巻号一覧
19 巻 (1969)
- 4 号 p. 477-
- 3 号 p. 331-
- 2 号 p. 185-
- 1 号 p. 1-
19 巻, 4 号
選択された号の論文の24件中1～24を表示しています
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V.C. SAXENA, S.K. BAPAT, B.N. DHAWAN1969 年 19 巻 4 号 p. 477-484
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーAntihistaminic drugs produce side effects by acting on the central nervous system, the most consistent of them being sedation. Since many sedative drugs possess anticonvulsant property also, antihista-ninics have been occasionally tried in the treatment of epilepsy and related disorders (1-3). At the same time there are also reports of increased frequency of seizures in epileptic patients (4) and of convulsions in normal individuals (5) with certain antihistaminic drugs.
Swinyard et al. (6) reported diphenhydramine and tripelennamine to be active in supramaximal electroshock test but much inferior to diphenylhydantoin. Stone et al. (7) reported the ability of cyproheptadine to antagonize electrical and nicotine induced convulsions in mice. In view of the availability of very limited information regarding the anticonvulsant activity of these drugs it was considered important to investigate this effect in detail. The results of such a study, it was anticipated, would not only provide information on their anticonvulsant property but would also help in selecting drugs for the treatment of allergic manifestations in epileptic patients. A preliminary report of part of this work has been published (8).抄録全体を表示PDF形式でダウンロード (289K) -
玄番 宗一, 山本 研二郎, 上田 重郎1969 年 19 巻 4 号 p. 485-493
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーMitochondrial ion transport has been studied by many investigators since the early work of Bartley and Davies (1). Passive ion extrusion was observed on aged mitochondria or on fresh mitochondria with valinomycin (2-5). On the other hand, metabolism dependent ion retention (6-8), ion uptake (9-17) and ion extrusion (18-20) have been found on mitochondria. It is suggested that there are some unknown factors which control ion movement in the mitochondria.
Presently, in order to clarify the factor, movement of potassium and magnesium was studied in the mitochondria of the kidney cortex and liver of rats. A metabolism dependent potassium and magnesium ion extrusion was observed in the presence of a respiratory substrate, and this extrusion was converted to retention by further addition of 1.0 mM of ATP. This effect of exogeneous ATP was disccussed.抄録全体を表示PDF形式でダウンロード (333K) -
川崎 晃義, 樫本 威志, 吉田 博1969 年 19 巻 4 号 p. 494-501
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーTo clarify the mechanisms regulating the function of smooth muscle the relations of changes in metabolism to its function have been examined by several investigators. Adrenaline is known to depress the motility of the intestine and the uterus and it also increases the content of cyclic AMP and the activity of phosphorylase a (1-3). Experiments have shown that on addition of adrenaline the increase in phosphorylase a activity is preceded by the increase in the cyclic AMP level and the decrease in motility (1, 2). Thus, the relation between the content of cyclic AMP and the motility of the intestine seems interesting. This paper reports the effects of cyclic AMP and its derivative on isolated ileum. The hypothesis that cyclic AMP is an intracellular messenger for transmitting information from outside the cell by hormones and neurotransmitters, including catecholamines (4, 5) is discussed on the basis of the results.抄録全体を表示PDF形式でダウンロード (239K) -
中島 光好, 前田 清, 関谷 淳1969 年 19 巻 4 号 p. 502-509
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーCotten and Cooper (1) showed that cardiac glycosides blocked the positive inotropic response to norepinephrine (NE) in the dog heart during hypothermia. The principal cause of its negative inotropic response to NE has been studied by some investigators. The negative inotropic response to NE is primarily the result of a decrease in the velocity of cardiac contraction (2) and its occurrence is related to the maximum plasma level of NE. The contractile force increased until the estimated plasma concentrations of NE reached 8 to 10 mμg/ml and decreased at higher concentrations. The glycosides apparently inhibited the uptake of NE by the heart (3).
More detailed analyses have been performed with isolated heart preparations. The production of the negative inotropic response to NE was observed only after ouabain was given at 27°C, but ouabain had no significant effect on the contractile response to NE at 37°C in isolated guinea-pig hearts (4). On the other hand, Godfraind and Godfraind-De Becker (5), who tested the response to NE in isolated spontaneously beating guinea-pig atria treated with ouabain, noted that the negative inotropic action of NE was more marked with high concentrations or at high temperature of 37°C. They supposed that the negative inotropic response to NE was related to the toxic phase of ouabain.
