The transition of concentrations of FT-207 and 5-FU in the tumors as well as blood, along the process of time after administration of UFT, was studied from 32 cases of head and neck cancer patients. Comparing the initial administered group to the continual administered group on the blood concentration, and comparing also the irradiated group to the non-irradiated group on the tumoral concentration, the following conclusions are drawn.
1. On the blood concentrations, FT-207 showed the highest at 2-hours' measure and gradual decline, however, 5-FU reached its peak within 1 hour and then fell rapidly.
2. Concentrations of the continually administered group were higher than those of the initially administered group.
3. On the tumoral concentrations, measurement at 6-hours was the highest not only FT-207, but 5-FU, and remains high for at least 10-hours.
4. Concentrations of the irradiated group were higher than those of the non-irradiated group.
5. On the comparison between the blood and the tumoral concentration, FT-207 of the former was almost half that of the latter upon measurement, i.e. at 6-hours, between the irradiated group and the continually administered group. On the other hand, the T/B value of 5-FU was almost 26 between the same groups.
6. From the cases which both the concentrations of the blood and the tumors were simultaneously counted, these conclusions were confirmed. Moreover, the same tendencies were shown in the tumor of the neck lymphnode metastasis, and there were slight differences among the locations in one tumor.
Thereafter, UFT provided good safety and left a high tumoral concentration, especially 5-FU, over a long period of time. As the continual administration of 400 mg/day of UFT, divided into two a day, associated with radiation therapy should be a most valuable therapy, the good clinical results may be expected.

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Fibrin membranes, collagen membranes and gelatin capsules were used as rapping materials to prevent the diffusion of the implanted powder-like decalcified bone matrix. The powder-like decalcified bone matrix combined with rapping materials were implanted under the fascia of the abdominal muscle of rats to observe the effect on new bone formation by the rapping materials which were absorbed in the rat during different periods. In addition the histological changes of the decalcified bone matrix due to the response of the rat were also observed.
The results were as follows.
1. Implantation of the decalcified bone matrix alone showed the best bone formation ability, and the new bone formation was not promoted by using rapping materials.
2. Neither new bone formation nor calcification were observed in the groups sacrificed at 3 weeks and 5 weeks after the operation, but only a residue of the decalcified bone matrix were observed. This means that the bone formation ability was lost during these periods. Consequently, it is clear that if the decalcified bone matrix is kept in vivo for long time, the promotion of new bone formation does not occur.
3. When the implanted area suffers from the inflammation, the decalcified bone matrix was calcified again, but the new bone formation was not occurred.
4. The effect of the rapping materials was not outstanding, but it was considered that atelocollagen had the highest possibility for clinical application among the rapping materials which were experimented with in this study. It was felt that this would be even more so when combined with the purified Bone Morphogenetic Protein to make up the appropriate shape for implantation.

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Temporal or acute effects on the sensations of rat tongue with treatments of DMBA (9, 10-dimethyl-1, 2-benzanthracene) known as a strong carcinogen were studied electrophysiologically. Pathological investigations of the tongue treated with DMBA were also performed. Two to 8 weeks after DMBA injection under the tongue mucosa resulted in deep defects, induration and inflammation at the injected area. Taste responses to 0.01 M HCI from chorda tympani nerve increased significantly only when the mucosa showed induration. Erosion appeared within 1 week after periodical treatments by 5% DMBA with traumatic irritation (3 times/week), that turned to ulcer within 3 or 4 weeks. Eight weeks later, it showed rough surface, and then it was covered with whitish plaque after 12 weeks. Histologically, slight dysplasia was observed in the mucosal layer under the whitish plaque. These histological observations indicated that transformation of the tongue tissue in this study may be a precancerous condition. Chorda tympani nerve responses to 0.5 M sucrose treated by 5% DMBA with traumatic irritation were irreversibly decreased in 2 weeks. This irreversible effect on sucrose response might be caused by pathological changes of the tongue surface; speculatively, DMBA might interfere with the reproduction of sucrose receptor protein on the taste cell membrane. In contrast with sucrose, the magnitude of taste responses to 0.01 M HCl applied to the ulcerous tongue increased significantly. This fact suggested that taste nerve in the mucosal layer was directly stimulated by acid solutions as a result of the increase in membrane permeability caused by the inflammation. Tactile sensitivity from the lingual nerve was reversibly diminished in erosive or ulcerous tongue area, where the nerve itself might be damaged by DMBA treatments. In conclusion, it is apparent that histological changes of the tongue caused by DMBA treatment selectively altered the taste responses.

