巻号一覧
48 巻 (1988)
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48 巻, 1 号
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Kiminobu SUGAYA, Kazuhiko KUBOTA1988 年 48 巻 1 号 p. 1-6
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーEffects of diazepam (DZP), a synthetic benzodiazepine drug, and anthramycin (ATM), a benzodiazepine antitumor antibiotic produced by a certain species of streptomyces, on the uptake of 2-deoxy-D-(14C)-glucose (2-DG) in mouse brain neurons with or without cholecystokinin were examined. 2-DG uptake in neurons was evaluated by using an autoradiographic technique. The sulfated octapeptide CCK (CCK8) was injected intracisternally; DZP and ATM, intraperitoneally; and 2-DG, intravenously to mice. Autoradiograms prepared from the slices of the brain were converted to false color images. CCK8 (1 μg/mouse) markedly stimulated the 2-DG uptake in neurons in the various regions of the brain, but the stimulative effects of CCK8 was almost completely suppressed after an intraperitoneal administration of 1.0 mg/kg of DZP or 0.5 mg/kg of ATM. Since it has been previously shown that these doses of DZP and ATM almost completely reversed the antinociception produced by 1 μg/mouse of CCK8, the present results on the 2-DG uptake in the mouse brain are considered to further support the antagonism between CCK8 and DZP or ATM in the central nervous system.抄録全体を表示PDF形式でダウンロード (617K) -
Miwa MISAWA, Tatsuyuki TAKATA1988 年 48 巻 1 号 p. 7-13
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーEffects of platelet-activating factor (PAF) on the rat airways were investigated. Male Wistar rats were anesthetized, and PAF was inhaled into the lungs through a tracheal cannula for 5 min using an ultrasonic nebulizer. The bronchomotor response was measured with a modified Konzett-Rössler method in rats immobilized with decamethonium bromide. The inhalation of PAF caused a marked bronchoconstriction, dose-dependently, in a concentration range of 0.0001 to 0.01%. The bronchoconstrictor potency of PAF was about ten times higher than that of ACh. On the other hand, histamine inhalation gave only a slight bronchoconstriction even at the high concentration of 0.1%. The bronchomotor response to PAF was accompanied by a marked, sustained decrease in systemic blood pressure, in a dose-dependent manner. Repeated inhalations of PAF (0.001%) at an interval of 60 min resulted in a pronounced tachyphylaxis in the bronchoconstrictor response, but not in the hypotensive response. Combined inhalations of PAF with ACh or histamine did not produce a potentiation by PAF of the bronchoconstrictor responses to ACh and histamine. These findings show that PAF is a strong bronchoconstrictor agent in rats and that there is no interaction between PAF and other mediators in the acute bronchoconstrictor response.抄録全体を表示PDF形式でダウンロード (459K) -
Miwa MISAWA1988 年 48 巻 1 号 p. 15-22
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーNo good experimental model for studying rhinitis, has been hitherto available. In the present study, development of a new rhinitis model using chemical mediators was attempted, especially to establish an index of nasal congestion. Male Wistar rats were anesthetized with pentobarbital-Na. Nasal cavities were ventilated between both cannulae inserted into the nasopharynx and bilateral nostrils, with an artificial respirator. Intranasal resistance was recorded with a modification of a Konzett-Rössler apparatus as a change in ventilation overflow (VO). To provoke rhinitis, some mediators were inhaled into the nasal cavities with an ultrasonic nebulizer for 5 min. To assess the capillary permeability of the nasal mucosa, exudation of Evans blue was determined by injecting the dye before inhalations of mediators. Inhalation of histamine (0.01, 0.1, 0.3%), bradykinin (0.01, 0.1%) and ACh (0.3%) markedly increased VO, while inhalation of serotonin (0.01, 0.1, 0.3%) did not increase VO. Histamine, bradykinin and high concentration of ACh significantly increased the dye exudation in the nasal cavities, although serotonin did not. From the above results, it is concluded that 1) a new rhinitis model in which symptoms of nasal blockage and increased capillary permeability in nasal mucosa are quantitatively determined, was established, and 2) histamine- and bradykinin-inhalations can cause rhinitis-like symptoms, although serotonin-inhalation can not.抄録全体を表示PDF形式でダウンロード (522K) -