The present study was designed to investigate the mechanism of the negative inotropic response to NE after ouabain.抄録全体を表示PDF形式でダウンロード (291K) -
田中 潔, 林 玉朝1969 年 19 巻 4 号 p. 510-514
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーMorphine, tubocurarine and veratrine are known to cause motor excitement, hypertension and tachypnea, when they are applied into the cerebrospinal fluid (1-3). Since these drugs have completely different chemical structures, it appears rather strange to elicit analogous excitatory actions on the central nervous system. The facts that morphine and tubocurarine are histamine liberators (4), and that intraventricular histamine elicits hypertension (5), suggest the possibility that histamine might be the common mediator of the central excitatory action of these drugs. The present investigation was carried out on the attempt to verify this assumption.抄録全体を表示PDF形式でダウンロード (162K) -
M.A. MATIN1969 年 19 巻 4 号 p. 515-519
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーThe cholinolytic hallucinogens (atropine and hyoscine) reduce the acetylcholine content of rat brain (1) and certain parts of rabbit brain (2). The reduction in the acetylcholine content of the brain caused by these drugs may be related not only to their psychotomimetic effects (1, 3) but also to their amnesic effect (4) and electroencephalographic (EEG) effects (5, 6). The reduction in the acetylcholine content of certain parts of rabbit brain (2) may be related to the sleep like EEG pattern seen in these animals (5) but the corresponding EEG changes in rats have not been reported though atropine and hyoscine reduced the total acetylcholine content of rat brain (1) without any evidence of excitation or behavioural alerting. The purpose of the present paper has been to gather further information on the correlation between the EEG changes and the total acetylcholine content of the rat brain after the administration of atropine, hyoscine and total alkaloids of Datura alba. Total alkaloids of Datura alba were included in the study as the plant grows extensively all over India, contains mainly atropine and hyoscine (7) and frequently causes toxic effects like delirium, tremors, hallucinations and confusion similar to atropine poisoning.抄録全体を表示PDF形式でダウンロード (227K) -
高木 敬次郎, 高柳 一成1969 年 19 巻 4 号 p. 520-534
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーIn the previous papers (1-3) it has been reported that some partial agonists accelerate the liberation of acetylcholine from the isolated guinea pig and rat ilea to contract them, yet also antagonize the action of the released acetylcholine and that the intrinsic activity (4) or efficacy (5) of a drug is decided by two factors: acetylcholine liberating activity and inhibitory activity to acetylcholine. In this paper, the receptor mechanisms for partial agonists were studied on the ganglion free taenia caecum from the guinea pig, of which the acetylcholine liberation mechanisms are poor. Some of this work has already been briefly reported (6, 7).抄録全体を表示PDF形式でダウンロード (613K) -
中西 弘則, 堤内 正美, 大谷 弘一, 田中 日出夫, 武田 寛1969 年 19 巻 4 号 p. 535-542
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーRecent electrophysiological and anatomical studies on transmission between the sympathetic nerve and smooth muscle have confirmed the important role of a chemical substance acting in a manner similar to the chemical substance concerned with transmission between somatic nerve and skeletal muscle. A low frequency stimulation of the hypogastric nerve produced junction potentials on the smooth muscle of the vas deferens (1) and seminal vesicle (2) in the guinea-pig. The junction potentials may be due to the release of noradrenaline from the sympathetic nerve terminals, and this conjecture is supported by the following evidence. 1) The junction potentials were strongly depressed by pretreatment or intravenous injection of reserpine (3, 4), 2) The junction potentials were also depressed by guanethidine, bretylium and high doses of various α-blocking agents, such as phenoxybenzamine, phentolamine and yohimbine (5), 3) The intravenous injection of noradrenaline induced a burst of action potentials in smooth muscle which was associated with tetanic contraction (6), 4) Many investigators (7, 8) have demonstrated pharmacologically that the nature of the contractile response of the vas deferens to hypogastric nerve stimulation was probably of sympathetic origin, 5) The guinea-pig vas deferens and seminal vesicle contain a large amount of noradrenaline and also abundant noradrenaline containing fibers which have been observed among the smooth muscle cells (9, 10).