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The effect of oral surgical stress upon the body was psychophsiologically investigated using changes in blood sugar levels as a parameter, because both the endocrine and autonomic nervous systems are involved in the blood sugar control mechanism.
Subjects were selected among patients who were scheduled for extraction of an impacted cranter in the lower jaw at our outpatient clinic and had no family or past history of diabetes nor subjective symptoms of this disease. Since our preliminary experiment revealed that blood sugar variation of ± 10% was regarded to be within the range of measurement errors, the selected patients were divided into 3 groups based on the presence (increase or decrease) or absence of differences in blood sugar levels of more than 10% before and after operation. Citanest^® was used for infiltration local anesthesia in this study, because it contains no epinephrine which affects the blood sugar control mechanism.
Although there were no significant intergroup differences in sex, age, physique, obesity, meal, menstrual state, surgical site, amount of local anesthetic, operation duration, autonomic nervous function, personality or motional trend related to dental treatment, the patients showed various blood sugar changing patterns when they were put under surgical stress. As a result, we further determined inner environmental factors in detail and found different emotional patterns between groups with increased and decreased blood sugar levels. The group with increased blood sugar levels had anxiety about dental treatment at a significantly higher level. Since the autonomic nervous system and emotion have a close relationship and cooperate to control blood sugar levels, we then measured blood pressure and pulse rate, which are well-known physical parameters for the autonomic nervous system, during operation. As a result, changes in blood sugar levels before and after operation were related to the dynamics of these parameters, suggesting that emotional changes related to dental treatment praticipated in changes in autonomic nervous reactions and blood sugar levels while surgical stress was being applied to the body.
In conclusion, the use of changes in blood sugar levels as a parameter has great significance in the objective evaluation of patients' emotion under surgical stress.

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We reported one case of massive hemorraging from the stomach which developed suddenly after Mathé regimen I chemotherapy for tongue cancer. The massive hemorrhage was diagnosed as a side effect which occurred upon administration of large doses of combination chemotherapy for tongue cancer. We decided to add a stomach X-ray examination prior to the combination chemotherapy for the oral cancer.

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Eosinophilic granulomas of bones associated with abnormal chest radiographic findings are extremely rare.
Here we report case of an eosinophilic granuloma of the mandible associated with abnormal chest radiographic findings in a 27-year-old man. During the course of the first medical examination, the patient complained of an oppresive pain on the anterior labial gingival region (3 to 3). Histological findings were compatible with those of eosinophilic granuloma. X-ray examination revealed a diffuse radiolucent area in the median region of the mandible (3 to 2); also ring and reticular shadows in both lung fields. These findings suggested an eosinophilic granuloma with metastasis in the lungs after puncutre biopsy was not clearly established and the patient refused an open biopsy. During the 3 year follow up period, and up to the present, although the X-ray examination reveals a minor enlargement of the radiopaque areas in the lungs the patient has showed no subjective symptoms in relation to these lesions.

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We treated a case of chronic bilateral dislocation of the mandibular condyle that had been present for nineteen months.
The patient was treated conservatively by lever action using intraoral resin plates with built-up heels and by extraoral traction.
Although long-duration cases are commonly treated by open reduction, our method is useful for cases of edentulous.

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Oncocytoma is epithelial in origin and a very uncommon tumor. In oral cavity, it occurs in minor and major salivary glands.
Most of the tumors occur in the parotid glands, while occurances in the submandibular gland, the palate, the buccal region are rare.
Oncocytoma is histopathologically characterized by large cells (oncocytes) which have eosinophilic granular cytoplasm.
This paper reports one case of oncocytoma considered to have occurred in the submandibular gland of a 62-year-old woman.
The prognosis is fairly good after surgical treatment and there is no recurrence after one year and four months.

