Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by autoantibodies against platelets.
It is necessary for patients with ITP to increase their platelet count before tooth extraction because of an increased risk of bleeding complications.
In 1981 Imbach et al. reported that high-dose gamma-globulin therapy could increase the number of platelets in ITP.
Recently, this treatment has been used clinically in the oral surgical field. However, there are no clinico-statistical reports.
We clinically analyzed 12 patients with ITP who underwent tooth extraction under high-dose gamma-globulin therapy in our hospital from 1989 through 2004.
The results were as follows:
1. In 10 patients (83.3%), the platelet count increased to above 5×104/μ1. In 2 patients (16.7%), there was no elevation of the platelet level.
2. There were no severe side effects associated with therapy.
3. We consider high-dose gamma-globulin therapy very useful for increasing the platelet count immediately before tooth extraction in patients with ITP.
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