All issues
Successor
Volume 50 (1989)
- Issue 4 Pages 369-
- Issue 3 Pages 253-
- Issue 2 Pages 87-
- Issue 1 Pages 1-
Volume 50, Issue 4
Displaying 1-22 of 22 articles from this issue
- |<
- <
- 1
- >
- >|
-
Kouji MORIKAWA, Miki ICHIHASHI, Masato KAKIUCHI, Toshie YAMAUCHI, Hide ...1989 Volume 50 Issue 4 Pages 369-376
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSIn the present study, we attempted to evaluate the effects of various intravenous administered drugs, which had been shown to influence bladder function in anesthetized animals, on the cystometrogram in conscious rats placed in a restraining cage. Thiopental, diazepam, baclofen, clonidine and flavoxate, considered to act on the micturition center in the brain stem, hardly increased bladder capacity (time to micturition in cystometrogram) in conscious rats, but morphine, indomethacin and lidocaine, considered to act on the micturition center in the sacral cord or bladder mechanoreceptors, increased it. In a chronic conscious rat, histopathological findings show that the bladder tissue at 2 days after implantation of the catheter to the bladder showed experimental cystitis characterized by severe edema in the submucosa and an increase in prostaglandin E2 content, which is thought to stimulate directly and/or indirectly the capsaicin-sensitive sensory fiber in the afferent branch of the micturition reflex, and there was hyperreflexia characterized by decreases in both bladder capacity and urine volume. In conclusion, cystometrography in conscious rats placed in a restraining cage is thought to be a useful model for evaluating the true effect of a newly developed agent on bladder function.View full abstractDownload PDF (484K) -
Yu YAMAGUCHI, Yoko TANAKA, Kaori YAMADA, Yoshio BANDÔ, Masaru KU ...1989 Volume 50 Issue 4 Pages 377-386
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThis study examined the altered lipid metabolism and effects of drug treatments during the development of adjuvant arthritis in rats. Before its onset (day 9 post-adjuvant), large decreases were noted in the serum total cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels and, in particular, a large decrease in the lecithin-cholesterol acyltransferase activity. A large increase in the serum phospholipid level was also noted. As the arthritis progressed, the serum total cholesterol and HDL-cholesterol levels were rapidly reversed, finally reaching a level significantly higher than normal, together with rises in the serum free-cholesterol and lipid peroxide levels. These changes in serum lipids and enzyme activity could be normalized by treatment with cyclophosphamide, an immunosuppressive agent, but other than the serum triglyceride level, were not affected by treatment with indomethacin, a nonsteroidal anti-inflammatory drug, despite the fact that both drug treatments almost completely suppressed the progression of arthritis. These findings suggest that the abnormal lipid metabolism induced by adjuvant injection is not associated with the inflammatory activity, but associated with the immunopathologic response.View full abstractDownload PDF (431K) -
Yoshihisa KOGA, Naoya SODEYAMA, Shun SATOH, Tadashi TESHIGAWARA, Teruy ...1989 Volume 50 Issue 4 Pages 387-396
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSWe examined K+-induced relaxation instead of contraction in the presence of Ca-antagonists by measuring isometric tension in the tracheal smooth muscle isolated from guinea pigs. Cumulative administration of KCI (10-90 mM) induced a concentration-dependent contraction. When the muscle was pretreated with low concentrations of Ca-antagonists, cumulative administration of KCI caused a mild contraction, followed by a moderate relaxation. In the muscle pretreated with high concentrations of Ca-antagonists, KCI revealed a concentration-related relaxation without contraction. The potency ratios of Ca-antagonists to reverse the KCI-induced contraction to relaxation were nifedipine : verapamil : diltiazem= 94:4:1. This order of potency was quite similar to that of Ca-antagonists to relax the muscle precontracted with KCI (30 mM). Magnitudes of KCI (30 mM)-induced relaxation in the presence of Ca-antagonists were similar to those caused by Ca-antagonists in the KCI (30 mM)-precontracted muscles. Thus, K+-induced relaxation in the airway smooth muscle in the presence of Ca-antagonists may be due to the voltage-dependent increase in binding of Ca-antagonists to calcium channels.View full abstractDownload PDF (438K) -
