All issues
Volume 4, Issue 2
Displaying 1-13 of 13 articles from this issue
- |<
- <
- 1
- >
- >|
-
TOSHITAKE MUTO1955 Volume 4 Issue 2 Pages 83-91
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSDownload PDF (383K) -
THE RELATION BETWEEN THE BLOOD VOLUME IN THE STOMACH WALL AND THE TEMPERATURE OF THE STOMACH CONTENTGEN-ICHI YAMADA1955 Volume 4 Issue 2 Pages 92-97
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSPrevious reports from our Department have described the effects of some drugs on the vasomotory activities in the gastric wall. However, there is no literature available at present as yet concerning the vasomotory response of the capillaries in the stomach wall to the temperature of the stomach contents. A series of experiments undertaken in an attempt to demonstrate the correlation between the blood volume in the stomach wall and the temperature of the stomach contents have yielded biologically significant results.View full abstractDownload PDF (227K) -
AKIRA UENO, FUMIO TAKENAKA1955 Volume 4 Issue 2 Pages 98-102
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSThe purpose of this communication is to describe a new type of flowmeter for measuring blood flow in living animals. Previously we could not record automatically the quantity of the blood flow continuously by various methods. By means of our measurement (Fig. 1), however, the blood flow can be recorded continuously on the smoked paper of kymograph and the quantity measured with calibration. The principle of our method is, like the method of Fleisch (1) and Moe (2), based on Poiseuille's formula which is represented as follows: V /t= (p1-p2)πr4/8lη
After the administering heparin to the animal, the blood is allowed to pass through a glass tube connected to cannulae inserted into the exposed vessel. And then the pressure differences at the two points of the tube are recorded by means of a new type of Hg-manometer which was originated by the authors. When the viscosity (η) of the liquid (blood), diameter (r) and length (l) of the tube are constant, the rate of flow (V/t) according to Poiseuille is proportional to the pressure differences (p1-p2) recorded by the above manometer.View full abstractDownload PDF (305K) -
YOSHITO KOBAYASHI, SHIGERU OHASHI, SETSUYA TAKEUCHI1955 Volume 4 Issue 2 Pages 103-110
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSIn a previous paper [Kobayashi, Ohashi and Takeuchi (1)] we reported that when calcium or sodium salt of mesoxalic acid was administered to dogs and rabbits made diabetic with alloxan, the sugar content of their urine either was reduced or dropped to zero and their blood sugar level fell. Further, if the animals were more severely afflicted, ketone bodies in the blood and the NPN of the urine also decreased. It was reported that none of these effects of mesoxalate was visible in depancreatized dogs. It seems obvious, therefore, that the activity of mesoxalates on alloxan diabetic animals is closely related to the function of the pancreas. Herein is reported a series of experiments conducted to clarify the mechanism of action of the compounds.View full abstractDownload PDF (327K) -
YOSHITO KOBAYASHI, SHIGERU OHASHI, SETSUYA TAKEUCHI, YOSHIO IKEDA1955 Volume 4 Issue 2 Pages 111-117
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSThe results of experiments on the antidiabetic activity of calcium and sodium mesoxalate were reported (1). This is a report on the acute and chronic toxicity of these drugs.View full abstractDownload PDF (469K) -
PART 2. COUGH DEPRESSING ACTIONS OF VARIOUS DRUGSYOSHITOSHI KASÉ1955 Volume 4 Issue 2 Pages 118-129
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSA method devised by the author for evaluation of any given antitussive was published some time ago (1). The present paper gives a description of the antitussive effects determined by the method of various drugs other than morphine derivatives.View full abstractDownload PDF (516K) -
PART 3. “COUGHING DOG” AND ITS APPLICATIONYOSHITOSHI KASÉ1955 Volume 4 Issue 2 Pages 130-135
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSI gave out two methods (1) for evaluation of the effects of antitussives. In the initial stage of my experiment the cough attacks were induced in an unanesthetized dog either by mechanically stimulating with a bristled stimulator the mucous membranes of the tracheal bifurcation (method 1) or by electrically stimulating the ramus trachealis nervi laryngici cranialis (method 2). However, the bloody surgical procedures required in either method made it impossible to use the same dog in a series of experiments or to continue the daily administration of an antitussive over a long period of time for observation of possible changes in its effects. Accordingly, the methods have since been so improved as to make a continuous use of one and the same dog possible. The improved method, though the same in principle as method 1, differs from it in that the mechanical stimulation of the-tracheal bifurcation is given by a bristled stimulator through a cannula inserted into a tracheal fistula surgically produced prior to the experiment.View full abstractDownload PDF (188K) -
MOTOO IIDA1955 Volume 4 Issue 2 Pages 136-144
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSOmoto, or Rhodea japonica, is a plant of the family Liliaceae sometimes growing wild, but more widely cultivated as garden plant, in Japan. It has been used from olden times to prepare drugs against heart diseases but there have been rather few reports on its active principles. As shown in Table 1, Murashirna (1) has extracted rhodein from its rhizomes, Nakaya and Tanno (2) rhodeatoxin from its leaves and Kono rhodealin A also from its leaves.
