巻号一覧
50 巻 (1989)
- 4 号 p. 369-
- 3 号 p. 253-
- 2 号 p. 87-
- 1 号 p. 1-
50 巻, 3 号
選択された号の論文の16件中1～16を表示しています
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Ikuko KIMURA, Masayasu KIMURA, Leonora Rivera PANCHO1989 年 50 巻 3 号 p. 253-261
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーThe effects of the active principles of crude ginger (a traditional Sino-Japanese medicine), the gingerols, on the contractile responses to eicosanoids were compared using isolated mouse and rat blood vessels. Leukotrienes (LT) C4 and D4, a thromboxane (TX) A2 derivative (U-46619), prostaglandins (PG) F2α, PG12-Na, PGE2, the stable PGI2 derivative TRK-100, and PGD2 induced contraction in longitudinal segments of mouse mesenteric veins in that order of potency. Exogenous arachidonic acid and PGE1, did not cause contraction. The mesenteric veins also contracted in response to noradrenaline (NA) and phenylephrine (PhE), but not to clonidine. The gingerols alone relaxed the muscle transiently and then augmented the response to PGF2α, PGE2, PGI2-Na, and TRK-100, but suppressed the response to PGD2, U-46619, LTC4, LTD4, NA and PhE. (±)-[6]-Gingerol also potentiated the PGF2α-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries. These results showed that (±)-[6]- and (±)-[8]-gingerols potentiated the contraction induced by prostanoids (except PGD2) and inhibited that produced by PGD2, TXA2, and LT, suggesting the modulation of eicosanoids-induced responses by (±)-[6]- or (±)-[8]-gingerol.抄録全体を表示PDF形式でダウンロード (443K) -
Yoko ANIYA, Yoshihiko OJIRI, Ryuji SUNAGAWA, Keiji MURAKAMI, Guan ZHEN ...1989 年 50 巻 3 号 p. 263-269
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーThe glutathione S-transferase activity in liver and kidney cytosol was significantly decreased in short term diabetes induced with streptozotocin, whereas no decrease in the transferase was observed in phenobarbital-treated diabetic rats. Toxicity of chloroform was potentiated in streptozotocin- or phenobarbital-treated rats. The decrease in liver cytosolic and microsomal glutathione S-transferase activity was observed in long term diabetic rats, and only microsomal transferase activity was restored by insulin treatment. There was no release of glutathione S-transferases into the serum in the diabetic rats, and the transferases were not inhibited by streptozotocin in vitro. These results showed that glutathione S-transferase activity decreased during diabetes, and this decrease may contribute to altering drug metabolism and toxicity in diabetes.抄録全体を表示PDF形式でダウンロード (416K) -
Seiji INOUE, Ka BIAN, Tomio OKAMURA, Hideki OKUNISHI, Noboru TODA1989 年 50 巻 3 号 p. 271-282
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーEffects of eperisone, an antispasmodic in skeletal muscle, were investigated in helical strips of dog saphenous artery and vein. Eperisone relaxed saphenous arteries and veins previously contracted with norepinephrine, serotonin, acetylcholine, K+, or Ba2+; but in contrast, it produced contractions in the blood vessels contracted with prostaglandin (PG) F2α. Treatment with eperisone attenuated the contractions induced by norepinephrine and serotonin in the arteries and those by clonidine and phenylephrine in the veins. Eperisone inhibited angiotensin II-induced relaxations, mediated possibly by endogenous PGI2, but did not alter relaxations caused by exogenous PGI2. Treatment with eperisone (10-5 M) potentiated the contractile response to electrical stimulation of adrenergic nerves; the potentiating effect was suppressed by yohimbine. The eperisone-induced contraction in PGF2α-contracted arteries was inhibited by treatment with indomethacin or aspirin, although cyclooxygenase activity was not inhibited by eperisone. These results may indicate that eperisone blocks postjunctional α1- and α2-adrenergic, muscarinic, serotonergic receptors and prejunctional α2 adrenoceptors and reduces PGI2 synthesis via a mechanism other than cyclooxygenase inhibition.抄録全体を表示PDF形式でダウンロード (617K) -
Kiyohisa UCHIDA, Takashi MATSUBARA, Kazumasa HIRAUCHI1989 年 50 巻 3 号 p. 283-288
