巻号一覧
56 巻 (1991)
- 4 号 p. 397-
- 3 号 p. 249-
- 2 号 p. 121-
- 1 号 p. 1-
56 巻, 1 号
選択された号の論文の17件中1～17を表示しています
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Atsushi Sugiyama, Shigeru Motomura, Keitaro Hashimoto1991 年 56 巻 1 号 p. 1-12
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーTo assess the cardiovascular effects of a new class I antiarrhythmic agent, NIK-244, and to compare them with those of flecainide, canine isolated, sinoatrial node, papillary muscle and atrioventricular node preparations cross-circulated with a donor dog were used. NIK-244 injected intraarterially into the isolated preparations showed dose-related negative chronotropic, negative inotropic, and coronary vasodilator effects, which are comparable to those of flecainide, and it also showed a dose-related negative dromotropic effect on both atrio-His (AH) and His-ventricular (HV) conduction. The prolongation of AH interval by NIK-244 was significantly more potent than that by flecainide, while that of the HV interval by NIK-244 was slightly more potent, but not significantly, compared with that by flecainide. NIK-244 administered intravenously into the donor dog showed bradycardic and depressor effects in both the donor dog and the cross-circulated sinus node and papillary muscle preparations, which are comparable to the effects of flecainide. Although the negative dromotropic effects of NIK-244 on both the donor dog heart and the cross-circulated atrioventricular node preparation started more slowly, they were more potent and longer-lasting than those of flecainide. Our results suggest that NIK-244 may be a more powerful and longer-lasting antiarrhythmic agent than flecainide, since the anti-arrhythmic action of class I drugs is considered to result from inhibition of the fast inward current, which is the most important depolarizing current responsible for the intraatrial and His-Purkinje-ventriclar conduction.抄録全体を表示PDF形式でダウンロード (570K) -
Hiroichi Nagai, Kunihiko Kitagaki, Shoichi Goto, Hiroshi Suda, Akihide ...1991 年 56 巻 1 号 p. 13-21
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーThe anti-allergic and anti-asthmatic activities of three potassium (K+) channel openers, cromakalim, pinacidil, and nicorandil, were investigated. 1) Fortyeight-hour homologous passive cutaneous anaphylaxis (PCA) in mice was not affected by cromakalim, pinacidil, or nicorandil. Ketotifen significantly inhibited the reaction. 2) Antigen-induced histamine release from sensitized guinea pig lung tissue was not affected by cromakalim, pinacidil or nicorandil (except for 10-4 M nicorandil). Salbutamol inhibited the release of histamine. 3) Histamine, serotonin and LTC4-induced vasculitis in rat back skin was not affected by any of these three K+ channel openers. 4) Antigen-induced constriction of isolated sensitized guinea pig tracheal muscle was relaxed by each of the K+ channel openers. 5) Constrictions of isolated guinea pig tracheal muscle caused by high potassium, histamine, LTC4, or U-46619 were clearly relaxed by each of the three K+ channel openers. 6) Increases of airway resistance caused by histamine, LTD4, or U-46619 in guinea pigs in vivo were inhibited by administration of each of the three K+ channel openers. 7) Experimental asthma caused by the IgE antibody and antigen system in guinea pigs was inhibited by each of the three K+ channel openers.抄録全体を表示PDF形式でダウンロード (430K) -
Issei Takayanagi, Mariko Harada, Katsuo Koike1991 年 56 巻 1 号 p. 23-31
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーConcentration-response curves of 4 muscarinic full agonists were progressively inhibited by 10 to 50-min treatments of the longitudinal muscle of guinea pig ileum with propylbenzilylcholine mustard (PrBCM, 3 × 10-6 M). A 90-min treatment with PrBCM had no further significant inhibitory effect on their curves. The 50-min treatment with PrBCM (3 × 10-6 M) completely inhibited the concentration-response curves of 6 partial agonists. The limiting effect of PrBCM observed on the concentration-response curves of the full agonists was not found on the curves of the partial agonists. These results suggest that there are two subtypes of M3-cholinoceptors, PrBCM-sensitive receptors and PrBCM-resistant ones. Pilocarpine, a partial agonist, shifted the concentration-response curve of carbachol, a full agonist, in a parallel fashion in the strips treated with PrBCM (3 × 10-6 M) for 50 min, suggesting that an interaction of pilocarpine with PrBCM-resistant cholinoceptors does not induce contraction. The full agonists contract the longitudinal muscle through the interaction of two cholinoceptors, PrBCM-sensitive and -resistant ones, while the partial agonists produce the contraction through the activation of PrBCM-sensitive ones.抄録全体を表示PDF形式でダウンロード (415K) -
