日本口腔外科学会雑誌
Online ISSN : 2186-1579
Print ISSN : 0021-5163
ISSN-L : 0021-5163
30 巻, 7 号
選択された号の論文の19件中1~19を表示しています
  • 低濃度酸, アルカリによる舌背表面の傷害を中心に
    高木 嘉子, 吉田 徹, 斎藤 智子, 塩田 覚
    1984 年 30 巻 7 号 p. 907-914
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    Tongue injuries are cuased mechanically, thermically, chemically and radiologically, although they are rarely observed clinically. Pathology and healing process of theselesions seem to have less been studied.
    Thus, we examined chemically induced tongue injuries by acid or alkali substances, mainyinjuries on tongue dorsal surface, using experimental animals as a part of this study.
    Wistar male rats of 6 weeks post partum were used as experimental animals. HC1 wasused as acid substance, while NaOH used as alkali substance. In order to give these injuriesunder constant conditions as far as possible, these experimental animals were generally anesthesizedwith Nembutal and a filter paper sufficiently soaked with HCl or NaOH was appliedto the anterior 2/3 part of tongue dorsal center. The concentration of each chemicals used inthis study was, 10, 20, and 30% with application time for 1, 3, and 5 minutes respectively.
    Immediately after application for a given time, the anterior 2/3 part of tongue includinginjured site was removed as soon as possible and the damage on the tongue dorsal surfacewas examined by light and scanning electron microscopes.
    In consequence the tongue dorsal surface was covered by well developed filiform papillaeand fungiform papillae having taste buds scattered among them, which was surely injuredeven when HCl or NaOH at low concentrations was applied for a short time. The degreeof injury with HCl was different from that with NaOH. Macroscopically, no remarkablechange occurred with HC1, although NaOH produced a change of color to dark brown.Histological and scanning electron microscopic examinations revealed more severely injuredfiliform and fungiform paillae and the epithelium of the interpapillary mucous membrane withthe increased drug concentration and prolonged application time and considerably destroyedtaste buds, suggesting functional disturbance. These injuries on the mucous epithelium showeda trend of detachment and epithelium with HC1, while NaOH tended to produce detachment, softening or fusion of epithelium.
    In either case, the lesion was mainly superficial with less extension of injury into thesubmucosal tissue, remaining at Grade I or II of chemical burns in general.
  • とくに初代培養細胞の所見とそれに対する制癌剤の影響について光顕および電顕学的検索
    田中 信幸, 横尾 恵美子, 岩城 博, 百瀬 文雄, 長瀬 麻理子, 平田 章二, 塩田 重利
    1984 年 30 巻 7 号 p. 915-922
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    Clear-cell adenoma is one of salivary tumors which was first reported by Corridan in 1956, but it is rarely encountered in the clinical practice.
    We recently experienced a case of so-called clear-cell adenoma occurred in the palate andcould obtain its primary culture cells. This culture cells were observed by light and electron microscopes for examining the influence of anticancer agents on culture cells.
    The tumor was wholly resected under general anesthesia and the patient is now in a good condition without relapse as of 4 years lapsed after operation.
    Clear-cell adenoma is said to be consisted of two types of cells by electron microscope, one is rich in organella such as mitochondria, rER, and tonofilament so that it seems to have a dark cytoplasma (organella rich cells). The other has less organella with glycogen granule, fat deposit, and vacuole and seems to have a light clear cytoplasma (organella poor cells).
    The primary culture cells contained much organella and round, amorphous secrete-like granule with high electron density. When anticancer agents (5-FU, MMC) were acted against these cells, secrete-like granule disappeared followed by the appearance of fat deposit-like substance which then decreased in number to form vaculoes.
  • 石川 秀俊
    1984 年 30 巻 7 号 p. 923-936
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    Salivary gland function was evaluated quantitatively using sequential salivary gland scintigraphy. 99mTc-pertechnetate at a dose of 3m Ci was i.v. administered. The analysis was performed by means of gamma camera attached with high resolution parallelhole collimator or bilateral collimator and computer system. As a stimulation test, 200mg ascorbic acid granules were i.v. administered after 35 minutes. Bilateral parotid and submandibular glands were selected as region of interest (ROI) and the average value was calculated for data analysis.
