巻号一覧
18 巻 (1968)
- 4 号 p. 373-
- 3 号 p. 281-
- 2 号 p. 139-
- 1 号 p. 1-
18 巻, 2 号
選択された号の論文の23件中1～23を表示しています
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松田 好弘1968 年 18 巻 2 号 p. 139-152
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーOne of the difficulties to give the exact information on the pharmacological effects of catecholamines and the related sympathomimetic amines in the central nervous system is the not-easy access of the amines through the blood-brain barriers. Although many investigators have postulated the manifestation of the arousal waves of the EEG in response to the systemically administered adrenaline, there are many controversies whether the effects are direct or not (1). There have been reports showing that the systemically administered adrenaline produced a deactivation of the spontaneous EEG (2, 3). On the other hand, it is well-known that the direct application of adrenaline to the brain structure such as the injection of the amines into the cerebrospinal fluid produces the sleep-like behaviors and analgesia in animals (4-8). In accord with the behavioral responses the dogs are shown to exhibit the sleep pattern in the spontaneous EEG (8). Taking advantage of the easy penetration of catecholamines through the blood-brain barriers in the kitten and the chiken, the effects of catecholamines on the behavior and the EEG have been studied (9). Based on the responses of the infant animals to the amines, the adrenergic receptor in the central nervous system has also been discussed (11). There is no assurance, however, that the changes in EEG and behavior produced by catecholamines administered intraventricularly in the adult animals and systemically in the infant animals are brought about by the similar mechanism. Therefore, the generalization of catecholamine classification and receptor hypothesis in the central nervous system based on the experiments in infant animals could not be accepted so simply. Moreover, the mode and the site of action of catecholamines thus administered can not be clearly answered. In the present experiment, effects of intraventricularly administered adrenaline to the EEG and the possibility of their modifications by adrenergic blockers were examined in rabbits in order to gain some informations on the mode and the site of action of the amines.抄録全体を表示PDF形式でダウンロード (909K) -
藤井 昭男, 今村 貞夫, 鈴木 守1968 年 18 巻 2 号 p. 153-161
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーThe occurrence of 5-hydroxytryptamine (5-HT) in the mast cells of the rat skin has been demonstrated by many investigators using a biochemical method (1-7). However, Parratt and West (7) have reported that there is no correlation between the distribution of mast cells and the level of 5-HT in different layers of rat skin. According to them, the level of 5-HT in the abdominal epithelium is higher than that in the subcutaneous tissue which is reported to contain a larger amount of mast cells and endogenous histamine. They have concluded that most part of 5-HT in the rat skin is present outside of mast cells (6). Recently, a histochemical method for demonstrating the endogenous 5-HT in different tissues has been developed by Scandinavian investigators (8-11). The present experiment is an attempt to show the distribution of 5-HT in the morphological components of various parts of rat skin using this technique.抄録全体を表示PDF形式でダウンロード (1416K) -
木村 美恵子1968 年 18 巻 2 号 p. 162-168
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリー5-Hydroxytryptamine (5-HT, serotonin) is widely distributed in both the vegetal and animal kingdoms. The biological importance in plants of an analogue of serotonin, the auxin, 3-indolylacetic acid, has been well known. Recently, it has also been reported that serotonin is present in several vegatebles. The fluorescence histochemical demonstration of monoamines has been developed by Scandinavian investigators (1). This technique, now widely available, has made a great contribution to the study of neuron activity in animals. Udenfriend et al. (2) were the first to demonstrate the physiologically abundant presence of monoamines in plants such as; Musa paraddiaca L. (banana), Lycopersium esculentam Mill. (tomato) and Persea Americana Mill. (avocado). Monoamines have been found in the fruits and leaves of these plants and the contents have been reported shortly. However, no histochemical study on the distribution of the amines have been done. In the present experiments, the author attempted to demonstrate histochemically the presence of monoamines, especially serotonin, in the various organs and tissues of Musa Basjoo SIEB. (plantain), Musa paradisiaca L. (banana), Allium Cepa L. (onion) and other plants.抄録全体を表示PDF形式でダウンロード (1102K) -
