巻号一覧
27 巻 (1977)
- 6 号 p. 755-
- 5 号 p. 601-
- 4 号 p. 481-
- 3 号 p. 333-
- 2 号 p. 183-
- 1 号 p. 1-
27 巻, 3 号
選択された号の論文の22件中1～22を表示しています
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Tetsuo MAGARIBUCHI, Hiromichi NAKAJIMA, Akio KIYOMOTO1977 年 27 巻 3 号 p. 333-339
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーEffects of diltiazem on K-induced contracture of the smooth muscle were examined in the isolated taenia coil and stomach strip of the guinea pig. Results were compared with those of lanthanum ion (La3+). K-contracture was evoked by isotonic K-Krebs solution. La3+ inhibited K-contracture of the taenia coli and effects on the phasic response were found to be more remarkable than on the tonic response. After the removal of La3+, the phasic response almost regained its normal magnitude, whereas the tonic response was significantly augmented. In contrast to the effects of La3+ . diltiazem inhibited the tonic response more markedly than the phasic response in both taenia coil and stomach strip. Inhibition of the phasic response was elicited, in association with decrease in the frequency of spike discharge during rapid depolarization of the membrane. The effects of diltiazem were completely reversed after washing out the compound. It is assumed that although both La3+ and diltiazem inhibit the transmembrane influx of Ca2+. additional mechanisms rnav differ.抄録全体を表示PDF形式でダウンロード (268K) -
Norimichi NAKAHATA, Hironori NAKANISHI, Takehiko SUZUKI1977 年 27 巻 3 号 p. 341-349
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーDifferences in sensitivity to catecholamines between colon and duodenum were examined in tissues from the rat, monitoring the depressive effect of catecholamilies on contractile response to acetylcholine (ACh). The sensitivity of colonic tissue to ACh was higher than that of duodenal. Epinephrine (Ep, 10-7 g/ml) depressed the contractile response to ACh in the colonic tissue, but not in the duodenal. The depressive effect of Ep on the contractile response to ACh is attributed to the stimulation of adrenergic beta-receptors in the colonic tissue as the depression disappeared by pretreatment with propranolol (10-6 g/ml). There was no difference on the depressive effect of papaverine on the contractile response to ACh, except when low concentrations were used. Dibutyryl cyclic AMP (10-4 g/ml) depressed the contractile responses of both tissues to ACh. After treatment with Ep (10-7 g/ml), cyclic AMP content was increased in the colonic tissue but not in the duodenal. However, papaverine (3×10-6 g/ml) and a higher dose of Ep (10-6 g/ml) increased cyclic AMP content in both tissues. The increase of cyclic AMP and the decrease of tension caused by Ep were not correlated in these tissues. However, a positive correlation was observed between the depressive effect of Ep on the contractile response to ACh and the increase of cyclic AMP content in these tissues.抄録全体を表示PDF形式でダウンロード (348K) -
Haruo TACHIZAWA, Wataru TSUKADA, Tadashi SAITO, Takeshi AKIMOTO1977 年 27 巻 3 号 p. 351-359
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーThe properties of prostaglandin synthetase systems (PSSs) in the renal medulla of the rat and rabbit, and inhibition by ketoprofen, indomethacin, ibuprofen, phenylbutazone and aspirin were investigated in relation to their anti-inflammatory, analgesic, antipyretic and ulcerogenic activities. Rat and rabbit PSSs produced prostaglandin (PG)E and PGF from arachidonic and dihomo-γ-linolenic acids and had an optimal pH of 8.5 and 7.5 for PGE formation, respectively. Only a slight loss of activity occurred with lyophilization. In the rat PSS. all drugs tested were inhibitory in the order of ketoprofen, ibuprofen, indomethacin and aspirin, respectively. In the rabbit PSS, the same potency relationship was also found. Drug sensitivity of the rat PSS was remarkably lower than that of the rabbit PSS. Significant correlations were noted between the inhibitory potencies of the drugs against both PSSs and other in vivo pharmacological activities within the same species.抄録全体を表示PDF形式でダウンロード (359K) -
