巻号一覧
37 巻, 8 号
選択された号の論文の17件中1～17を表示しています
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網野 かよ子1991 年 37 巻 8 号 p. 1413-1426
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーThere are two main radiation effects in therapy of malignant tumors, one is the direct cytotoxic effect of radiotherapy and another is the immunological response in the host.
To investigate the state of the immunological response after radiation, the rise and fall of killer cell and cytokine activities were studied in an experimental tumor system using BALB/c mice and syngeneic Meth-A fibrosarcoma.
The mice, inoculated with X-ray treated Meth-A (Rad-Meth-A-mice), acquired antitumor immunity as demonstrated by a Meth-A challenge test. Moreover, the mice inoculated with Mitomycin C treated Meth-A (MMC-Meth-A-mice) also acquired the same immunity.
The effector cells in Rad-Meth-A-mice and in NINIC-Meth-A-mice were mainly cytotoxic T lymphocytes (CTL).
The maximum CTL activity was noted on Day 14 and 21 after inoculation in Rad-Meth-A-mice and MNIC-Meth-A-mice. The spleen lymphocytes of Rad-Meth-A-mice produced Interleukin 2 (IL-2), Lymphotoxin (LT) and Interferon (IFN). On the other hand, the spleen lymphocytes of MMC-Meth-A-mice produced IL-2 and LT, but not IFN.
Moreover, the responsiveness of spleen lymphocytes to IL-2 increased in quantity.
Ia antigen positive ratio of spleen macrophages that were taken from Rad-Meth-A-mice and MMC-Meth-A-mice increased.
Taken together, these results suggest that Meth-A treated with either X-ray or Mitomycin C can induce a specific antitumor immunological response in mice.抄録全体を表示PDF形式でダウンロード (4049K) -
宮木 克明, 村上 賢一郎, 瀬上 夏樹, 飯塚 忠彦1991 年 37 巻 8 号 p. 1427-1439
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーHistological and morphologic changes after surgical incisions at the junction of the disk and retrodiscal tissue (disk plication surgery) on rabbit temporomandibular joint (TMJ) were studied. The experimental groups of a total of 20 animals were divided into three groups; i. e. disk plication surgery, simple arthrotomy on the upper joint cavity, and arthrotomy on both upper and lower joint cavity (sham operation group).
The results were obtained as follows:
1. In four weeks after surgery, the incision at the junction of the disk and retrodiscal tissue had healed without any abnormal episode on TMJ structure. At 24 weeks after surgery, neither significant morphologic change of the TMJ nor destructive change was observed.
2. No significant abnormal change of TNIJ structures was induced by simple arthrotomy on both upper and lower joint cavities at the 24 weeks post-operative observation.抄録全体を表示PDF形式でダウンロード (23617K) -
特に組織発生について風岡 宜暁1991 年 37 巻 8 号 p. 1440-1453
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーSixteen cases of adenocarcinoma arised from salivary glands were investigated in terms of immunohistochemical detections of lysozyme, secretory component, lactoferrin, keratin (total keratin, KL-1, PKK1) and S-100. The following results were obtained:
4 of 16 adenocarcinoma were positive for lysozyme, and lysozyme staining existed in well and moderately differentiated carcinomas. 7 of these adenocarcinomas showed a positive staining for secretory component, of which 1 had well, 5 moderate and 2 poor differentiated types. Localization of lysozyme and secretory component was frequently detected in the relatively well differentiated tumors. The combined findings of these two substances were considered to be the universal marker for the functional differentiation of adenocarcinoma.
Staining reaction for lysozyme, secretory component and lactoferrin was observed in the tumors 25%, 44% and 38% respectively. Immunohistochemical staining for these materials were mainly localized in the interlated ducts but lacked in excretory ducts in the normal salivary gland.
Keratin is a marker for the epithelial cells and tumors. All the adenocarcinomas were positive for total keratin and KL1, and 4 of these tumors-showed for reduced PKK1 staining with irregular distribution.
S-100 staining appeared in serous acinus cells nerves and skeletal muscles, but rnyoepithelial cells were devoid of S-100 reaction. It is suggested that adenocarcinoma in salivary gland origin did not originate front the terminal secretory epithelium.抄録全体を表示PDF形式でダウンロード (11275K) -
尾崎 輝彦, 岡本 哲治, 藪本 正文, 明見 能成, 高田 和彰1991 年 37 巻 8 号 p. 1454-1465
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーWe have established serum-free culture system for normal epithelial cells and cancer cells derived from oral mucosa and the salivary gland. It was found that oral cancer cells were able to grow in a serum-free medium supplemented with insulin, transferrin, sodium selenite, 2-aminoethanol and 2-mercaptoethanol disignated RD5F as same as that in the medium supplemented with 10% FBS. On the other hand, normal epithelial cells were not able to grow in a serum-free medium supplemented with factors as above. Thus hormone and growth factor requirement for proliferation of normal epithelial cells were studied in a serum-free medium. It was revealed that normal epithelial cells absolutely required EGF or FGF for the growth in a serum-free culture. Furthermore, we have studied effects of. EGF and FGF on the growth of oral cancer cells in a serum-free culture and expression of these factor receptors on the cell by radioligand receptor assay.