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Granular cell tumor is a rare lesion of unknown origin. The oral cavity, particularly the tongue, appears to be the most common site of the lesion. We experienced two cases of granular cell tumor in the tongue.
Case 1: A 12-year-old female visited our clinic complaining of a mass in the left lateral margin of the tongue. The lesion occurred about 4 years ago and had not caused any pain and discomfort. It was excised under local anesthesia on July 27, 1984.
Light microscopically, the lesion was composed of a diffuse proliferation of large cells with eosinophilic granules. They contained diastase-resistant PAS-positive granules. Electron microscopical examination showed the basement membrane surrounding each tumor cell and, in cytoplasm many lysosome-like vacuoles contained electron dense particles or myelin figures. No relapse of the tumor was seen 18 months after the operation.
Case 2: A 39-year-old female visited our clinic, complaining of a mass in median dorsum of the tongue. The tumor was resected under local anesthesia on October 6, 1985. The patient was relieved of her complaint without any recurrence at 6 months after the operation. Under light microscopy, the tumor showed a marked proliferation of the tumor cells with abundant eosinophilic granular cytoplasm. In the covering epithelium, pseudoepitheliomatous hyperplasia was found. Under electron microscopy, the tumor cells were surrounded by the basement membrane. In cytoplasm, there were numberous granules with a limiting membrane.
Our investigation by light and electron microscopic examination showed the basement membrane surrounding each tumor cell and in cytoplasm, and many lysosome-like vacuoles containing electron dense particles or myelin figures. But myofibrils were not found. These findings suggest that the histogenesis of the granular cell tumor is a neurogenic origin.

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The author experienced a case of pyogenic granuloma on the tongue of pregnant woman. The patient, a 29-year-old woman, referred to my clinic because of tumor on the tongue occuring 10 days earlier on October 3, 1986. Histology showed no abnormality except 9 months of pregnancy. Routine clinical laboratory tests were almost normal. Examination revealed that the tumor was a round mass of about 4 mm in diameter, which was reddishblack with yellow area and well-defined. Clinically, it was diagnosed as a benign tumor of the tongue and resected under local anesthesia. The removed mass measured 6×4×3mm and the surface was plain. The cutting plane was reddish-black and elastic soft. Histo-pathological finding revealed that the tumor was lined by squamous epithelium, capillary tissues, and edema was observed. From these findings, it was diagnosed histo-pathologically as pyogenic granuloma. The post-operative course was uneventful and there was no recurrence 8 months after the operation.

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This report was undertaken to reveal the process of changes occuring in the alveolar clefts secondarily transplanted with fresh autogenous particulate cancellous bone and marrow of iliac bone, the frequency of the bone bridge formation in the alveolar cleft, and the time of bone bridging after the operation.
The subjects were 87 cases with alveolar clefts, which consisted of 14 cleft lip and alveolus, 55 unilateral cleft lip and palate, and 18 bilateral cleft lip and palate. The average age at the time of bone grafting was 13 years 0 month with a range from 8 years 5 months to 22 years 1 month. The materials used in this investigation were periapical and occlusal radiographs taken before and after the bone grafting.
The information obtained was summarized as follows:
1. The frequency of the bone bridge formation in the alveolar clefts by one year postoperatively was 84.9% as a whole, and it had a tendency to decrease as the patients age increased.
2. The bone bridge formation was completed from three to six months in the majority of the cases, and the average bone bridging time was 5. 4 months after the operation. The completion of the bone bridge formation was likely to delay, as the time of operation was later.
3. No significant relation was observed between rate of successful bone formation in the clefts and the sex of the patient or the type of clefts.

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This study investigated the pre and post-operative changes of mandibular movement by means of mandibular kinesiograph for mandibular prognathism which indicated sagittal splitting ramus osteotomy. After surgery, the following was observed.
1. On the frontal plane for habitual opening and closing movement, the condition of asymmetry or deviation decreased.
2. The smoothness in the opening and closing movement speed increased.
3. There was no notable change observed in the stability of rest position or the relation ship between the rest position and intercuspal position.
4. On the frontal plane of the lateral gliding path, the angle of the path tended to resemble that of the normal group.

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Hemangioma is a common tumor in the region of oral surgery, but cases including phlebolith are relatively rare.
We encountered a case of hemangioma with a phlebolith on the tip of the tongue. We analyzed the composition of the phlebolith using computer aided microanalyser and energy dispersive spectrometer.
The patient was an 82-year-old woman with swelling on the tip of the tongue.
The tumor was resected using an Nd-YAG laser. The tumor was 10×10×10 mm in size, and the phlebolith was 1.5×1.2×1.0 mm in size. Histopathological diagnosis indicated cavernous hemangioma.
The main components of the phlebolith were found to be Ca and P using the energy dispersive spectrometer, and the Ca/P ratio was 1.86. Ca and P was recognized in the center region of the phlebolith by computer-aided microanalyser finding.