Tetsuo MAGARIBUCHI, Hiromichi NAKAJIMA, Akio KIYOMOTO1977 年 27 巻 3 号 p. 361-369
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーEffects of diltiazem on electrical and mechanical activities of isolated guinea pig taenia coli were studied by means of the double sucrose-gap method. In the spontaneously active preparations, diltiazem (2.2×l0-6 M) suppressed both electrical activity and isometric contraction, while electrical and mechanical activities evoked by the depolarizing current pulse were not affected at the concentration of 2.2 β 10-6 M. In the presence of 2.2×10-5 M diltiazem, the evoked contractile force and the number of repetitive firings during depolarization were reduced, whereas the single spike was almost unchanged or somewhat inhibited. At 2.2×10-4 M diltiazem, both electrical and mechanical activities were almost abolished. The contractile force and single spike suppressed by diltiazem were partly reversed by the addition of 5 mM CaCl2. There was little significant change in membrane potential and membrane resistance. Similar but somewhat weaker effects were observed when NaCl was replaced with sucrose. In some preparations, 2.2×10-4 M diltiazem reduced the contractile force without significant influence on the electrical activity in Na+-free Locke solution. CoCl2 (3 mM) inhibited the evoked activities in both normal and Na+-free solutions. Possible mechanisms for the relaxing effects of diltiazem on isolated guinea pig taenia coil were discussed.抄録全体を表示PDF形式でダウンロード (364K) -
Koji FURUNO, Shigeo SUZUKI, Kozo HIRATA1977 年 27 巻 3 号 p. 371-378
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーEffects of dehydration and sodium D-glucaro-l, 4-lactone on kanamycin distribution in the kidneys, liver, lungs, spleen and cochleae were determined after intramuscular injection of the antibiotic into male rats. Coincident changes in plasma concentration and urinary excretion of the antibiotic were also measured. After administration of 30 mg/kg of kanamycin, dehydrated rats showed slower plasma elimination and urinary excretion of the drug as compared with normal animals. When the dehydrated rats were pretreated with sodium D-glucaro-l, 4-lactone, however, both the plasma half-life of drug elimination and the rate of urinary drug excretion were in good parallel to those of normal animals. In the organ distribution study, dehydrated rats showed delayed removal of kanamycin from all organs as compared with normal animals. The extremely high level of the antibiotic in the kidney was about two orders of magnitude higher than found in other organs. In addition, the kidney showed different time course patterns for tissue levels in dehydrated rats. In dehydrated rats given sodium D-glucaro-l, 4-lactone, the antibiotic levels in all organs followed the same pattern as in normal rats. When a lower dose of kanamycin was given to the dehydrated rats, the drug was cleared from the plasma with a decreased half-life. The tissue distribution percentages also decreased in all organs as the dose was lowered in dehydrated rats and with 1 mg/kg of kanamycin, only the kidney content was higher than that in sodium D-glucaro-l, 4-lactone-treated animals.抄録全体を表示PDF形式でダウンロード (319K) -
Hidenori OHASHI, Kyozo NAITO, Tadashi TAKEWAKI, Toshiaki OKADA1977 年 27 巻 3 号 p. 379-387