    Subjects enrolled in this study included 20 cases of normals, 21 cases of suspected Sjögren's syndrome, 5 cases of established Sjögren's syndrome, 20 cases of xerostomia and 10 cases of radiation xerostomia.
    The analysis was made by determining parameters as follows: 1) RI uptake by parotid gland at 10, 20, 30 minutes after injection, 2) RI uptake by submandibular gland at, 10, 20, 30 minutes after injection, 3) maximum uptake time, 4) uptake ratio of left to right parotid glands, 5) secretion rate after stimulation, 6) reaction time after stimulation, 7) RI uptake by parotid gland at 40, 50, 60 minutes after injection, and 8) RI uptake by submandibular gland at 40, 50, 60 minutes after injection.
    Concerning RI uptake rate by parotid and submandibular glands, these values in patients with suspected Sjögren's syndrome, xerostomia and radiation xerostomia increased with time lapse similar to those in normal cases. In established Sjögren's syndrome, however, higher uptake rates were obtained at, 10, 20, and 30 minutes after injection with both parotid and submandibular glands. The maximum uptake time by parotid and submandibular glands in normal subjects were 31.4±3.7 and18.4±10.4 minutes respectively. A significant difference as for the maximum uptake time was noted only in patients with suspected Sjögren's syndrome. The uptake ratio of left to right parotid glands showed no difference in patients with suspected and established Sjögren's syndrome and xerostomia. Some higher left to right uptake ratios were observed in several patients with radiation xerostomia. Although decreased secretion rate and/or delayed reaction time after stimulation were noted in established Skigren's syndrome and radiation xerostomia cases, no difference was observed in suspected Sjögren's syndrome and xerostomia cases as compared to normal subjects.
    RI uptake by parotid and submandibular glands at 10 and 40 minutes after injection, secretion rate and reaction time after stimulation were useful for evaluating salivary gland function.
    A quantitative analysis using sequential salivary scintigraphy is considered to be a valuable technique for evaluating various salivary gland diseases.
  • 浜田 幸人
    1984 年 30 巻 7 号 p. 937-956
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    Osteoradionecrosis is a serious complication occurring after radiotherapy for cancer of the oral cavity. It is often observed after surgical intervention in the irradiation filed. For preventing osteoradionecrosis, it thus seems adequate to administer antimicrobic agents before and after tooth extraction. No reports on the concentration of antimicrobic agents in these oral tissues with modified circulation system by irradiation has been yet available. In the present study, 1000 R of 3000 R radiation was given to the right mandible of rabbits and the concentration of DOXY was measured in the right mandibular gland, mandible, tongue margin, mandibular gingiva and plasma 3 days, 1 and 2 weeks, and 1, 3 and 6 months after irradiation. Each sample was taken 2 hours after 10mg/kg DOXY i. v. injection. For observing fi ne vessels in 3000 R irradiated group, on the other hand, acrylic resin was infused through the right and left common carotid artery and the right tongue margin was observed by electron scanning microscope.
    Experimental results:
    1) The drug concentration becomes high after 1 and 2 weeks of irradiation followed by decrease to normal level after 1 month. However, it shows an increasing trend again after 3 months. On the other hand, the ratio of tissue drug level to plasma one is normal or slightly low at 3 and 6 months after radiation.
    2) The tongue papilla capillaries becomes narrow showing a constricted part 1 week after irradiation. No capillary network is however observed after 1 month and only protrusion of short capillaries from the venule is observed.
    From these results, the drug concentration in irradiated oral tissues seems to somewhat decrease when an antimicrobic agent is administered after ratiotherapy. If the amount of drug is increased and a good pharmacokinetic antimicrobic agent is administered, however, the drug concentration in irradiated oral tissues seems sufficient to prevent clinical infections.