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーOxacephem antibiotics have been developed to increase the antibacterial activity of cephem antibiotics, but the effect of 1-oxygen replacement of cephem antibiotics on blood coagulation activities is not yet known. Therefore, latamoxef (LMOX), flomoxef (FMOX) and their 1-S congeners were examined for their effects on prothrombin time, activated partial thromboplastin time, plasma prothrombin and Factor VII levels, plasma and liver descarboxyprothrombin (PIVKA-II) levels, and liver microsomal vitamin K epoxide reductase activities in rats kept on a vitamin K-deficient diet. Under the vitamin-deficient states, LMOX, FMOX and their 1-S congeners inhibited the vitamin K epoxide reductase, although the effect of FMOX or its congener was much less than that of LMOX, and they decreased the blood clotting activities in rats fed a vitamin K-deficient diet. However, no difference was found in these effects between LMOX and its 1-S congener or between FMOX and its 1-S congener. This result suggests that the 1-oxygen replacement of cephem antibiotics is not responsible for the hypoprothrombinemic effect of the antibiotics.抄録全体を表示PDF形式でダウンロード (322K) -
Katsuji HOSHI, Naoto SENDA, Sumiko FUJINO1989 年 50 巻 3 号 p. 289-293
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーCobaltous chloride (CoCl2) caused very marked decreases of cytochrome P-450, b5 and total heme contents and an increase of heme oxygenase activity. On the contrary, phenobarbital (PB) increased hepatic drug-metabolizing enzymes, but the total heme content remained unchanged. On the other hand, amitriptyline (AMT) caused a marked increase of δ-aminolevulinic acid (δ-ALA) synthetase activity at 12 and 24 hr. In addition, the contents of total heme and cytochrome b5 and the activities of aminopyrine (AM) N-demethylase and aniline (AN) hydroxylase at 24 hr were also increased by AMT, whereas cytochrome P-450 content did not change. This may be explained by the fact that AMT would increase hepatic heme synthesis through the prolonged induction of δ-ALA synthetase, but it may not cause an increase in cytochrome P-450 heme because there are increases in the contents of cytochrome b5 and total heme.抄録全体を表示PDF形式でダウンロード (277K) -
Michio YAMAMURA, Hiroyuki NAKAGAWA, Kayoko MAEDA, Kiyoshi KINOSHITA, R ...1989 年 50 巻 3 号 p. 295-305
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーThe effects of mafoprazine, a new phenylpiperazine derivative, on the central dopaminergic system were studied. Mafoprazine, like chlorpromazine and haloperidol, reduced the apomorphine-induced cage-climbing behavior in mice, emesis in dogs and stereotyped behavior in monkeys; methamphetamine-induced hyperlocomotion and group toxicity in mice; and agitation in rats. Mafoprazine inhibited the unilateral circling behavior induced by methamphetamine and apomorphine in rats with 6-hydroxydopamine-induced lesions in the unilateral nigrostriatal neuronal tract. The potency of mafoprazine in these experiments was almost equal to that of chlorpromazine and about one-tenth that of haloperidol. The cataleptogenic activity of mafoprazine was lower than those of chlorpromazine and haloperidol. Mafoprazine potentiated clonidine-induced hypothermia. These results suggest that mafoprazine has a relatively selective postsynaptic dopamine D2-receptor blocking action in the nucleus accumbens compared with chlorpromazine and haloperidol and suggest that mafoprazine also has α2-adrenoceptor-stimulating actions.抄録全体を表示PDF形式でダウンロード (551K) -
Katsuya YAMASAKI, Yoshiaki GOTO1989 年 50 巻 3 号 p. 307-313
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーStimulatory effects of systemically administered gamma-aminobutyric acid (GABA) on gastric acid secretion and vagal efferent activity were studied in anesthetized rats. Intravenous injection of GABA (400 mg/kg) significantly increased gastric acid secretion. The secretagogue effect of GABA on the gastric acid secretion was partially attenuated by vagotomy by approximately 60%. Atropine (1 mg/kg, s.c.) completely abolished the stimulatory effect of GABA on the acid output. GABA, at secretagogue doses, enhanced the firing rate of vagal efferent activity. These results suggest that the secretagogue action of intravenously injected GABA is primarily mediated by muscarinic mechanisms and that the stimulation of the central vagal efferent pathway might trigger the excitatory action of systemic GABA.抄録全体を表示PDF形式でダウンロード (403K) -
