巻号一覧
30 巻 (1980)
- 6 号 p. 763-
- 5 号 p. 579-
- 4 号 p. 405-
- 3 号 p. 273-
- 2 号 p. 129-
- 1 号 p. 1-
30 巻, 2 号
選択された号の論文の19件中1～19を表示しています
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S.K. KULKARNI, A. ARZI, P.N. KAUL1980 年 30 巻 2 号 p. 129-135
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーAdministration of perphenazine, tremorine, nicotine and harmine induced Parkinson-like symptoms in rats and mice. The efficacy of quipazine, a serotonin agonist, in antagonizing these drug-induced Parkinsonian symptoms was assessed. Combinations of this drug with other antiparkinsonian agents such as scopolamine, diphenhydramine and amantadine were also studied in the manifestation of Parkinson-like symptoms in the animal models. The results indicate that quipazine, a central serotonergic agent, counteracted some of the drug-induced symptoms of pseudo-parkinsonism in laboratory animals. Cholinergic, dopaminergic and histaminergic receptors play an important role in the manifestations of these symptoms.抄録全体を表示PDF形式でダウンロード (464K) -
Yohkazu MATSUSHIMA, Munekazu GEMBA1980 年 30 巻 2 号 p. 137-143
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーWe examined the properties of Mg2+ transport in rat kidney cortex slices and the effects of diuretics were also studied. Incubation with 1 mM 2, 4-dinitrophenol, or under anaerobic conditions, sharply inhibited Mg2+ influx, while markedly stimulating Mg2+ efflux. Under conditions of hypothermia, partial inhibition of Mg2+ influx and significant enhancement of Mg2+ efflux were observed. Mg2+ influx was not affected by ouabain, by altering CaCl2 concentration in the medium, or by a change of Ca2+ content in the slices. Incubation with 1 mM ethacrynic acid or mersalyl depressed Mg2+ influx and stimulated Mg2+ efflux, p-chloromercuribenzoic acid (5×10-4 M) had a similar effect and furosemide had no effect on Mg2+ transport. These results suggest that Mg2+ influx is mediated by an energy-dependent process which is dissociated from ouabain-sensitive Na+ transport and Ca2+ flux. Sulfhydryl groups may be involved in the process of Mg2+ influx.抄録全体を表示PDF形式でダウンロード (429K) -
Saizo YANAURA, Tsutomu SUZUKI, Teiko KAWAI1980 年 30 巻 2 号 p. 145-155
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーUsing an automatic food intake measuring apparatus (“food intakometer”), we recorded the approach behavior to food, eating behavior and food intake of morphine dependent rats and examined the relationship among these factors and morphine dependence. Morphine dependent rats were produced by the drug-admixed food (DAF) method. In the choice trial of free feeding group, morphine dependent rats showed only the approach behavior both to drug-free diet and to morphine-admixed food, then ate the morphine-admixed food and approached the drug-free diet at the same period. Eating behavior in the case of morphine-admixed food was observed not only at night but also during the day time in the morphine dependent rats. In the choice trial of the limited feeding group, preference for morphine rapidly increased in every choice trial of each session and the preference rate became stable at about 60%. Eating patterns of these rats were similar to these in the free feeding group. When these rats were given morphine prior to the choice trial, eating behavior of those on the morphine-admixed food was inhibited dose-dependently, while eating behavior of these on the drug-free diet was enhanced dose-dependently. When these rats were allowed free access to drug-free diet for 1 hour previously to the choice trial, eating behavior of the rats on the morphine-admixed food in the choice trial was markedly enhanced. Thus, the rats clearly showed drug-seeking behavior and seemed to be able to distinguish between the need for morphine and satisfaction without it. Morphine dependent rats apparently can control their required maintenance dose.抄録全体を表示PDF形式でダウンロード (701K) -
Katsuji OGUCHI, Shinichi KOBAYASHI, Ryohei KOIDE1980 年 30 巻 2 号 p. 157-164
