巻号一覧
47 巻 (1988)
- 4 号 p. 333-
- 3 号 p. 209-
- 2 号 p. 107-
- 1 号 p. 1-
47 巻, 3 号
選択された号の論文の15件中1～15を表示しています
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Kenji HIRATE, Hisashi KURIBARA, Sakutaro TADOKORO1988 年 47 巻 3 号 p. 209-216
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーCharacteristics of acquisition processes of discrete shuttle avoidance response were investigated in 3 lines of Wistar strain rats: HLA:Wistar, JLA:Wistar, Std:Wistar and in F344/Du Crj rats. Std:Wistar and F344/Du Crj rats rapidly acquired the avoidance response, showing an avoidance rate of higher than 90% until the middle stage of the 1st training session in which 120 trials were carried out, and they also maintained a high level of avoidance response in the latter sessions. HLA:Wistar and JLA:Wistar rats, however, exhibited a poorer acquisition of the avoidance response than Std:Wistar and F344/Du Crj rats. These two lines of Wistar rats finally achieved average avoidance rates of around 80% after 5 sessions of training and showed a long-lasting warm-up period in each session. Std:Wistar and F344/Du Crj rats had more resistance than the other two lines to extinction of the acquired avoidance response. Chlorpromazine (2-8 mg/kg, i.p.) suppressed the avoidance response in a dose-dependent manner. The sensitivities to chlorpromazine were higher in the order of J LA:Wistar>HLA:Wistar>Std:Wistar≈ F344/Du Crj rats. These results suggest that there are major breeder differences even in the same strain of rats in their behavioral and physiological characteristics. The present results also suggest that Std:Wistar rats show extremely close characteristics with those of F344/Du Crj rats.抄録全体を表示PDF形式でダウンロード (405K) -
Kotaro GOTANDA, Teruyuki YANAGISAWA, Keisuke SATOH, Norio TAIRA1988 年 47 巻 3 号 p. 217-227
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーCardiac and coronary vasodilator effects of gentamicin (GM) were investigated in isolated, blood-perfused papillary muscle, sino-atrial (SA) node and atrioventricular (AV) node preparations of dogs. GM (0.3-100 μmol) was injected intraarterially. GM produced an increase in coronary blood flow in all preparations. In paced papillary muscle preparations, GM reduced the force of contraction. In spontaneously beating papillary muscle preparations, GM decreased the rate of automaticity and the force of contraction. In SA node preparations, GM decreased the sinus rate. In AV node preparations, GM injected into the posterior septal artery (which supplies the AV node) increased AV conduction time and in large doses, produced third-degree AV block. In the same preparations, GM in large doses injected into the anterior septal artery (which supplies the His-Purkinje-ventricular system) prolonged AV conduction time (i.e., intraventricular conduction time) and reduced the amplitude of ventricular bipolar electrograms. The order of potencies of GM on the above cardiovascular variables is as follows: Coronary blood flow≥ventricular muscle contraction>ventricular automaticity>SA nodal automaticity>AV nodal conduction>intraventricular conduction. This cardiovascular profile is different from those of organic calcium-antagonists, but rather similar to that of manganese ions, reflecting its own mechanism of action.抄録全体を表示PDF形式でダウンロード (561K) -
Masafumi OSHITA, Yuji IWANAGA, Shigeki HASHIMOTO, Kouji MORIKAWA, Ikun ...1988 年 47 巻 3 号 p. 229-235