Tadashi MIZUTA, Tomio SEGAWA1989 年 50 巻 3 号 p. 315-326
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーThe effects of chronic treatment with imipramine or lithium on serotonin (5-HT) receptor subtypes were analyzed in the frontal cortex, hippocampus and choroid plexus of rat brain by quantitative receptor autoradiographic procedures, using radioligands [3H]-5-HT, [3H]-8-hydroxy-2-(di-n-propylamino)tetralin ([3H]-8-OH-DPAT), [125I]-iodocyanopindolol ([125I]-CYP), [3H]-mesulergine and [125I]-7-amino-8-iodo-ketanserin ([125I]-ketanserin) or [3H]-spiperone. Chronic i.p. administration of imipramine (20 mg/kg/day for 21 days) decreased the densities of 5-HT1, 5-HT1A, 5-HT1C, and 5-HT2 sites in the frontal cortex, hippocampus and choroid plexus. Lithium (2 mEq/kg/day for 21 days) also decreased the densities of 5-HT1, 5-HT1C, and 5-HT2 sites in the frontal cortex, and the densities of those including 5-HT1A sites in the hippocampus and choroid plexus. Imipramine and lithium very markedly decreased the density of 5-HT1C, sites in the choroid plexus. We propose that methods employing quantitative receptor autoradiographic analysis can be used to characterize and understand the local effects of these drugs on 5-HT receptor subtypes.抄録全体を表示PDF形式でダウンロード (725K) -
Effects of Central Nervous System-Acting Drugs on Urinary Bladder Contraction in Unanesthetized RatsHitoshi KONTANI, Mikiko NAKAGAWA, Takeshi SAKAI1989 年 50 巻 3 号 p. 327-332
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーWe studied the effects of drugs on urinary bladder contraction in unanesthetized (UA) rats using the same method as that previously employed to investigate similar effects in urethane and α-chloralose-anesthetized (A) rats. The surgical procedure was performed under halothane anesthesia, and after the recovery, the rats were restricted in a Ballman cage during the experiment. The pattern of the cystometrogram obtained in UA rats was very similar to that in A rats, and almost the same pattern was maintained for at least three hours. Baclofen (10 mg/kg, i.p.), morphine (10 mg/kg, i.p.) and pentobarbital (20 mg/kg, i.p.) completely inhibited the bladder contraction at doses only double those at which the same drugs inhibited the bladder contraction in A rats when i.v. injected. When the bladder pressure rose almost to the level of the peak pressure existing before injection of these drugs, the instilled solution leaked from the penis. On the other hand, even after injection of diazepam (5 mg/kg, i.p.) at a dose five times greater than the minimum amount necessary for complete inhibition of bladder contraction in A rats, the bladder contraction accompanying micturition continued in UA rats. It appears that the inhibitory effect of diazepam on bladder contraction in rats is potentiated by anesthesia.抄録全体を表示PDF形式でダウンロード (281K) -
Xiao ZHANG, Tomio SEGAWA1989 年 50 巻 3 号 p. 333-345
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーThis study investigated the effects of selective blockade of dopamine D-1 receptors by SCH 23390 and selective stimulation of the receptors by SKF 38393 on the binding characteristics of 3H-spiperone labeled D-2 receptors in rat striatum. Selective blockade of D-1 receptors by 50 nM SCH 23390 significantly decreased the affinity of dopamine agonist for 3H-spiperone labeled D-2 receptors, but did not influence dopamine antagonist binding to D-2 receptors. Selective stimulation of D-1 receptors by SKF 38393 (100 nM) did not affect either dopamine agonist or antagonist binding to D-2 receptors. The characteristics of the effect of SCH 23390 on dopamine agonist binding to D-2 receptors was similar to those of GTP, but different from those of sodium ion. This effect could not be due to a direct modification of D-2 receptors by SCH 23390. Pertussis toxin (IAP) treatment significantly decreased the affinity of dopamine agonist for D-2 receptors and reduced the abilities of both SCH 23390 and GTP to decrease the affinity of dopamine agonist for D-2 receptors. These results suggest, therefore, putative interregulatory mechanism between dopamine D-1 and D-2 receptors and the possible involvement of a pertussis toxin sensitive protein in this mechanism.抄録全体を表示PDF形式でダウンロード (673K) -