On the other hand, it is well known that monoamine oxidase (MAO) and catecholO-methyl transferase (COMT) degrade noradrenaline to deaminated and methylated metabolites. However, there are a few inconsistent results concerning the effect of MAO inhibitor on the contractile response of the guinea-pig vas deferens to hypogastric nerve stimulation. For instance, Kamijo et al. (11) and Brown and Gillespie (12) have assumed that MAO inhibitors do not potentiate the effect of catecholamine released by nerve smonoamine oxidase and catechol-O-methyl transferase on the junction potential recorded from the guinea-pig seminal vesicle in response to hypogastric nerve stimulatiotimulation, whereas Bhargava et al. (13) have observed that MAO inhibitors, such as pheniprazine and tranylcypromine, and a COMT inhibitor, pyrogallol, potentiated the contractile response of the guinea-pig vas deferens to hypogastric nerve stimulation.
The present study was, therefore, undertaken to examine the effect of inhibition of monoamine oxidanse and catechol-O-methyo transferase on the iunction potential recorded from the guinea-pig seminal vesicle in response to hypogastric nerve stimulation.抄録全体を表示PDF形式でダウンロード (465K) -
中西 弘則, 武田 寛1969 年 19 巻 4 号 p. 543-550
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーThe spontaneous mechanical activity of the cultured chick embryonic auricle is inhibited to a considerable extent by acetylcholine (ACh) (1), while the mechanical and electrical activities of cultured ventricle is practically unaffected by the drug (1, 2). The difference of snesitivity to ACh between the auricle and ventricle may be due to the presence or absence of cholinergic innervation, which may increase the sensitivity to ACh. On the other hand, many investigators suggest that ACh increases the permeability of the cell membrane to K+, and allows the resting potential to come near the K+-equivallent potential (3-5). It would be neccessary to study the effect of ACh on the intracellular membrane potential of auricle, because the cultured cells were often completely excitationcontraction uncoupled (6). The cultured preparation enables one to study the effect of ACh on the cell membrane potential without interfering with the nerve component or neighbor cells Jellinek et al. (7) demonstrated the absence of nerve tissue in the cultured cell clusters and Dahaan and Gottlieb (8) observed no electrical interaction among conjoint cells.抄録全体を表示PDF形式でダウンロード (328K) -
EMILIO MARMO, SALVATORE DI GIACOMO, ALDO IMPERATORE1969 年 19 巻 4 号 p. 551-562
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーDas von Justin-Besançon and Mitarb. (1) synthetisierte Metochlopramid (siehe Abb. 1) wird weitgehend bei zahlreichen klinischen Leiden (die besonders den Magendarmapparat betreffen) ausser per os auch auf intravenösem oder intramuskulärem Wege angewandt. Das Fehlen einer systernatischen Untersuchung über die elektrokardiographischen Veränderungen, die durch die intravenüse Verabreichung von Metochlopramid verursacht werden, veranlasste uns, eine Reihe von Untersuchungen an der normalen oder vorbehandelten Ratte durchzufiihren. Bei der Vorbehandlung wurde entweder ein Ganglioplegicum (Hexamethonium), ein Parasympathicolyticum (Atropin), ein α-Adrenolyticum (Pentolamin), ein β-Adrenolyticum (H 56/28), ein Katecholamindepletor (Reserpin) oder ein bekanntes Herzgift (Emetin; 4, 6) angewandt.抄録全体を表示PDF形式でダウンロード (942K) -
高野 静子1969 年 19 巻 4 号 p. 563-568
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーIt has been reported that the splenic smooth muscles of several species of animals can be contracted with noradrenaline (1-4), adrenaline (1, 3-9), isoproterenol (1, 3-5), acetylcholine (5-8), serotonin (7), histamine (1, 7), tyramine (7), angiotensin (10), or BaCl2. The existence of alpha-adrenergic receptors has been confirmed in the splenic smooth muscles in the cat, dog, kid, rabbit, and human (1, 5, 8, 11). The stimulation of the alpha-adrenergic receptors in the spleen produces contraction of the organ. It is of interest that isoproterenol, which stimulates the beta-adrenergic receptors, contracts the spleen in cats and mice, but the drug relaxes it in mice when the concentration was very low. The isoproterenol-induced contraction of the spleen in cats can be inhibited by dichloroisoproterenol or dibenamine (1), and the isoproterenol-induced relaxation of it in mice can be inhibited by MJ-1999 or propranolol (4). Two explanations are possible for these findings; one is that there are beta-adrenergic receptors in the spleen and the other is that isoproterenol stimulates the alpha-adrenergic receptors in the spleen to produce contraction. As to the mechanism of the contraction of the spleen produced by acetylcholine, Burn and Rand proposed hypothesis in 1960: acetylcholine releases noradrenaline and adrenaline in the spleen, and these catecholamines produce the contraction (12, 13).