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーMuscle strips from the longitudinal or circular muscle of the chicken rectum were used to determine changes in membrane potential during field stimulation as recorded using the sucrose-gap method. Stimulation with single square pulses (0.1 msec duration) evoked junction potentials elicited by transmitter released from nerve endings. Facilitation in amplitude of excitatory junction potentials (EJPs) was seen during repetitive stimulation in the longitudinal muscle, but in the circular muscle, EJPs reduced. Neither atropine nor hyoscine (up to 10-5 g/ml) reduced EJPs. These drugs abolished the depression of EJPs in the circular muscle produced by repetitive stimulation. Anticholinesterases (2×10-8 2×10-6 g/ml) reduced the EJPs. The inhibitory effect was produced without affecting the membrane resistance of smooth muscle and was completely antagonized by atropine (10-6 g/ml). Drugs that abolish the adrenergic functions did not affect the EJPs. These results suggest that nerves involved in the EJPs are non-cholinergic and non-adrenergic in nature, and the motor transmission to the smooth muscle may be inhibited by cholinergic nerves, presumably presynaptically.抄録全体を表示PDF形式でダウンロード (381K) -
Tsukasa SAKURADA, Kensuke KISARA1977 年 27 巻 3 号 p. 389-395
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーThe effect of p-CPA and 5-HTP followed by p-CPA on sleep was studied in rats with olfactory bulb lesions (O.B. lesioned rats). In these rats, electrodes were chronically implanted to record the EEG (frontal cortex and dorsal hippocampus), the cervical electromyogram and eye movements. The REM sleep stage was selectively decreased from 24 to 32 hours after 200 mg/kg of p-CPA in the sham lesioned rats, whereas both the slow wave sleep and REM sleep stages were markedly decreased by the same dose of p-CPA in the O.B. lesioned rats. In both sham and O.B. lesioned groups, the slow wave sleep and REM sleep stages decreased from 24 to 32 hours after 400 mg/kg of p-CPA and the percentage of decrease in the slow wave sleep stage was much larger with 400 mg/kg of p-CPA than with 200 mg/kg of p-CPA. However, the REM sleep stage disappeared from 24 to 32 hours after 200mg/kg and 400mg/kg of p-CPA. In the 0.B. lesioned rats, the insomnia produced by 200 mg/kg and 400 mg/kg of p-CPA disappeared with 5-HTP (5 mg/kg). On the other hand, the insomnia produced by 200 mg/kg of p-CPA did not recur with 5-HTP in the sham lesioned rats, but with 400 mg/kg there was a recurrence. These results suggest that the enhanced effect of p-CPA and 5-HTP followed by p-CPA in the O.B. lesioned rats is due to changes in the sensitivity of the serotonergic system in the brain.抄録全体を表示PDF形式でダウンロード (270K) -
Fumio HONDA, Yoshihiko SATOH, Kyoichi SHIMOMURA, Hisashi SATOH, Hideyo ...1977 年 27 巻 3 号 p. 397-411
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーEffects of sulpiride on the central nervous system were studied in catalepsy induction (I) and antagonism to gnawing behaviour (II) induced by apomorphine and methamphetamine in normal rats, and in antagonism to rotational behaviour (III) induced by apomorphine and methamphetamine in rats with substantia nigra unilaterally lesioned chronically by microinjection of 6-hydroxydopamine. Sulpiride was administered orally and intraventricularly, and the effects of sulpiride were compared to those of haloperidol and chlorpromazine administered through the same routes. In oral administration, sulpiride was almost inactive in (I), and was several hundreds to a thousand times less potent than haloperidol in (II) and (III), while chlorpromazine was 20 to 150 times stronger than sulpiride. In intraventricular administration, sulpiride was almost equipotent to haloperidol in (I), and was equally effective to or 2 to 3 times more effective than halopridol in (III), although several times less potent than haloperidol in (II), and chlorpromazine was least potent among the drugs in all respects. These findings suggest that sulpiride is essentially a potent inhibitory substance on dopamine receptors in the central nervous system and the rather weak central effects of peripherally given sulpiride are due to poor penetration through the blood brain barrier.抄録全体を表示PDF形式でダウンロード (588K) -
Reiko TANAKA, Kengo NAKAI1977 年 27 巻 3 号 p. 413-419