Michio KOJIMA, Yoshihisa KITAMURA, Yasuyuki NOMURA, Hideaki SADA, Nich ...1988 年 48 巻 1 号 p. 23-30
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーDevelopmental changes in the substrates for cholera toxin (CTX)- and pertussis toxin (PTX)-catalyzed ADP-ribosylation in cardiac (ventricular) cell membranes were studied in fetal (16- to 20-day), neonatal (0- to 20-day) and adult (2- to 3-month) rats. The CTX and PTX substrates were determined by the method of CTX-catalyzed and PTX-catalyzed ADP-ribosylation of the α-subunit of GTP-binding (G) proteins, respectively. As early as fetal day 16, three substrates (45-, 47- and 52-kDa proteins) were identified for CTX-catalyzed ADP-ribosylation and one substrate (41-kDa protein) for PTX-catalyzed ADP-ribosylation. The levels of the three CTX substrates (fmol/mg tissue) increased with development between fetal day 16 and neonatal day 16, and then they decreased to their adult levels. The level of the one PTX substrate (fmol/mg tissue) changed as follows: the substrate decreased between fetal day 16 and the day of birth, increased abruptly for 4 days neonatal and increased slowly thereafter until neonatal day 16, and then decreased to the final adult level. The PTX substrate seems to reach a nearly maximum level earlier than the CTX substrates. This information is essential for understanding the developmental changes in the transmembrane signaling system between membrane receptors and their effectors which are coupled with the stimulatory and inhibitory G proteins.抄録全体を表示PDF形式でダウンロード (608K) -
Hitoshi KONTANI, Yoichi KAWABATA1988 年 48 巻 1 号 p. 31-36
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe nature of morphine-induced urinary retention was studied in anesthetized rats in which the bladder contraction accompanying micturition could be observed. Morphine (0.1 mg/kg, i.v.) prolonged the micturition interval and increased the level of micturition threshold. Morphine (1 mg/kg, i.v.) completely inhibited bladder contraction and bladder pressure was elevated until solution leaked from the penis, but the bladder pressure after inhibition by morphine (1 and 5 mg/kg, i.v.) did not significantly rise over the peak pressure level during micturition before injection of morphine. The inhibitory effect of morphine (1 and 5 mg/kg, i.v.) was reversed by naloxone (0.1 mg/kg, i.v.). Morphine (5 mg/kg, i.v.) did not increase the pressure induced by infusion of solution from near the bladder neck to the urethra. After intracerebroventricular (i.c.v.) and intrathecal (i.t.) administration of morphine (1 μg), the micturition interval was prolonged and the level of micturition threshold was increased. Morphine (5 μg, i.c.v and i.t.) inhibited bladder contraction and naloxone (5 μg, i.c.v. and i.t.) reversed the inhibitory effect of morphine injected by the same administration route. From these results, urinary retention induced by systematically injected morphine was considered to result from inhibition of bladder function mediated via opioid receptors of the micturition centers in the supraspinal and spinal regions.抄録全体を表示PDF形式でダウンロード (426K) -
Hiroshi MORI, Qiang XU, Osami SAKAMOTO, Yuki UESUGI, Yutaka ONO, Akihi ...1988 年 48 巻 1 号 p. 37-46
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーIn the present paper, we confirmed that a delayed type hypersensitivity response can be elicited against Meth A tumor (Meth A-DTH) in BALB/c mice bearing the primary tumor. This response was augmented by lipopolysaccharide. We examined the effects of 4 kinds of Chinese herbs including A. capillans, S. doederleinii, A. macrocephala and S. subprostrata on the Meth A-DTH, and the results were compared with that of the herbs on picryl chloride-induced delayed type hypersensitivity (PC-DTH). All of the herbs examined augmented the Meth A-DTH 10 days after the primary tumor transplantation, and S. doederleinii, A. macrocephala and S. subprostrata prevented the decay of the response on the 20th day, but A. capillaris did not. On the other hand, none of the herbs affected the PC-DTH. When both DTH responses were caused simultaneously in the same mouse, Meth A-DTH decayed 20 days after the transplantation but PC-DTH did not. In this case, the effects of these 4 herbs on Meth A-DTH and PC-DTH were essentially the same as those seen in the case of separate experiments. The previous and present results suggest that A. capillans shows antitumor activity mainly through a direct cytotoxicity, although this herb might have certain components to enhance Meth A-DTH, and the other herbs display the activity through the enhancement of T cell-mediated tumor immunity, particularly tumor specific DTH.抄録全体を表示PDF形式でダウンロード (689K) -
