The mucosal tissue model (M. M.) was constructed in vitro by culturing the cells in collagen lattice. M. M. consists of the submucosal tissue model (S. M. M.) and epidermal cells which grew out from the epithelial fragment on S. M. M.
In fabricating S. M. M., fibroblasts derived from rabbit oral mucosa were brought into the conditioned collagen solution, and were cultured in three-dimentional condition for 7 days. Fibroblasts were trapped in collagen lattice, and the original size of collagen lattice was gradually reduced. Thus, S.M. M. was fabricated.
Subsequently, the mucosal epithelial fragment, which was taken from oral mucosa of the same rabbit, was put onto S. M. M. The fragment on S. M. M. was cultured under the same conditions.
Cultivated for 7 days, the epithelial cells from the fragment covered the surface of S. M. M. as the confluent cell sheet.
Cultivated for 28 days, a regular basal cell layer was found with overlying strata of differentiating cells.
The epidermis became thick, and the incipient pegs penetrating S. M. M. were seen. The fabricating M. M. proved to be useful for investigating mucosal wound healing and mucosal disease in vitro, and for mucosal tissue graft.

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The nuclear DNA content and nuclear area of 22 jaw cysts, 15 benign and 40 malignant tumors and 4 other or unknown lesions of the oral cavity were measured with smear preparations stained with Feulgen reaction to study the characteristics of these lesions and to evaluate their diagnostic value as well as the relationship to the clinical course and histology.
The nuclear DNA histograms of normal cells were all included in Type I with the modal peak at 2Cand there were no cells having DNA over 4 C. The histogram pattern of the jaw cysts was similar to that of normal cells in most cases, but the histogram of odontogenic keratocysts with a slight subpeak at 4 C (Type II) or with an increased 3 C peak (Type IV) seemed to indicate the neoplastic nature of the cyst. In most benign tumors, the histogram pattern was either Type II or Type III with the modal peak located in the regions from 1.5 C to 2.5 C. The presence of chromosomal changes, however, was indicated by the increase of the 3 C peak and by the occurrence of a distinct peak at 4 C or of cells with higher DNA content. The histograms of epidermoid carcinomas, undifferentiated carcinomas and a malignant melanoma were characterized by a broad distribution with no evident modal peak or its shift to the right. Excepting a few cases, such features were not evident in carcinomas of the salivary glands. The nuclear area was relatively small in the latter lesions, in particular in adenoid cystic carcinoma.
In contrast to epidermoid carcinomas, there were many carcinomas of glandular origin that could not be diagnosed as malignant because of the similarity in the DNA histogram pattern to that of benign tumors. The results indicated the presence of low malignant type in salivary gland carcinoma. In these carcinomas, the increase of 3 C peak could be related to the occurrence of metastasis, T staging and prognosis, whereas in epidermoid carcinomas, no relationship was found between the T staging or prognosis and the DNA content that was increased in cases with metastasis. Histologically, the DNA content and nuclear area were increased in carcinomas of poor differentiation or those with higher nuclear atypia.