EGF stimulated growth of adenocarcinoma cells derived from the salivary gland (SAC) but inhibited that of squamous cell carcinoma (SCC) cells at the concentration which stimulate growth of other cells. FGF stimulated growth of SAC but did not have any effect on SCC cells. Furthermore, we could not find any significant differences in the expression of EGF and FGF receptors of these cells. Taken together, it was revealed that oral cancer cells exhibited lowered or lost requirement of EGF and FGF for growth compared to normal epithelial cells. These results strongly suggested the possibility that EGF and/or EGF receptor expressed in SCC cells were functionally different from that of normal epithelial cells.抄録全体を表示PDF形式でダウンロード (5059K) -
下顎頭所見を中心に鈴木 明1991 年 37 巻 8 号 p. 1466-1479
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーThe study was carried out to investigate the effect of calcitonin (ECT), an analogue of natural eel calcitonin, on the mandibular condyles of rats with experimental osteoporosis induced by triethylene thio-phosphoramide (TEPA) by histology, scanning electron microscopy and computer aided microanalysis.
Wistar rats were divided evenly into 6 groups. The animals of the Normal Group were given distilled water once a day for 7 days, and those of TEPA Group were given 10mg of TEPA/kg by single injection. Those of TEPA·ECT5, TEPA·ECT10, TEPA·ECT20 and TEPA·ECT40, Groups were given 10mg of TEPA/kg by single injection and then received 5, 10, 20 and 40U of ECT/kg, respectively, once a day for 7 days.
1. In TEPA Group, the cells of the zone of differentiation and hypertrophy decreased in cell number and in thickness. By scanning electron microscopy, the matrix of cartilage and bone decreased. By computer aided microanalysis, the concentrations of Ca and P on the condyles decreased.
2. In TEPA·ECT5 and TEPA·ECT10, Groups, the zone of hypertrophy increased in cell number and in thickness as compared with those of TEPA Group. By scanning electron microscopy and computer aided microanalysis, the condyles showed changes similar to those in TEPA Group.
3. In TEPA·ECT20 and TEPA·ECT40, Groups, there were cell numbers and thicknesses in the zone of differentiation and hypertrophy as compared with those of TEPA, TEPA·ECT5, and TEPA·ECT10 Groups. By scanning electron microscopy, the matrixes of cartilage and bone were similar to those in the Normal Group. By computer aided microanalysis, in TEPA·ECT20 Group, the distribution of Ca and P were similar to those of the TEPA Group. In TEPA·ECT40, Group, however, the distributions of Ca and P showed those of between the Normal and TEPA Groups.
4. The results of the present study indicated that ECT inhibited the progress of disorders of rat mandibular condyles induced by TEPA and the effects of ECT were related to the doses of ECT.抄録全体を表示PDF形式でダウンロード (9799K) -
成因ならびに文献的考察中島 健, 藤本 誠一, 立石 晃, 樋田 謙二郎, 安光 千昭, 原 巌, 山田 長敬, 福山 宏1991 年 37 巻 8 号 p. 1480-1484
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーAnomalies of first branchial cleft are rare lesions that were classified as two types by Work. Type I incorporates ectodermal elements from the first branchial cleft only. Type if incorporates ectodermal elements from the first branchial cleft and mesodermal elements from the first and second branchial arches.
We experienced a Type II anomaly of first branchial cleft occurring in an 8-month-old infant. The sinus was located anterior to the right sternocleidomastoid muscle and opened at the right submandibular region through a fistulous tract. Histopathologically the sinus and tract wall was lined by keratinized squamous epithelium with adenexal skin structures and cartilage components. However, we also observed peudostratified ciliated epithelium with lymphoid tissue in part of sinus and tract wall. This finding suggested that this anomaly originated from not only first branchial cleft but second branchial cleft.抄録全体を表示PDF形式でダウンロード (5140K) -
高山 泰男, 松永 心子, 桜井 希巳江, 田津原 広行, 山野井 弘充, 関和 忠信, 堀 稔, 田中 博, 小宮山 一雄1991 年 37 巻 8 号 p. 1485-1489
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーA case of desmoplastic fibroma arising in the mandible in a 41-year-old female was reported.