Motoyoshi SAKAUE, Takayoshi KUNO, Chikako TANAKA1988 年 48 巻 1 号 p. 47-56
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーA novel type of monoclonal antibodies against cyclic GMP were produced to study the immunocytochemical distribution of cyclic GMP in the rat brain. Cyclic GMP conjugated to bovine serum albumin with glutaraldehyde was used as an immunogen, and monoclonal antibodies were produced. The one monoclonal antibody which did not crossreact against other nucleotides was applied to the immunocytochemistry of the rat brain. Cyclic GMP immunoreactivities were distributed unevenly in the rat brain. The cerebellar cortex, hippocampus and cerebral cortex contained a high degree of cyclic GMP immunoreactivity, while most of the white matter was not stained. In the cerebellar cortex, stellate cells and Golgi cells showed intense immunoreactivities, but granule cells showed weak immunoreactivities. Approximately 60-80% of the Purkinje cells showed intense immunoreactivities, while the remaining ones showed only weak staining. The pyramidal cells in the cerebral cortex and hippocampus also showed intense immunostaining. Some glial cells adjacent to the Purkinje cells also stained. The nuclei of cyclic GMP-immunoreactive cells were not stained. These immunocytochemical distributions of cyclic GMP are in fairly good agreement with reported the biochemical data and the immunocytochemical distribution of guanylate cyclase. These monoclonal antibodies should be helpful for elucidating the physiological role of cyclic GMP in the brain.抄録全体を表示PDF形式でダウンロード (2090K) -
Machiko MATSUMOTO1988 年 48 巻 1 号 p. 57-66
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe present study was undertaken to clarify the site for the sympathoinhibitory action of ketanserin in anesthetized rats. Intravenous (i.v.) administration of ketanserin (0.5 and 5 mg/kg) produced a decrease in preganglionic adrenal sympathetic nerve activity (ANA) that is accompanied with hypotension and bradycardia. Intracerebroventricular (i.c.v.) administration of ketanserin (200 μg/rat) also decreased ANA, blood pressure (BP) and heart rate (HR). Intrathecal (i.t.) administration of ketanserin (200 μg/rat), on the other hand, affected neither ANA, BP nor HR. These results indicate that the site of the sympathoinhibitory action of ketanserin is the supraspinal structures, and not at the spinal cord level. In addition, the decrease in ANA after i.v. administration of ketanserin (0.5 and 5 mg/kg) was attenuated significantly with pretreatment of 5, 7-dihydroxytryptamine (200 μg/rat, i.c.v.) or 6-hydroxydopamine (200 μg/rat, i.c.v.). These findings suggest that the adrenal sympathoinhibitory action of ketanserin may be centrally mediated via both serotonergic and noradrenergic pathways in rats.抄録全体を表示PDF形式でダウンロード (686K) -
Kyozo YAMANAKA, Ikunobu MURAMATSU, Shigeru KIGOSHI1988 年 48 巻 1 号 p. 67-76
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーMuscarinic receptor binding was examined in bovine adrenal medullary microsomes following exposure to tetranitromethane (TNM) that modifies tyrosine and cysteine residues in proteins. The TNM (10-100 μM) treatment of adrenal medullary microsomes caused a concentration-dependent and irreversible reduction in the maximum number of binding sites (Bmax) for /-(3H)quinuclidinyl benzilate (QNB), with a slight increase in the equilibrium dissociation constant (KD). Typically, about a 36% decrease and a 1.3-fold increase in the corresponding values were obtained at 50 μM of TNM. The alteration in the Bmax was partially prevented by atropine but not carbamylcholine, and it was not reversed by subsequent treatment with dithiothreitol, a disulfide reducing agent. The change in the KD was unaffected by these agents. The TNM (50 μM) treatment also caused a slight decrease in the affinity of atropine and pirenzepine (for both the high and low affinity sites), and it caused a slight decrease in the affinity of carbamylcholine at the high affinity site, with a large loss of the low affinity site. Thus, the results indicate that TNM causes a loss of muscarinic binding sites and a decrease in the binding affinity of muscarinic receptors in bovine adrenal medulla, probably through modifications of functional groups such as tyrosine residues.抄録全体を表示PDF形式でダウンロード (752K) -
