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Volume 19 (1969)
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- Issue 2 Pages 185-
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Volume 19, Issue 2
Displaying 1-21 of 21 articles from this issue
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SEIMEI OSUMI, MOTOHATSU FUJIWARA1969 Volume 19 Issue 2 Pages 185-193
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSThe presence of octopamine in the secretion of the salivary gland of Octopus vulgaris was first demonstrated by Erspamer (1). Kakimoto and Armstrong (2) showed the occurrence of this amine in various tissues of rabbits treated with monoamine oxidase inhibitors. However, paper chromatographic studies of the tissue level of octopamine did not give precise information about small changes of the amine level. Based upon the reaction that octopamine is converted quantitatively to p-hydroxybenzaldehyde by periodate oxidation in ammonia alkaline medium (3), the amount of tissue and blood octopamine could be evaluated by measuring the ultraviolet absorption of the oxidation product. In the present experiments the distribution of exogenously administered octopamine and the accumulation of endogenous octopamine after a monoamine oxidase inhibitor were studied in the blood, brain stem, heart, submaxillary glands, spleen and stomach of the rat.View full abstractDownload PDF (411K) -
KAZUSHIGE SAKAI, KEIGO YASUDA, NORIO TAIRA, KOROKU HASHIMOTO1969 Volume 19 Issue 2 Pages 194-198
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSNorephedrinetheophylline (NET), l-7[2-(1-methyl-2-hydroxy-2-phenyl-ethylamino)ethyl] theophylline hydrochloride, has molecules of caffeine and ephedrine in its chemical structure as follows:
Since diuretic effects of aminoalkyl derivatives of theophylline were investigated by Hildebrandt (1) in 1952, pharmacological properties of these compounds have been elucidated by several workers (2, 3). Among these derivatives, NET was specially studied by Wagenmann and Taugner (4) and Mehmel et al. (5) on its cardiovascular effect. When caffeine and ephedrine are combined to NET, the pharmacological properties are very different from those of caffeine and ephedrine. NET does not show such a marked stimulatory effect on the central nervous system as that of constituents, and its positive chronotropic effect is very slight or converted to the negative one. These observations were attracting the authors' attention to test competition between this compound and catecholamines which seemed likely as a cause of diminution of the cardiovascular effect of this compound. The authors selected the renal vascular bed which is most sensitive to the adrenergic varoconstrictor action and very suitable to test α-adrenergic blocking effect of this compound.View full abstractDownload PDF (194K) -
NOBORU TODA, NAOHISA FUKUDA, KIRO SHIMAMOTO1969 Volume 19 Issue 2 Pages 199-210
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSA new antihypertensive drug, 2-(2, 6-dichlorophenyl-l-amino)-imidazoline hydrochloride (ST-155) (1-5) which structurally resembles tolazoline has been reported to possess no adrenergic alpha-receptor blocking action as does tolazoline (1). Clinical trials show that ST-155 effectively reduces the blood pressure level of hypertensive patients who have not responded to any other antihypertensive drugs (2). Peripheral vascular resistance is decreased (2) and cardiac work is considerably reduced (4) in correspondence with the manifestation of a blood pressure fall in hypertensive patients.
Nayler et al. (6) have postulated that the beta-adrenergic mechanism is involved in the hypotensive action of ST-155 from results observed in dog heart-lung bypass preparations (7) in which the hypotensive action is blocked by propranolol and pentolinium. In the present experiments the mode of hypotensive actions of ST-155 was investigated more extensively on anesthetized rabbits, since this species always exhibited the marked and consistent depressor response to the drug. The results preclude the participation of the beta-adrenergic mechanism in hypotensive action. Actions of ST-155 on central and peripheral cardiovascular mechanisms were postulated to be responsible for its hypotensive action in anesthetized rabbits.View full abstractDownload PDF (465K) -
V.N. SHARMA, R.L. MITAL, S.P. BANERJEE, H.L. SHARMA1969 Volume 19 Issue 2 Pages 211-223
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSThe signs and symptoms due to extrapyramidal tract involvement are amongst the most common side effects in tranquillizer therapy, which is uniformly present in all the six group of drugs used in medicine (1). With many of these drugs, severe extrapyramidal symptoms are uncommon, but with those phenothiazines which contain a piperazine moiety in their side chain such untoward effects are the rule rather than exception ; e.g. trifluoperazine, prochlorperazine and perphenazine. Since these are the valuable drugs in psychiatry, control of their f .trapyramidal side effects offers an important challenge.