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Osteocartilaginous exostosis (osteochondroma) is a benign lesion that occurs in the epiphyses of the long bones, primarily in the femur and tibia. It is cartilage capped bony growth protruding from the surface of the affected bone. Osteocartilaginous exostosis of the mandibular condyle is rare, and only a few cases have been reported in literature.
In this paper, we report on a case of osteocartilaginous exostosis occurring in the left mandibular condyle. The patient, a 33-year-old woman whose complaint was a facial asymmetry and malocclusion, was examined on May, 8, 1986. She had first noticed a painless swelling at the left temple 3 years previously. Palpation revealed that the left mandibular condyle was swollen and dislocated from the fossa. Trismus was not found, suggesting that the cartilaginous cap had functioned as an articular cartilage. The radiologic views demonstrated the presence of a large bony mass protruding from the medial aspect of the mandibular condyle. The surgically excised tumor showed osseous tissue covered with a hyaline cartilage of varying thickness. The patient was followed without evidence of recurrence for 7 months after the surgical operation.

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Carcinomas occurring in the jaws are rare.
We have recently experienced two cases of carcinomas occurring in the mandible.
Case No.1: A 53-year-old woman was referred who had swelling in the retromolar region. Radiographic examination showed a radiolucent region with regular margin at mandibular angle. Pathological examination revealed mucoepidermoid carcinoma.
Case No.2: A 57-year-old woman was referred who had painful swelling in the left mandible. Radiographic examination showed a radiolucent region with an irregular margin in the left mandible.
Pathological examination revealed squamous cell carcinoma.
These carcinomas were metastasized to submandibular lymphnode on their affected side.

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Lichen planus is considered to be a precancerous condition, and in the west, it is not rare for cases of lichen planus in the mucosa of the lips or oral cavity to become malignant in comparison with such lesions occurring in the skin. Among the cases of lichen planus of the oral mucosa in Japan, there are very few which have become malignant. In oral surgery, no cases have been reported such as the present one where lesions of lichen planus were diagnosed to be cancerous in the initial histopathological examination and then the focus of the same lichen planus, shifted into cancerated lesions in the same institution, thereby confirming malignant changes.
The present case was a 63-year-old man with erosive lichen planus in the bilateral buccal mucosa. The synthetic retinoid preparation etretinate was administered orally, but the symptoms did not improve, and the left buccal lesion where a biopsy was performed 6 months after the first examination was found to have developed into squamous cell carcinoma. The cancerous lesion was cured by administration of peplomycin and radiotherapy. At present, 5 years and 6 months after irradiation, its development course including the right lesion has made satisfactory progress.

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In direct relation to the extension of the average span of human life, the incidence of the double cancer has been increased, though still uncommon in the oral region.
The case of a 57 year old female, in whom an adenocarcinoma of the sigmoid colon was followed by a squamous cell carcinoma of the left mandible, is reported herein. The onset of the latter occurred forty two months after a successful excision of the earlier carcinoma.
Based on retrospective survey of 82 cases of oral-related double cancer reported in past Japanese literature, the results are summarized as follows:
1) Sex: Male/Female=2.9/1
2) Age: 89.1% of cases occurred over the fifth decade of life.
3) Interval of the cancers. Majority of the cases (83.1%) had the second cancer within 5 years.
4) Gastrointestine proved to be the most highly affected system (56.9%) in oral-related double cancers.
5) In regard to the histopathological typing of both cancers, squamous cell carcinoma and adenocarcinoma were the two major constituent types?

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The effect of the pre-operative therapy on the formation of new bone was examined in ten cases of gingival carcinoma of the mandible. All of the cases was treated with radiotherapy and/or chemotherapy before surgical operation. The effect of the pre-operative therapy was evaluated on the histopathological basis of classification by Oboshi and Shimosato. As a results, the formation of new bone was notably observed in four of ten cases. These four cases were G.III or IV in Oboshi and Shimosato's classification. Such active formation of new bone progressed along the periosteum and aponeurosis.

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Two cases of the rarely observed temporomandibular joint (TMJ) clicking in the neonate were reported.
In the first case, a female baby of nine days after birth was referred to our clinic and showed bilateral TMJ clicking every time milk was taken in from her mother. On the first occasion, we could not find any gross anomaly in the face nor stomatognathic system. We followed up without any treatment. At the age of three years she had experienced TM J clicking only during yawning, and her maxillofacial and occlusal development, and teeth eruptions, masticatory function were within the normal range.
This case was followed periodically for about four years. During her last visit at four years of age, the TMJ click disappeared spontaneously.
The second case was a four-day old female infant, who exhibited bilateral TMJ clicking upon-taking in milk and yawning withot any physical anomaly.