Radiological examination revealed a poorly circumscribed lesion and many non-uniferm spotty radiolucent appearances were noticed.
For treatment, a portion of the tumor was resec ted from 2 to 7 of the mandible.
Histopathological examination revealed that the tumor was composed of the interlacing bundles of dense collagenfibers and fibroblasts.
The case reported here was considered to be an atypical in radiological findings, arid to be a typical in histopathological findings.抄録全体を表示PDF形式でダウンロード (6836K) -
辻 龍雄, 早津 良和, 前田 寛治, 井上 敬, 佐々木 功典, 篠崎 文彦1991 年 37 巻 8 号 p. 1490-1491
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーPDF形式でダウンロード (3660K) -
秋葉 正一, 青木 秀史, 尾嶋 徹1991 年 37 巻 8 号 p. 1492-1493
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーPDF形式でダウンロード (3881K) -
中村 康洋, 天笠 光雄, 二藤 彰, 佐藤 仁, 泉 祐幸, 塩入 重彰, 塩田 重利, 草深 公秀, 岡田 憲彦, 宮崎 和廣1991 年 37 巻 8 号 p. 1494-1498
発行日: 1991/08/20
公開日: 2011/09/13
ジャーナル フリーCrohn's disease is defined as a granulomatous inflammatory condition affecting sectionsfrom the oral cavity to anus. A 57-year-old female suffering from Crohn's disease with oralmanifestations is reported in this paper. She had ulcerative lesions in the oral cavity, in theesophagus and in the anus. She also suffered from a Sjögren's syndrome like condition. Theoral manifestations of the patient were aphthous ulcer, mucosal tag, pyostomatitis vegetans, nodular swelling on the dorsum of the tongue and gingivitis.抄録全体を表示PDF形式でダウンロード (5291K) -
第1報簡易検診法について栗田 賢一, 石井 拓男, 成田 幸憲, 小木 信美, 湯浅 秀道, 池田 憲昭, 河合 幹, 榊原 悠紀田郎, 中垣 晴男1991 年 37 巻 8 号 p. 1499-1505
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーIn mass screening for temporomandibular dysfunction a simple method for examiningtemporomandibular joint function is needed because examination time for individuals islimited. Moreover, examinees should be classified according to the degree of temporomandibulardysfunction. NVe developed a new examination method which classified the dysfunctionaccording to (1) maximal mouth opening, (2) TM J sound, (3) muscle pain, (4) TMJ painon palpation, and (5) pain on movement of mandible. One score point was given to eachpositive symptom, and a total score was added together. Therefore, each individual could beclassified into 6 dysfunction grades from 0 to 5 points. The results were compared to thoseby the conventional TMJ examination method reported by Helkimo in 272 Japanese.
The result showed that our examination method evaluated individual TMJ function moreaccurately than Helkimo's method, because the values for maximal horizontal movement anddeviation during opening or closing movement were not correctly measured by Helkimo'sexamination method in the limited time.抄録全体を表示PDF形式でダウンロード (1474K) -
西原 一秀, 野添 悦郎, 三村 保, 丸谷 和弘, 川越 佳昭, 成田 信, 北野 元生1991 年 37 巻 8 号 p. 1506-1511
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーThe leiomyomatous hamartoma is uncommon in the oral cavity. We recently experienceda case of multiple hamartomas of the tongue with palatal recess in a 15-day-oldboy.
The two hamartomas were located on the dorsal surface of tongue along the medianline as polypoid masses measuring 10× 10× 4 mm and 4× 3mm.
The two masses were removed under general anesthesia. Microscopically, the posteriormass was composed of heterotopic smooth muscle fibers interspersed with salivary glandtissue, blood vessels, lymphatic vessels and adipose tissue. Myxomatous fibrous tissue wasobserved in the subepithelial area of the mass.
The anterior mass was an ill-defined focus composed of smooth muscle and blood vesselwith mucosal cover.
Histopathological diagnosis was multiple leiomyomatous hamartomas of the tongue.
The postoperative course was uneventful.
Neither recurrence nor metastasis occured in these one year after the surgical operation.This report is the third case of multiple leiomyornatous hamartomas of the tongue found inthe literature.抄録全体を表示PDF形式でダウンロード (7863K) -
佐藤 仁, 天笠 光雄, 佐藤 和子, 山田 隆文, 川口 哲司, 冨塚 謙一, 石井 純一, 小林 裕, 塩田 重利, 岡田 憲彦, 井上 ...1991 年 37 巻 8 号 p. 1512-1516
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーMultiple oral cancers have been found more frequently today than in past years.The reason may be due to the progress of therapeutic result and the long term follow-up observationafter success of prompt and effective treatment of the first primary lesion.