Several intriguing views, regarding the relationship of tranquillizing activity and extrapyramidal reactions are reported in literature. Freyhan (2), Brune et al. (3) and Haase (4) are of the opinion that the ability of a drug to induce parkinson like syndrome bears a positive correlation with its therapeutic efficacy, and that the fine motor extrapyramidal reactions are “conditio sino qua non” for the essential efficacy of neuroleptic drugs. Conversely, Cole and Clyde (5), Brooks (6) and Hollister (1), believe that the suppression of parkinsonism does not lead to the impairment of therapeutic efficacy of tranquillizers and that the clinical appearance of extrapyramidal syndrome in no way predicts the therapeutic response of a tranquillizer.
An endeavour to find out the inter-relationship of parkinsonism and antipsychotic activity of tranquillizers can profitably be made by taking the hypothesis of McGeer et al. (7) into consideration. According to these suggestions, there is an equilibrium within the brain between the two groups of biogenic amines: serotonin-catecholamine on one hand, while acetylcholine-histamine on the other. Parkinsonism is characterized by an imbalance between these two systems and can be corrected either by increasing the neurohumoral content of one system or by decreasing that of the other.
Since the therapeutic efficacy of phenothiazine group of tranquillzer bears a close correlation with their antiserotonin (8) and antiadrenergic (9) activity, the two possible ways to inhibit parkinsonism, without interfering with antipsychosis, could be to enhance their antihistaminic or antiacetylcholine action. But potent antihistaminics amongst phenothiazine series e.g. promethazine, or ethopropazine possess little tranquillizing activity, while perphenazine and trifluoperazine which are weak antihistaminic are on the other hand potent tranquillizers. Therefore, the only way to reduce their parkinsonism liability is to increase their antiacetylcholine like action. Since oximes are well known as antidotes for organophosphorous poisoning (anti DFP), we speculated that anticholinergic quaternary oximes of phenothiazine drugs can provide a tranquillizer with lesser liability of extrapyramidal reaction and that the study with these compounds is likely to furnish certain clues for the inter-relationship of thses two actions, one desirable and the other unwanted.View full abstractDownload PDF (545K) -
SHUNICHI INOUE1969 Volume 19 Issue 2 Pages 224-233
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSAlthough 1, 2, 3-trihydroxybenzene (pyrogallol) is known to inhibit the activity of catechol-o-methyltransferase (COMT) (1, 2), its clinical application is limited because of toxic effects such as formation of methemoglobin and degeneration of the kidney and liver (3). Pyrogallol has been useful only as an experimental tool to modify the metabolic process of exogenous as well as endogenous catecholamines. The present experiments were facilitated by the facts that 1, 3, 5-trihydroxybenzene (phloroglucinol, THB) and 2, 4, 6-trihydroxy-l-propiophenone (THPP) showed the definite spasmolytic action in experimental animals (4, 5) and that these compounds relieved the spastic disorders of the urinary tract, bile duct and uterus in patients (6). Based on the experimental findings that the mode of spasmolytic action is neither atropine-like, anti-histamine-like, nor papaverine-like, Cahen (4) has suggested a direct musculotropic action of these compounds. Hattori et al. (7) have shown that trihydroxybenzenes inhibit slightly to markedly COMT activity in vitro. The acute, subacute and chronic toxicity tests of THB in experimental animals confirmed that it is of low toxicity and wide margin of safety (8). In the present experiments the pharmacodynamic effects of THB and THPP on the smooth muscle organs were tested taking into consideration whether the spasmolytic actions of trihydroxybenzenes are correlated with COMT inhibition and subsequent potentiation of the action of catecholamines.View full abstractDownload PDF (444K) -
KEIJIRO TAKAGI, ISSEI TAKAYANAGI, TSUTOMU IRIKURA, KEIGO NISHINO, MASA ...1969 Volume 19 Issue 2 Pages 234-239
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDuring works on anti-5-hydroxytryptamine activity of tryptamine derivatives, 3-(2'-benzylaminoethyl)-5-methoxyindol hydrochloride (S-8) of which a chemical structure is shown in Chart 1 has been found to be a potent competitive inhibitor of 5-hydroxytryptamine (HT) action on the fundus of the isolated rat stomach, the isolated guinea pig uterus and the isolated guinea pig taenia caecum (taenia coli). It has been also found that S-8 depresses a rise of blood pressure of the rat caused by HT.View full abstractDownload PDF (218K) -