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーEffects of mercurials on rat erythrocytes were studied morphologically using an electron microscope. In the scanning study, the normal biconcave shape of the erythrocytes was changed to rugged surface spherocytes when mercuric chloride was added to the erythrocyte suspension. Methylmercuric chloride produced an irregularity of cell shape with spicules including the final stage of spherocytes. p-Chloromercuribenzoic acid formed crenated cells with protrusion, then spherocytes. By a carbon replica technique, it was revealed that control erythrocytes had a granular surface structure; however the surface of mercuric chloride-treated and methyl-mercuric chloride-treated erythrocytes appeared less granulated. By a negative staining technique, severe damage was observed on the erythrocytes lysed by mercurials. As a decrease in content of reduced glutathione, inhibition of glucose-6-phosphate dehydrogenase activity and formation of methemoglobin in erythrocytes treated with mercurials to induce hemolysis were not observed, it was concluded that the hemolysis induced by mercurials was not due to a disturbance in erythrocyte metabolism but rather to the direct action of mercurials on the cell membrane.抄録全体を表示PDF形式でダウンロード (404K) -
Tadashi FUJITA, Masahide YASUDA1977 年 27 巻 3 号 p. 421-428
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーEffect of fluorescent products from the reaction of malonaldehyde with dipalmitoyl phosphatidylethanolamine on the content of lipids in plasma and liver of rats was examined, and results are as follows: Growth of rats was suppressed by daily intraperitoneal administration of fluorescent products (10 or 50 mg/kg) for 7 days. Levels of triglycerides and total cholesterol in the plasma tended to decrease but that of phospholipids increased significantly by the administration of fluorescent products in a dose of 50 mg/kg/day. On the other hand, content of triglycerides in liver decreased by about 26% at a dose of 10 mg/kg and 23% at a dose of 50 mg/kg. Total cholesterol and phospholipids showed a slight diminution. Free fatty acid content in the liver was almost constant. Thiobarbituric acid values in the plasma and liver increased significantly by treatment with the fluorescent products, especially the values at a rate of increase were higher in the plasma than in the liver. No significant changes were observed in the relative fluorescence intensity between control animals and groups treated with fluorescent products. Serum lipoprotein patterns after Agarose gel electrophoresis revealed diffuse hands in the pre-β- and β-regions.抄録全体を表示PDF形式でダウンロード (284K) -
Masahide YASUDA, Tadashi FUJITA1977 年 27 巻 3 号 p. 429-435
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーEffect of lipid peroxidation on phospholipase A2activity vas examined in rat liver mitochondria. Content of lipid peroxides in rat liver mitochondria was markedly increased in the presence of ascorbic acid (0.1 mM) and ferrous ion (40 μM), as compared to the control. Phospholipase A2 activity in mitochondria vsas activated by approximately 60% after lipid peroxidation. Mg2+-activated ATPase activity in mitochondria was markedly stimulated by about 200% following treatment with ascorbic acid and ferrous ion. There was no difference in calcium content of mitochondria before and after lipid peroxidation.抄録全体を表示PDF形式でダウンロード (269K) -
Abdul RAZZAK, Hiromu KAWASAKI, Showa UEKI1977 年 27 巻 3 号 p. 437-444
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーClonidine at doses of 0.5-1.0 mg/kg i.p. produced an initial rise followed by a sustained fall in blood pressure. The initial pressor response became more marked and the onset of hypotensive effect was delayed as the dose was increased to large doses such as 10-50 mg/kg given intraperitoneally. The heart rate was markedly reduced soon after clonidine administration and the bradycardia lasted for more than 2 hours. Both the initial pressor and subsequent hypotensive effects of clonidine were reduced by pretreatment with phentolamine, the initial pressor effects were suppressed by propranolol which did not affect the hypotensive effects. This initial pressor effect was potentiated while the hypotensive effect was reduced after bilateral vagotomy and pretreatment with either 6-hydroxydopamine or atropine. The bradycardia was significantly reduced by propranolol, atropine and bilateral vagotomy. Central sympathetic as well as parasympathetic mechanisms may be involved in cardiovascular changes after large doses of clonidine in urethanized mice.抄録全体を表示PDF形式でダウンロード (275K) -