Tsuyoshi KIHARA, Midori INOUE, Hiroshi KANETO1989 Volume 50 Issue 4 Pages 397-401
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSWhether or not the suppressive effect of α- and β-adrenergic blockers, phentolamine and propranolol, on the development of tolerance to morphine could be substituted for each other was investigated in mice. Daily co-administration of either one of the blockers with morphine suppressed the development of analgesic tolerance to morphine as far as the treatment was continued without affecting the analgesic effect per se; however, the suppressive effect was lost from the day of the substitution for the other blocker and tolerance developed as rapidly as in the control group treated with morphine alone. Co-administration of both blockers with morphine also maintained the analgesic effect on the 1 st day for 10 days, but when the administration of either one or both blockers was eliminated from the 6th day, the development of tolerance was initiated. These results suggest that the mechanisms of α- and β-blockers for the suppression of the development of analgesic tolerance to morphine are different from each other and that adrenergic blockers may produce a specific alteration in the mechanism for the development of tolerance to morphine.View full abstractDownload PDF (261K) -
Yoshio TSUCHIYA, Tomokazu HOSOKAWA, Yutaka KASUYA1989 Volume 50 Issue 4 Pages 403-410
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSIn this study, the effects of carotid chemoreceptors on reflex tracheal constriction were investigated in anesthetized, paralyzed, and artificially ventilated mongrel dogs. Reflex tracheal constriction was measured as changes in the intratracheal pressure of an air-filled balloon introduced into the rostral side of the transected trachea. A hypoxic condition was produced by ventilating the dog with 12%O2-88% N2. The reflex tracheal constriction induced by histamine inhalation to the bronchial side was reduced by section of the bilateral sinus nerves. The hypoxic condition significantly potentiated the reflex tracheal constriction induced by histamine inhalation. The potentiated reflex tracheal constriction during hypoxia was abolished by section of the bilateral sinus nerves. The afferent electrical stimulation to the central cut end of the vagus nerve caused a reflex tracheal constriction. The reflex tracheal constriction was significantly potentiated by hypoxia, and the potentiating response was abolished by section of the bilateral sinus nerves. The infusion of NaCN into the bilateral carotid arteries significantly potentiated the reflex tracheal constriction. The NaCN-induced potentiating effect was abolished by section of the bilateral sinus nerves. These results suggest that hypoxia potentiates the vagal reflex-induced tracheal constriction and that the hypoxia-induced potentiating effects may be mediated by carotid chemoreceptors.View full abstractDownload PDF (434K) -
Yoshimi KITADA, Miyuki MORITA, Akihiro NARIMATSU1989 Volume 50 Issue 4 Pages 411-419
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSSeveral cardiotonic agents (MCI-154, sulmazole, pimobendan and adibendan) were examined for their ability to influence Ca2+-activated tension development and MgATP-activated tension development in the absence of free Ca2+ (rigor tension), using the chemically skinned fiber from guinea pig papillary muscles. MCI-154, sulmazole, pimobendan and adibendan all increased the tension development induced by pCa (-log[Ca2+]M) 5.8 in a concentration-dependent manner (10-6 to 10-4 M). The order of the potency was as follows: MCI-154>pimobendan>adibendan>sulmazole. MCI-154 enhanced the maximum tension developed at pCa 4.4 but sulmazole, pimobendan and adibendan did not enhance it. MCI-154, but not sulmazole, pimobendan and