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーThe activity of mitochondrial monoamine oxidase (MAO) from human placenta was measured with mixtures of labelled and unlabelled tyramine, serotonin (5-HT), benzylamine and β-phenylethylamine (PEA). Tyramine deamination was inhibited by benzylamine and PEA but not by 5-HT, while benzylamine deamination was inhibited by tyramine and PEA, but not by 5-HT. 5-HT deamination was inhibited by tyramine, benzylamine and PEA and PEA deamination was inhibited by tyramine, benzvlamine and 5-HT. These results suggest that MAO in human placenta has multiple catalytic sites or consists of different enzymes. Probably, tyramine, benzyl-amine and PEA are deaminated oxidatively at a common catalytic site while 5-HT is deaminated at another catalytic site. Benzylamine deamination was inhibited in a mixed noncompetitive fashion by tyramine and PEA in air, but benzylamine deamination was competitively inhibited by PEA at higher concentrations of oxygen. The deaminations of other substrates were inhibited competitively by other substrates, in air. Reciprocal plots of PEA deamination with benzylamine, 5-HT and tyramine gave hyperbolic curves.抄録全体を表示PDF形式でダウンロード (501K) -
Ryuji TAKEDA, Yasunori MOMOSE1980 年 30 巻 2 号 p. 165-172
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーActions of acetaldehyde on membrane potentials and membrane resistances of Aplysia neurons were studied using an intracellular recording and current injection technique. Several functionally different neurons in the abdominal ganglion of A. kurodai were identified on the basis of their morphological and electrophysiological characteristics. Application of between 5 and 50 mM acetaldehyde produced depolarization of the membrane, in all types of cells investigated. This depolarization was accompanied by an increase in the rate of spike discharge. The amplitude and the rates of rise and fall of the action potential were reduced and the duration of the spike was prolonged. Acetaldehyde had no significant effect on the input resistances of ganglion cells. These actions of the aldehyde were observed to be similar in the completely isolated neuron-soma preparation separated from the neighbouring cells or synapses.抄録全体を表示PDF形式でダウンロード (503K) -
Toyozo HASHIMOTO1980 年 30 巻 2 号 p. 173-186
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーEffects of intrarenal-arterial (i.r.a.) and intravenous (i.v.) infusions of PGE2, I2 and F2α on systemic blood pressure (BP), heart rate (HR), renal blood flow (RBF), urine volume (UV), renal function and plasma renin activity (PRA) of the renal venous blood (RVPRA) were investigated. A dose-dependent fall in BP was observed with PGE2 and I2 and was accompanied by a tachycardia (PGE2<I2, i.r.a.<i.v.). PGE2 and I2 induced increases in RBF and UV in a roughly dose-dependent manner (PGE2>I2, i.r.a.>i.v.), however, antidiuresis was observed with the highest intravenously given dose of PGI2 (300 ng/kg/min) such being ascribed to a pronounced hypotension. Changes in electrolyte excretion induced by PGE2 and I2 were similar to the pattern of those in RBF or UV. Neither PGE2 or I2 produced any significant changes in the glomerular filtration rate (GFR). The diuretic effect of PGE2 and F2α correlated with osmolar clearance (Cosm) (r=0.89, p<0.01 ; r=0.55, p<0.01) and free water clearance (CH2O) (r=0.52, p<0.01 ; r=0.83, p<0.01), whereas that of PGI2, only with Cosm (r=0.74, p<0.01). PGF2α produced the weakest changes in the parameters described above. PGE2 and I2 (30 ng/kg/min, i.r.a.), but not PGF2α, produced a significant elevation of RVPRA without any significant change in BP. These findings suggest that PGE2 plays a primary role in the kidney, whereas PGI2 is important in the regulation of the systemic circulation, and that PGE2, I2 and F2α all have different modes of action in producing diuresis. Both PGE2 and I2 may participate in the control of renin secretion.抄録全体を表示PDF形式でダウンロード (923K) -
Minoru OHTSUKA, Jo MORI, Keiji TSUJIOKA, Shigenobu KUMADA1980 年 30 巻 2 号 p. 187-198
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーThe sympathetic inhibitory mechanism in dog urinary bladder was studied. The bladder contractions induced by electrical stimulation of the pelvic nerve both proximal and distal to the pelvic plexus and by intraarterial administration of tetramethylammonium (TMA) were inhibited by stimulation of the hypogastric nerve and intraarterial injection of catecholamines. The inhibition by hypogastric nerve stimulation was more potent at the low frequency of pelvic nerve stimulation than at the high frequency. The inhibition of contraction induced by stimulation of the pre-plexal pelvic nerve was antagonized by phentolamine