Multiple cancer involving oral cancer were observed frequently in the multicentric areassuch as the stomach, lung, and esophagus but rarely found in the thyroid.
The patient with double cancer of the tongue and thyroid was found due to material fromradical neck dissection for tongue cancer.抄録全体を表示PDF形式でダウンロード (9043K) -
池田 洋一, 森川 雅之, 茅野 晃弘, 西嶋 克巳, 永山 久夫1991 年 37 巻 8 号 p. 1517-1522
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーPleomorphic adenoma is the most common tumor in all salivary glands. It affectsat the parotid gland in the major salivary gland or palatal mucosa in the minor salivarygland, but it seems to be rare in the cheek, lip, and tongue.Recently we have experienced four cases of pleomorphic adenoma of the cheek and theupper lip, and reported that outline as follows:
1. At the cheek was one case (44-year-old female), at the upper lip were three cases (23-year-old male, 42-year-old female, 74-year-old female).
2. In all cases, the tumor was covered with fibrous capsula, and clearly separated fromthe marginal tissues, so we have enucleated the tumors.
3. We thought that echography, CT, xeroradiography was more useful for the tumorsize, the relation to marginal tissues, the diagnosis of quality and inner structure of the tumorin pleomorphic adenoma of the cheek.
4. During the observation ranging from six months to three years and nine months, therewas no recurrence and the prognosis was good for all cases.抄録全体を表示PDF形式でダウンロード (8358K) -
第1報 二次性上皮小体機能亢進症患者のオルソパントモグラムを中心に中井 康寿, 竹内 学, 松田 匡房, 金田 敏郎1991 年 37 巻 8 号 p. 1523-1532
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリー107 patients with secondary hyperparathyroidism underwent subtotal parathyroidectomyor total parathyroidectomy with forearm autograft in our hospital. NVe attempted oralroentgenographic evaluation with their orthopantomogram just before this operation.
1. 95 patients (88.8% of total) had abnormal findings on their orthopantomogram.
2. Among six regions of lamina dura, temporomandibular joint, trabecula, mandibularcortical bone, mandibular canal and maxillary sinus floor line, we found a high frequency ofabnormality at the lamina dura (71.4%) and mandibular canal (72.9%).
3. Panoramic Radiograph Index (PRI) which was a total of abnormal findings score ofsix regions was correlative with roentgenographic changes of hand and serum alkaline phosphataselevel.
4. PRI was not correlative with period of hemodialysis treatment, serum parathyroidhormone level and total weight of removed parathyroid glands.
5. Orthopantomogram is useful for evaluation of bone disease in secondary hyperparathyroidismpatient.抄録全体を表示PDF形式でダウンロード (8116K) -
林 解平, 石井 保雄, 伊東 俊祐, 小笠原 利行1991 年 37 巻 8 号 p. 1533-1545
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーThe clinical description of a case of the first and second branchial arch syndrome (Hemifacial microsomia) was presented. A patient, 17 year 8 month old female as clinicallymanifested a presence of a small auricle was displaced inferiorly, stenosed to external auditorycanal and absence of rt-tragus, hypoplastic deformations of rt-maxilla, Zygoma mandibularramus, and underdevelopment of soft tissue over the affected side of the face. And so a postoperative small scar was showed on the rt-angle of the mouth where she had been operatedon for macrostomia when she was 9 years old.
Associated anomalis that were not exhibited were the spine, cervico-thoratic vertebra andelse extremities.
Radiographic and C.T. scanning examinations revealed at the abscence of the rtcondyleprocess and malformation of rt-mandibular ramus, zygomatic arch, temporalbone. The mildly clock-wise rotation of the mandible was shown on cephalometric analysis oflateral head film. As a result facial asymmetry and micrognathia were confirmed.
For surgical approaches, that Le Fort I osteotomy and constructed by iliac bone grafton the affected side, compensatory sagittal splitting osteotomy on the normal ramus wereperformed at one-stage. In addition, we presented a review of literatures.抄録全体を表示PDF形式でダウンロード (13281K) -
菅原 利夫, 森 悦秀, 瀧田 正亮, 川本 知明, 加納 康行, 南 克浩, 三島 克章, 作田 正義1991 年 37 巻 8 号 p. 1546-1551
発行日: 1991/08/20
公開日: 2011/07/25
ジャーナル フリーPycnodysostosis is a rare and hereditary sclerosing bone disorder characterized bydwarfism, open cranial sutures, mandibular angle loss and hypoplasia of the maxilla. Weexperienced to treat a 39-year-old female patient and analyzed her general, oral, and maxillofacialmorphology.
We mentioned characteristics of the disease and discriminating points of similar diseases.抄録全体を表示PDF形式でダウンロード (9253K)
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