巻号一覧
2 巻 (1952 - 1953)
- 2 号 p. 89-
- 1 号 p. 1-
2 巻, 1 号
選択された号の論文の9件中1～9を表示しています
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KIYOSHI TANAKA, NOBORU KAN1952 年 2 巻 1 号 p. 1-6
発行日: 1952年
公開日: 2007/02/16
ジャーナル フリーThough no objection has been offered to the reports of various authors (1, 2, 3, 4), stating that the blood pressure changes distinctly during and after the electrically induced convulsion, the detailed mechanism of the change remains to be elucidate.
Recently Schoetensack and Hann (5) have given a new interpretation of the mechanism based on their experiment in cats. They found that the blood pressure simply rose and never fell below the normal level after electroshock in unanesthetized and curarized cats, while it was merely depressed in animals anesthetized with barbiturate. According to them, the pressor response was abolished by yohimbin and therefore it was attributed to the secretion. of epinephrine, and the depressor response was potentiated by eserine and prevented by atropine, indicating that acetylcholine was liberated.
For the last several years we have been engaged in a research on the physiological changes induced by electroshock in experimental animals and have ascertained that the responses of blood pressure were not attributable solely to the liberation of chemical transmitters such as epinephrine or acetylcholine (6). The present report presents the results of our experiments and our view on the nature of the pressor and depressor responses to electroshock.抄録全体を表示PDF形式でダウンロード (258K) -
YOSHITOSHI KASE1952 年 2 巻 1 号 p. 7-13
発行日: 1952年
公開日: 2007/02/16
ジャーナル フリーSo far as I know there are two methods of testing cough depressing drugs. In Ernst's method (1) Lugol's solution is injected into one of the pleural cavity of a cat to cause a state of cough readiness. Another is Eichler-Smiatek's (2), in which cough attacks are brought about in a guinea pig by spraying. sulphuric acid into a compartment in which the animal is kept. These methods, however, are not effectual enough to cause cough attacks constantly at the desired time, and can hardly be employed for evaluation of cough remedies. I therefore have devised two methods. Method 1 is to apply mechanical stimulation to the mucous membranes of the air passages to cause a fit of coughing ; method 2 is to apply electric stimulation to the sensory nerve branch of the trachea.抄録全体を表示PDF形式でダウンロード (305K) -
MASAYUKI NAKATSUKA, JUNSO MATSUMOTO1952 年 2 巻 1 号 p. 14-22
発行日: 1952年
公開日: 2007/02/16
ジャーナル フリーPDF形式でダウンロード (720K) -
TSUNEYOSHI TANABE, TAKEHIKO SUZUKI1952 年 2 巻 1 号 p. 23-31
発行日: 1952年
公開日: 2007/02/16
ジャーナル フリーIt is generally believed that the Hatcher's cat method as modified by Magnus for digitalis assay is most reliable because of the accuracy and constancy of its results. According. to many authors (1, 2, 3, 4, 5), the variation in the susceptibility of, cats to digitalis was more pronounced than was described by Van Wijngaarden (6). McFarlane and Masson (3) reported that there were probably two species of cats which differed in their resistance to digitalis. Recently experiments on the bioassay of digitalis by this cat method had been carried out at pharmacological laboratories in certain different districts of Japan, each using the same preparations. The results varied considerably and this study was undertaken to investigate those factors which may produce such discrepancies.
The method devised includes many factors that may influence the results, for example family and species of the cats, sex, weight and the state, of nutrition. Many cats obstinately, refused to take food in the cage and this fasting state resulted in an emaciated animal. These animals were used to determine the effects of the state of nutrition on the value obtained by the assay. It is felt that the variability and/or the discrepancy of the results may be caused by any one or combination of these factors.抄録全体を表示PDF形式でダウンロード (387K) -
YOSHIO TOGAMI1952 年 2 巻 1 号 p. 32-46
発行日: 1952年
公開日: 2007/02/16
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II. INFLUENCES OF THE SPLENIC COMPONENTS OF HOG, RABBIT AND HORSEYOSHIO TOGAMI1952 年 2 巻 1 号 p. 47-51
発行日: 1952年
公開日: 2007/02/16
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KENJI URAGUCHI, FUMINORI SAKAI, SUMINOBU MORI, SADASUKE OKANO1952 年 2 巻 1 号 p. 52-64
発行日: 1952年
公開日: 2007/02/16
ジャーナル フリーDuring and after the war, many clinicians in Japan witnessed unexpected febrile reactions following intravenous injections of the oficinal products of glucose-solution in ampuls which were apparently made to conform to the pharmacopoeia requirements. Main purpose of our present investigations is to contribute to solve this common problem in the postwar time. So far as the pharmacopoeial products of glucose-powder are concerned, the important rôle of pyrogens as a cause of clinical pyrexia cannot be ignored, as shown in the conclusion of our previous report (1). We have no doubt of the fact that certain moulds and yeasts as well as bacteria existing in glucose-powders are capable to produce pyrogens under a suitable humidity and temperature, and presumably even in a “dry” state of the powders. In the experiments regarding glucose-powder, as shown in the previous report, pyrogens were accompanied generally with pyrogen-producing microbes in experimental materials, and then they could be easily separated from microbes in case of necessity. Now, in the present attempt to determine the pyrogenecity of glucose-solution in ampuls, we must dear with a rather more involved matter, since all the samples to be adopted here are free from any mycologically or bacteriologically positive evidence as to the possible presence of microbes in them.
