巻号一覧
24 巻 (1974)
- 6 号 p. 817-
- 5 号 p. 659-
- 4 号 p. 493-
- 3 号 p. 335-
- 2 号 p. 175-
- 1 号 p. 1-
24 巻, 5 号
選択された号の論文の20件中1～20を表示しています
- |<
- <
- 1
- >
- >|
-
Kazushige SAKAI, Shigeru SUGANO, Norio TAIRA, Koroku HASHIMOTO1974 年 24 巻 5 号 p. 659-669
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーIn order to accumulate fundamental data concerning circulatory pharmacological studies using Beagles, vascular responses to 28 drugs of the coronary, renal, mesenteric and femoral vascular beds were investigated. It is expected that there may he qualitative differences among the responses to hydralazine, lobeline, DMPP, nicotine, procaine and TEA of Beagles and those of mongrel dogs reported previously. When peripheral vascular responses to norepinephrine, ACh, adenosine and histamine were examined quantitatively, no significant differences were observed between Beagle and mongrel dogs regarding sensitivities to the four tested drugs.抄録全体を表示PDF形式でダウンロード (370K) -
Hisakuni HASHIMOTO, Yutaka KASUYA1974 年 24 巻 5 号 p. 671-680
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーThe mechanisms of the CA-potentiating action of DMA, 1-phenyl-l-(2, 5-dimethoxyphenyl)-3-piperidinobutanol, were investigated in cats. DMA specifically prolonged the duration of the cardiovascular responses to adrenaline and isoproterenol. The responses to noradrenaline were only slightly potentiated. While DMA inhibited the disappearance of intravenously injected adrenaline and isopro terenol from blood plasma, the disappearance of noradrenaline was only slightly inhibited. It is suggested that the inhibitory effect of DMA on the disappearance of adrenaline contributed to the potentiating effect of DMA on the pressor response to adrenaline. The increase of the plasma level of 3H-CAs by DMA was not accompanied by any reduction in the total amount of their metabolites. In rabbits, the synergistic effect was observed on the delayed disappearance of plasma 3H-adrenaline among DMA, pyrogallol and tranylcypromine. It is concluded that the DMA-sensitive inactivation process of circulating catecholamines is different from the O-methylation or the monoamine oxidation of catecholamines and has a higher affinity for adrenaline and isoprotcrenol than for noradrenaline.抄録全体を表示PDF形式でダウンロード (401K) -
Tsutomu URUNO, Issei TAKAYANAGI, Masako TOKUNAGA, Kazuhiko KUBOTA, Kei ...1974 年 24 巻 5 号 p. 681-686
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーAntioxytocin activities of bile salts and their effects on phosphodiesterase (PDE) activities and the intracellular level of cyclic AMP in the rat uterus were investigated, and the mode of action of the bile salts was compared with that of papaverine or Aspaminol. The bile salts, chenodesoxycholate, desoxycholate, ursodesoxycholate and cholate significantly decreased PDE activities and a good relationship between the PDE activities and the antioxytocin activities of the bile salts was observed. Chenodesoxycholate and desoxycholate significantly increased the intracellular level of cyclic AMP in the rat uterus. The exogenously applied CaCl2 potentiated the inhibitory responses of the rat uterus to papaverine, aminophylline responses of the rat uterus to papaverine, aminophylline and bile salts, while the inhibitory response to Aspaminol was greatly reduced by excess CaCl2. These results indicate that the antioxytocin action of the bile salts may be exerted through an increase in the intracellular level of cyclic AMP. Further, the results support the theory that there are two mechanisms for “papaverine-like” antipasmodics.抄録全体を表示PDF形式でダウンロード (269K) -
Seiji KUZUNA, Naohiko MATSUMOTO, Kiyohisa KAWAI1974 年 24 巻 5 号 p. 687-693
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーThe pharmacological activities of five metabolites of an anti-inflammatory compound, 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284) were investigated and compared with TAI-284 and phenylbutazone. The metabolite IIb (cis3'-hydroxy-cyclohexyl, β-form) was almost equivalent to TAI-284 regarding antiinflammatory activity as estimated by the carrageenin edema test, and was more active than TAI-284 in the analgesic activity estimated by the phenylquinone writhing test and determination of the ulcerogenic activity. The metabolites IIa (cis-4'hydroxy-cyclohexyl) and IV (cis-3'-hydroxy-cyclohexyl, α-form) had about half the anti-inflammatory activity and one third to one quarter the analgesic activity of TAI-284, however the degree of ulcerogenicity was considerably lower than that of TAI-284. 1 (4'-oxo-cyclohexyl) was less active, and III (trans-4'-hydroxy-cyclohexyl) showed the weakest activity comparable to that of phenylbutazone. Antipyretic activities of all five metabolites were much lower than those of TAI-284. As the pharmacological activities of metabolites varied greatly according to the position of the hydroxyl group on the cyclohexane ring of TAI-284, it is feasible that the distribution pattern and affinity of the metabolites for receptors could be modified.抄録全体を表示PDF形式でダウンロード (249K) -