adibendan, enhanced the tension development induced by pMgATP (-log[MgATP]M) 6.0 in the absence of free Ca2+. MCI-154, sulmazole, pimobendan and adibendan concentration-dependently (10-7 to 10-4 M) increased the force of contraction in isolated guinea pig papillary muscles. The order of the potency was as follows: MCI-154> adibendan>pimobendan>sulmazole. These results demonstrated that the Ca2+-sensitizing action on the contractile system may be involved in the positive inotropic action of MCI-154, sulmazole, pimobendan and adibendan, and that MCI-154 is the most potent among these drugs. Furthermore, sulmazole, pimobendan and adibendan did not enhance the interaction of actin and myosin, suggesting that the mechanism of actions of these drugs are qualitatively different from that of MCI-154.View full abstractDownload PDF (455K) -
Atsushi SUGIYAMA, Makio KOBAYASHI, Gozoh TSUJIMOTO, Shigeru MOTOMURA, ...1989 Volume 50 Issue 4 Pages 421-427
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSCGRP-immunoreactive nerve fibers were histologically stained in the endocardium and perivascular layer of coronary vessels of canine hearts. To examine the physiological role of the CGRP in the heart function, effects of exogeneous CGRP on the hearts were studied using canine isolated, blood-perfused heart preparations. CGRP exerted dose-related potent vasodilator effects with a minimal increase in the developed tension of the papillary muscle, but slightly decreased the sinoatrial rate. The vasodilator effects were unaffected by the pretreatment of either atropine or propranolol. These specific functional effects on the coronary artery are well in accordance with the anatomical localization of CGRP. Taken together, CGRP seems to play an important role in the regulation of coronary vascular tone, while it has only a small functional role in inotropism and chronotropism in canine hearts.View full abstractDownload PDF (353K) -
Terumasa MINO, Junko SUZUKI, Haruki HAYASHI1989 Volume 50 Issue 4 Pages 429-433
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe thrombolytic effect of locally or systemically administered recombinant human tissue-type plasminogen activator (rt-PA) was investigated in comparison with the effect of tissue culture urokinase (TCUK), using a model of femoral artery thrombosis in rabbits. An 1251-labeled fibrinogen thrombus was formed in the femoral artery following injury of the intima by diluted sulfuric acid, and thrombolytic activity was evaluated one hour after the end of infusion of the agents. Local infusion of rt-PA (500-10, 000 IU/kg) and TCUK (10, 000 IU/kg) induced a marked thrombolysis. When rt-PA and TCUK were injected systemically in a high dose (200, 000 IU/kg), rt-PA but not TCUK had a significant thrombolytic activity. In these cases, rt-PA was not accompanied by systemic activation of the fibrinolytic system, as evaluated by unaltered levels of α2-antiplasmin in the plasma, while TCUK led to a substantial decrease in the α2-antiplasmin level. These results suggest that systemically administered rt-PA but not TCUK induce a significant thrombolysis without systemic activation of the fibrinolytic system in cases of peripheral artery thrombosis.View full abstractDownload PDF (312K) -
Yasuhiro NISHIBE, Mitsuko HAMATAKA, Toshiaki HASEGAWA, Jiro IKEUCHI, T ...1989 Volume 50 Issue 4 Pages 435-443
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe effect of successive administration of the corticosteroid alclometasone dipropionate (ACM) on the hepatic drug-metabolizing system was examined using male and female rats. Although some pharmacological changes such as increases in plasma enzyme activity, lipid level and protein concentration appeared similarly in ACM-treated male and female rats, the activities of 7-alkoxy-coumarin 0-dealkylase, especially the O-depropylation activity, decreased dosedependently by ACM administration only in male rats. ACM did not affect the hepatic drug-metabolizing activity in female rats and mice of both sexes. Also, ACM did not inhibit androgen-independent aniline hydroxylase activity even in male rats. The time course of changes of the drug-metabolizing system in male