The present experiments were undertaken to examine whether there were beta-adrenergic receptors in the spleen, and to confirm the hypothesis proposed by Burn and Rand.抄録全体を表示PDF形式でダウンロード (249K) -
唐木 英明, ガネシャナンダン , 池田 三義, 浦川 紀元1969 年 19 巻 4 号 p. 569-577
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーIn a previous report (1) it was shown that in guinea pig taenia coli hypertonically added 40 mM K induced a large tension and that both tissue Ca and 45Ca uptake of the muscle measured after a 4 minutes wash increased, while in 152 mM K/0 mM Na medium only a small tension remained and 45Ca uptake did not increase while tissue Ca decreased. It has also been shown that the tonic response in hypertonic 40 mM K medium is dependent on aerobic breakdown of carbohydrates and blocked by sodium transport inhibitor (2-4). The tonic response in 152 mM K/0 mM Na medium was however shown to be unaffected by a sodium transport inhibitor and not solely dependent on aerobic breakdown of carbohydrates (4).
The present investigation is concerned with the changes in tension, uptake of 45Ca measured after a 4 minutes wash and tissue Ca in varying concentrations of Na and K in the external medium, and also the effects of inhibitors of metabolism and sodium transport in guinea pig taenia coli.
A part of this work has already been represented (5).抄録全体を表示PDF形式でダウンロード (390K) -
浦川 紀元, 池田 三義, 斉藤 友紀雄, 酒井 豊1969 年 19 巻 4 号 p. 578-586
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーHypertonically added high-potassium induced a tension development in the guinea pig taenia coli, which was composed of two distinct parts, a phasic response and a tonic one (1, 2). The tonic response was dependent on the aerobic breakdown of carbohydrate and was abolished by substrate removal, anoxia, a decrease in temperature, 2, 4-dinitrophenol (DNP), lithium substitution and ouabain. These factors had little or no effect on the phasic response. From these data it was suggested that the phasic response is a passive process, whereas the tonic response is an active one depending on metabolism. A part of this concept is supported by the finding that the application of high K caused an increase in oxygen consumption that accompanies the muscle tension change (3). In the present paper, effects of factors inhibiting tension development, viz. glucose removal, low oxygen, decrease in temperature, DNP and ouabain, on oxygen consumption in high-potassium medium were studied.抄録全体を表示PDF形式でダウンロード (384K) -
高折 修二, 矢田 憲子, 森 源三郎1969 年 19 巻 4 号 p. 587-596
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーThe previous paper (1) has shown that effects of psychotropic agents on the exploratory behavior of rats placed into a symmetrical Y-shaped box are modified by degree of familiarity with the apparatus. In the experienced rats which had received the training trials in the box three or four times, chlorpromazine and diazepam produced a prolongation of the start latency with decrease in the ambulation and rearing scores. However, diazepam shortened the start latency and increased the ambulation scores in the inexperienced animals which had never been placed in the apparatus.
Although major and minor tranquilizers have been found to interfere with normally trained conditioned avoidance responses (2-5), information about the effects of these agents on poor performance of rats is still insuficient. Rech (6, 7) has reported that amphetamine and scopolamine improve conditioned avoidance behavior for rats which performed poorly, in spite of extensive training, in a shuttle-box procedure. The present experiments were designed to determine effects of several psychotropic agents on Sidmantype avoidance responding in the good- and poor-performed rats.抄録全体を表示PDF形式でダウンロード (425K) -
大鳥居 健1969 年 19 巻 4 号 p. 597-603
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーThe report that dichlorisoprenaline, DCI, the first introduced beta-adrenergic receptor blocking agent, could block beta-adrenergic receptors initiated a research for other beta-receptor blocking agents.