KAZUYOSHI KURAHASHI, MOTOHATSU FUJIWARA1969 Volume 19 Issue 2 Pages 240-248
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSThere have been numerous studies on the distribution of endogenous histamine (1-5). Many mammalian tissues contain large to small amounts of histamine preformed. Amongst them skin, stomach and lung contain extremely high concentration of histamine. These organs are exposed to the outside directly or indirectly and prone to traumatic injury. The tissue level of histamine has been estimated with the bioassay procedure using isolated guinea-pig intestine or uterus. The fluorometric analysis of tissue histamine was devised by Shore et al. (6). The method involves extraction of histamine to n-butanol from alkalinized perchloric acid tissue extracts, return of the histamine to an aqueous solution and condensation with o-phthalaldehyde (OPT) to yield a product with strong and stable fluorescence. This fluorometric determination of tissue histamine is simple, precise and sensitive, but inadequate for the analysis of brain histamine because of the presence of interfering substance. Kremzner and Pfeiffer (7) have shown that the major interfering substance, spermidine, is separable from histamine by the use of a phosphorylated cellulose column. After that, Medina and Shore (8) modified the Kremzner and Pfeiffer procedure so as to increase the sensitivity. In the present experiments the Medina and Shore's modification for the fluorometric analysis of tissue histamine was carefully re-examined for the application to pharmacological studies.View full abstractDownload PDF (385K) -
YUKICHI IWATA1969 Volume 19 Issue 2 Pages 249-259
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSHoefke and Kobinger reported that 2-(2, 6-dichlorphenylamino)-2-imidazoline hydrochloride, ST-155 (Fig. 1), had a long-lasting hypotensive action in dogs and rabbits (1). Then Kobinger and Walland (2), and Toda et al. (3) also observed the similar results in animal experiments. The mechanism of its action, however, has not been thoroughly understood. Hoefke and Kobinger suggested that the hypotensive action of ST-155 might be due to the inhibition of the center of sympathetic nervous system as well as to the modification of baro- and chemoreceptor reflex (1). From the fact that continuous intracerebroventricular infusion of minute doses of ST-155 (0.1-1.0 μg/kg) lowered the systemic blood pressure in rabbits, Toda et al. supposed that its hypotensive action could be mediated mainly by the central nervous system. But, they also mentioned that the hypotensive action of ST-155 was not explained solely by its action on the central nervous system, since the pretreatment with hexamethonium or guanethidine could not abolished this action (3).
It is remarkable that this drug shows a significant difference by species. In rabbits, small doses of ST-155 lower the blood pressure, but the hypotensive action of this drug is not manifestly observed in cats and rats. On the contrary, the efficient antihypertensive doses in rabbits raise the blood pressure in cats and rats.
Moreover, it is reported that this drug has a hyperglycemic action and that the species difference is also observed in this hyperglycemic action as in the hypotensive effect (1, 3).
In the present report, the mechanism of the hyperglycemic action of ST-155 has been analyzed in rats, since a hyperglycemic response of rats to ST 155 is much more significant than other animals, and the relationship between the effect of this drug on blood pressure and blood sugar has been discussed.View full abstractDownload PDF (564K) -
RYUICHI KATO, AKIRA TAKANAKA, KINICHI ONODA1969 Volume 19 Issue 2 Pages 260-267
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSIt has been reported that the alteration in the effect of various drugs is often related to the alteration in the rate of drug-metabolism (1-10). For example, the administration of the phenobarbital and various drugs markedly decreased the effects of numerous drugs through increases in the activities of drug-metabolizing enzymes of liver microsomes (1-5). On the other hand, the effects of various drugs were increased in fasted or low protein diet fed rats through decreases in the activities of drug-metabolizing enzymes (6, 7).