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe pharmacological profile of a new alpha-1 adrenoceptor antagonist, α-ethyl-3, 4, 5-trimethoxy-α-(3-((2-(2-methoxyphenoxy)ethyl)amino)propyl) benzene-acetonitrile fumarate (HV-723), was studied in vitro. In dog mesenteric arteries, HV-723, prazosin and yohimbine competitively inhibited noradrenaline-induced contraction: the pA2 value of HV-723 (9.37) was apparently larger than that of prazosin (8.22) and yohimbine (7.18). However, HV-723 showed no or only a slight inhibition on the contractile responses to 5-HT, KCl and prostaglandin F2α. HV-723 also showed potent alpha-1 adrenoceptor antagonist activity in the dog mesenteric and saphenous veins. However, HV-723 showed little antagonist activity on the pre and postsynaptic alpha-2 adrenoceptors, beta-1 and beta-2 adrenoceptors and muscarinic receptors. HV-723 also inhibited the sympathetic contraction induced by electrical transmural stimulation in the dog mesenteric arteries, and the inhibition of HV-723 was about 10 times more potent than that of prazosin. However, 3H-noradrenaline release evoked by electrical stimulation was not influenced by HV-723. These results clearly show that HV-723 is a potent and selective alpha-1 adrenoceptor antagonist.抄録全体を表示PDF形式でダウンロード (338K) -
Midori HIRAI, Noboru KITAMURA, Takeshi HASHIMOTO, Takashi NAKAI, Tatsu ...1988 年 47 巻 3 号 p. 237-243
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe binding of the Biphenyl-substituted piperazine derivative, [3H]GBR-12935, a selective dopamine uptake inhibitor, to the post-mortem human putamen was studied. Inhibition curves by dopamine uptake inhibitors suggested the existence of two populations of [3H]GBR-12935 binding sites: one is potently inhibited by mazindol and/or nomifensine, and the second binding site is benztropine- and/or GBR 12909-sensitive. In the human putamen, [3H]GBR-12935 labeled both these two distinct binding sites. The [3H]GBR-12935 binding displaced by mazindol was enriched in the mouse and rat striatum, but not in the cultured mouse neuroblastoma cell N1E-115. The mazindol-sensitive [3H]GBR-12935 binding site increased in the presence of sodium and markedly decreased in the putamen from parkinsonians (45% of controls). On the other hand, the [3H]-GBR-12935 binding displaced by benztropine showed no sodium-dependent increase and was not decreased in the putamen from parkinsonians. In the putamen from schizophrenics, the [3H]GBR-12935 binding did not significantly change in the density, while that displaced by mazindol tended to increase. It is concluded that in the human putamen, [3H]GBR-12935 binds to two distinct sites. One site is partially sodium-dependent and appears to be associated with a high-affinity dopamine uptake system on dopaminergic nerve terminals. The second binding site shows no sodium-dependency and may be associated with a nondopaminergic and/or extraneuronal DA uptake system.抄録全体を表示PDF形式でダウンロード (385K) -
(Meriones unguiculatus)Toyoshi UMEZU, Hisashi KURIBARA, Sakutaro TADOKORO1988 年 47 巻 3 号 p. 245-252
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe acquisition process of the discrete shuttle avoidance response and effects of psychoactive drugs on the established avoidance response were examined in Mongolian gerbils. The gerbils acquired the avoidance response very fast and attained an avoidance rate of higher than 90% until the 2nd training session. The established response rate (frequency of shuttles) was about 2.2/min. Methamphet amine, cocaine, scopolamine, atropine and morphine facilitated the avoidance response, eliciting an increase in the response rate. In particular, the effect of morphine was very marked. In contrast, chlorpromazine, haloperidol, pilocarpine, physostigmine, pentobarbital and diazepam suppressed the avoidance response, eliciting a dose-dependent decrease in both the response and avoidance rates. Methamphetamine, cocaine, scopolamine, atropine and morphine increased spontaneous motor activity in the experimental chamber in which neither electric shock nor conditioned stimulus was delivered during the observation period. However, the drug effects were not quantitatively identical with those in the avoidance response. These results suggest that the behavioral characteristics of gerbils are similar to those of mice in the discrete shuttle avoidance situation.抄録全体を表示PDF形式でダウンロード (362K) -