and propranolol, whereas the inhibition of contraction induced by stimulation of the post-plexal pelvic nerve and by TMA treatment were antagonized only by propranolol. It is concluded that inhibition by hypogastric nerve stimulation of bladder contraction induced by pelvic nerve stimulation is composed of two different components. One occurs at the ganglia in the pelvic plexus and is mediated by α-adrenoceptors. The other occurs at the post-plexal pelvic pathway, probably at the ganglia in the bladder wall or on the muscle cells, and is mediated by β-adrenoceptors. Moreover, the α-adrenergic action facilitated the pelvic nerve excitation in its pathway from the ganglionic cell bodies to the muscle cells.抄録全体を表示PDF形式でダウンロード (765K) -
Teruo NAKADATE, Takamura MURAKI, Ryuichi KATO1980 年 30 巻 2 号 p. 199-206
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーThe subcutaneous administration of chlorpromazine (CPZ) caused a dose response increase in plasma glucose and cyclic AMP levels in fed male mice. Hexamethonium abolished the elevation of both plasma glucose and cyclic AMP. Propranolol did not inhibit the elevation of plasma glucose but inhibited the increase of plasma cyclic AMP. In contrast, phentolamine and yohimbine completely suppressed the elevation of plasma glucose but not that of plasma cyclic AMP. These results indicate that the hyperglycemia due to CPZ was mediated through the stimulation of α-adrenoceptor and on the contrary CPZ increased plasma cyclic AMP through the stimulation of β-adrenoceptor and that the increase in plasma glucose induced by CPZ was independent of the activation of adenylate cyclase and the increased plasma cyclic AMP. In addition, in contrast to phentolamine and yohimbine, phenoxybenzamine was ineffective to prevent the hyperglycemia induced by CPZ. Moreover, a higher dose of dihydroergotamine was required to inhibit the hyperglycemia.抄録全体を表示PDF形式でダウンロード (569K) -
Seiji ICHIDA, Kozo OKADA, Motome TERAO1980 年 30 巻 2 号 p. 207-211
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーThe effect of verapamil on K-stimulated 45Ca uptake (the difference between uptake in 60 mM-Ko medium and 5 mM-Ko medium) was studied using a synaptosomal fraction from rat brain. Verapamil inhibited K-stimulated 45Ca uptake, but not 45Ca uptake in 5 mM-Ko media (1 mM- and 0.1 mM-Cao media). The concentrations of verapamil inducing 50% inhibition of K-stimulated 45Ca uptake (ID50) in 1 mM- and 0.1 mM-Cao media were not significantly different, being about 10-4 M and 2×10-4 M, respectively. Like verapamil, Mn++ inhibited only K-stimulated 45Ca uptake, but its ID50 values in 1 mM- and 0.1 mM-Cao media were about 1.7 mM and 0.2 mM, respectively. It is considered from these findings that both verapamil and Mn++ specifically inhibit K-stimulated 45Ca uptake, but that the modalities of their inhibitory effects on K-stimulated 45Ca uptake are different.抄録全体を表示PDF形式でダウンロード (338K) -
Atsushi KUROSAWA, Hiroyasu KAGEYAMA, Thoppil M. JOHN, Ryoji HIROTA, Sh ...1980 年 30 巻 2 号 p. 213-220
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーIn our previous study, neonatal treatment with hydrocortisone was shown to produce a marked retardation of pituitary-adrenocortical development in infant rats. The present investigation was an attempt to determine whether or not the retarded activity is caused by functional changes in brain monoamine systems. In rats treated with hydrocortisone (0.5 mg/rat, s.c.) on the 2nd day of life, the development of whole brain was suppressed significantly. However, norepinephrine, dopamine and serotonin contents in the brain were higher in these rats than in controls. These changes of mono-amine contents were apparent in the hypothalamus, diencephalon and pons-medulla oblongata. Our data suggest that monoaminergic nervous systems are potentiated with hydrocortisone in these brain regions, although the results do not necessarily explain the retarded hypothalamo-pituitary function.抄録全体を表示PDF形式でダウンロード (533K) -
Miwa MISAWA, Saizo YANAURA1980 年 30 巻 2 号 p. 221-229