rats showed a rapid decrease in cytochrome P-450 content and O-depropylation activity following successive treatments with ACM, but there was a slow onset in the decreases of the O-demethylation and O-deethylation activities of 7-alkoxy-coumarin. When ACM was withdrawn, the O-demethylation and O-deethylation activities rapidly returned to their control levels, while recovery of the O-depropylation activity was slow. These results suggested that ACM inhibits the hepatic drug-metabolizing enzyme activity associated with a specific form(s) of androgen-dependent cytochrome P-450 in male rats.View full abstractDownload PDF (647K) -
Hiroaki ARAKI, Yoshimi UCHIYAMA-TSUYUKI, Yasuko KARASAWA, Hironaka AIH ...1989 Volume 50 Issue 4 Pages 445-453
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSEffects of minaprine, a psychotropic drug, on changes in monoamines and their metabolites were examined in Mongolian gerbils with 5-min occlusion of the common carotid arteries. Noradrenaline (NA), dopamine, serotonin (5-HT), 5-hydroxyindol acetic acid, homovanillic acid and 3, 4-dihydroxyphenyl acetic acid contents in the cortex, hippocampus and striatum remained unaltered during a 5-min occlusion. NA levels in the cortex, hippocampus and striatum and 5-HT levels in the hippocampus and striatum significantly decreased 30 min-2 hr after re-circulation. Particularly, minaprine significantly inhibited the decrease of 5-HT in the hippocampus. These observations suggest that the effect of this drug on delayed neuronal death in the CA1 neurons in the hippocampus in Mongolian gerbils with occluded common carotid arteries may be related to the serotonergic system.View full abstractDownload PDF (372K) -
Shigekatsu W. KOHNO, Hiroshi HASHII, Keiko OGINO, Hideki YAMAMURA, Kat ...1989 Volume 50 Issue 4 Pages 455-466
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSEffects of oxitropium bromide (Ba253), which was administered by inhalation, on the resting and stimulus-induced airway resistance were examined in the artificially ventilated guinea pig and compared with those of ipratropium bromide (Sch1000), atropine and isoproterenol. Results obtained were as follows: 1) Ba253 as well as other reference compounds hardly affected the resting resistance. 2) Ba253 strongly and persistently inhibited the acetylcholine (ACh)-induced resistance. Sch1000 caused a similar but relatively weaker inhibition than Ba253. Either atropine or isoproterenol caused only a transient inhibition. 3) The increase in resistance induced by histamine, serotonin, leukotriene D4 or antigen was prevented by Ba253. Atropine, Sch1000 and isoproterenol also inhibited these reactions, but the effects and the duration were generally weaker and shorter than those of Ba253. 4) Repeated inhalations of Ba253 for 7 days did not influence the inhibition of the ACh-induced increase in airway resistance by this drug. However, isoproterenol tended to attenuate the suppression of the resistance by the drug. From these results, it is suggested that Ba253 is a useful inhalant drug for asthma.View full abstractDownload PDF (563K) -
Effects of CV-3611, a New Free Radical Scavenger, on Ischemic Heart Failure in Conscious Beagle DogsMasao TANABE, Go KITO1989 Volume 50 Issue 4 Pages 467-476
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe effects of CV-3611, a new free radical scavenger, on coronary circulation failure and infarct size after ischemia/reperfusion were studied in conscious beagle dogs. The dogs underwent occlusion of the left circumflex coronary artery for 60 min and then were reperfused for 14 days. The dogs were divided into three groups: a control group, a pre-treated group that received CV-3611 or α-tocopherol, and a post-treated group that received CV-3611. During occlusion, varying degrees of ventricular arrhythmia were noted; after reperfusion, the arrhythmia tended to become severe. CV-3611 at a daily dose of 10 mg/kg or 30 mg/kg and α-tocopherol at a daily dose of 60 mg/kg reduced the incidence of overall post-occlusion arrhythmia. Coronary blood flow in the control group was reduced to 20% of the preocclusion level at 7 days after reperfusion, whereas in the CV-3611 and α-tocopherol treated groups, the decreased coronary flow was remarkably suppressed. The infarct size for the CV-3611 and α-tocopherol-treated groups, measured at 14 days after reperfusion, was reduced by 70% when compared with the control group. Based on these observations, it is proposed that CV-3611 exerts its beneficial effects on ischemic tissue by protecting against oxygen free radical-mediated damage induced by ischemia/reperfusion.View full abstractDownload PDF (515K) -