  • 全自動画像解析装置を応用した正常発育群の定量化
    夏目 長門
    1984 年 30 巻 7 号 p. 957-972
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    In order for successful surgical intervention to be performed for restoration of normal oral muscular function to patients suffering from cleft lip, it is necessary to determine the optimal time for operation taking into account the developmental stage of the orbicularis oris muscle. The present investigation is a morphometric approach using an automatic image analyser for generating basic reference data. The orbicularis oris muscle was quantitatively analysed from a total of 120 rabbits, raging from immediately after birth to 180 days old, at which time growth is considered to be almost complete. The results are summarized as follows:
    1. By measuring the diameter of the orbicularis oris muscle fibers, visualized as circular profiles, it was established that the immature orbicularis oris muscle at birth underwent rapid growth until day 30 with development being most prominent during the first 15 days. Whether interference with the tissue during this period is appropriate requires discussion.
    2. In order to detect morphological changes associated with growth, morphometric estimation by plotting a histogram of the crosssectional area of the oricularis oris muscle was carried out. The results demonstrated that the majority of fibers immediately after birth had areas of less than 20 μ2 while 100 days thereafter, very large fibers of 1000 μ2 and above were observed. However, even at time points 140, 160 or 180 days, when growth is thought to be completed, some fibers were found to be less than 100 μ2 in area, suggesting that their development had been halted sometime during the process. Thus, it appears that growth is not merely a uniform in crement of area with time for all fibers, but rather that a more complicated process is involved, with individual fibers showing both rapid or slow in creases in size.
    3. Increase in numbers of fibers associated with growth was obscrved in the first 30 day period wth no further significant increment being apparent thereafter.
    4. To facilitate an objecive estimate of alteration in shape associated with the growth of the orbicularis oris muscle, a morphometric coefficient was calculated. The results illustrated that the initially almost circular fibers later become more angular in appearance with increased diameter.
    5. Morphometric analysis of the area of nuclei within the fibers revealed very little change and therfroe this parameter would not appear to serve as an appropriate measure of muscle growth.
    6. A comparison of the respective growth rates of the orbicularis oris muscle and the total cross-sectional area of the lips demonstrated that, with increase in time, a larger proportion of the total was occupied by the orbicularis oris muscle.
  • 向江 富士夫, 竹之下 康治, 平河 孝憲, 岡本 学, 岡 増一郎
    1984 年 30 巻 7 号 p. 973-979
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    There are some patients with various equivocal complaints, but without any detected organic damage.
    The variation of R-R interval on E. C. G.(C. V.R-R) was measured and investigated if its data was reasonable for diagnosis of such non-organic disease.
    Two hundred and twenty four oral surgery patients and 37 healthy volunteers of either sex were examined. The age range was 10 to 79 years old.
    The control group did not have any heart disease, autonomic ataxia or non-organic disease. The C.V.R-R of the control group showed decreasing tendency followed with age increase, but no sex difference.
    The C.V.R-R of the non-organic group such as the patients who had T.M.J. arthrosis or unidentified complaints revealed lower scores than of the control group. Therefore it was concluded that C.V.R-R is usable to screen non-organic patients.
  • 後藤 昌昭, 古閑 塾, 古賀 正章, 田中 稔夫, 木原 誠一郎, 嘉村 痔人, 副島 渉, 香月 武
    1984 年 30 巻 7 号 p. 980-985
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    In the early 1970s, when human fibrinogen preparation of high concentration became available, fibrin sealing technique was employed for wound management after surgery, This report is about the bacteriological characteristics of the fibrin adehsion system.
    Twelve kinds of bacteria were inoculated on fibrin slants. Some bacteria grew on the slants after five days. The fibrin slants were completely dissolved by S. aureus and S. marcescence, and incompletely by P. cepacia, P. aeruginosa and S. epidermidis.
    To clarify the relationship between bacterial number and fibrinolysis, the series of 10-fold dilutions of S. aureus were inoculated on the fibrin slants. Growth of S. aureus was remarkable. The fibrin saint on which 10 cells/ml were inoculated was dissolved after only two days. Even in the case of 10 cells/ml inoculum fibrinolysis was observed after twelve days.