It has been reported that species and sex differences in the effects of dugs are often related to the difference in the rate of drug metabolisms (1, 8-11).
It is well known that there are marked individual differences in the effects of various drugs in animal and clinical experiments. On the other hand, it has been considered that such individual differences may be due to differences in the sensitivity of the target organs. However, there are no direct evidence for supporting such opinion on the basis of the drug level in the target organs. The present study, therefore, is designed to determine whether the individual differences in the effects of pentobarbital and zoxanolamine are correlated to the difference in the sensitivity or in the drug level of the target organ.View full abstractDownload PDF (254K) -
J.N. SHARMA, R.C. SRIMAL1969 Volume 19 Issue 2 Pages 268-274
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSPharmacological properties of a potent neuroleptic agent, 2-chloro-ll-(4'-methyl) piperazino-dibenzo (b, f) (1, 4)-thiazepine (HF-2159) have been described by Stille et al. (1). Its profile of activity is in between chlorpromazine and haloperidol, both of which have marked effects on somatic reflexes (2-6). The present investigation has been undertaken to study the effect of HF-2159 on the somatic reflexes integrated at the spinal and the supraspinal level. Preliminary results of this study have appeared (7).View full abstractDownload PDF (347K) -
HEITAROH IWATA, KIMIO KARIYA, SEIGO FUJIMOTO1969 Volume 19 Issue 2 Pages 275-281
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSJanakidevi et al. (1) showed that the ciliated protozoan, Tetrahymena pyriformis, could biosynthesize both of adrenaline and noradrenaline, while the flagellated protozoan, Crithidia fasciculata, biosynthesized only adrenaline. Accordingly, Blum et al. (2) studied the effect of reserpine on the protozoan and found that it inhibited growth and decreased the catecholamine content. Furthermore, Blum (3) investigated the effects of drugs which interacted with the action of catecholamine in mammals, on the glycogen content and growth of Tetrahymena, and suggested a relationship between glycogen synthesis and the control system for adrenergic metabolism in Tetrahymena.
Later, serotonin was also discovered in both Crithidia and Tetrahymena by Janakidevi et al. (4). Furthermore, Blum et al. (5) suggested that clofibrate, a hypolipidemic agent, inhibited glyconeogenesis or activated glycogenolysis in Tetrahymena. And recently, Blum (6) reported that adrenergic control system of Tetrahymena influenced a peroxisomal enzyme which acted the first step of glyconeogenesis from acetyl-CoA.
In an earlier publication from our laboratory (7), we recognized that the growth of Tetrahymena was promoted by dibenamine or ergotamine. The present paper is on the effect of the compounds used in previous experiments, on growth during 72 hours, and on the cell growth and division in one life cycle of the protozoan.View full abstractDownload PDF (203K) -
KEISUKE HATTORI, MASAKO MATSUURA, MOTOHATSU FUJIWARA, KIRO SHIMAMOTO1969 Volume 19 Issue 2 Pages 282-286
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSThe inhibitory action of 1, 2, 3-trihydroxybenzene (pyrogallol) on the activity of catechol-O-methyltransferase (COMT) is well known (1-4). Recently, 1, 3, 5, -trihydroxy-benezene (phloroglucinol) and 2, 4, 6-trihydroxy-l-propiophenone (THPP) have been shown to exert spasmolytic action in experimental animals and to relieve spastic disorders of the urinary tract and biliary ducts in patients (5-10). Comparing the relative effects of trihydroxybenzenes on the smooth muscle organs, Inoue and associates (11-13) have found that these compounds possess catecholamine-like actions and potentiate the effect of catecholamines. Therefore, it is expected that phloroglucinol and THPP also inhibit the COMT activity. In the present experiments, the effects of phenol, phenolic ethanolamines, dihydroxybenzenes, trihydroxybenzenes and related compounds on the COMT activity of rat liver were studied in vitro.View full abstractDownload PDF (249K) -
KEISUKE HATTORI, MASAKO MATSUURA, KIRO SHIMAMOTO1969 Volume 19 Issue 2 Pages 287-290
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSPharmacological studies on the tetrahydroisoquinoline derivatives isolated from various plants including Phellodendron amurense Rupr. showed short-lasting blocking effects on the ganglionic and skeletal muscle synapses (1-5). In addition, the compounds potentiated the effects of catecholamines. Xylopinine, a semi-synthetic product of phellodendron, showed long-lasting sedative and hypotensive effects in experimental animals (6, 7). The latter effect was ascribed to the block of the adrenergic alpha-receptors. Recently, Iwasawa and Kiyomoto (8) have presented an extensive study on the relationship between the chemical structures of a series of tetrahydroisoquinolines and their pharmacological effects. Among the derivatives, 1-(3, 4, 5-trimethoxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydro-isoquinoline proved to be a potent hypotensive and bronchodilating agent. The inhibition by pronethalol of its stimulating effect on cardiac rhythm indicates the stimulation of the adrenergic beta-receptors in the heart.