Tomohisa HATTORI, Tadashi NAGAMATSU, Mikio ITO, Yoshio SUZUKI1989 Volume 50 Issue 4 Pages 477-485
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSIn this study, we investigated the antinephritic effects of TJ-8014 and crude drugs in TJ-8014, in comparison to dipyridamole, on original-type anti-GBM nephritis in rats. TJ-8014 (2.0 and 3.0 g/kg/day, p.o., for 12 days) markedly inhibited the urinary protein excretion and the elevation of the plasma urea nitrogen (UN). In addition, TJ-8014 was effective in inhibiting the histopathological changes of hypercellularity and adhesion in glomeruli. Although dipyridamole (0.4 g/kg/day, p.o., for 12 days) had no effect on the plasma UN level, it was as effective as TJ-8014 on the other parameters. When each crude drug which constitutes TJ-8014 was given p.o., daily at 0.2 g/kg, only Holen was effective in inhibiting the urinary protein excretion as well as histopathological changes. Ginseng radix reduced both the hypercellularity and the adhesion, while Bupleuri radix, Glycyrrhizae radix and Zizyphi fructus reduced only the hyper cellularity. TJ-8014 and dipyridamole inhibited the platelet aggregation in normal and nephritic rats. These results indicate that TJ-8014, like dipyridamole, has a beneficial effect on original-type anti-GBM nephritis in rats and the antinephritic action of TJ-8014 may be partly due to the antiplatelet action of this agent.View full abstractDownload PDF (543K) -
Mark C. Austin, Peter W. Kalivas1989 Volume 50 Issue 4 Pages 487-490
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe mu-opioid agonist, DAGO, and the indirect GABAA antagonist, picrotoxin, produced a dose-dependent increase in horizontal motor activity following injection into the nucleus accumbens that was independent of dopamine release. Injection of muscimol into the ventral pallidum antagonizes the motor stimulant effect of dopamine agonists. It was shown that muscimol abolished the locomotor stimulant effect of DAGO microinjection into the nucleus accumbens, and partially antagonized the effect of picrotoxin.View full abstractDownload PDF (227K) -
Kazuhiro TAMURA, Hiroshi KOGO1989 Volume 50 Issue 4 Pages 491-494
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSThe purpose of this paper was to evaluate the anti-ovulatory effects of indomethacin, aspirin and melatonin by examining the LH sensitive 13, 14-dihydroprostaglandin F2α forming capacity in rat ovary. When ovulation was blocked by aspirin or melatonin, the forming capacity was strongly suppressed, and these effects were reversed by hCG injection. However, the ovulation blockage by indomethacin did not accompany the inhibition of the forming capacity. These results show that aspirin and melatonin block the ovulation via the hypothalamuspituitary level, and indomethacin acts directly on the ovary.View full abstractDownload PDF (210K) -
Katsuo TAKASHI, Itsuki FUJITA, Kazumine KOBARI1989 Volume 50 Issue 4 Pages 495-498
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSEach addition of some short chain fatty acids (SCFAs) into casamino acids-yeast extract culture media at a concentration of 2 mg/ml reduced the production of heat-labile enterotoxin (LT) from enterotoxigenic Escherichia coli in proportion to the elongation of carbon chain from C-2 to C-7. The LT-production was inversely recovered by the addition of longer chain fatty acids. The reduction of LT-production by SCFAs seems to depend on the disturbance of the biosynthesis of LT itself, since LT was not detected in the cells treated with n-heptyric acid at 2 mg/ml, which abolished the LT-production.View full abstractDownload PDF (182K) -