Tohru MASUKAWA, Midori SAI, Yoshihiro TOCHINO1989 年 50 巻 3 号 p. 347-349
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーCyclohexene-1-one (CHX) dose-dependently caused the elevation of blood glucose levels in both fed and fasted mice. Adrenalectomy considerably prevented the elevated blood glucose with CHX, and plasma adrenaline assays revealed about a three to fifteen-fold rise after CHX treatment. These findings indicate that the CHX-induced hyperglycemia may be largely mediated by adrenaline released from the adrenal medulla.抄録全体を表示PDF形式でダウンロード (147K) -
Masaru CHIHARA, Takahide NOMURA, Masakatsu TACHIBANA, Hiroko NOMURA, Y ...1989 年 50 巻 3 号 p. 350-353
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーIn isolated rat hepatocytes, mepacrine stimulated the conversion of [1-14C]oleate into 14C02 and depressed the formation of acid-soluble products from [1-14C]oleate. The action of mepacrine on [1-14C]oleate oxidation was not affected by exogenously applied phospholipase A2 (from Crotalus adamanteus venom) or arachidonic acid. It is suggested that mepacrine may exert its metabolic effects in isolated rat hepatocytes by a mechanism independent of phospholipase A2 inhibition.抄録全体を表示PDF形式でダウンロード (202K) -
Mikio NAKAMURA, Kunie KAMATA, Hakubun INOUE, Minoru INABA1989 年 50 巻 3 号 p. 354-356
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーEffects of several opioid peptides administered in the lateral cerebroventricle on the changes in blood adrenaline (AD) levels were examined at 10, 20 and 30 min after the start of immobilization in conscious rats. β-Endorphin, (D-Ala2)-Met-enkephalinamide, morphiceptin and (D-Ala2, D-Leu5)-enkephalinamide produced significantly lower elevations of AD than the control, and the effect was enhanced by naloxone. The effect of dynorphin, however, was almost the same as that of the control.抄録全体を表示PDF形式でダウンロード (126K) -
Yoshimi UCHIYAMA-TSUYUKI, Hiroaki ARAKI, Yasuko KARASAWA, Hironaka AIH ...1989 年 50 巻 3 号 p. 357-361
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーChanges in cerebral monoamine metabolism were investigated in gerbils following a 5-min ischemia. During ischemia, monoamines were not changed, and 3-methoxy tyramine increased remarkably. After re-circulation, noradrenaline and serotonin decreased, and 5-hydroxyindole-3-acetic acid increased. Dopamine was not significantly changed: but its metabolites were elevated. At 1, 3 and 7 days after the ischemia, monoamine metabolism did not change. We discussed the possibility that these monoamine metabolism changes in the early period of reflow might be related to the delayed neuronal damage.抄録全体を表示PDF形式でダウンロード (209K) -
Yoshiyuki MINAMI, Hisashi ONOUE, Noboru TODA1989 年 50 巻 3 号 p. 362-365
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーAcetylcholine, substance P and nitroglycerin applied intra and extraluminally to the perfused dog femoral artery segment with endothelium caused depressor responses. Endothelium denudation abolished the responses to acetylcholine and substance P. EC50 ratios of extra-versus intraluminal acetylcholine and substance P were 43 and 79, respectively, whereas those of nitroglycerin did not differ. Physostigmine potentiated the response to extraluminal acetylcholine. Acetylcholine seems to be degraded partly by cholinesterase in the arterial wall. Acetylcholine and substance P applied extraluminally are expected to reach the endothelium and release endothelium-derived relaxing factor.抄録全体を表示PDF形式でダウンロード (178K) -
Masayuki UCHIDA, Osamu KAWANO, Noriyuki MISAKI, Osamu IRINO1989 年 50 巻 3 号 p. 366-368
発行日: 1989年
公開日: 2006/08/25
ジャーナル フリーThe prostaglandin E (PGE) generation level (PGE level) in the gastric mucosa was investigated in relation to the healing and relapse of acetic acid-induced gastric ulcers in the rat. The PGE level around ulcers showed higher levels after ulcer induction and decreased during the ulcer diminishing period. Thereafter, the PGE levels showed an inclination to increase during the ulcer exacerbation period. In reulcerated rats, PGE levels were significantly higher. In conclusion, a high level of PGE may indicate an ulcer exacerbation state.抄録全体を表示PDF形式でダウンロード (132K)
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