Following an introduction of pyrogallol as a pharmacological or biochemical tool for the inhibition of catechol-O-methyltransferase (COMT) activity (9), Hattori et al. (10) have shown that trihydoxybenzene moiety other than pyrogallol inhibits also the enzyme activity. Cahen (11, 12) and Inoue (13, 14) have demonstrated the enhancing effect of trihydroxybenzenes on the responses of the adrenergically innervated organs to stimulation of the adrenergic nerve and to administration of catecholamines. Although the distribution of COMT in the body is not fully understand, those organs such as intestine, bile duct, ureter and sphincter muscle of the urinary bladder, which respond to catecholamine with motor inhibition, are supposed to contain a definite activity of the enzyme. The adrenergic stimulating nature of tetrahydroisoquinoline in the beta-receptor origin promted the present experiments, in which the effect on the activity of the rat liver COMT were studied in vitro. Additional studies were made on the activity of rat liver monoamine oxidase (MAO), because the enyme is also responsible for inactivation of catecholamines and the inhibition might result in a potentiation of the action of the amines.View full abstractDownload PDF (205K) -
HIDEAKI KARAKI, MIYOSHI IKEDA, NORIMOTO URAKAWA1969 Volume 19 Issue 2 Pages 291-299
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSIn previous publications it was reported that barium in concentrations from 0.5 to 20 mM induced tension development in isolated guinea pig taenia coli, which response was dependent on the presence of external calcium (1), and that total Ca content did not change but 45Ca uptake of the cellular fraction which did not exchange within 4 minutes increased above control level during Ba-induced tension development (2). It was also mentioned that Ba increased Ca entry in taenia coli and that this Ca probably plays an essential role during tension development (2).
On the other hand, hypertonically added 40 mM K-induced tonic tension development in taenia coli was noted to be composed of phasic and tonic phases and it was proposed that in the phasic contraction, sufficient Ca is released from a cellular site to initiate contraction, whereas in the tonic contraction enough Ca crosses the membrane to initiate and also to maintain contraction(3). However, the movement of Ca in the above processes has not been studied systematically. This work was undertaken to study the movement of Ca in taenia coli during Ba- and high-K-induced tension developments by investigating the total Ca, 45Ca uptake and efflux and 45Ca uptake of the cellular fraction which did not exchange within 4 minutes.
A part of this work has already been reported (2, 4).View full abstractDownload PDF (427K) -
(II) CENTRAL ACTIONS OF PIPERIDINE, PYRROLIDINE AND PIPERAZINEYOSHITOSHI KASÉ, TAKESHI MIYATA, YUICHIRO KAMIKAWA, MIKIKO KATA ...1969 Volume 19 Issue 2 Pages 300-314
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSIn the previous paper (1), it was reported that there are fundamental differences in pharmacological activities between alicyclic and aliphatic amines, and especially piperidine and pyrrolidine in alicyclic amines show pronounced synaptotropic actions similar to those of nicotine.
Both of piperidine and pyrrolidine are normal constituents in the mammalian urine (2-5) and brain (6, 7). Furthermore, piperidine is normally present in human cerebrospinal fluid (8). When tritiated piperidine was given intravenously to the rabbit, it shows a definite distribution in the brain and particularly concentrates to the caudate nucleus, corpora quadrigemina and cortical region (9). However, nothing is known what kind of role piperidine plays in the brain. We have presumed that piperidine (and pyrrolidine also) might be an endogenous synaptotropic substance as Euler (10) and Abood (9) had stated before, serving some neural functions in the regulation of behaviour. In this respect, we have demonstrated that piperidine can be produced from pipecolic acid, an intermediate of lysine metabolism, by decarboxylase in the brain tissue (11).