T.K. GUPTA, R.P. KOHLI, SURENDRA S. PARMAR, R.C. ARORA1968 年 18 巻 2 号 p. 169-174
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーRole of monoamine oxidase in the metabolism of epinephrine and norepinephrine has not so far been fully established. In man and rodents Axelrod (1) has postulated that o-methylation is the first and principal step in the metabolism of catecholamines and that the methylated derivatives of epinephrine (metanephrine) and norepinephrine (normetanephrine) undergo further oxidative deamination by monoamine oxidase. Such an inactivation of catecholamines has been reported by Axelrod (1) and Whitby et al. (2) to be dependent upon tissue and species variations. Furthermore, differences observed between circulating or injected and endogenously released amines have indicated that monoamine oxidase plays an important role in tissue metabolism of catecholamines (3, 4). In the present study attempts have been made to show correlationship between monoamine oxidase inhibition and changes in the vascular effect of injected epinephrine and norepinephrine. Some newer quinazolone hydrazides (5) and quinazolone hydrazines (6) synthesized as monoamine oxidase inhibitors, reported earlier for their anti-convulsant properties (7), were used to investigate their effects on epinephrine and norepinephrine induced pressor responses in cats.抄録全体を表示PDF形式でダウンロード (306K) -
3. EFFECTS OF MONOAMINES AND THEIR PRECURSORS堤内 正美1968 年 18 巻 2 号 p. 175-184
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーKido (1) has shown that even a small dose of reserpine could produce severe ulcers in the gastrointestinal tract of cats when combined with stress, such as hypothalamic stimulation and electrical shock through the grid on the floor of the cage. Hartry (2) and Sawrey and Sawrey (3) also reported that ulcers were produced by a small dose of reserpine and stress in rats. The author (4, 5) previously reported that ulcer formation by reserpine and stress had a close correlation with the decrease in monoamines, i.e. serotonin and norepinephrine, in the gastrointestinal tract, and that syrosingopine and tetrabenazine could produce similar ulcers when combined with grid shock. From these findings he speculated that the decrease in peripheral as well as central monoamines contributed important factors in ulcer formation by reserpine and grid shock. If it is true that the decrease in monoamines is the cause of ulcer formation by reserpine and grid shock, it has to be inhibited by a replenishment of monoamines or their precursors. In the present study, the effects of MAO inhibitor, monoamines and their precursors on ulcer formation by reserpine and grid shock were investigated. Moreover, the effects of drugs which block the autonomic nerves were also investigated to confirm the observation of Kido (1) that in splanchnectomized and vagotomized cats ulcers were hardly produced by reserpine and grid shock.抄録全体を表示PDF形式でダウンロード (1851K) -
福田 道男1968 年 18 巻 2 号 p. 185-199
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーIt has been pointed that adrenergic β-receptor is greatly concerned in the salivary secretion of amylase, which is one of the main digestive enzymes (1). It has also been noticed that the repeated administrations of isoprenaline which has a strong affinity to β-receptor for catecholamines show a marked enlargement of the salivary glands (2-11). On the other hand, it has been also demonstrated that dibenamine, one of the potent α-adrenergic blocking agents, and guanethidine, an antiadrenergic agent, show a gradual atrophy in the salivary gland after the chronic administration (11, 12). Although there are many reports concerning the enlargement of the submaxillary glands treated with isoprenaline, little has been known whether this enlargement is due to the β-action of isoprenaline and whether it produces an enzymatic alterations in the enlarged salivary glands. The present study deals with the effects of β-adrenergic blocking agent on the development of the enlargement induced by the chronic administration of isoprenaline in rat submaxillary glands from the histological, histochemical, biochemical and pharmacological points of view.抄録全体を表示PDF形式でダウンロード (4072K) -
松尾 茂, 藤原 元始, 島本 暉朗1968 年 18 巻 2 号 p. 200-209