Seiji KUZUNA, Naohiko MATSUMOTO, Tadahiko KOMETANI, Kiyohisa KAWAI1974 年 24 巻 5 号 p. 695-705
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーA potent anti-inflammatory compound, TAI-284, and its optical isomers were subjected to the pharmacological, toxicological and metabolic studies in rats, mice and guinea-pigs. In anti-inflammatory, analgesic and antipyretic activities examined in rats and mice, the d-isomer was the most potent, followed by the racemate, and the l-isomer was the lowest. Similar results were obtained regarding toxicity and ulcerogenicity. The d-isomer maintained the highest plasma level, followed in decreasing order by the racemate and the l-isomer, when they were administered orally to rats. In the same experiment, the plasma level of the l-isomer's metabolites was the highest, followed in decreasing order by that of the racemate's metabolites and that of the disomer's metabolites. In Vitro, the l-isomer was most rapidly transformed into the metabolites while the d-isomer was most slowly transformed. On the other hand, the d-isomer was as potent as the l-isomer in the anti-inflammatory activity in guineapigs. In this species TAI-284 is hardly biotransformed into the metabolites. It is postulated that the rate of biotransformation of these compounds has a great influence on their pharmacological activities.抄録全体を表示PDF形式でダウンロード (423K) -
Masao KOIDA, Masakatsu TAKAHASHI, Hiroshi KANETO1974 年 24 巻 5 号 p. 707-714
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーThe major metabolite of morphine in human urine, morphine 3-glucuronide, was conjugated to bovine serum albumin by action of a water soluble carbodiimide. Immunization of rabbits with the conjugate produced the antibody which effectively bound 14C-labeled morphine. By comparing the potency of various morphine-related compounds to inhibit the binding, the specificity of the antibody was characterized. The ranking in the order of decreasing affinities to the antibody was codeine or morphine 3-glucuronide, morphine, codeine 6-glucuronide, dihydrocodeine, morphine 6-glucuronide and nalorphine. The results indicated that the hapten structure was correctly reflected in the specificity, except that recognition of the glucuronyl moiety by the antibody was not as sharp as had been expected. When the antibody was used for radioimmunoassay of urine sample, the urinary excretion patterns of morphine and codeine in rats could be followed easily for more than 5 days after the drug administration. In addition, experiments were carried out to estimate the excretion patterns of dextromethorphan and dihydrocodeine in humans. Based on the results, it is suggested that the morphine 3-glucuronide directed antibody can be utilized for radioimmunoassay of morphine and its 3-glucuronide in urine.抄録全体を表示PDF形式でダウンロード (328K) -
Yoshitsugu OSUMI, Chikako TANAKA, Shuji TAKAORI1974 年 24 巻 5 号 p. 715-720
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーTyrosine and tryptophan contents in the plasma and brain, and noradrenaline and serotonin contents in the brain were measured in spontaneously hypertensive rats (SHR) and two normotensive strains, Wistar/Kyoto rats (WKR) and Wistar/Carworth rats (WCR) to investigate the quantitative relationship between monoamines and their precursor amino acids in the brain of SHR. WKR is the parent strain of SHR. Tyrosine level in the plasma and brain of SHR was significantly lower than that in WCR, whereas tryptophan level in the plasma and brain of SHR was higher than that of WCR. The levels of these amino acids were the same in SHR and WKR. Noradrenaline and serotonin contents in the brain stem of SHR and WKR were lower than the respective contents of WCR, while no difference was found in noradrenaline and serotonin contents in the telencephalon of these 3 strains. In SHR, 1.0% L-tyrosine ingestion for 5 days produced a slight but significant fall of the blood pressure accompanied by an increase of tyrosine in the plasma and brain. However, noradrenaline in the brain stem did not change following the L-tyrosinc feeding. These results suggest that differences in contents of the monoamines and their precursor amino acids in SHR and WKR could be due to genetic factors in a specific closed colony.抄録全体を表示PDF形式でダウンロード (260K) -