Thereafter, several compounds, such as pronethalol [Black and Stephenson (I) ], propranolol [Black et al. (2)], H56/28 [Åblad et al. (3)] and others, have been described as capable of producing more potensive and selective blockade of beta-adrenergic receptor sites.
Recently a new beta-adrenergic receptor antagonist, 4-(2-hydroxy-3-isopropylamino-propoxy)-indole (LB-46) (4), has been introduced. This compound is a basic indole with a side-chain characteristic of beta-adrenergic receptor blocking agents.
Investigation was performed to make clear an antagonistic effect of this compound against isoprenaline, adrenaline and noradrenaline in comparison with the above-men-tioned beta-adrenergic receptor blocking agents.抄録全体を表示PDF形式でダウンロード (303K) -
高木 敬次郎, 高柳 一成, 太田 和子1969 年 19 巻 4 号 p. 604-612
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーIt is generally accepted that norepinephrine and epinephrine exert their physiological actions by reacting with two distinct types of adrenergic receptors, α- and β-receptors. Dopamine differs from norepinephrine in not having the hydroxyl group in the side chain. It has been found that dopamine in the peripheral tissues evokes a different type of effect, as fall in blood pressure in dog, guinea pig and rabbit (1-5). Specific dopamine receptors in the renal and mesenteric vessels of the dog were proposed (6).
The aim of this paper is to determine if dopamine and its derivatives have specific dopamine receptors in the taenia caecum and tracheal muscle from the guinea pig and the vas deferens from the rat. Furthermore, the role of dopamine in the intestinal smooth muscle will be discussed in this paper.
Some of the results has been briefly reported at the 46 general meeting of the Physiological Society of Japan (7).抄録全体を表示PDF形式でダウンロード (323K) -
森田 雅夫, 杉本 治良, 上田 紀子, 馬屋原 宏1969 年 19 巻 4 号 p. 613-618
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーIt is well known that denervated skeletal muscle differs from the normal not only morphologically and functionally but also in its response to drugs (1, 2). Recently, our colleagues have reported that the recovery of morphologically changed muscle function in denervated muscle can be promoted by the administration with L-methionine (3), and that L-methionine has the effect of increasing the influx of potassium into an anterior tibial muscle (4).
Walker et al. (5) reported in 1966 that in denervated skeletal rat muscle the myofibrils were reduced in number, the nuclei and their near structures had become obscure, lamellar structures had appeared, and the basement membranes of the sarcolemmae and disappeared, and Miledi et al. (6), thereafter, reported in 1968 that in denervated diaphragm muscle especially the mitochondria had become smaller soon after denervation.
In the present experiment, anterior tibial muscles were denervated and their changes, especially those in ATPase activity, were examined by means of both light and electron microscopes.抄録全体を表示PDF形式でダウンロード (1027K) -
大鳥居 健1969 年 19 巻 4 号 p. 619-620
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーPDF形式でダウンロード (83K) -
N. BAGCHI, R.B. ARORA, M. SINGH1969 年 19 巻 4 号 p. 620-621
発行日: 1969年
公開日: 2007/02/02
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久保 孝夫, 三須 良実1969 年 19 巻 4 号 p. 621-623
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーPDF形式でダウンロード (137K) -
J.N. SINHA, K.M. DHASMANA, K.S. DIXIT, K.P. BHARGAVA1969 年 19 巻 4 号 p. 623-625
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーPDF形式でダウンロード (159K) -
OM CHANDRA, K.C. SINGHAL, K.P. GUPTA1969 年 19 巻 4 号 p. 625-626
発行日: 1969年
公開日: 2007/02/02
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OM CHANDRA, K.P. GUPTA, K.C. SINGHAL1969 年 19 巻 4 号 p. 627-628
発行日: 1969年
公開日: 2007/02/02
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永田 充宏, 今村 一輝, 杉本 治良1969 年 19 巻 4 号 p. 628-629
発行日: 1969年
公開日: 2007/02/02
ジャーナル フリーPDF形式でダウンロード (68K)
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