Shin YOMOGIDA, Kimiko KOIWAI, Yoshihiro SHIBA, Masaaki ISHIKAWA, Yoshi ...1989 Volume 50 Issue 4 Pages 499-502
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSMixed-function oxidase activities of hepatic microsomal preparations from rats were examined after intraperitoneal administration of sizofilan (SPG), an immunomodulator. Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-demethylase and aniline hydroxylase.View full abstractDownload PDF (218K) -
Norifumi YONEHARA, Huei-Yann TSAI, Ji-Qiang CHEN, Reizo INOKI1989 Volume 50 Issue 4 Pages 503-506
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSSubstance P-like immunoreactivity (SPLI) and methionine-enkephalinlike immunoreactivity (MELI) were determined in salivary glands from rats by radioimmunoassay. In all salivary glands investigated (submandibular gland, sublingual gland and parotid gland), SPLI and MELI were detected. The amount of both peptides is comparable to or relatively higher than those found in any other peripheral tissue. The level of SPLI showed a tendency to increase following chronic treatment with morphine; the enhancement in the submandibular gland and the sublingual gland was especially remarkable. The level of MELI was decreased, particularly in the submandibular gland.View full abstractDownload PDF (189K) -
Masaru KUNITOMO, Yoko TANAKA, Kaori YAMADA, Yu YAMAGUCHI, Yoshio BAND& ...1989 Volume 50 Issue 4 Pages 507-510
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSAnthranilic acid (ANA), a metabolite of tryptophan, was examined for its immunopotentiating properties. Administration of ANA (12 mg/kg/day, p.o.) significantly enhanced the development of adjuvant arthritis in rats, although not in a dose-related manner. ANA tended to enhance adjuvant disease moderately suppressed by pretreatment with cyclophosphamide (CY), an immunosuppressive agent. ANA (3-30 mg/kg/day, p.o.) also caused a dose-related enhancement in the antibody formation to sheep erythrocytes (SRBC) in mice.View full abstractDownload PDF (182K) -
Ryuichi YAMAMOTO, Chikako NUKI, Hideyuki KOMIDORI, Koichiro TAKASAKI1989 Volume 50 Issue 4 Pages 511-514
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSIn the isolated guinea pig ileum, the effects of /-ephedrine on the twitch response to field stimulation were investigated in the presence of propranolol. Ephedrine and clonidine inhibited the twitch response but not the contraction to exogenous acetylcholine. The inhibitory effect of clonidine was significantly diminished by yohimbine pretreatment. However, the inhibitory effect of ephedrine was not influenced by yohimbine, sulpiride or 6-hydroxydopamine (6-OHDA) pretreatment. Most of this action of ephedrine appeared to be cholinergic prejunctional in nature, but unrelated to activation of prejunctional α2-adrenoceptors and dopamine sensitive receptors on the cholinergic nerves in this preparation.View full abstractDownload PDF (202K) -
Yukitsuka KUDO, Ryuichi ISHIDA1989 Volume 50 Issue 4 Pages 515-519
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSTo clarify the antivertiginous effect of afloqualone, an antispastic drug, we examined its action on the vestibular nervous system in cats. The results suggest that afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site.View full abstractDownload PDF (230K) -
Hiroshi OZAKI, Koichi SATO, Kiyoshi SAKATA, Hideaki KARAKI1989 Volume 50 Issue 4 Pages 521-524
Published: 1989
Released on J-STAGE: August 25, 2006
JOURNAL FREE ACCESSEndothelin induced rapid increase followed by a decrease in cytosolic Ca2+ ([Ca2+]i) and a slow increase in muscle tension in the vascular smooth muscle strip of rat carotid artery. Thus, the endothelin-induced contraction was smaller, and it, became gradually greater than high K-induced contraction at a given [Ca2+], i. In Ca2+-free solution, endothelin induced a transient increase in [Ca2+]i and a sustained contraction. These results suggest that endothelin-induced contraption is due to the increase in [Ca2+]i, the time-dependent change in Ca2+-sensitivity of contractile elements, and the mechanism which is independent of the increment in [Ca2+]i.View full abstractDownload PDF (203K)
- |<
- <
- 1
- >
- >|