Isamu YAMAGUCHI, Jo MORI, Fumio HONDA, Hiroyuki NISHIZAKI, Shigenobu K ...1974 年 24 巻 5 号 p. 721-728
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーThe cholinergic innervation of endocrine-like cells (probably identical with gastrin containing cells, G-cells) in dog antro-pyloric mucosa was studied histochemically, and was compared with that of secretory cells in fundic mucosa. Endocrine-like cells and cholinergic nerve fibers were detected by formaldehyde-HCl treatment and acetylcholine esterase (AChE) staining, respectively. In the fundic mucosa, cholinergic nerve fibers were widely observed along the oxyntic glands, particularly in their middle area. Cholinergic nerve fibers were seen in close proximity to the bases of secretory cells, and the distribution of cholinergic nerve fibers well coincided with that of parietal cells and chief cells. Cholinergic nerve fibers were detected also in the antropyloric mucosa, but they were rather restricted to the basal half of the mucosa. In this region endocrine-like cells were seen after formaldehyde-HCl treatment. Denmonstrating cholinergic nerve fibers and endocrine-like cells simultaneously in one section, we found that the former came in close proximity to the bases of endocrinelike cells. These results suggest that cholinergic nerve fibers control not only the production of gastric juice from the fundic mucosa but also the release of gastrin from the antropyloric mucosa.抄録全体を表示PDF形式でダウンロード (685K) -
Isami SHUDO1974 年 24 巻 5 号 p. 729-735
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーThe plasma 3H-radioactivity level showed a high value 1 hr after intraperitoneal injection of 3H-metaproterenol and it lowered lineraly to reach 40% of the peak level 5 hr after administration. Radioactivity distributed to the kidneys and liver was markedly higher than that in other organs. Forty per cent of the amount given orally was excreted in the 24 hr urine specimen. The major part of metaproterenol was excreted in urine as an unchanged compound in the early stages after administration and the remainder in the form of glucuronide in the late stages. It is concluded that the absorbed metaproterenol remains unmetabolized for a considerable length of time in the body and high plasma levels are maintained for a relatively long period.抄録全体を表示PDF形式でダウンロード (254K) -
Yasuhiko SASAKI, Shigeyuki TAKEYAMA1974 年 24 巻 5 号 p. 737-745
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーThe fibrinolysis induced by intraperitoneal injection of adrenaline in the rat was inhibited by prior intraperitoneal injection of very low doses of α-adrenergic blocking agents. For example, 5 μg/kg of phenoxybenzamine or 10 μg/kg of phentolamine was sufficient to prevent almost completely the fibrinolysis induced by 1 mg/kg of adrenaline. These α-blockers also inhibited the fibrinolysis induced by serotonin and bisobrin, but a much higher dosage was required. Phenoxybenzamine did not inhibit the adrenaline-induced fibrinolysis when the drug was injected after the injection of adrenaline. No inhibitory effect was observed with β-blockers, dichloroisoproterenol, pronethalol and practolol, even at a dose of 10 mg/kg, although propranolol at a dose of 3 mg/kg did exert an inhibitory effect. The involvement of peritoneal blood vessels in adrenaline-induced fibrinolysis is suggested.抄録全体を表示PDF形式でダウンロード (357K) -
Noboru TODA1974 年 24 巻 5 号 p. 747-761