Hiroshi SAITO, Kitaru SUDA, Martin SCHWAB, Hans THOENEN1977 年 27 巻 3 号 p. 445-451
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーThe fiber outgrowth induced by ACh, dibutvryl cyclic AMP and dibutyryl cyclic GMP in explanted chick embryonic dorsal root ganglia differed distinctly from that by nerve growth factor (NGF) and submandibular gland extract of adult male mice. Ginsenoside Rb1 potentiated the effects of NGF and submandibular extract at concentrations of 3 and 30 μM. but did not potentiate the effects of ACh, dibutyryl cyclic AMP and dibutyryl cyclic GMP. NGF-antihody inhibited the effects of NGF, but not the effects of ACh, dibutyryl cyclic AMP and dibutvryl cyclic GMP. Concanavalin A and KCL did not promote fiber outgrowth.抄録全体を表示PDF形式でダウンロード (269K) -
Tsukasa SAKURADA, Hiroyuki KOHNO, Takeshi TADANO, Kensuke KISARA1977 年 27 巻 3 号 p. 453-460
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーPharmacological actions of spermidine (SPD) and spermine (SPM) in mice given these polyarnines by intracerebral injection (i.c.) were investigated. The spontaneous motor activity (SMA) assessed by the photocell counter method did not change immediately following injection of 80 μg SPD, but was enhanced 24 hours after the injection of 40 or 80 μg. A significant decrease of SMA was not immediately evident after the administration of 40 μg SPM but was demonstrated 24 hours later. Mice given single doses of 20 μg SPD exhibited increase in weight gain and those given 40 μg showed no significant difference, whereas a conspicuous decrease in weight occurred in mice given 80 μg of SPD. The body weights of mice given single doses of 10 μg SPM remained much the same, while significant weight losses occurred in both the SPM 20 μg and 40 μg dosed groups. There was a significant prolongation of pentobarbital induced sleep 6 days after the injection of high doses of SPD or SPM. Similar prolongation of sleeping time was also evident 30 minutes after the injection of SPM. A maximal hypothermic response with a fall by about 1°C was observed immediately following injection of 80 μg of SPD and 24 hours after the injection of 40 μg SPM, respectively.抄録全体を表示PDF形式でダウンロード (287K) -
Takamura MURAKI, Yukiko TOKUNAGA1977 年 27 巻 3 号 p. 461-462
発行日: 1977年
公開日: 2006/12/19
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Haruo TACHIZAWA, Tadashi SAITO, Takeshi AKIMOTO1977 年 27 巻 3 号 p. 462-464
発行日: 1977年
公開日: 2006/12/19
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Yasushi KURAISHI, Yoshimi MISU, Hiroshi TAKAGI, Kyozo HAYASHI1977 年 27 巻 3 号 p. 464-467
発行日: 1977年
公開日: 2006/12/19
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Nobuyoshi YOSHIDA, Kohtaro TANIYAMA, Hiromasa ARAKI, Hiroshi MATSUMOTO1977 年 27 巻 3 号 p. 468-470
発行日: 1977年
公開日: 2006/12/19
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Yukihide MAEDA, Tatsuo FURUKAWA1977 年 27 巻 3 号 p. 470-473
発行日: 1977年
公開日: 2006/12/19
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Seigo FUJIMOTO1977 年 27 巻 3 号 p. 473-475
発行日: 1977年
公開日: 2006/12/19
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Kazuo ICHIHARA, Yuichi SAITOH, Yasushi ABIKO1977 年 27 巻 3 号 p. 475-478
発行日: 1977年
公開日: 2006/12/19
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Tomio SEGAWA, Haruki HAYASHI, Masami NAKANO, Hiroko MURAKAMI, Chizuru ...1977 年 27 巻 3 号 p. 478-480
発行日: 1977年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (159K)
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