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The present study describes the results of chemotherapy by cisplatin combined with the radiation therapy. A total of 12 patients with the head and neck cancer were treated. The location of the primary site was the maxillary sinus in 4 cases, the tongue in 2 cases, the maxillary gingiva in 2 cases and the mandibular gingiva in 2 cases. The buccal mucosa and mandibular bone were affected in each one case. The Histological types of the tumors were squamous cell carcinomas in 11 cases and adenocarcinoma in one case.
Six patients were treated by intraarterial injection of cisplatin and another six patients were treated by intravenous injection of cisplatin. Total dose from 30 to 50 Gy of irradiation was administrated to both groups. Results of the therapy of 10 patients were CR in 6 cases, PR in 3 cases and NC in one case. The CR rate was 60 percent and PR rate was 30 percent. CR was achieved in all 4 cases treated by intraarterial administration of cisplatin.

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A 23-year-old female patient with severe trismus caused by myositis ossificans progressiva was reported. Her trismus developed at the age of 14 and it progressed gradually. At 15 years of age she was diagnosed myositis ossificans progressiva by orthopedists.
On admission a maximum interincisal opening of 0.5 mm was noticed but mobility of bilateral masseter muscles was not remarkably disturbed. The routine hematological studies including alkaline-phosphatase revealed normal. Computed tomograms showed the bridging of high-density mass between the right coronoid process and the zygoma, and it was diagnosed as heterotopic ossification of the insertion of the right temporal muscle.
Judging from the past medical history that her symptoms were resistent to administration of diphosphonate (EHDP) and adrenal cortical hormones and that she was not in the active state of disease then, surgical treatment of bilateral coronoidectomy and excision of calcified mass in the right temporal muscle was carried out. An interincisal opening of 30 mm was achieved at the time of the operation. The postoperative course was uneventful except that trismus developed again because of poor physiotherapy. One year after the operation, X-ray examination revealed no recalcification in the operated location.

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The present study was designed to investigate the relation between the shape and length of the styloid process and age. At the first step, as experimental study we examined the relation between the styloid process at skull and axial view of the layer for the Orthopanthomograph Model (Panoramax) and calculated the image distortion in panoramic radiography.
Then as clinical study we examined the relation between the age and the styloid process for 633 patients aged 9 to 88 that visited to our clinic.
Results were summarized as follows:
I. It was confirmed that the styloid process was located in axial view of the layer for the Orthopanthomograph Model (Panoramax).
2 Magnification in panoramic radiographs was 1.2, calculated using a simplified model devised by us.
3. In all patients, the length of the styloid process tended to increase with advancing age.
4. No distinct difference was found between male and female for elongation of the styloid process.
5. The difference of styloid process length between left side and right increased with advancing age.
6. The shape of the styloid process was classified into two types due to mineralization continuity, that is, one was split type and the other was non-split type. With all patients, the proportion of the split type markedly decreased with age. However cases with elongated styloid process were not related to increasing age. In all patients the proportion of the split type was 17.5%, but in the elongated styloid process it was 40.7%.

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We treated the majority of displacements and dislocations of mandibular condyle fragments surgically and other cases with conservative treatment for years. Inauires were made of case records of 123 patients with a diagnosis of fractures of condylar process in our ward in the 15-year-period 1971 through 1985 to observe results. Sixty-six of 123 patients responded to the questionnaire. They were composed of 36 patients with surgical treatment and 30 with conservative treatment. After analyses, we obtained the following results.
1. In functional views of the temporomandibular joint, prognoses of displacements and dislocations of condylar fragments were just as good as those of no displacements and deviations when they are treated surgically.
2. Prognoses of surgical treatments of condylar fractures were not influenced by patient age, situation and the location of fracture of condylar process and period from trauma to treatment.
3. The surgical treatments resulted in four cases of paresthesias in the cheek and two cases of paralyses at a part of facial nerve.
4. We usually chose preauricular or submandibular approaches and the scars following incisions did not cosmetically please 27.8 per cent of the patients.
From the above, we assume that indications for surgical treatment of condylar fractures of the mandible are for elderly patients with displacements and adults with dislocation of fragment, bilateral displacements, lateral displacement or displacement which have lasted more than two weeks after trauma.

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Cystic hygroma is an uncommon benign tumor which may grow so large as to make serious symptoms. The most common site for cystic hygroma is neck. Many reports about its treatment had been presented up to date, but we consider surgical excision the best treatment. Recently we experienced two cases of cystic hygroma in which surgical excision was made which had yet no recurrence.