Renato Gaggi, Anna Maria Gianni1991 年 56 巻 1 号 p. 33-41
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーDiscrete brain sections were obtained from rats once or repeatedly (once a day for 5 days) given i.p. nifedipine, verapamil or diltiazem at doses ranging from 5 to 20 mg/kg. The biogenic amines and metabolites in the hypothalamus, brainstem, hippocampus, striatum, cortex and thalamus-midbrain were determined by high-performance liquid chromatography with electrochemical detection. The drug-induced changes, displaying regional specificity and differences according to the various compounds, suggested that: (a) serotonergic systems were activated, especially in fasted rats or after repeated treatment; (b) the dopaminergic system of the striatum was inhibited by nifedipine which did reduce the HVA levels and the HVA/DA, as well as the DOPAC/DA, ratio. These effects disappeared after repeated treatment. It was also speculated that the data obtained could be of great interest in view of the possible use of calcium antagonists to treat disorders of the central nervous system.抄録全体を表示PDF形式でダウンロード (422K) -
Akio Fujimura, Hiroyuki Kajiyama, Kyo-ichi Ohashi, Akio Ebihara1991 年 56 巻 1 号 p. 43-51
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーWe have previously demonstrated a time-dependent variability in the diuretic effects of S-8666, a new loop diuretic with uricosuric activity, in young rats. The present study was undertaken to determine whether such a daily variation in the effects of the agent exists in aged rats. S-8666 (30 and 90 mg/kg) was orally given at 12:00 a.m. (day trial) or at 12:00 p.m. (night trial) in young (10-11 week old) and aged (23-24 month old) Wistar rats. Urine was collected for 8 hours after the agent; and urinary excretions of sodium, S-8666 and its active metabolite S-8680 were determined. Urinary excretions of volume and sodium following S-8666 at 12:00 a.m. were greater than those at 12:00 p.m. in the young and aged animals. Urinary excretions of S-8666 and S-8680 were also greater in the day trial compared to those in the night trial in both groups of rats. In the day and night trials, there were significant correlations between urinary S-8666 + S-8680 and the diuretic effects in both groups of rats. These findings indicate that the diuretic effects of S-8666 also vary with its time of dosing in aged rats. The time-dependent variations in urinary S-8666 and S-8680 might be involved in this phenomenon.抄録全体を表示PDF形式でダウンロード (353K) -
Kazumasa Shimizu, Tsuyoshi Kaburagi, Shinjiro Nakajyo, Norimoto Urakaw ...1991 年 56 巻 1 号 p. 53-59
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーIn the present experiment, we studied the inhibitory mechanism of Na+ depletion on high K+-induced contraction by simultaneously measuring reduced pyridine nucleotides (PNred) or oxidized flavoproteins (FPox) fluorescence and contractile tension of the guinea pig ileal longitudinal muscle. Tension, PNred and FPox were all reversibly increased by the addition of hyperosmotic 65 mM KCl (H-65K+). A high K+, Na+-deficient (Iso-154K+) solution induced a contraction followed by a gradual relaxation and gradually decreased PNred fluorescence. A hyperosmotic addition of NaCl to the Iso-154K+ solution prevented the decreases in tension and PNred fluorescence. Addition of pyruvate or oxaloacetate restored the decrease in Iso154K+-induced contraction, but not the decrease in PNred fluorescence. In contrast to the PNred fluorescence, an application of the Iso-154K+ solution increased the FPox fluorescence which was not significantly changed by an addition of NaCl, pyruvate or oxaloacetate. These results suggest that the inhibitory mechanism of Na+ depletion on the Iso-154K+-induced contraction is an inhibition of glucose utilization.抄録全体を表示PDF形式でダウンロード (342K) -
Niro Inaba, Norihisa Inazu, Hiroshi Kogo, Tetsuo Satoh1991 年 56 巻 1 号 p. 61-69
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーThe pharmacological effects of antiestrogens on ovarian aldo-keto reductase and ovulation were investigated in rats. The activities of reduction of 13, 14-dihydro-15-keto-PGF2α, 4-benzoylpyridine and menadione in ovarian cytosol were significantly decreased by antiestrogen treatments, and the ovulation was completely inhibited. However, administration of luteinizing hormone-releasing hormone at 3:00 p.m. on the day of proestrus restored both enzyme activities and ovulation, which were inhibited by antiestrogens, to control levels. These results indicate that nonsteroidal antiestrogen inhibits the luteinizing hormone surge on the day of proestrus in 4-day cycling rats and that ovarian aldo-keto reductase may be closely involved in the ovulatory process in rats.抄録全体を表示PDF形式でダウンロード (535K) -
