A retrospective study was performed to determine the grade of oral mucositis and compare it to the frequency of opioid use in patients receiving radiotherapy or chemoradiotherapy for head and neck tumors. We classified 249 patients into three groups according to the radiation dose given in the oral cavity (Group A: 0Gy, 73 patients; Group B:<40Gy, 66 patients; Group C≥40Gy; 110 patients). The incidences of Gr.2 oral mucositis were 4.1%, 28.8% and 75.5% of the patients in groups A, B and C, respectively. Opioids were used by 12.3%, 30.3% and 44.5% of the patients in groups A, B and C, respectively, and there was a significant difference in frequency of opioid use among 3 groups (P<0.001). In Group C, there was a significant correlation between the severity of oral mucositis and frequency of opioid use (P<0.001).
In other words, an opioid was used for head and neck tumors treated with a radiation dose in the oral cavity of more than 40Gy, depending on severity of oral mucositis.

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Frequency that complication of the stomatitis and the oral mucosal ulcer associated with the chemotherapy of leukemia is high. We report a severe case of multiple oral mucosal ulcers with the infection of Pseudomonas aeruginosa induced by chemotherapy of acute Leukemia. The patient was a 35-year-old woman, and multiple ulcers by which surface show light green were admitted on 12 days after beginning of the chemotherapy. A mechanical removal of the ulcer surface bacillus adhesion thing was effective though administering antibiotics and oral cleaning was ineffectual.

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We report on a case with self-inflected gingival injury in a schizophrenic patient. A 54 year-old female presented with multiple ulcers on her gingiva. The lesions were localized to the facial attached gingiva, but no other mucosal changes were evident in the mouth. The patient was diagnosed as having gingival trauma caused by excessive and improper toothbrushing. The gingival trauma was cured in one week by making the patients aware that it was caused by incorrect toothbrushing.

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