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Vascularization of grafted bones has been the title of a number of morphological studies. However, there are few published papers following up dynamic changes of blood flow in process of vascularization. In view of these facts, I investigated a morphological study concerning vascularization of grafted bones and also diurnal dynamic changes of blood flow in grafted bones using the microsphere technique.
Methods
Using male wister rats as test animals, autologous tibia (about 1 cm) was grafted into the bipedicle tubed abdominal flap (4×2cm) established on the abdominal wall. The animals were sacrificed at 3 days, 1, 2, 3 and 4 weeks after the bone graft, and pathological preparations and transparent preparations were prepared. Then, microsphere ¹²⁵I was injected into the left venticle immediately and at 3 days, 1, 2, 3 and 4 weeks after the operation, and radioactivities were counted by Beckman Ganma Radiation Counter. By using a Mutoh Desitizer, the bone reconstruction rate was determined.
Group A...Tibia without periosteum
Group B...Longitudinally-cut tibia without periosteum and marrow
Results
1. Vascularization in the bone grafted into the flap
1) In both Groups A and B vascularity appeared at day 3 after the operation.
2) Vascularization in the cortical bone of the grafted bone appeared earlier in Group B as compared to Grooup A.
3) In Group A, the medullary vascularization almost completed in about 3 weeks, at which period vascularization in the cortical bone exceeded that observed in Group B.
4) Changes in blood flow determined by the microsphere technique showed almost similar patterns for both Groups A and B: Namely, the blood flow showed an increasing tendency to reach its peak at week 2, followed by a decrease at week 3 and slight increase at week 4.
2. Bone reconstruction associated with vascularization
1) Bone reconstruction appeared at week 1 after the operation and it occurred in the region where accelerated vascularization was seen.
2) In Group B, bone reconstruction started in the earlier stage and progressed gradually in the entire grafted bone. Until week 2, the bone reconstruction in Group B was superior to that in Group A.
3) In Group A, the bone reconstruction exceeded that of Group B from week 2. In particular active bone reconstruction was seen in the medullary cavity where pronounced vascularization was observed.

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By immunoperoxidase technique, human submandibular salivary glands were studied for presence and distribution of various salivary proteins including secretory component (SC), lactoferrin (Lf), lysozyme (Ly), carcinoembryonic antigen (CEA) and alpha-l-antitrypsin (α₁-AT). All types of these glycoproteins were present in intercalated duct cells which especially showed strong staining intensities for Ly and Lf. Faint staining, for both glycoproteins were also observed in striated ducts. Sc was present in interlobular duct and serous acinar cells but absent in mucous acinar cells. Staining for SC was generally faint or moderate but increased in intensity at the luminal aspect of interlobular duct cells. CEA was mainly located at the luminal surface of both acinar cells and intercalated duct cells. A small amount of α₁-AT was observed in the cytoplasm of all types of epithelial cells. These findings indicate that intercalated duct cells carry high activities of productions of various glycoproteins. Moreover, we confirmed that S-100 protein is specific in myoepithelial cells of salivary glands.

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Asialofetuin sialyltransferase from Triton X-100 extracts of fetal calf liver resolved by phosphocellulose column chromatography into two fractions, designated A and B in order of elution. Survey of the isomeric nature of sialyllactose formed and also of efficiencies of various substrates, which include asialofetuin, β-eliminated asialofetuin, asialoorosomucoid and bovine and porcine submaxillary mucins, has made it clear that fraction A contains Galβ1→4GlcNAcα2→6 sialyltransferase (associated with the synthesis of N-glycosidicaly linked sugar chains) while fraction B contains Galβ 1→3 GalNAc α2→3 sialyltransferase (associated with the synthesis of O-glycosidically linked sugar chains). In addition, fraction A appears to contain a small amount of another sialyltransferase that transfers sialic acidα 2→3 g, lycosidically to N-glycosidically linked sugar chains, but its separation from the majorα 2→6 enzyme has yet been unsuccessful. The chromatographic conditions shown above have been utilized to demonstrate (i) that the major sialyltransferase of the rat liver and human placenta is identical to the above-described A and B, respectively, and (ii) that even primary rat hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene contains no Galβ1→3 Ga1NAc α 2→3 sialyltransferase.

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Using fresh human femurs, compression test under uniaxial and triaxial stress states and tension test were performed. Then the physical properties of bone which involves some porosity werc studied. It was observed that the initial yield point and peak strength under triaxial conditions were significantly higher than those under uniaxial conditions, and these values decreased for tension tests. On the basis of these experimental results, the failure envelopes for initial yield point and peak strength under side pressure were determined. The Drucker-Prager's failure criterion wasfound suitable to describe the bone failure behavior.

