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巻頭言
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岡本 俊宏2024 年 70 巻 9 号 p. 355
発行日: 2024/09/20
公開日: 2024/11/20
ジャーナル フリーPDF形式でダウンロード (505K)
総説
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德増 誠一2024 年 70 巻 9 号 p. 356-363
発行日: 2024/09/20
公開日: 2024/11/20
ジャーナル フリー1 . A Basic Framework of a Medical Malpractice Lawsuit; Section 2 of the text
Customary, Article 709, 715 of the Civil Code, in regards to tort, or Article 415 of the Civil Code, in regards to default, is selected as a legal bases for a claim for damages in a Medical Malpractice Lawsuit.
Allegation propositions in a Medical Malpractice Lawsuit are thought of as Negligence, Infringement of Rights or Interests, Damage, and Causation.
Negligence is judged on the basis of the Medical Standards, on the premise of the facts which Doctors were able to know at the time of the medical treatment; Negligence is structured as being judged prospectively.
In contrast, Causation is judged on the basis of reasonable inference, from presumptions of various facts, on the premise of all information which became evident at the time of trial after the time of the medical treatment; Causation is structured as being judged retrospectively.
2 . Specific Examples of Considerations in Judgments; Section 3 of the text
Specific Examples of Considerations in Judgments are as described in Section 3 of the text抄録全体を表示PDF形式でダウンロード (960K)
原著
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川嶋 雅之, 前田 豊信, 御代田 駿, 小嶋 忠之, 加藤 靖正, 高田 訓2024 年 70 巻 9 号 p. 364-371
発行日: 2024/09/20
公開日: 2024/11/20
ジャーナル フリーIt is well known that extracellular pH (pHe) tumor tissue is acidic, and sometimes induces matrix metalloproteinase-9 (MMP-9) expression, invasion and metastasis. The small G protein RhoA plays a role in the intracellular signaling pathway for acidic pHe. In this study, PAK6 and PAK7, two of the p21 activated kinases (PAKs) that are known to act downstream of small G proteins, were investigated and their role in acidic pHe signaling inducing MMP-9 expression was examined. PAK6 and PAK7 double knockout cell variants (PAK6/7 KO cells) of mouse B16-BL6 melanoma were prepared via the CRISPR / Cas9 method. MMP-9 activity and mRNA levels were analyzed by gelatin zymography and quantitative PCR, respectively. Enforced expression of PAK6/7 decreased the induction of MMP-9 in parental B16-BL6 cells. On the contrary, the acidic pHe-induced MMP-9 expression level in PAK6/7 KO cells was higher than in parental cells, while MMP-9 induction was absent in PAK6/7 KO cells at neutral pHe. When PAK6/7 KO cells were rescued by introduction of vectors expressing wild type PAK6/7 and its mutants including constitutively active and kinasedead forms, acidic pHe-induced MMP-9 expression was suppressed by the introduction of wild-type and constitutively active PAK6/7, but not by the kinase-dead forms. These results suggest that PAK6/7 play a role of negative feedback in acidic pHe signaling to induce MMP-9 expression.抄録全体を表示PDF形式でダウンロード (965K)
症例報告
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藤村 愛, 助川 信太郎, 廣瀬 勝俊, 小野 早和子, 中村 友哉, 古木 良彦2024 年 70 巻 9 号 p. 372-378
発行日: 2024/09/20
公開日: 2024/11/20
ジャーナル フリーSolitary fibrous tumor (SFT) is an intermediate malignant tumor of the soft tissue. The specific fusion gene NAB2-STAT6 is detected in SFT. Although SFT occurs systemically, SFT of the oral floor is extremely rare. We report a case of SFT of the oral floor with NAB2-STAT6 fusion gene. A 54-year-old man had noticed a painless swelling in his oral floor for four years. Intraoral examination revealed a globular, wellcircumscribed, and elastic hard mass. Under a clinical diagnosis of benign tumor, the tumor was resected with the local anesthesia. Histological examination revealed the proliferation of spindle cells with branching vessels. RT-PCR confirmed the presence of the NAB2 exon4‒STAT6 exon2 fusion gene, and a diagnosis of SFT was made. There was no evidence of recurrence after one year and five months of follow-up.抄録全体を表示PDF形式でダウンロード (3786K) -
柳沢 佑太, 野上 晋之介, 岩間 亮介, 大竹 義雄, 佐藤 舜, 山内 健介2024 年 70 巻 9 号 p. 379-384
発行日: 2024/09/20
公開日: 2024/11/20
ジャーナル フリーChronic bilateral dislocation of the temporomandibular joint is a relatively rare disorder that occurs when TMJ dislocation has not been repaired for a long period of time. It is often treated by surgical repositioning. We report a case of chronic bilateral anterior dislocation of the temporomandibular joint due to six months of neglect, which was treated via a bilateral intraoral vertical ramus osteotomy (IVRO). The patient was a 62-year-old man. He developed TMJ dislocation triggered by excessive opening of the mouth due to yawning. The patient was advised to see an oral surgeon, however he left the condition untreated for six months. Thereafter the patient was diagnosed with chronic temporomandibular joint dislocation and was referred to the Department of Oral and Maxillofacial Surgery, Tohoku University Hospital. The painless opening amount was 40 mm and the mouth could not be closed. Panoramic radiographs showed anterior dislocation of the bilateral temporomandibular joints. We attempted to restore the condyle under general anesthesia, however repositioning of the condyles was difficult, so a bilateral osteotomy (IVRO) was performed on the jaw to close the mouth. Three years after surgery, the oral mobility range was maintained at 36 mm, and no recurrence was observed.抄録全体を表示PDF形式でダウンロード (2801K) -
兵藤 俊介, 齋田 昂佑, 竹内 豪, 佐野 泰斗, 仲谷 佐奈子, 後藤 満雄2024 年 70 巻 9 号 p. 385-389
発行日: 2024/09/20
公開日: 2024/11/20
ジャーナル フリーNevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is an autosomal dominant disorder characterized by odontogenic keratocyst (OKC), multiple basal cell carcinoma, and a variety of congenital anomalies. A 5-year-old boy was referred to our hospital because of incidental cystic lesion findings in the mandible. He was diagnosed with NBCCS based on clinical findings and diagnostic criteria. Diagnosis of this syndrome tends to be delayed. In this case, eruption guidance and appropriate dermatological follow-up has been performed.
We subsequently identified a PTCH1 germline mutation of Tyr668Ter, which was a nonsense mutation. In addition, we discuss the relationship between the specific region, called the sterol-sensing domain in PTCH1 and OKC manifestations.抄録全体を表示PDF形式でダウンロード (2049K)
支部学術集会講演題目
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2024 年 70 巻 9 号 p. 390-394
発行日: 2024/09/20
公開日: 2024/11/20
ジャーナル フリーPDF形式でダウンロード (2639K)
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