Purpose: In B-mode ultrasonographic examination (B-mode image), medullary thyroid carcinomas appear as irregularly shaped or ovate nodules suggestive of follicular adenomas and papillary carcinomas, respectively. In histologic studies, stromal components of medullary carcinoma such as amyloid deposition, fibrosis, and calcification vary from case to case. Ultrasonographic expression of these stromal factors remains unclear, however. The following studies were carried out to determine how these stromal factors are presented in B-mode images.
Subjects and Methods: We used images from 22 cases of medullary carcinoma examined ultrasonographically and histologically. Ultrasonographic findings of these 22 medullary thyroid carcinomas were divided into two groups according to the shape of the nodules and into two more groups based on presence or absence of coarse, strong echoes. Histologic specimens of these 22 cases of medullary carcinoma were stained with Congo-red and Elastica van Gieson, and amyloid and fibrous tissues were evaluated semi-quantitatively.
Results and Discussion: Eight of 22 cases ,were placed in the ovate group (36.4%); 14 in the irregularly-shaped group (63.6%). The amounts of amyloid and collagen tissues were significantly abundant in the irregularly-shaped group (p=0.0195 and p=0.0014, respectively). Coarse, strong echoes were found in 15 cases, 13 of which were in the irregularly shaped group. All cases with coarse, strong echoes showed histologic evidence of calcification Frequency of coarse, strong echoes tended to increase with amount of amyloid deposition.
Conclusion: Medullary thyroid carcinomas shown as irregularly-shaped nodules contained abundant amounts of such histologically demonstrated stromal tissues as amyloid and collagen tissues. Medullary thyroid carcinomas containing large amounts of amyloid tissue produced many coarse, strong echoes.
View full abstract