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーTransmembrane potentials were recorded from single cells of isolated rabbit left atria. Action potentials generated by electrical stimulation were markedly depressed or completely abolished by Ca++ chelating agents, EGTA and EDTA (4 and 5 mM), in association with a decrease in the resting membrane potential. Automaticity was initiated. EGTA-induced automaticity was abolished by the addition of 2 mM Ca++. Changes in the membrane potential induced by 5 mM EGTA were reversed by 3 to 5 mM Ca++. Reduction in [Na+]0 from 162 mM to 74 or 52 mM delayed the initiation of automaticity, slowed the automatic rate, shortened the duration of automaticity and decreased the action potential amplitude. Magnesium ions (0.1 to 0.2 mM) abolished automaticity induced by EGTA. The resting potential was not significantly changed. Increasing concentrations of Mg++ to 0.5 to 2 mM made preparations unresponsive to electrical stimulation. The addition of Mn++ in concentrations higher than 2 mM abolished EGTA-induced atuomaticity in association with increased resting potential. Electrical stimulation generated action potentials, which were not abolished by increasing concentrations of Mn++ but by tetrodotoxin. Atrial contractions abolished by EGTA were temporarily restored by 3 mM Mn++ Automaticity induced by these chelating agents may be associated with increased resting permeability for Na+, permitting membranes to depolarize to a level at which action potentials generate spontaneously. It appears that upon excitation Mg++ decreases the membrane permeability for Na+.抄録全体を表示PDF形式でダウンロード (592K) -
Atsuko HAYASHI, Shizuko TAKANO, Toshiko HASHIKAWA, Yasushi ABIKO1974 年 24 巻 5 号 p. 763-770
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーThe effects of nitroglycerin, dipyridamole, papaverine and anoxia on the cellular redox state were investigated in the inner and outer layers of the left ventricular wall, in open-chest dogs anesthetized with morphine and pentobarbital. As an index of the cellular redox state, the NAD+/NADH ratio was employed. The NAD+/NADH ratio was calculated by direct measurements of NAD+ and NADH in the tissue. In the control dog, the NAD+/NADH ratio in the inner layers was usually lower than that in the outer; a transmural gradient of the NAD+/NADH ratio across the left ventricle was detected. Anoxia was produced by discontinuation of artificial respiration for 3 min. In the anoxic dog, the NAD+/NADH ratios in both the layers were markedly lower than those obtained in the control dog. The transmural gradient of the NAD+/NADH ratio was not modified by the injection of either dipyridamole (250 μ/kg, i.v.) or papaverine (2 mg/kg, i.v.), but it was increased by the production of anoxia, while it was abolished by the injection of nitroglycerin (20 μg/kg, i.v.). The possible mechanisms of the beneficial action of nitroglycerin against angina pectoris are discussed with special reference to the myocardial redox state.抄録全体を表示PDF形式でダウンロード (372K) -
Masao ENDOH, Tomohiko KIMURA, Koroku HASHIMOTO1974 年 24 巻 5 号 p. 771-778
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーEffect of manganese ions (Mn) on the mammalian ventricular myocardium was investigated using the isolated blood-perfused papillary muscle from the canine right ventricle. Mn caused dose-dependently an increase in blood flow above 0.1 mg and negative inotropic and chronotropic effects above 0.3 mg, while there was little change in the configuration of EMG even at a dose of 30 mg of Mn. The effects of Mn on the contraction and blood flow of the papillary muscle preparation were reversible. Norepinephrine, caffeine and calcium induced a positive inotropic effect almost to the same extent in the control or in the depressed state after Mn treatment, while periarterial nerve stimulation definitely caused a diminished increase in the contractile force after Mn treatment. Furthermore, in the automatically beating papillary muscle the positive chronotropic responses to norepinephrine and periarterial nerve stimulation were more readily blocked by Mn than the positive isotropic ones. These observations suggest that Mn affects not only contraction but also catecholamine release and pacemaker potential.抄録全体を表示PDF形式でダウンロード (325K) -
Isamu YAMAGUCHI1974 年 24 巻 5 号 p. 779-786
