood vessels. These endothel-like rings seem to be completed with the destructive process going on in the inner cell masses. In some of these cell agglomerations there were asteroid bodies extracellularly within the cell masses. Although they are situated somewhat eccentrically and the cell masses seem not to concentrate on them, these cell proliferations should be regarded as small reactional foci having some relation to the causative organisms.

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