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーN, N'-Diphenyldicarbamate-1, 1-demethylol cyclopentane (Camalon), clinically available as antispasmodic, sedative and skeletal muscle relaxant, has been pharmacologically studied by Fournier et al. (1) and Shimamoto et al. (2). However, no experimental evidence to demonstrate the skeletal muscle relaxing action of the agent has been presented in the experimental animals. The present experiments were undertaken to study the mode of action of this agent on the spinal reflex mechanism in mice and cats.抄録全体を表示PDF形式でダウンロード (564K) -
VI. THE MODE OF ACTION OF ORGANOPHOSPHORYL CHOLINE IN VITRO AND IN VIVO木村 正康, 室 郁子, 橋本 久邦, 池田 浩子1968 年 18 巻 2 号 p. 210-217
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーDuring studies on acetylcholine-its receptor complexes system in drug action, the authors designed the anticholinergic agent of more fitting structure to acetylcholine (ACh) receptor (1), and synthesized the new compound of dicyclohexyl thionothiolphosphorylcholine (NP245) (2). This compound NP245 has more potency 2.43 times than d-tubocurarine (d-TC) as curare-like action, 3/100 times of neostigmine as anticholinesterase action, and 1/1000 times of atropine as antispasmodic action. Particularly, combining selectively with ACh receptor, it has played the part of a useful tool for researching of the ACh receptor (3). This paper reports experiments on the mode of action of NP245 in vitro and in vivo, moreover, on its metabolic fate in rats.抄録全体を表示PDF形式でダウンロード (438K) -
VII. ON ANTICHOLINERGIC ACTIVITY OF COMPOUNDS CONTAINING 1, 3-DIOXOLANE MOIETY木村 正康, 平井 嗣郎, 高井 明1968 年 18 巻 2 号 p. 218-223
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーBy Fourneau and others (1) in 1944, it has been reported that F2268, which is one of 1, 3-dioxolane derivatives, is a potent cholinergic agent. According to them, cholinergic activity of these analogues decreases gradually as making along the length of 2-alkyl chain in these structures. From the analysis for dose-response curves of these derivatives, Ariëns and his co-workers (2, 3) have shown that in the case of hydrogen, methyl and ethyl radicals at the 2-position of dioxolane structure, each of these derivatives has almost a cholinergic activity, while in the case of propyl radical it shifts more or less to anticholinergic property, what is called “partial agonist”, and then the hexyl radical changes completely it into anticholinergic activity. On the other hand, the analogus compound (anacoline), which has diphenyl radicals at 2-position of dioxolane structure and piperidinium radical in place of trimethyl ammonium radical in these analogus structures, has been synthesized (4), and its anticholinergic and antihistaminic properties have been observed (5). The purpose of this study is to design the structure with a potent atropine-like activity by means of researching out of the full antagonist of compounds containing 1, 3-dioxolane moiety.抄録全体を表示PDF形式でダウンロード (298K) -
(I) ACTIVITIES OF NADPH-LINKED ELECTRON TRANSPORT AND DRUG-METABOLIZING ENZYME SYSTEMS IN LIVER MICROSOMES OF TUMOR-BEARING RATS加藤 隆一, 高仲 正, 高橋 惇, 小野田 欽一1968 年 18 巻 2 号 p. 224-244
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーIt has recently been recognized that the metabolism of lipid soluble compounds by liver microsomal enzymes is highly important factors for controlling the action and toxicity of various drugs (1-5). This fact is, especially, important for some drugs which should be converted to the active metabolite in vivo (5-7). Some carcinogenic and carcinostatic compounds, such as dimethylnitrosamine, 2-acethylaminofluorene, 4-nitroquinoline N-oxide and cyclophosphoramide, belong to this group (8-11). The activities of drug-metabolizing enzymes of liver microsomes are markedly altered by several factors, such as, the administrations of different kind of lipid soluble compounds and anabolic hormones, starvation, low protein diet, formaline and adrenaline stress, alloxan diabetes, hyperthyroidism, adrenalectomy, viral hepatitis and hepatectomy (1, 3, 12-20). In a preliminary work, * we observed a decrease in the metabolism of pentobarbital, meprobamate and strychnine in Walker 256 carcinosarcoma bearing male rats. However, there are clear sex difference in the alternation of activities of drug-metabolizing enzymes by the non-physiological conditions. For example, starvation, formalin and adrenaline stress, alloxan diabetes, hyperthyroidism and adrenalectomy markedly decrease the activities of most of the enzymes in male rats, while they did not significantly alter or rather increased the activities in female rats (13, 14). It would be, thus, interesting to investigate whether the decrease in the metabolism of drugs by liver microsomes of the tumor-bearing rats is only limited to male rats. Moreover, whether the activities of other drug-oxidizing enzymes, drug-reducing enzymes and electron transport systems is affected or not by tumor-bearing was investigated. Furthermore, in order to obtain some insights in the mechanism of decrease in the activities of drug-metabolizing enzymes in tumor-bearing rats, the effect of phenobarbital treatment on these enzyme activities in control rats and tumor-bearing rats was comparatively investigated.抄録全体を表示PDF形式でダウンロード (1426K) -