Masahisa ASANO, Kaoru MASUZAWA, Masayoshi KOJIMA, Kyuzo AOKI, Tomohiro ...1988 年 48 巻 1 号 p. 77-90
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーEffects of calcium channel blockers and of calmodulin antagonist on the contractile responses to norepinephrine (NE) were compared between strips of mesenteric arteries from 6- and 14-week-old spontaneously hypertensive rats (SHR) and age-matched, normotensive Wistar-Kyoto rats (WKY). The ratio of the maximum contraction developed by NE to that by 60 mM KCI was significantly increased in strips from 14-week-old SHR. Niludipine, verapamil and diltiazem antagonized the maximum NE contraction to a greater extent in strips from 14-week-old SHR than in those from the WKY. However, the antagonism by niludipine of the KCI- or caffeine-induced contraction was not significantly different between the strips from 14-week-old SHR and those from WKY. In strips from 6-week-old rats, there was no difference in the antagonism by niludipine of the maximum NE contraction. On the other hand, the effect of W-7 on the maximum N E contraction was not significantly different between the strips from 14-week-old SHR and those from WKY. Schild plot analyses demonstrated that a, -adrenoceptors were the same for the strips from SHR and WKY. These results suggest that the enhanced maximum NE contraction in the mesenteric artery from 14-week-old SHR reflects the increased transmembrane influx of calcium, and the activity of calmodulin seems to be the same for the two strains.抄録全体を表示PDF形式でダウンロード (1067K) -
Yukiyoshi YANAGIHARA, Hiroshi KASAI, Toshio KAWASHIMA, Takao SHIDA1988 年 48 巻 1 号 p. 91-101
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe effects of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1, 2-a]pyrimidin-4-one potassium salt (TBX), a new antiallergic drug, on passive cutaneous anaphylaxis (PCA) mediated by homologous IgE or IgG antibody were investigated in rats and guinea pigs. TBX (i.v. and p.o.) clearly inhibited IgE- and IgGa-mediated homologous PCAs in rats, without showing any inhibition of the skin reactions caused by histamine, serotonin and bradykinin in contrast to the inhibition of prostaglandin E1-induced skin reaction. Neither adrenalectomy nor propranolol treatment modified TBX's inhibition of the former PCA. With regard to tachyphylaxis to TBX, it was demonstrable in IgE-mediated homologous PCA in rats when they were pretreated with TBX (0.5 mg/kg, i.v.), followed 60 min later by a second dose of the drug (0.05 mg/kg, i.v.). There was no cross-tachyphylaxis between disodium cromoglycate (DSCG) and TBX. Homologous PCA caused by guinea pig IgE was also inhibited in a dose-dependent fashion by i.v. and p.o. administrations of TBX, although higher doses of TBX were needed to inhibit guinea pig PCA than the rat one. Interestingly, TBX showed more potent inhibition of both rat and guinea pig homologous PCAs than DSCG or tranilast. The results obtained indicate that TBX is an orally effective antiallergic agent displaying no antagonistic actions on the chemical mediators released.抄録全体を表示PDF形式でダウンロード (705K) -
Yukiyoshi YANAGIHARA, Hiroshi KASAI, Takao SHIDA1988 年 48 巻 1 号 p. 103-112