Hirohumi KODA, Tsuneichi HASHIMOTO, Kinya KURIYAMA1988 年 47 巻 3 号 p. 253-259
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーEffect of buflomedil [4-(1-pyrrolidinyl)-1-(2, 4, 6-trimethoxyphenyl)-1-butanone hydrochloride] administration on central monoaminergic systems was investigated using male Wistar rats. Single administration of buflomedil (300 mg/kg, p.o.) induced a significant increase in the content of homovanillic acid without altering the content of dopamine (DA) and also caused a significant decrease in choline acetyltransferase (ChAT) activity in the corpus striatum. In addition, both L-glutamic acid decarboxylase activity (GAD) and γ-aminobutyric acid (GABA) content showed a significant decrease in the substantia nigra following a single administration of buflomedil. These results indicate that buflomedil enhances DA turnover in the nigro-striatal DA pathway, possibly by activating nigro-striatal DA neurons, or by suppressing striatal cholinergic interneurons and/or striatonigral GABAergic neurons.抄録全体を表示PDF形式でダウンロード (369K) -
Hideki YAMAMURA, Masafumi TAIRA, Hideo NEGI, Fumio NANBU, Shigekatsu W ...1988 年 47 巻 3 号 p. 261-271
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe effects of 2, 3, 5-trimethyl-6-(12-hydroxy-5, 10-dodecadiynyl)-1, 4-benzoquinone (AA-861), a selective 5-lipoxygenase inhibitor, on immunological or non-immunological release of slow reacting substance of anaphylaxis (SRS-A) and histamine and its effects on experimental asthma were investigated. AA-861 showed a dose-dependent inhibition of SRS-A release, with no effect on histamine release from passively sensitized guinea pig, monkey (M. irus) and human lung fragments. An analysis of the anaphylactic diffusate from the human lung fragments, using the combined technique of high performance liquid chromatography and radioimmunoassay, revealed that AA-861 markedly suppresses biosynthesis of the leukotrienes. However, this drug inhibits the release of histamine as well as SRS-A from lung fragments of anaphylactic monkey (M. mulatta) and in the Ca ionophore-stimulated rat peritoneal cavity. AA-861 suppressed the anaphylactically-induced airway resistance in mepyramine- and cimetidine-treated guinea pigs. These results suggest that AA-861 may be clinically effective for treating allergy-related asthma by modulating the 5-lipoxygenase pathway and that an inhibitory mechanism of histamine release by AA-861 may be present in some species.抄録全体を表示PDF形式でダウンロード (628K) -
Shigeki MIYAKE, Hiroshi SHIGA, Hiroyuki KOIKE, Hiroshi MIZUNO, Ryousuk ...1988 年 47 巻 3 号 p. 273-283
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーRS-1893, 2-[2-chloro-4-(2, 3, 4, 5-tetrahydro-3-oxo-6-pyridazinyl)]-phenoxy-N-(2-morpholinoethyl)-acetamide, is a newly synthesized compound whose structure is different from that of cardiac glycosides and beta-stimulants. The in vitro cardiotonic action of RS-1893 was about 3 times more potent than that of milrinone. This action is most likely due to inhibition of phosphodiesterase-III, as has been suggested for many other cardiotonic agents . In pentobarbital anesthetized dogs, RS-1893 (1-30 μg/kg, i.v.) produced dose dependent increases in left ventricular dP/dtmax and cardiac output and caused decreases in blood pressure and total peripheral resistance with a relatively small increase in heart rate. Central venous pressure decreased markedly, suggesting venous vasodilation. The in vivo cardiotonic action of RS-1893 was 3 times more potent than that of milrinone and was not affected in the presence of a large dose of propranolol. Oral administration of RS-1893 (0.03 and 0.1 mg/kg) also produced a dose-related increase in cardiac contractility in conscious beagles. The increase in LVdP/dtmax reached a maximum in 1-3 hr after administration and lasted for more than 8 hr. Thus, RS-1893 appeared to be an orally active cardiotonic agent with vasodilator properties, probably acting on both arterioles and veins.抄録全体を表示PDF形式でダウンロード (562K) -