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A three-dimentional finite element model of a human mandible was presented, which is tended to make clear the mandible fracture mechanism. In making a numerical analysis, lateral and vertical loads were applied changing direction on the finite clement model of the human mandible. The tendency of the fracture was valuated for each case. Then, it was observed that in many cases the fracture was caused at the condylar process, and at the portion where the loads were applied to the inner side, fractures tended to be severer on the inner side than on the outer side. It was shown that the location and direction of loading were important factors to determine the fracture tendency.

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It is conceived that serum-free culture is very useful in investigating the mechanism of cell differentiation and growth, or in studying the substance which affects them. It was attempted to culture the gingival carcinoma cell (Ca 9-22) in a serum-free condition to investigate the substance which affected the growth and differention of the oral cancer. Ca 9-22 SF was established as a result, which was grown in long-term culture in the serum-free defined medium. Subculture of Ca 9-22 SF was usually performed once every two weeks using trypsin and soybean trypsin inhibitor. Ca 9-22 SF grew 2 days after inoculation and the doubling time at exponential growth phase was estimated to be about 18 hours which was the same as Ca 9-22, but the achieved final cell concentration was lower than that of Ca 9-22. In the chromosomal analysis, the patterns of chromosomal distribution of both cell lines were similar and both modes were 59. The marker chromosome of Ca 9-22 SF was undetectable. Ca 9-22 SF was transplantable to nude mice but the carcinogenetic efficiency in mice (2/6) was lower than that of Ca 9-22 (5/6). The formed nodule was histologically determined as squamous cell carcinoma but was well differentiated in contrast to that of Ca 9-22 which was moderately differentiated. Ca 9-22 SF is considered to maintain the character of the oral cancer cell and is able to grow in the defined medium free of serum, hormones or growth factors, so that it is expected to be used in studying the effects of various substances on the growth and the differentiation of the oral cancer.

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It was reported in the previous paper that Ca 9-22 SF, which was derived from human gingival carcinoma cells, was established in long-term culture in the serum-free defined medium. Ca 9-22 SF was considered to maintain the character of oral cancer cells, because it was successfully transplantable to the nude mice and the formed nodule was histologically determined as squamous cell carcinoma. It was therefore belived that Ca 9-22 SF might be the most suitable cell to study the substance which affected the growth and differentiation of the oral cancer. As a first step to search for the substance which affected the growth of the oral cancer, the growth factors were examined on the effect on the DNA synthesis of Ca 9-22 SF by the method of the double labeling of radioisotopes, ³H-uridine and ¹⁴C-thyrnidine. The following growth factors were used: Epidermal growth factor (EGF, 1 ng/ml-1μg/ml), fi broblast growth factor (FGF, 100 pg/ml-100 ng/ml), platelet derived growth factor (PDGF, 0.005-5 units/ml), insuline (100 ng/ml-100μg/ml) and hydrocortisone (100 ng/ml-100μg/ml). Fetal bovine serum (FBS, 0.01-10%) was used as a control. The growth stimulating efficiency of each growth factor was evaluated by comparing the rate of ¹⁴C-thymidine incorporation two days after addition of pre-labeled ³H-uridine. Contrary to expectations, the DNA synthesis of Ca 9-22 SF was significantly suppressed by EGF. This suppressive effect may not be cytotoxic but the mechanism of the growth suppression is unknown at present. FGF and PDGF had no effect on the DNA synthesis of Ca 9-22 SF in the serum-free condition but in the condition containing a small amount of serum (0.5%) they clearly stimulated the DNA synthesis of Ca 9-22 SF. Insuline and hydrocortisone did not have any effect on Ca 9-22 SF. The double labeling technique of radioisotopes was considered to be useful in investigating the substance which affected the growth of the oral cancer.