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe ability of 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1, 2-a]pyrimidin-4-one potassium salt (TBX) to inhibit histamine release from both peritoneal exudate cells (PEC) containing mast cells and lung fragments of rats was investigated in vitro. Low concentrations of TBX dose-dependently inhibited IgE-mediated histamine release from PEC of passively sensitized animals; its IC50 was 5.1×10-9 g/ml. When TBX was added simultaneously with the antigen challenge, the highest inhibition was obtained. In contrast, extension of preincubation time with the agent resulted in a marked decrease in the inhibition of histamine release. The potent inhibition of histamine release by TBX was observed equally in glucose-free as well as complete Tyrode's solution, whereas TBX reduced its inhibitory action in Ca2+-free or D2O -supplemented medium. In addition, TBX inhibited compound 48/80- but not calcium ionophore A23187-induced histamine release from normal PEC. With regard to the intracellular cyclic AMP level in normal PEC, it was significantly enhanced by a high concentration of TBX (10-3 g/ml). TBX also inhibited antigen-induced histamine release from lung fragments of actively immunized animals. Interestingly, TBX displayed non-competitive inhibition of cyclic AMP-dependent phosphodiesterase derived from lung homogenates; its K1 value was 8.70×10-4 M.抄録全体を表示PDF形式でダウンロード (772K) -
Masatoshi HORI, Michiaki NAKAYA, Kazue NODA, Kazumasa SHIMIZU, Shinjir ...1988 年 48 巻 1 号 p. 113-119
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe effects of Li+ substitution for external Na+ in the medium on a 60 mM KCl (60K+)-induced contraction were compared in the ileal longitudinal smooth muscles isolated from monkey, rabbit, guinea pig and rat. Li+ substitution inhibited the 60K+-induced contraction in the ileum of all the animal species. Greater inhibitory effect was observed with the increase in external Li+ concentration and the increase in incubation period with Li+. Intracellular Li+ contents of these muscles also increased with the increase in external Li+ concentration and the incubation period. Thus, a good correlation was obtained between Li+-induced inhibition of 60K+-induced contraction and the increase in Li+ content. However, close examination revealed that the contraction in monkey and rat ileum was inhibited by much lower Li+ accumulation than that in guinea pig and rabbit ileum, suggesting the existence of species difference in the sensitivity of the ileal smooth muscle to the inhibitory effect of Li+ substitution, and a mechanism for the species differences in the inhibitory action of Li+-substitution was discussed.抄録全体を表示PDF形式でダウンロード (427K) -
Noboru NAKAHARA, Yoshinori IGA, Fumio MIZOBE, Gosei KAWANISHI1988 年 48 巻 1 号 p. 121-130
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe effects of intracerebroventricular (ICV) injection of ethylcholine aziridinium ion (AF64A) (3 nmole/2 μl, each lateral ventricule), a putative selective cholinotoxin, on learning behaviors and choline acetyltransferase (ChAT) activity were studied in rats. AF64A-treated rats (AF64A-rat) exhibited deficient performance in a passive avoidance task and a delayed alternation task in the T-maze, but demonstrated superior avoidance response in a two-way shuttle avoidance task. These changes in learning behaviors were associated with the selective decrease of hippocampal ChAT activity. Physostigmine (0.1 mg/kg, i.p.) significantly improved the retention latency of AF64A-rats in the passive avoidance task. AF64A-rats receiving physostigmine (0.2 mg/kg, i.p.) exhibited a slight but not significant improvement of performance in the delayed alternation task in the T-maze. These findings suggested that ICV injection of AF64A may be useful for producing an experimental amnesia model with hippocampal cholinergic hypofunction like Senile dementia of the Alzheimer type (SDAT), if appropriate learning tests are selected.抄録全体を表示PDF形式でダウンロード (769K) -
Kiminobu SUGAYA, Matti O. MAIMETS, Kazuhiko KUBOTA1988 年 48 巻 1 号 p. 131-136
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe interaction of ceruletide (CER) and apomorphine (APO) was studied in mice. APO and CER were injected subcutaneously. In wheelcage experiments, lower doses (50 to 100 μg/kg) of APO depressed dose-dependently the locomotor activity in mice, but a higher dose (1 mg/kg) of APO produced a smaller effect than 100 μg/kg of APO. CER (20 μg/kg) slightly depressed the locomotor activity in mice. The coadministration of APO and CER caused stronger inhibition in the locomotor activity than the single administration of these drugs. The effects of APO and CER on the neuronal uptake of 2-deoxy-D-(14C)-glucose (2-DG) were also examined. APO (50 and 1000 μg/kg) inhibited the 2-DG uptake in most regions of the brain, although the inhibitory effect was larger at lower doses. CER inhibited the 2-DG uptake in some regions, but enhanced it in others. The combination of APO and CER markedly enhanced the 2-DG uptake. Thus, it was difficult to correlate the effects of the combination of APO and CER on locomotor activity with 2-DG uptake.抄録全体を表示PDF形式でダウンロード (406K) -