(II) IN VIVO METABOLISMS AND EFFECTS OF DRUGS IN TUMOR-BEARING RATS加藤 隆一, 高仲 正, 大島 孝夫1968 年 18 巻 2 号 p. 245-254
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーIn a previous paper it was reported that the activities of drug-metabolizing enzymes of liver microsomes were markedly decreased in male and female rats bearing Walker 256 carcinosarcoma (1). It was often observed that the activities and in vivo metabolism of many drugs in rats under various conditions were related to the activities of drug-metabolizing enzymes of liver microsomes (2-10). For example, the activities of drug-metabolizing enzymes were markedly increased in the rats treated with the barbiturates, carcinogenic polycyclic hydrocarbons and anabolic hormones, in consequence the in vivo metabolisms of drug were markedly increased and the effects of various drugs were markedly decreased (3-6). The purpose of present studies is to investigate the effect and toxicity of drugs in rats bearing Walker carcinosarcoma 256 and the correlation among the alternations of the effect and toxicity of drugs, the in vivo metabolisms of drugs and the activities of drug-metabolizing enzyme systems of liver microsomes.抄録全体を表示PDF形式でダウンロード (568K) -
G.P. GUPTA, K.N. DHAWAN, B.N. DHAWAN1968 年 18 巻 2 号 p. 255-259
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーLysergic acid diethylamide (LSD-25) and morphine have been shown to antagonise certain actions of each other. LSD-25 antagonises morphine induced analgesia in rats (1) and emesis in dogs (2). It also blocks the miotic action of morphine (3). On the other hand, morphine blocks LSD-25 pyrexia in rabbits (4). The present study was undertaken to investigate if morphine could antagonise the central hypotensive action of LSD-25 reported by Ginzel (5).抄録全体を表示PDF形式でダウンロード (252K) -
榎本 つね, 峰下 哲, 重井 達朗1968 年 18 巻 2 号 p. 260-265
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーIt was reported previously that pretreatment of rats with a crude preparation of stem bromelain, a thiolprotease obtained from pineapple plant, effectively protected the animals against adrenaline-induced pulmonary edema (1-3). The present study was undertaken to examine whether the edema-preventive effect of the enzyme is due to its proteolytic activity. For this purpose, purified and activated stem bromelain was prepared. A part of this was then inactivated by N-ethylmaleimide, a specific SH-inhibitor. The edema-preventive effects of the two enzyme preparations were compared.抄録全体を表示PDF形式でダウンロード (364K) -
G.P. GUPTA, K.N. DHAWAN, J.N. SINHA1968 年 18 巻 2 号 p. 266-267
発行日: 1968/06/01
公開日: 2007/02/02
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RANJIT ROY CHAUDHURY1968 年 18 巻 2 号 p. 267-268
発行日: 1968/06/01
公開日: 2007/02/02
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M.L. GUPTA, B.P. JAJU, K.P. BHARGAVA1968 年 18 巻 2 号 p. 268-269
発行日: 1968/06/01
公開日: 2007/02/02
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泉 堯, 藤野 澄子, 万谷 俊, 田中 護1968 年 18 巻 2 号 p. 269-270
発行日: 1968/06/01
公開日: 2007/02/02
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安部 陽一, 森本 史郎, 山本 研二郎, 上田 重郎1968 年 18 巻 2 号 p. 271-272
発行日: 1968/06/01
公開日: 2007/02/02
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田所 昌夫, 山口 勲, 寺岡 諄, 酒井 文徳1968 年 18 巻 2 号 p. 272-273
発行日: 1968/06/01
公開日: 2007/02/02
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松木 勝彦, 岩本 多喜男1968 年 18 巻 2 号 p. 274-276
発行日: 1968/06/01
公開日: 2007/02/02
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佐久間 昭1968 年 18 巻 2 号 p. 276-277
発行日: 1968/06/01
公開日: 2007/02/02
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鹿取 信, 重井 達朗1968 年 18 巻 2 号 p. 277-279
発行日: 1968/06/01
公開日: 2007/02/02
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畠山 茂, 重井 達朗1968 年 18 巻 2 号 p. 279-280
発行日: 1968/06/01
公開日: 2007/02/02
ジャーナル フリーPDF形式でダウンロード (472K)
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