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Periapical cemental dysplasia is generally regarded as a disease that develops al the apical region of vital teeth as a result of proliferation of the connective tissue of the periodontal membrane. The commonest type of lesion in multiple and occurs most often in middle age females. Though in Europe and America there have been many reports of the disease, there arc very few in Japan.
The author encountered a case of multiple periapical cemental dysplasia in a 53-year-old female. Because of the lack of symptoms, this case was detected incidentally on radiological examination. The radiographic findings revealed areas of radiopacity ranging in size from rice grain to the tip of the little finger, located around the apices of 54 45 65421 1267 Except for the region of upper left second biscupid, those radiopaque masses were separated by a thin radiolucent space from the surrounding normal bone and the apices of the involved teeth. The affected part around the apices of upper left second biscupid was partly radiolucent and partly radiopaque. All wisdom teeth showed retention and their roots exhibited hypercementosis-like findings.
Bone scanning with ^99mTc-MDP revealed deposition in each affected part. The right lower wisdom tooth and the growth attached to the root were removed en block and the tooth was examined following decalcification. The histopathological diagnosis was periapical cemental dysplasia accompanied by hypercementosis of the root of the left lower wisdom tooth.
The patient has been observed periodically for four years and there have been no clinical or radiological evidence of change, except for a small radiolucent area at the periphery of the lesion showing radiopacity.

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Recently we came across a case of adenoid cystic carcinoma in the soft palate rarely found in past medical literature. The patient, a 56-year-old woman, was treated by surgical resection of palatal tumor with immediate reconstruction of the palate after radio therapy and chemotherapy. The most difficult part was repairing the defects of the soft palate. Reconstruction was done by using a mucoperiosteal flap of hard palate. Detailed procedures of reconstruction are described and discussed in the paper.
Postoperative recovery was uneventful and, after 17 months, no evidence of recurrence or metastasis has been observed. Pronunciation disturbance was not serious and was much less than expected. No further complications nor adverse results due to the operation were observed.

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A case of acinic cell tumor in the left buccal mucosa has been reported. The patient was 64-year-old female, admitted for evaluation of a mass in the left buccal mucosa. A soft mass measuring 3.0×1.8cm was noticed in the left buccal mucosa. After an incisional biopsy, the tumor was treated by wide local excision. One year and 3 months after the operation, she was well with no evidence of recurrence or metastasis of the tumor.
Histologically, the tumor mainly consisted of serous-type cells including of a few vacuolated cells. Growth pattern of the tumor cells was a solid one. The tumor cells contained many basophilic granules in the cytoplasm, which were PAS-positive with diastase resistance and negative for mucicarmin staining. Ultrastructurally, the tumor cells generally consisted of large cells with abundant secretory granules which resembled serous cells of the normal acini. A few smaller tumor cells lacking secretory granules were also observed. Since the tumor showed slight atypia and no encapsulation, the tumor in this case was considered a low grade malignant. We support the hypothesis from the findings in this case that acinic cell tumor may represent a neoplasm of multipotential duct cells.

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In this report, we reported a case of malignant schwannoma in the submandibular region, reviewed 35 cases of malignant schwannoma in the head and neck region reported in the Japanese literature and discussed the pathological differential diagnosis.
The patient was a 73-year old woman referred by her dentist because of 4 her right submandibular lump. In the clinical examination including ultrasonic examination and xeroradiography, a benign tumor was strongly suspected. Based on the clinical diagnosis, surgical enucleation was carried out under local anesthesia. The tumor did not connect to the nerve or the submandibular gland. The specimen consisted of a nodular and smooth mass of grayishwhite tissue containing multiple cystic lesions and was examined by light microscope and electron microscope. The pathological diagnosis was malignant schwannoma. No adjuvant chemotherapy and radiotherapy were performed. At the present time the paitnet is comfortable without evidence of disease during 9 postoperative months.
Records of 34 patients found in Japanese literature and our new case wer reviewed. Of the 35 patients, one patient was excluded because of little information.
1. Sex: 15 men and 19 women.
2. Age: The age of the patients ranged from 13 to 73 years, with 65% of 34 patients between 20 to 49 years of age. Average age of 34 patients was 39.9 years, with no significant average age difference between men (40.9 years) and women (39. 1 years).
3. Anatomic distribution: 14 tumors were located in the neck and 9 in the maxilla. But there was no case primarily involving the mandible except one where the neck tumor invaded the mandible.
4. Initial sign and symptom: 25 of 34 patients were primarily seen because of the presence of a mass.
5. Treatment: 31 patients were treated primarily by resection and one patient was treated conservatively by irradiation because surgical intervention was impossible.
6. Prognosis: Of the 34 patients, 3 were without information about the prognosis. 16 of 31 patients developod local rccurrcnccs and 11 died at the time of the report.Because patients were counted as alivc regardless of the rccurrence at the time of the report in this review, it is probable that the longer the follow-up poriodis, the poorer the prognosisis.