    Dental plaque from six patients was cultivated on fibrin slants. Identification of these microorganisms based on certain biochemical test reactions showed that the plaque contained microorganisms which dissolved the fibrin sealants.
    It should be kept in mind that fibrin sealants can be dissolved by some oral microorganisms when fibrin sealing technique is used.
  • 冨田 幸伸, 大野 彰彦, 尾崎 登喜雄, 浜田 敏裕, 米田 和典
    1984 年 30 巻 7 号 p. 986-988
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    A rare case of mandibular radiulin cyst lined almosily with ciliated epithelium is reported in this paper.
    A 22-year old man was 1 efered lor itratment of the mandibular lesion. The patient had a long history of this lesion but he had not received the radical treatment bacause the symptoms were not so obvious. At the time of the reference, his left cheek was slightly swollen and the buccal side of 567 was moderately expanded. The crown of 6 decayed completely, but both neghboring teeth were vital. By the X-ray examination, dearly bordered radiolucent shadow located at the apial region of 6 was found, and the lesion was diagnosed as radicular cyst.
    Routine surgery was carreied out. The lesion and 6 were extirpated and the wound was closed. No evidence was observed after the operation. The histopathologic findings were as follows. The cyst wall was mainly lined with ciliated epithelium and partially with non-keratinized squamous epithelium. Some Muticarmine-positive mucous cells were scattered in the epotheraial layer of the region covered with ciliated cells, and the subepithelial layer corresponding to this area was mildly infiltrated by lymphocytes and plasma cells. On the other hand, in the connective tissue under the squamous epithelial lining the infiltration of neutrophiles and round cells was severe.
    About the derivation of ciliated epithelium found in the radicular cysts, especial in the mandibular lesions, some of opinions were mentioned but none of them has yet to be acepted generally. In consideration of the histopathologic figures and the other reported studies, it is most reasonable to think that ciliated epithelium found in this case was the result of metaplastic change, that is, derivated from squamous cells.
  • HLA抗原を含む検討
    仲宗根 康雄, 山城 正宏, 友寄 喜樹, 藤井 信男, 新崎 章
    1984 年 30 巻 7 号 p. 989-993
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    HLA Typing of Carcinoma Linguae in two Brothers.
    We examined prosthetic appliance, smoking, drinking, habits, and HLA antigen in 4 brothers including 2 patients with carcinoma linguae.
    In all these brothers, metal crown or artificial tooth was applied.
    Two brothers suffering from carcinoma linguae smoke about 20 cigarettes a day. while other two healthy brothers smoke about 40 cigarettes a day.
    All of them have a history of little drinking but no adverse habits in the food life to be mentioned specially.
    HLA typing of peripheral lymphocytes was performed by microlymphocytotoxicity method. In consequence, no increasing or decreasing trend of HLA antigen was demonstrated between the two groups.
  • 松本 康博, 瀬戸 皖一, 佐藤 淳一, 高田 典彦
    1984 年 30 巻 7 号 p. 994-999
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    Histochemical Study of Two Cases of Calcifying Odontogenic Cyst
    Case 1: X-rays of a 40-year-old woman revealed a cystic-like radiolucency in the anterior mandibule. Many epithelial cells proliferated into the underlying connective tissue. Large masses of ghost cells were observed. The ghost cells were stained yellow with van Glean stain. The calcified ghost cells reacted positively with PAS, alcian blue and resorcinfuchsin stain.
    Case 2: The patient, a 11-year-old boy, complained of swelling of the left maxilla. Islands of ghost cells were observed in the bone. The ghost cells showed a partial reaction to PAS but no reaction to alcian blue and resorcinfuchsin stain.