The mode of clinical occurrences of febrile reactions following glucose injections seemed to be sporadic, so far as the commercial solutions sealed in ampuls are concerned. It was sometimes reported that when an ampul packed in a box proved pyrogenetic to a patient, some of the rest of the ampuls packed with it in the same box did not always yield a similar reaction to other patients. Aside from pyrogenetic microbes, we have to determine whether or not pyrogens are common in all ampuls of the same lot-number. Supposing the amount of pyrogens contained to be small, susceptibilities of the patient would play an important part to exhibit an equivocal phenomena concerning febrile reactions in clinics. This is also one of the questions to be solved in our experimental investigations.抄録全体を表示PDF形式でダウンロード (666K) -
HIROSHI KUMAGAI, SETSURO EBASHI, FUMIKO TAKEDA1952 年 2 巻 1 号 p. 65-81
発行日: 1952年
公開日: 2007/02/16
ジャーナル フリーSince the isolation of the oxytocic principle from the posterior pituitary, the biological standardization of this principle has been made most extensively on the excised uterus of virgin guinea-pig mounted in a bath containing oxygenated Locke's solution (Guinea-pig Method).
Notwithstanding the high sensitivity of the excised guinea-pig uterus, it is by no means completely satisfactory in defining the responses quantitatively, the fact which is well known to any laboratory worker who ever resorted to this method of standardization, and that is the reason why development of another more reliable quantitative method is desired.
Factors that make the guinea-pig uterus unsuitable for quantifying its response to the oxytocic principle may be summarized as follows:
1. Whereas the uterus suitable for the guinea-pig method must be that of an animal in a definite stage of its growth, neither too young nor too mature, the body weight of an animal is by no means a faithful representation of the development of its sexual organ, i.e., uterus. Therefore, actual suitability of the uterus cannot be predicted until we have sacrificed the animal. In our experience, availability of a suitable uterus is less than one in every 5 animals sacrificed.
2. In many cases, uteri which soon after extirpation respond satisfactorily to the hormone become so sensitized sooner or later by the added hormone, as to interfere with further observations.
3. Guinea-pig uterus has a tendency of developing tetanic contractions in response to the hormone, i. e., it has a tendency of developing an “all or none” type response, which is unsuitable for quantifying the result.
4. Both contraction and relaxation of the guinea-pig uterus are rather slow processes, and even after the hormone has been washed out, it takes relatively long time to regain its initial relaxed state.
5. The response of the guinea-pig uterus to the hormone is generally inconstant.
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SACRA SACON1952 年 2 巻 1 号 p. 82-87
発行日: 1952年
公開日: 2007/02/16
ジャーナル フリーSince the precursive work of Zondek were reported, many of the reports containing the investigations for the gonadotropic hormone are made public. The excretion of hypophyseal gonadotropin in the urine of castrated persons was discovered in postmenopausal and castrated women by Aschheim (1928) and in castrated men by Hamburger (1931). Recently, it is said that the gonadotropic hormone present in castrated urine is of hypophyseal origin, and in pregnancy, is chorionic (1).
The purpose of this work reported here, was to investigate the character of the gonadotropic activity in the urine of castrated women. Then I started to compare it with the gonadotropic substance in the urine of pregnant women, and then I excluded the toxicity in castrated urine, corrected the method of extraction and established an assay method in order to obtain the high efficacy.抄録全体を表示PDF形式でダウンロード (253K)
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