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The carbon dioxide laser has many advantageous characteristics. The edge of a laser irradiated wound is covered by only a thin layer of necrotic substances. Moreover, the irradiation is made without any physical damage to the remaining tissue.
So if we can vaporize the superficial tissue of mucosal lesions, we will be able to treat leukoplakia, papilloma, and lichen planus.
Before clinical application, we examined dog's tongue healing after defocused carbon dioxide laser irradiation. The irradiated tissues were dissected in order to examine by light and scanning electron microscopes with spot size 5 mm and output power 10-20W. We irradiated the lesions of leukoplakia, papilloma and lichen planus. As a result we think the carbon dioxide laser is useful to treat leukoplakia, papilloma and erosion type of lichen planus.

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Cleiodocranial dysostosis is a rather rare bone development disease and is characterized by abnormalities of the skull, clavicles and teeth.
We experienced a case of cleidocranial dysostosis in a 48-year-old man.
The patient was of short stature and could bring his shoulders medially. The maxilla appeared underdeveloped, so that the mandible was relatively prognathous. In the oral cavity, the palate was high with a groove along the median palatine suture.
Roentgenographic examinations revealed the following: The fontanels remained open and the sutures were unossified. The maxilla and mandible contained at least eighteen unerupted teech. A cyst involving the retained teeth was present in the mandibular premolar region on the right side. The lateral portions of the clavicles were absent. Spina bifida occult and coxa vara were present.

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It is well known that neurofibrom and neurilemmoma are neurogenic tumors. So these tumors occur everywhere neural tissue exists. But they are rarely observed in the oral region, especially the lip.
We treated five cases of neurogenic tumors of the lip. Four cases were diagnosed as neurofibrom and one was neurilemmoma.
Case 1: A 15-year-old boy had a pigeon egg size tumor at the middle lower lip, and suffered from the lesion for ten years. He had been treated 7 and 8 years before visiting our clinic. The tumor excision was performed in 1966 and 1968 by us. The lesion was diagnosed as neurofibrom by the specimen.
Case 2: A 17-year-old boy complained of swelling of the right upper lip. The tumor was excised under local anesthesia and diagnosed as neurofibrom.
Case 3: A 23-year-old female's upper lip lesion was excised and diagnosed as neurofibrom histopathologically.
Case 4: A 22-year-old female had elastic-hard and well-scribed swelling at the middle of the lower lip. The lesion was diagnosed as plexiform neurofibrom.
Case 5: A 24-year-old man had noticed the swelling of the right angle of his mouth 4 years before. Tumor was excised completely and diagnosed as neurilemmoma.
No reccurence was observed in these 5 cases till now.