Akira Shimada, Tomoji Yanagita1991 年 56 巻 1 号 p. 71-77
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーTo observe the dispositional and functional tolerance to and physical dependence on barbital, the influence of repeated administration of the drug on serum barbital levels, coordinative motion, body weight, and cortical evoked potential was assessed. Rats administered the first dose of barbital showed marked impairment of gross behavior and then loss of the righting reflex. While they were repeatedly treated with barbital for a 4-week period, the CNS depression became weaker and weaker, and loss of the righting reflex was no longer observed. Serum barbital levels after administration of barbital tended to decrease by the 28th day of repeated drug administration. Coordinative motion was markedly impaired after administration of the first dose, but gradually recovered during the repeated administration period. Barbital at 100 mg/kg, i.p., prolonged the latent time of the evoked potential in normal untreated rats but not in tolerant rats. During the withdrawal period, no particular change was observed in the animals' gross behavior. However, body weight loss and shortening of the latent time of the evoked potential were observed at 60 to 72 hours of withdrawal. These results suggest that cortical evoked potenitial can serve as a useful method for observing tolerance to and physical dependence on barbital.抄録全体を表示PDF形式でダウンロード (344K) -
Akiko Yamamoto, Ken-ichi Shikada, Takehisa Iwama, Mitsuaki Sakashita, ...1991 年 56 巻 1 号 p. 79-84
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーWe have investigated the effect of NZ-107, an inhibitor of bronchoconstriction induced by slow reacting substance of anaphylaxis (SRS-A), on tracheal responses to adenosine in the guinea pig. In the presence of an adenosine uptake inhibitor, dipyridamole (1 μM), NZ-107 (0.3-1 μM) enhanced adenosine-induced relaxation in 30 nM leukotriene D4 (LTD4)-precontracted trachea, whereas aminophylline (AP, 10-30 μM), an adenosine receptor antagonist, markedly inhibited it. NZ-107 (1 μM) also enhanced the relaxation induced by forskolin, an adenylate cyclase activator, but not that by nitroprusside (NP), a guanylate cyclase activator. AP (30 μM) affected neither forskolin nor NP-induced relaxation. NZ-107 (1 μM) and AP (30 μM) inhibited to about the same extent the contractile response to an adenosine A1 receptor agonist, the R(-)-enantiomer of N6-(2-phenylisopropyl)-adenosine (R-PIA). The R-PIA-induced contraction was completely blocked by 5 μM indomethacin. NZ-107 (1 μM) did not affect the contraction induced by PGD2, but significantly reduced that of PGF2α. AP (30 μM) had no effect on PGF2α- and PGD2-induced contractions. These results suggest that NZ-107 may have a unique profile for adenosine responses in bronchial asthma.抄録全体を表示PDF形式でダウンロード (330K) -
Changes in Convulsion Susceptibility of Lidocaine by Alteration of Brain Catecholaminergic FunctionsYoshimichi Yoshimura, Toshihiro Dohi, Shoukichi Tanaka, Kazuaki Takada ...1991 年 56 巻 1 号 p. 85-91
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーInfluences of the manipulation of brain catecholaminergic neuronal activity on the incidence of lidocaine-induced convulsions in mice were studied and compared with those of pentylenetetrazol (PTZ)-induced convulsions. α-Methyl-p-tyrosine (α-MPT) decreased both brain noradrenaline (NA) and dopamine (DA) levels, and disulfiram decreased the NA level and increased the DA level. The incidence of lidocaine-induced convulsions was decreased by treatments with α-MPT and disulfiram, while that of PTZ was increased by either treatment. The incidence of lidocaine-induced convulsions was slightly, but not significantly increased by L-dihydroxyphenylalanine (L-DOPA), although the brain DA level was increased by L-DOPA. Methamphetamine and desipramine increased the incidences of lidocaine-induced convulsions. These results may suggest that brain catecholaminergic neurons, differing from their role in inhibiting control of PTZ-seizure, act to facilitate lidocaine-induced convulsions.抄録全体を表示PDF形式でダウンロード (369K) -
Walter I. Silva1991 年 56 巻 1 号 p. 93-96