  • 梶山 稔, 黒川 英雄, 橘本 清徳, 野村 信人, 矢野 茂良
    1984 年 30 巻 7 号 p. 1000-1005
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    The pleornorphic adenoma in the oral cavity is a tumor originating from both major and minor salivary glands. This tumor is the most common neoplasm among all salivary gland tumors and its incidence is the highest concerning the parotid gland in major salivary glands and at the palate in minor salivary glands. However, it is said that this tumor seldom occurs on the lip.
    We have recently experienced one case of pleornorphic adenoma considered to have originated at the minor salivary gland in the upper lip.
  • 石橋 利文, 福田 廣志, 染谷 さき子, 田所 重映
    1984 年 30 巻 7 号 p. 1006-1016
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    Arteriovenous malformations of the jaws are considered to be rare lesions, A-14-year-old school boy was referred from a hospital for profuse bleeding after the extraction of the mandibular right first molar. Orthopantomography showed an irregular radiolucency extending from the mandibular right lateral incisor region to the right mandibular notch and dental film showed “soap bubble” appearance. In angiogram the main feeding vessels appeared to be the right facial artery, the right lingual artery, the right inferior alveolar artery, the right massteric artery and the right buccal artery. Expecially the right facial artery was as enlarged as the right external carotid artery. Embolization of the facial artery was performed to decrease the blood flow in the region of the mandibular lesion. The next day under nasoendtracheal general anesthesia, preparations were made for enucleation by the ligations of the right external carotid, right lingual and right facial arteries. The enucleation of the tumor was carried out by an intraoral approach. The beginning of the operation was followed by profuse bleeding. However, after the ligation of the right inferior alveolar artery, hemorrhage was controlled and the tumor was removed with relative ease. The postoperative course was entirely without complications. Anorthopantomography taken one year and seven months after the operation showed significant osseous regeneration in the area of the lesion. The pathological diagnosis was arteriovenous malformation.
  • 藤田 寛, 中村 博行, 栗山 和典, 鄭 漢忠, 富田 喜内
    1984 年 30 巻 7 号 p. 1017-1024
    発行日: 1984/07/20
    公開日: 2011/09/13
    ジャーナル フリー
    Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of unknown etiology characterized by fever, hemolyticanemia with erythrocyte fragmentation, hemorrhagic tendency due mainly to thrombocytopenia, fluctuating neurological abnormalities and kidney dysfunction. As far as the literature is reviewed, there is no apparent report of dental or oral surgery in TTP because this disease has rather poor prognosis.
    We recently had the opportunity to perform oral surgery such as dental extraction, apicoectomy and cyst extirpation in a 18 year-old male patient with TTP. We described the oral management for hemorrhagic tendency and infection due to immunological dysfunction with the patient during surgical procedure.
  • 大塚 しおり, 福崎 博生, 斎藤 文明, 杉崎 正志, 田辺 晴康, 福武 公雄, 山崎 亨
    1984 年 30 巻 7 号 p. 1025-1031
    発行日: 1984/07/20
    公開日: 2011/09/13
    ジャーナル フリー
    Osteopetrosis was first reported by Albers-Schonberg in 1974. This disease is characterized by failure of the primary spongiosa for some reason and extraordinary thickness and density of the cortical portion of the osseous system.
    We experienced a case of osteopetrosis compricated with osteomyelitis of a jaws. Patients was 60 year-old man, he had foiled periodontitis apicalis and had teeth extracted about 3 years ago. The patient was successfully treated by removal of sequester by covering the raw surf ace bone with periosteum sufficiently under antibiotic therapy.
  • 久保倉 弘孝, 長田 道哉, 石川 好美, 遠藤 盛孝, 林 誠一, 大村 進, 増田 元三郎, 藤田 浄秀
    1984 年 30 巻 7 号 p. 1032-1038
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    Lipoma in submandibular space is considered relatively rare.
    Authors reported two cases of submandibular space lipoma noted in 37 year-old male and 34 year-old female with special emphasis to diagnostic significance of CTscan.
    CT number showed about -100 Hounsfield units in submandibular mass that was characteristic of lipoma.