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The lymphoepithelial cyst commonly occurs on the lateral aspect of the neck, but rarely in the oral cavity.
The cyst is characterized by a cystic cavity lined by stratified squamous epithelium, surrounded by lymphoid tissue.
We report a case of the oral lymphoepithelial cyst in the right ventral surface of the tongue with some discussion.
The case was 73 year-old female who complained of a small mass on the right ventral surface of the tongue. As clinical findings, the mass had 10mm×7mm oval shape, clear border, smooth surface, and was elastic soft.
The prognosis is fairly good after surgical treatment and there is no recurrence after one year.

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Three cases of cervical lymphoepithelial cysts were reported. The first case was a 61 year-old female with a tumor in the right lateral cervical region. Ultrasonographic examination revealed a typical cystic pattern. The histopathological diagnosis was lymphoepithelial cyst (so called branchial cyst) and it was in accordance with the clinical diagnosis. The second case, a 53 year-old female, had a large mass from the left parotid region to the lateral cervical region. Preoperative ultrasonographic examination revealed the co-existence of a solid and cystic pattern. Clinical diagnosis was a parotid tumor. Histologic examination of the extirpated specimen revealed that the cystic region was a lymphoepithelial cyst and the solid region was a foreign body granuloma. The third case was a 55 year-old female who had a tumor at the right submandibular region. From the results of ultrasonographic and CT examinations a cyst was suggested. But the sialogram of the submandibular gland and the site of the lesion suggested a tumor. The pathological diagnosis was a lymphoepithelial cyst. Ultrasonograms accurately showed the inner nature of the lesions in all cases.

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Neurilemmoma is a benign nerve sheath tumor arising from the Schwann cells. Most of these tumors arise in the head and neck region but rarely in the mandible. We present a case of central neurilemmoma of the mandible.
A 36 year-old woman referred to us on July 30, 1984 complained of paresthesia the right lateral border of tongue and right side of lower lip. The clinical diagnosis was suspected kerato cyst. Biopsy specimen was taken and diagnosed neurilemmoma showing mixed type of Antoni A and B. Removal of this tumor was performed under general anesthesia on Nov. 9, 1984.
In a review of literature from 1959 to 1986, we were able to find 16 cases of central neurilemmoma of the mandible.

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Recently, there have been few patients with suppurative arthritis of the temporomandibular joint, following the improvement of in antibiotics therapy in recent years.
A case of acute suppurative arthritis of the temporomandibular joint in a 47 year-old man is presented. He first visited our hospital in February 1984 with the chief complaint of pain in the left mandible. Regarding his general status, he had anorexia, and a general feeling of dullness and locally he had rotation of occlusion, difficulty in opening his mouth, diffuse swelling of the mandibular joint and pain and tenderness.
We examined him by conventional radiographic computed tomography, Ga-cintigraphy, single contrast and double contrast arthrotomography, bacteriological tests and arthroscopy. We aspirated pus and concluded that the cause of his ailment was bacterial, and after antiinflammatory therapy, discharge of pus and irrigation the patient is progressing favorably.
After healing of the inflammation, clinical and radiographic observations indicated ankylosis of the temporomandibular joint. Therefore we performed an examination and arthroscopic surgery.
It is suggested that in this case, arthritis of the temporomandibular joint had an important secondary effect on the form and function of the temporomandibular joint after the respite of the inflammation.

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Clinical study of 6315-S (FMOX, Flomoxef) in various infections in the field of oral surgery were carried out. 6315-S was administered by intravenous injection at a daily dose of 2 g (1 g×2 times) to 25 patients with various infections.
Cases consisted of 16 with maxillary ostisis, 4 phlegmon of the floor of the mouth, 2 peritonsillar abscess, 1 pericoronitis, 1 palatal abscess and 1 sialoadenitis submandibularis.
The following results were obtained. The clinical effects obtained in subjective judgement were excellent in 5 cases, good in 15 cases, fair in 4 and poor in 1. The clinical effects obtained in judgement by point were classified as excellent in 5 cases, good in 19 and poor in 1. Effective rate in subjective was 80.0%. Effective rate in judgement by point was 96.0%.
The only side effect was diarrhea in one case.
In the laboratory examinations, elevations of s-GOT and s-GPT in one case were observed.
The results indicated the usefulness of 6315-S in the treatment of various infections in the field of oral surgery.

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