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This paper described a rare case of jaw trismus caused by the hyperplastic coronoid process and reported the result of a study on the positional interrelation between the process and the zygomatic arch.
A 19-year old boy visited our clinic with complaint of long-standing jaw trismus. The trismus was severe and no lateral movement of the jaw was noticed. Clinical examinations could not reveal any pathologic finding except tenderness on the coronoid process region. On orthopantomograhic and horizontal tomographic films, the overgrown process was found and the coronoid process was situated near the inner surface of the zygomatic arch. By these results, it was found that the overgrown coronoid process interfered with the movement of the mandible.
The coronoidectomy was carried on the both sides. The positional interrelation between the inner surface of the arch and the process detected by the preoperative X-ray films was found to be correct. Good jaw movement was gained postoperatively.
The extirpated process was very thick and extremely elongated and was examined histopathologically. Narrow bone marrow and its surrounding thick cortical layer in which some lines dyed densely by H-E, which were thought to be the result of the bone deposition, were observed. But no neoplastic figure could be found.
The positional interrelation between the process and the arch was examined by using both sagittal and horizontal tomography. The results concerned with volunteers were as follows: At the time of teeth occluded, the tip of the process was situated vertically 1.1mm±5.0 (right side) and 0mm±3.9 (left side) above the lower border of the arch.
The horizontal distance between the inner aspect of the arch and the process was calculated as 9.5mm±5.1 (right) and 9.7 mm±5.2 (left). From these data, it was clarified that the diversity of the coronoid position was unexpectedly great. Regarding the reported case, the tip of the process was situated extremely above the lower edge of the arch (right was 16 mm above and left 18 mm) and the process situated near the inner surface of the arch (the distance was 3mm on the right and 0mm on the left). These findings were greatly out of the range of the standard classfication of the controls. By the facts mentioned, tomography was thought to be valuable in examining the anatomic position of the coronoid process.

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The patient, a 73-year-old man, was referred for reposition of his cross bite, because of temporomandibular joint dislocation. The induced dislocation was supposed to be due to abnormal resorption of the condylar head, obsolete fractures of the mandible and the malar bone in childhood, and also application of the unsuitable full dentures in the maxilla and mandible over ten years ago. The treatment was carried out by restricting operation for anterior movement of the condyle through amputation of the zygomatic arch and pushing downward. The patient has recovered with good relation of occlusion and is comfortable with the result of the operation.

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Pycnodysostosis was first described as an independent entity by Aoike (1954) and named by Marouteaux and Lamy (1962). This lesion is a hereditary and sclerosing bone disease characterized by dwarfism, open cranial sutures, peculiar facial profile and blunt mandibular angle.
In the present report, two cases of pycnodysostosis in two brothers, aged 33 and 31, were studied. They had a history of multiple spontaneous fractures of lower extremities and their parents were first cousins. The elder (Case 1) was admitted to our hospital for treatment of pathological fracture of the mandible that may have been caused by severe osteomyelitis following the extraction of the left lower second molar. The patient was successfully treated by mandibulectomy and immediate reconstruction with A-O plate under antibiotic therapy.
In the patients with pycnodysostosis, a severe osteomyelitis in the jaws seems to easily happen after dental infection because of extreme bone density and abnormal dentition. This fact may indicate a necessity of careful dental treatment and surgery in the patients with sclerosing bone dysplasia such as pycnodysostosis.

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Pleomorphic adenoma is a common Tumor in salivary gland Sheldon has originally proposed the term “myoepithelioma” to the tumors exclusively composed of basket cells in his study on so-called mixed tumor. There are two types of tumor cells derived from myoepithelial cells. One type is hyaline (plasmacytoid) cell, other type is spindle cell. We have examined a case of so-called myoepithelioma exclusively composed of hyaline cells in soft palate of 57 year-old female. In this paper we described clinicopathological feature of so-called myoepithelioma.

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Although the fracture of an alveolar bone occurs most frequently singly or in ccmbination with other fractures of the maxilla and mandible, we experienced a rare case of the mandible alveolar bone fracture.
A 45-year-old man was admitted to the hospital because of the low lip injury and limitation of jaw motion.
Examination showed that the oral cavity was detached from the mandible body and the low alveolar bone from the right first molar to left second molar had a horizontal fracture.
The alveolar segment was fixed by circumferential wiring of the mandible and intact teeth in the line of the alveolar bone fracture have been maintained.