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーWhile researching the mechanisms of gastric secretagogue action of morphine, the effects of hexamethonium, atropine and secretin on morphine-induced gastric secretion were studied, and were compared with those on food-, histamineand tetrapeptide-induced gastric secretion in conscious dogs, and on histamine-, tetrapeptide and bethanecol-induced gastric secretion in anesthetized dogs. Effect of acute bilateral vagotomy on the gastric secretion was also investigated in anesthetized dogs. Results are discussed in relation to the mechanisms involved in the stimulation and inhibition of gastric secretion, and the following suggestions are made. Direct vagal excitation of oxyntic glands and endogenous gastrin plays an important role in food-induced secretion in innervated and denervated fundic pouches, respectively. Exogenous gastrin stimulates gastric secretion activating cholinergic post-ganglionic nerve fibers in conscious dogs. In anesthetized dogs, however, exogenous gastrin induces its secretagogue action mainly by a direct action on oxyntic glands. A close similarity was observed between morphine-induced secretion and food-induced secretion in denervated fundic pouches when inhibitory activities of drugs were compared. It is thus concluded that endogenous gastrin plays an important role in the gastric secretion induced by morphine.抄録全体を表示PDF形式でダウンロード (339K) -
Yasuhiko KUROSAWA1974 年 24 巻 5 号 p. 787-795
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーThe effects of alcohols on MAO activity in beef and rat liver mitochondria were studied. MAO activity was determined manometrically using tyramine (1×10-2 M) as substrate and expressed as O2 uptake in 60 min. At concentrations of 0.1 to 10%, methanol and ethanol increased MAO activity in both beef and rat liver mitochondria. Activation of MAO by ethanol was reversible. Ethanol increased MAO activity of beef liver mitochondria using butylamine, amylamine, benzylamine, beta-phenylethylamine, tryptamine or serotonin as substrate. The pH optima of MAO in beef liver mitochondria were at pH 7.0 and pH 7.5 in the absence and presence of ethanol. On addition of 1% ethanol, the Km value (2×10-2 M) did not change but the Vmax vlaue increased two-fold. The pS-activity curve of MAO was sigmoidal and on addition of ethanol, MAO was inhibited by a high concentration of substrate. Ethanol decreased the inhibition of MAO by pheniprazine or pargyline. These results suggest that addition of ethanol does not affect the dissociation constant of the enzyme-substrate complex, but accelerates reaction steps occurring after the enzyme-substrate complex has been formed.抄録全体を表示PDF形式でダウンロード (328K) -
Tadashi ISO1974 年 24 巻 5 号 p. 797-801
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーIn the present study, it was confirmed that the contractile response of isolated guinea-pig ileum to ATP and acetylcholine was enhanced by lowering Mg++ in the medium and reduced by low Call. However, differing from acetylcholine, the contractile response to ATP at low concentration of 3×10-6 to 3, ×10-5 M was not reduced by lowering Ca++ from 1.8 to 0.1 mM in Mg++-free medium. On the other hand, the potentiative action of 5'-AMP on the ATP-induced contraction observed in normal Tyrode solution disappeared at 0.1 mM Ca++ in Mg++-free medium. It was also observed that not only the inhibitory effect of 5'-AMP and adenosine on the acetylcholine-induced contraction, but also that of adenosine on the ATP-induced contraction was augmented by lowering Ca++ in the medium. From these findings, it is suggested that the disappearance of the potentiative action of 5'-AMP may be due to the inhibitory action of the adenosine moiety in the molecule augmented by low Ca++.抄録全体を表示PDF形式でダウンロード (206K) -
Toshimichi TSUBOI, Yoshiko OHSAWA, Kohsaku ISHIKAWA, Kouichi YOSHIDA, ...1974 年 24 巻 5 号 p. 803-808
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーStudies of the isoproterenol-induced necrotic heart perfused under an anoxic condition were performed to determine the changes of metabolism and mechanical function. It was found that the increased concentration of glucose in a perfusion medium enabled the necrotic heart to preserve mechanical functions during anoxia. However, in the normal heart the protective effect of high glucose concentration was not significant. High glucose concentration enhanced anaerobic glycolysis in the necrotic heart during anoxia but had no significant effect on the levels of myocardial high energy phosphates.抄録全体を表示PDF形式でダウンロード (255K) -
S.K. KULKARNI, P.C. DANDIYA1974 年 24 巻 5 号 p. 809-810
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (90K) -
Hideomi FUKUDA, Tsugutaka ITO, Satoe HASHIMOTO, Yoshihisa KUDO1974 年 24 巻 5 号 p. 810-813
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (187K) -
Hiraku OZAWA, Kimie AIHARA, Fujio ABE, Kazunobu SUGAWARA1974 年 24 巻 5 号 p. 814-816
発行日: 1974年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (115K)
- |<
- <
- 1
- >
- >|