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーWe have designed a new method for continuous recording of the output of respiratory tract fluid, the approach representing a modification and combination of the intratracheal electrode and stopper methods which we had employed originally. Electrical resistance change indicated alteration in the output of respiratory tract fluid, without alteration in composition and temperature of fluid, tracheal muscular tone or respiratory movement, at least, within a physiological range. Among the expectorant drugs thus tested, pilocarpine, 100 and 200 μg/kg given intravenously, significantly and in a dose dependent manner augmented the output of the fluid about 5 minutes after the administration. Given orally in a dose of 2 mg/kg, the output of fluid increased in about 20 minutes. Senega syrup, 0.3 ml/ kg had no effect when given intravenously, yet, 2 ml/kg given orally increased the output of fluid within 5 minutes, thereby suggesting that the related secretagogic activity is due to a reflex action following stimulation of the gastric mucosa. Emetine, 2 mg/kg given orally increased the output about 20 minutes after administration while glyceryl guaiacolate, 50 mg/kg had no effect. We propose that our method be used to evaluate expectorants for clinical use as the continuous monitoring of the output of respiratory tract fluid apparently provides a more accurate assessment.抄録全体を表示PDF形式でダウンロード (513K) -
Kazushige SAKAI, Michitaka AKIMA, Yoshikazu HINOHARA, Machiko SASAKI, ...1980 年 30 巻 2 号 p. 231-241
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーRat isolated small intestine was perfused at a fixed flow rate through the superior mesenteric artery with whole rat blood recycled from a devised oxygenator-reservoir. As indicated by perfusion pressure, tissue glucose and oxygen consumption, and histological studies, the perfused intestine remained in a viable state over the perfusion period of 2 hr. Rapid absorption of glucose from the intestinal tract was observed after the intraduodenal injection. When single doses of acetaminophen were injected into the duodenal lumen or poured over the perfused intestine, the absorption was rapid and dose-dependent. Shortly after single intraduodenal injections of salicylamide, salicylamide in free and conjugated forms (sulfate and glucuronide) appeared in the circulating blood. These results indicate that the vascularly perfused intestinal preparation has wide applications in biochemical experimental fields.抄録全体を表示PDF形式でダウンロード (852K) -
Kazuko NEMOTO, Seiichi HASHIMOTO, Takeyuki IKENO, Hiroshi KUZUYA1980 年 30 巻 2 号 p. 243-249
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーChanges in the substrate specificity of monoamine oxidase in the rat submaxillary gland were examined after ligation of the excretory duct and after denervation by postganglionic sympathectomy. Atrophy of the parenchymal cells after ligation of the excretory duct was observed, but such was not so clear after the denervation. The rate of decreases in the enzyme activity after the duct ligation was highest with serotonin, intermediate with dopamine and tyramine and lowest with β-phenylethylamine, used as substrates. The proportion of form A monoamine oxidase was examined using clorgyline as an inhibitor specific for form A enzyme; approximately 95 %, 90 % and 85 % of the total enzyme activities were attributed to form A enzyme in the intact glands, in the denervated glands and in the duct ligated glands, respectively. These results indicate that 90 % of the enzyme activity in the parenchymal cells and almost of all the enzyme activity in the sympathetic nerves of the gland may be attributed to form A enzyme and the atrophy of parenchymal cells after the duct ligation results in a decrease in form A enzyme more markedly than form B.抄録全体を表示PDF形式でダウンロード (466K) -
Hajime YASUHARA, Sadao NAKAYAMA, Takato MAYAHARA1980 年 30 巻 2 号 p. 251-255
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (350K) -
Norio HIMORI1980 年 30 巻 2 号 p. 255-258
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (255K) -
Saizo YANAURA, Jiro UESUGI, Tsutomu SUZUKI, Teiko KAWAI1980 年 30 巻 2 号 p. 258-261
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (240K) -
Hitoshi ITO, Keishiro SHIMURA1980 年 30 巻 2 号 p. 262-264
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (202K) -
Hisashi KURIBARA, Sakutaro TADOKORO1980 年 30 巻 2 号 p. 264-268
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (387K) -
Kyoichi SHIMOMURA, Yoshihiko SATOH, Jo MORI1980 年 30 巻 2 号 p. 268-271
発行日: 1980年
公開日: 2006/12/19
ジャーナル フリーPDF形式でダウンロード (197K)
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