  • 海野 智, 長田 道哉, 川辺 良一, 高橋 徳昭, 増田 正樹, 藤田 浄秀
    1984 年 30 巻 7 号 p. 1039-1046
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    We examined the clinical and pathological features in 20 patients of pyogenic granuloma on the tongue who were treated in the Department of Oral Surgery, Faculty of Medicine, Yokohama City University Hospital.
    Clinical features: The site of occurrence was most frequent in the dorsum and apex, which accounted for 85% of the lesions. A history of trauma was noted in 6 cases (30%), all of which had pyogenic granuloma arisen from the apex and tongue margin. The duration from the first episode to the time of admission was about 2.2 months on the average. Two cases (10%) showed one recurrence.
    Pathological features: The superficial layer of pyogenic granuloma was ulcerative with predominant inflammatory changes such as dilation of capillaries, cellular infiltration and granulaiton. On the other hand, in the deeper region located in the lower stalk where almost no cellular infiltration was observed, a dense colony of capillaries and endothelial cells was separated by the connective tissue and arranged in a small leaf-like fashion, providing a finding suggestive of tumorous lesion. In a part between them, a mild cellular infiltration was observed, which seemed to be a transitional part from the deep tumorous lesion to the superficial glanulomatous lesion.
    Watching the relationship of the degree of inflammation to the tumorous lesion, we concluded that pyogenic granuloma on the tongue was of capillary hemangioma accompanying granulation secondarily caused by trauma or infection.
  • 石橋 利文, 野堀 幸夫
    1984 年 30 巻 7 号 p. 1047-1051
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    Neurilemoma of the oral cavity is a rare disease, especially that of the cheek. The authors encountered a 29 year-old woman, who had a tumor in the buccal mucosa of the right mandibular molar. On may 15, 1978, under local anesthesia, the tumor was easily removed en bloc. Six years later, she is well and free of tumor. On section the tumor measured 11×7×7 mm, was encapsulated, light yellowish white, soft and resilient in consistency. Microscopically there was palisading of the nuclei of the tumor cells, and the pathological diagnosis was neurilemoma. The clinical and pathological findings of 12 cases of neurilemoma of the cheek reported in Japan, including ours, were discussed.
  • 浦島 一博, 浦出 雅裕, 臼井 誠, 宮崎 正
    1984 年 30 巻 7 号 p. 1052-1056
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    A case of angiokeratoma occurring in the dorsal surface of the tongue of a 6-year-old boy was presented. Histopathologically, numerous dilated capillaries showing “blood cyst” like pattern in subepitherial portion of the tongue lesion were observed. Covered epithelium showed slight parakeratosis.
  • 第2報: フィプリン接着剤 (Tisseel®-Kit) の口腔外科領域各種手術への応用と創傷治癒効果
    久保 四郎, 山本 悦秀, 小松 世潮, 砂川 元, 玄番 涼一, 伝庄 信也, 小浜 源郁
    1984 年 30 巻 7 号 p. 1057-1065
    発行日: 1984/07/20
    公開日: 2011/07/25
    ジャーナル フリー
    This report describes a clinical application of fibrin adhesive consisted of high concentrated human fibrinogen, thrombin and blood coagulation factor XIII (fibrin stabilizing factor). Fibrin adhesive is a biological substance which is completely absorbed from bio-tissues dissimilar to conventionally used synthetic adhesives. In addition, this agent has an excellent adhesive property, firm elasticity and superior tissue affinity.
    We applied this method in 37 cases undergone various operations in the oral surgery, including 1) adhesive fixation of isolated skin flaps or frozen cerebral dura mater (Lyodura®) against soft tissue defects in the cheek and tongue, 2) adhesive fixation of mucoperiosteal flaps against bare bone, 3) adhesive fixation of isolated skin flaps or lyophilized porcine skin flaps against bare bone and 4) application in palatoplasty, that is, adhesive fixation of platal flaps and lyophilized porcine skin flaps against palatal bone. The application of this agent was revealed from this study to be superior in its favorable tissue adhesive property, local hemostasis and wound healing effect. We also described indications of this method in the oral surgery.
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