Much research has been made on the vasodepressive action of fresh defibrinated blood (1-5) and foreign serum (6-15). It is reported that histamine (16), acetylcholine (17), adenyl derivatives (18), etc., which contained blood, are the main substances, and furthermore that new substances as Kallikrein (19), substance P (20), substance Z (21), Felix-Lange's substance (22), Vesiglandin (23), and Bradykinin (24) which had their origin in living tissues brought down blood pressure. Previously Hongo and Ueno (25) have found that an intravenous injection of plasma, warmed at 37°C for 18-24 hours, showed a transitorily marked hypotensive effect on the blood pressure of cats. It is the purpose of this experiment to show that this active substance which appeared in the warmed plasma has been pharmacologically investigated, especially with regard to the mechanism of the vasodepressive effect.
Studies on medicinal herbs employed in hypertension have been recognized as being very important, but in Chinese. Medicine there is no word corresponding to hypertension so that the search for such become difficult. Fortunately, however, there is the word ‘hsüeh pi’, which means impairment of the circulation, and there are also statements of symptoms that may presumably be taken as those referring to hypertension. The writer therefore, collected materials based on the above, and investigations were first made on Panax Shinseng Nies, var. Notoginseng Burkill, and the results are indicated herein. According to Pen Ts‘ao Kang Mu, Panax Shinseng Nies, var. Notoginseng Burkill is a product of Kuang Shi Shên (China), and was employed as a medicine not much earlier than the time that Li Shi-Chên (1) first wrote about it in Pen Ts‘ao Kang Mu. Hence in books on Chinese Medicine earlier than this time there is no mention made of it. The assertions of Chinese Medicine are based on a special hypothetical theory of Yüng Yang, and the medicinal effects of Panax Shinseng Nies, var. Notoginseng Burkill also conform to this, so that a verbatin translation of this into English is difficult. The writer accordingly will dwell only on those aspects related to the application of this drug in blood congestion and hypertension. The writer has not yet actually seen this herb in its original form, but according to Ishidoya (2) the drug sold in the market is the dried root of Panax Shinseng Nies, var. Notoginseng Burkill. Also regarding studies on this drug, there is only the work of Nozu (3) in the literature, which states that : 1) Alcoholic extracts of the drug lower the blood pressure in rabbits.
Reflexes are appropriate reactions which can be employed for the purpose of testing drug actions on the central nervous system. We have used them for studies of Tetrodotoxin, poison contained in organs, particularly in ovaries of Fugu, a poisonous kind of globe fish living in Japan. The poison is considered to be a central paralysant, because hypesthesia, paresthesia, motoric paralysis and finally respiratory stillstand are the symptoms of its poisoning, and there are also studies which establish its central action.