Recently, Nawa (3) has obtained crystalline glycosides rhodexins A and B from dried leaves and roots of Omoto by means of specially contrived methods.
The chemical structure of rhodexins A and B has been ascertained to be as shown in Table 2 by Nawa et al., but only a few results of animal experiments with the glycosides have been reported to date (Table 3).
The author of this paper has undertaken to test the effects of these glycosides on isolated hearts of frogs, in comparison with those of digitoxin, and thus obtain a glimpse of the action of these chemicals upon living organisms.View full abstractDownload PDF (478K) -
MOTOO IIDA1955 Volume 4 Issue 2 Pages 145-154
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSThe author has previously examined the effects of the new glycosides rhodexin A and B found in the leaves and the rhizome of Omoto or Rhodea japonica on isolated hearts of frogs and found that both show cardiac effect, which is similar to that of digitoxin. Then, I tried to follow up their effect on the mammalian hearts and using isolated hearts of guinea-pigs and rabbits as material, have studied the effects of rhodexin on them and the influence of CaCl2 and KCl on its effect on the heart, as reported in the following.View full abstractDownload PDF (837K) -
MASATAKA EGAMI1955 Volume 4 Issue 2 Pages 155-159
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSDownload PDF (303K) -
MASATAKA EGAMI1955 Volume 4 Issue 2 Pages 160-167
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSDownload PDF (483K) -
HEITAROH IWATA, MASAYUKI YAMAOKA, MASATOSHI MINAMI, IWAO YAMAMOTO1955 Volume 4 Issue 2 Pages 168-175
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSThe halogenated alkylamines, so called nitrogen mustards (NM) investigated during the last World War as a potential warfare agent, have become useful tools in biology and medicine for their ability to increase the spontaneous mutation rate in plants and animals (1) and to palliate leukemia, lymphoma and lung carcinoma (2).
Recently, Ishidate et al, (3) have paid attention to the lower toxicity of nitrogen mustard-N-oxides (NMO) which had been prepared by Stahmann (4) in 1946 comparing to their original amines, and demonstrated that methyl-bis-β-chloroethylamine-N-oxide (MBAO, Nitromin) had an equal inhibitory potency to methyl-bis-β-chloroethylamine (MBA) on Yoshida-sarcoma.
Meanwhile, on the pharmacology of NM, many studies had been done, as seen in the review of Phillips (5), but no pharmacological research has yet been made about NMO.
The purpose of the present paper is to determine the pharmacological properties of NMO, especially of Nitromin, and of the correlation with their original amines.View full abstractDownload PDF (284K) -
HIROSHI TAKAGI, MOTOHATSU MATSUMURA, AKIRA YANAI, KIKUO OGIU1955 Volume 4 Issue 2 Pages 176-187
Published: 1955
Released on J-STAGE: February 16, 2007
JOURNAL FREE ACCESSDuring recent years the electrical phenomena associated with spinal reflex functions have been recorded by means of electrodes placed on the ventral and dorsal roots or on the dorsal cord.
The physiological significance of these electrical phenomena has been determined to a certain extent by neurophysiologists.
More recently, Magoun and his associates (1, 2, 3) found that. the reticular formation of the brain stem has descending inhibitory and facilitatory influences upon the spinal reflex activity.
The electrophysiological study of the effect of morphine on the spinal reflex has been reported by Wikler (4), but its effect on the reticular formation of the brain stem remains to be investigated.
The precise analysis concerning the sites of action of analgesics on the various afferent pathways of pain has been performed by Fujita et al. (5, 6) in our laboratory. The effects of these drugs on the spinal reflexes, however, are not yet sufficiently settled.
The purpose of the present investigation is to obtain further information respecting the effect of some analgesics and related drugs on the reflex activity of the spinal cord, and to trace the relationship between their effect and the function of reticular formation of the brain stem.View full abstractDownload PDF (610K)
- |<
- <
- 1
- >
- >|