Yutaka GOMITA, Minehiro MORIYAMA, Yasuyuki ICHIMARU, Yasunori ARAKI1988 年 48 巻 1 号 p. 137-141
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーNeural effects of aversive stimulation of dorsal central gray (DCG) were studied by [14C] 2-deoxyglucose (2-DG) autoradiography in rats. After training the animals to escape DCG stimulation by pressing a lever, they were injected i.p. with [14C] 2-DG and then allowed to resume the escape lever pressing for DCG stimulation. Reliable effects of the brain stimulation on the autoradiogram were found in the dorsal fasciculus of Schütz, periventricular gray and superior colliculus. Moderate effects were found in the reticular formation near the periventricular gray and in the claustrum. These data indicate that the neural signal activated by DCG stimulation is transmitted through an ascending nerve pathway over the superior colliculus via the dorsal Schütz bundle and reaches the periventricular system in the diencephalon.抄録全体を表示PDF形式でダウンロード (377K) -
Toshio OBATA, Toru EGASHIRA, Yasumitsu YAMANAKA1988 年 48 巻 1 号 p. 142-144
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーWhen allyl formate (AF) was administered to rats, the marked elevation of B-form MAO activity in plasma was found with β-PEA as a substrate. In contrast, in the case of carbon tetrachloride (CCl4), A-form MAO activity elevated predominantly. The deaminations of 5-HT and β-PEA in these plasma treated with AF or CCl4 were not inhibited completely by a high concentration of MAO inhibitor, deprenyl or clorgyline. These results indicate the there may be two or more distinct amine oxidases released from the liver and other organs in response to CCl4 or AF.抄録全体を表示PDF形式でダウンロード (236K) -
Jun YAMADA, Yumi SUGIMOTO, Hiromi WAKITA, Kazuyoshi HORISAKA1988 年 48 巻 1 号 p. 145-148
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーThe hypothermia elicited in mice by intracerebroventricular injection (i.c.v.) of serotonin (5-HT) was studied. The 5-HT-induced hypothermia was attenuated by methysergide and pindolol, although ketanserin and p-chlorophenylalanine were without effect. These results suggest that 5-HT-induced hypothermia is produced by the direct activation of the 5-HT1 receptor. In addition, haloperidol, pimozide and α-MT inhibited 5-HT-induced hypothermia, which indicates that the dopaminergic systems are also involved in 5-HT-induced hypothermia in mice.抄録全体を表示PDF形式でダウンロード (289K) -
Makishige ASANO, Chiyoji OHKUBO, Akihiko SASAKI1988 年 48 巻 1 号 p. 149-152
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーA pre-existing plastic rabbit ear chamber was modified to be applicable for intravital-microscopic observations in pharmacological as well as pathophysiological studies on inflammation. The chamber consists of a base disk, a mica (or glass) cover-slip and a holder ring. The base disk has a round-table with a central protrusion in which a heat conductor of platinum wire is so implanted near the protrusion that thermal stimulation can be given to the regenerated tissue between the table and the coverslip.抄録全体を表示PDF形式でダウンロード (470K) -
Gen YASUDA, Yoshimi MISU1988 年 48 巻 1 号 p. 153-156
発行日: 1988年
公開日: 2006/08/25
ジャーナル フリーEffects of some prostaglandins (PGs) on adrenergic transmission were studied in guinea pig pulmonary arteries preloaded with 3H-norepinephrine. PGE1 and PGE2 at 0.1 to 100 nM concentration-dependently inhibited 3H-release and contraction evoked at 5 Hz. This inhibition was antagonized by diphloretin phosphate. PGF2α at 1 to 100 nM had no effect on evoked 3H-release and contraction. PGI2 at 1 to 100 nM also failed to modify evoked 3H-release, but markedly and concentration-dependently decreased evoked contraction. There exist presynaptic inhibitory PGE1 and PGE2 receptive sites on adrenergic neurons innervating guinea pig pulmonary arteries, whereas PGF2α and PGI2 produced no effect on the adrenergic neurons.抄録全体を表示PDF形式でダウンロード (305K)
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