Shigeru MOTOMURA, Masanori OHTA, Kenji OHYAMA, Keitaro HASHIMOTO1988 年 47 巻 3 号 p. 285-291
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーRelease of atrial natriuretic peptide (ANP) was investigated using the isolated right atrium (RA) cross-circulated with heparinized arterial blood of the donor dog. ANP concentration of the blood was measured by radioimmunoassay. The plasma ANP concentration of the arterial blood of the donor dog (ANP-D) which perfused the RA preparation was 111±18 pg/ml (n=4), while the ANP concentration of venous blood leaving the RA preparation (ANP-A) was 1680±220 pg/ml (n=4). In comparison, the plasma ANP concentration of venous blood leaving the isolated papillary muscle of the right ventricle (ANP-V) was 106±19 pg/ml (n=4), which was not significantly different from the ANP-D concentration. When the right atrium was electrically driven at a rate of 100 beats/min, almost the same rate as the spontaneous sinoatrial rate of 98±6 beats/min (n=4), the ANP-A concentration was not changed (1630±160 pg/ml, n=4). When the driving rate was increased to 200 beats/min, the ANP-A concentration was significantly increased to 2250±130 pg/ml (n=4). These results suggest that ANP is exclusively secreted from the atrium, but not from the ventricle, and that release of ANP is directly related to atrial rate.抄録全体を表示PDF形式でダウンロード (380K) -
Kiyoshi FUKUI, Takeshi OKAHARA, Toshiaki TAMAKI, Shoji FUJIOKA, Hirosh ...1988 年 47 巻 3 号 p. 293-300
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーWe investigated the effects of leukotrienes (LTs) C4 and D4 on renal function and hemodynamics of dogs. LTC4 (0.5 μg/min, infused into the renal artery), but not LTD4 (1 μg/min), caused an increase in renal blood flow, urine flow, urinary excretion of sodium and potassium, and rate of free water reabsorption, with a concomitant rise in systemic blood pressure. Intrarenal infusion of LTC4 under conditions of constant renal perfusion pressure induced no significant effect on renal blood flow or urine formation. Infusions or LTC4 and LTD4 into the renal artery induced no change in the release of prostaglandins, PGE2, PGF2α, 6-keto-PGF1α or thromboxane B2 into renal venous blood. From these findings, we concluded that the renal effects of LTC4 were secondary responses to a rise in systemic blood pressure.抄録全体を表示PDF形式でダウンロード (428K) -
Yoshiki IWABUCHI, Chihiro AOKI, Taizo MASUHARA1988 年 47 巻 3 号 p. 301-310
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe actions of dobutamine (DOB) and terbutaline (TER) on the secretion of marker glycoprotein (GP) from the secretory cells of the glands and secretion of fluid from rat submandibular gland (SMG) were investigated in combination with two antagonists, metoprolol (MET) and ICI-118551 (ICI). The ED50 value of fluid secretion was 8.7 mg/kg for DOB and 5.9 mg/kg for TER. MET, administered prior to either agonists at a dose of 40 mg/kg, inhibited the fluid secretion. However, the blocking effects of ICI were considerably lower than those of MET. The electrophoretic profiles of GP in DOB-evoked saliva were similar to those in TER-evoked saliva, and included two characteristic main bands of GP I (130 KDa) and GP IV (21.5 KDa) from the acinar cells and a minor band of GP III (31 KDa) which originated in the cells of the granular tubules. When MET was administered at a dose of 5 mg/kg prior to DOB, the intensity of band I decreased, whereas that of band III did not change. These results showed that the SMG of rats contains both β1- and β2-adrenoceptors and that β-receptors which mediate the secretion of GP from the acinus and fluid from the gland are mainly of the β1-subtype.抄録全体を表示PDF形式でダウンロード (562K) -
Yoshiyuki INADA, Masao TANABE, Katsuyoshi KAWAZOE, Kohei NISHIKAWA1988 年 47 巻 3 号 p. 311-322