There has been an interest also in one of other alicyclic amines, piperazine, since it not only shows pharmacological activity such as emetic action (12) but also induces neuromuscular actions similar to those produced by inhibitory transmitters such as γ-aminobutyric acid (13, 14).
In due consideration of the results described above, the central actions of alicyclic amines, especially those of piperidine, have been investigated in our laboratory.
A number of drugs acting on the central nervous system (CNS) contain piperidine, pyrrolidine or piperazine groups in their chemical structures. It is well known that these alicyclic amino groups play essential or, at least, important role for the production of drug actions. Abood et al. (15-17) have reported the conspicuous psychotropic actions of piperidine- and piperazine-derivativand in connection with psychotropic properties of piperidine and piperazine.
Nevertheless, little is known about the central actions of piperidine, pyrrolidine and piperazine per se.
The present report is concerned with central actions especially neurophysiological and behavioural effects of piperidine, pyrrolidine and piperazine. Although central actions of morpholine have also been roughly studied, the amine was far weaker in its activities. So, the actions of morpholine are not described in this paper.View full abstractDownload PDF (722K) -
RYUICHI KATO, AKIRA TAKANAKA, HATSUE SHOJI1969 Volume 19 Issue 2 Pages 315-322
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSThe activity of drug-metabolizing enzymes of liver microsomes is inhibited by various compounds and the administration of these compounds markedly alters the pharmacological activities of other drugs (1-3).
Iproniazid is a well-known inhibitor of monoamine oxidase and it was the first compound of hydrazine derivatives as the inhibitor of drug metabolizing enzymes (4). Moreover, the other monoamine oxidase inhibitors, such as JB 516 (phenylisopropylhydrazine) and W 1544 (phenethylhydrazine) inhibited the metabolism of hexobarbital and meprobamate (5-7). La Roche and Brodie (6) showed that the activity of these compounds as the inhibitor of hexobarbital metabolism is not related to their ability to inhibit monoamine oxidase.
On the other hand, it has been established that the compounds of low lipid solubility are not metabolized by liver microsomes (8). It is, therefore, likely that the lipid solubility of hydrazine derivative may be an important factor for the inhibition of drug-metabolizing enzymes.
In the present communication, we wish to report that isoniazid and many other hydrazine derivatives inhibit the oxidation of hexobarbital, pentobarbital, meprobamate and carisoprodol and the N-demethylation of aminopyrine both in vitro and in vivo in relation to their lipid solubility.
These results are typical example to show that the lipid solubility of compounds is more important factors rather than their chemical configuration for the inhibition of drugmetabolizing enzymes of liver microsomes.View full abstractDownload PDF (369K) -
AKIRA SAKUMA, SACHIKO OH-ISHI1969 Volume 19 Issue 2 Pages 323-324
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDownload PDF (94K) -
MOTOHIKO UEDA, MORIHARU SAWAI, MASARU KAWAKAMI, TETUO MINESITA, HIROSH ...1969 Volume 19 Issue 2 Pages 324-325
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDownload PDF (92K) -
KENJI SUZUKI, TAKASHI ABIKO, NOBUYOSHI ENDO, TSUTOMU KAMEYAMA, KEN-ICH ...1969 Volume 19 Issue 2 Pages 325-327
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDownload PDF (133K) -
KEIJIRO TAKAGI, SUSUMU OKABE, SHINGO YANO, KOICHIRO KAWASHIMA, RYUICHI ...1969 Volume 19 Issue 2 Pages 327-329
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDownload PDF (159K) -
S.S. GANESHANANDAN, HIDEAKI KARAKI, MIYOSHI IKEDA, NORIMOTO URAKAWA1969 Volume 19 Issue 2 Pages 329-330
Published: 1969
Released on J-STAGE: February 02, 2007
JOURNAL FREE ACCESSDownload PDF (99K)
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