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Two cases of oral carcinoma associated with hypercalcemia are reportedwith a brief survey of nine similar cases. The first case was a 65-year-old man with an epidermoid carcinoma of the mandible (T4N3M0). The serum calcium which was 4.4mEq/l at the initial examination became 5.5mEq/l three weeks after resection of the primary lesion and neck dissection. Despite intensive therapy with a steroid and hydration, the serum calcium level was elevated to 9.9mEq/l in a month with concomitant hypophosphatemia and the patient suddenly died of cardiac arrest. The serum parathyroid hormone (PTH) level was increased to 1.7ng/ml, but the excised tumor tissue was negative for PTH. No abnormality of the parathyroid was noted during neck dissection. Postoperative bone scintigram with Tc showed radioisotope accumulation in the ileum and other bones, but metastasis was not confi rmed because of lack of radiolucency. PTH was most suspected as the cause of hypercalcemia but definite evidence, was not obtained. The second case was a 86-year-old woman with a recurrent epidermoid carcinoma (T4N3M0) of the mandible. The lesion was treated by irradiation. Lung metastasis became evident during the treatment and approximately three months later, an elevation of the serum calcium (6.0mEq/l) associated with leukocytosis (24, 600/cumm) was first noted. Although hypercalcemia was controlled by steroid and hydration therapy, blood leukocyte count constantly increased to 178, 000/cumm in two weeks and the patient finally died of kidney insufficiency. Hypercalcemia, in all likelihood, resulted from the tumor with colony-stimulating activity, but the precise mechanism was not elucidated. The importance of hypercalcemia in the treatment of patients with carcinoma of the oral region was stressed because the clinical symptoms and signs of hypercalcemia are often indistinguishable from those of advanced carcinoma with metastasis and toxicity of anti-tumor agents and radiotherapy.

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Two cases with the mandibular defect were reconstructed with free vascularized osteocutaneous iliac grafts using deep circumflex iliac vessels as the stem. The immediate and late postoperative results after about 3 years follow-up were very satisfactory from the functional as well as the aesthetic aspect.

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Postoperative changes of various hard tissue landmarks, U₁, L₁, point B, Pog, over jet and over bite, were assessed for 17 cases of prognathism that had been surgically corrected by Obwegeser-Dal Pont technique, by means of a series of lateral cephalograms at four times: preoperatively, immediate-postoperatively, 3 months postoperatively and more than 6 months postoperatively.
During intermaxillary fixation U₁ might move upwards and anteriorly in some cases. More than 6 months postoperatively each of U₁, L₁, point B and Pog tended to move upwards, or upwards and anteriorly. In the period of immediate-postoperative time to 3 months postoperatively, movement of each landmark varied significantly. It was probably caused by postoperative orthodontic treatment. Neither over jet nor over bite changed postoperatively. It suggested that postoperative orthodontic treatment could help the stability of anterior occlusal relationship.
Anterior movement of Pog was larger than that of L₁ presumably because of lingual inclination or (and) displacement of lower anterior teeth.
No correlation was found between horizantal or vertical extent of displacement by surgery, and amount of postoperative change of Pog. However, cases of larger amount of vertical extent of displacement showed large variety of postoperative vertical changes of Pog, suggesting poor stability of these cases.
It was also discussed that postsurgical dento-facial changes could be affected by intermaxillary xation, postoperative orthodontic treatment, mobile tendency of teeth and occlusal interdigitation.

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A case of large mucous cyst occurred under the buccal mucosa of a 47year-old male was reported.Minor salivary gland cysts are usually small, 1cm or less indiameter. This cyst extended from the posterior lip to the, retromolar region, 5cm in diameter. From surgical findings, this cyst originated in the glan dula, labiales.
Histological examination revealed a well defined mucous cyst, no epithelial lining. Histopathological diagnosis was an extravasation.

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