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe antihypertensive activity of a new angiotensin converting enzyme (ACE) inhibitor, CV-5975, (R)-3-[(S)-1-carboxy-5-(4-piperidyl)pentyl]amino-4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzothiazepine-5-acetic acid, was examined in normotensive rats and various hypertensive animal models. In spontaneously hypertensive rats, CV-5975 (1 to 10 mg/kg, p.o.) had a dose-related, sustained antihypertensive action, which was more potent and longer than that of enalapril. The potency and duration of action of CV-5975 was intensified when it was administered repeatedly or combined with hydrochlorothiazide. CV-5975 (1 mg/kg, p.o.) inhibited the ACE activity of plasma and tissues; inhibition on the ACE activity of the aorta, kidney, and brain was marked when CV-5975 was administered repeatedly. In 2-kidney, 1 clip hypertensive rats (1 to 10 mg/kg, p.o.) and dogs (0.3 and 1 mg/kg, p.o.), CV-5975 had a marked, sustained antihypertensive action, which was more marked than that of enalapril. In normotensive rats (10 mg/kg), 1-kidney, 1 clip hypertensive rats (3 and 10 mg/kg), and hyporeninemic DOCA/salt hypertensive rats (1 to 10 mg/kg/day), CV-5975 administered orally once or repeatedly reduced blood pressure, whereas enalapril did not. These results indicate that CV-5975 is a potent and long-lasting antihypertensive agent, the action of which is mediated primarily by inhibiting ACE activity and partly by some unknown mechanisms.抄録全体を表示PDF形式でダウンロード (645K) -
Kenji ONODERA, Kazutaka MAEYAMA, Takehiko WATANABE1988 年 47 巻 3 号 p. 323-326
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーHistamine levels in thiamine deficient rats were significantly lower in the hippocampus, amygdala, olfactory bulb, thalamus and pons-medulla oblongata than those of normal and pair-fed groups. In the case of the hypothalamus, thiamine deficiency produced a significant increase in histamine levels. These changes observed in the thiamine deficient group were reversed to the normal levels by supplying the normal diet. These data present a new finding that thiamine deficiency affects the central histaminergic neuron system as well as other monoaminergic systems.抄録全体を表示PDF形式でダウンロード (257K) -
Kazuo SUGIO, Noriko HORIGOME, Toshifumi INAMI, Yoshitaka TANAKA, Masao ...1988 年 47 巻 3 号 p. 327-329
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe bilateral hemispheric ischemia in rats was induced by the occlusion of bilateral common carotid arteries after permanent electrocauterization of bilateral vertebral arteries at the level of the second cervical vertebra. In ischemic rats, (a) electroencephalograms became flat immediately after occlusion of carotid arteries, and (b) mortalities reached maximum levels at day 3 after recirculation. These results suggested that a constant level of cerebral ischemia was produced in this rat model. Pentobarbital markedly inhibited the mortality in these ischemic rats, whereas cyproheptadine did not.抄録全体を表示PDF形式でダウンロード (147K) -
Motonobu MURAKAMI, Jung Keun YOO, Masami INADA, Takeo MIYAKE1988 年 47 巻 3 号 p. 330-332
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーWe examined the pathophysiological roles of the urea-urease-ammonia system in gastric ulcer disease using rats. Exposure of the stomach to ammonia (0.01-1.0%) decreased the transmucosal potential difference (PD) and histological injury in a concentration-dependent manner. Exposure of the stomach for 20 min to urea (0.025-0.2%) together with urease (100 IU) produced a decrease in PD and microscopic injury similarly, and the lesion was closely associated with the amount of ammonia produced. Urea and urease alone had no effect on the gastric mucosa. These results suggested the pathophysiological importance of urea, urease and ammonia in gastric ulcer disease.抄録全体を表示PDF形式でダウンロード (148K)
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