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーClathrin coated vesicles (CV) from bovine brain express the various alpha subunits of guanine nucleotide regulatory proteins (G-proteins): Go, Gi 1, 2, 3 and Gs. Western blot analysis using two different antisera revealed the presence of the 39-kDa Go, alpha subunit in CV. Antisera RM/1, in turn, demonstrated the expression of the short (45 kDa) and long (52 kDa) form variants of the Gs alpha subunit. The analysis demonstrates that the heterogeneity of alpha subunits of G-proteins in bovine brain tissue is also reflected in the CV transport organelles.抄録全体を表示PDF形式でダウンロード (212K) -
Walter I. Silva1991 年 56 巻 1 号 p. 97-100
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーClathrin coated vesicles (CV) from bovine brain were analyzed via Western blots for the presence of the alpha and beta subunits of guanine nucleotide regulatory proteins. The results with the common alpha antibody GA/1 revealed the presence of apparently undissociated G-protein subunits migrating at approximately 80 kDa. The predominant band was of about 39-41 kDa, with minor labeling observed in the 41-52 kDa range. Western blot analysis for G beta subunit(s) revealed the presence of a single band of about 35-36 kDa.抄録全体を表示PDF形式でダウンロード (216K) -
Taeko Hata, Eiji Itoh, Atsufumi Kawabata1991 年 56 巻 1 号 p. 101-104
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーCentral nervous system levels of serotonin (5-HT) and 5-hydroxy-indoleacetic acid (5-HIAA) in SART (specific alternation of rhythm in temperature)-stressed (repeatedly cold-stressed) rats were examined by HPLC-ECD. In SART-stressed rats, the levels of both 5-HT and 5-HIAA decreased in many brain areas. In the spinal cord, only the 5-HT level decreased. Therefore, the ratio of 5-HIAA to 5-HT increased only in the spinal cord. These results suggest that SART-stressed rats have some form of abnormality in the synthetic system of 5-HT.抄録全体を表示PDF形式でダウンロード (227K) -
Akio Fujimura, Kyo-ichi Ohashi, Akio Ebihara1991 年 56 巻 1 号 p. 105-108
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーA new loop diuretic with uricosuric activity, 6, 7-dichloro-5-(N, N-dimethylsulfamoyl)-2, 3-dihydro-2-benzofuran carboxylic acid (S-8666), was given orally at 12:00 a.m. or 12:00 p.m. in rats. The diuretic of S-8666 and the urinary excretions of the drug and its active metabolite S-8680 (N-demethyl S-8666) were greater at 12:00 a.m. than at 12:00 p.m.. Thus, the present study indicates that the diuretic effects of S-8666 varies with its administration time. Time-dependent variations in the amount of urinary excretions of S-8666 and S-8680 might be involved in the mechanisms for this phenomenon.抄録全体を表示PDF形式でダウンロード (221K) -
Hiroshi Nojima, Ikuko Kimura, Masayasu Kimura1991 年 56 巻 1 号 p. 109-112
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーWe examined morphological differences and compared the Ca2+-dependence between acetylcholine (ACh)-contractures in normal and denervated skeletal muscle cells. ACh (1 μM -1 mM) contracted the normal cells into a jackknife-shape. The higher the concentration of external Ca2+, the greater the ratio of responding cells/total cells observed and the sharper the angles of the “jackknives”. ACh contracted the denervated cells into a compression-form, and the contraction was dependent on the external Ca2+ These results indicate that ACh-contractures in both normal and denervated cells are external Ca2+-dependent.抄録全体を表示PDF形式でダウンロード (358K) -
Kazuho Abe, Megumi Takayanagi, Hiroshi Saito1991 年 56 巻 1 号 p. 113-116
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーNeurotrophic effects of CS23, a mutein of human basic fibroblast growth factor (bFGF), and recombinant human epidermal growth factor (hEGF) were compared in dissociated cerebellar cultures from embryonic (E20) and early postnatal (P0-5) rats. Both CS23 and hEGF promoted the survival of cerebellar neurons without distinction of ages of animals used. The maximum effects of CS23 were always larger than those of hEGF. These results suggest that both bFGF and EGF also function as neurotrophic factors in postnatal cerebellum.抄録全体を表示PDF形式でダウンロード (245K) -
Kazuyoshi Kurahashi, Hachiro Usui, Masatsugu Iwamoto, Shunji Aoki, Ats ...1991 年 56 巻 1 号 p. 117-120
発行日: 1991年
公開日: 2006/07/11
ジャーナル フリーThe preganglionic trunk of the superior cervical ganglion was implanted chronically into the carotid artery. A helical strip of the carotid artery with nerve was prepared, and electrical stimulation of the nerve caused a definite contraction. Part of the contraction was attenuated by phentolamine, and the remaining part of the contraction was nearly abolished by tubocurarine but not by hexamethonium and atropine. The present results clearly demonstrate that the carotid artery is reinnervated by preganglionic cholinergic fibers.抄録全体を表示PDF形式でダウンロード (155K)
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