The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
8 巻, 1 号
選択された号の論文の9件中1~9を表示しています
  • REIJI IMAIZUMI, HIROSHI YOSHIDA, HIDEO MATSUMOTO, TAKEHIKO OSAWA
    1958 年 8 巻 1 号 p. 1-8
    発行日: 1958年
    公開日: 2007/02/09
    ジャーナル フリー
  • REIJI IMAIZUMI, HIROSHI YOSHIDA, TOMITARO KITA
    1958 年 8 巻 1 号 p. 9-21
    発行日: 1958年
    公開日: 2007/02/09
    ジャーナル フリー
    Adrenaline and noradrenaline have been shown until recently to be metabolized according to the following three mechanism in vivo ;
    1) oxidative deamination of side chain by amine oxidase
    2) oxidation of the phenolic group of the ring to form adrenaline-quinone and adrenochrome
    3) conjugation of the phenolic group of the ring
    Previous studies in our laboratory presented evidence for existence of a new enzyme named adrenaline dehydrogenase, which catalyzes the oxidation of adrenaline and noradrenaline to their keto forms, adrenalone or noradrenalone respectively (1-3). Moreover, adrenalone has been found in blood of rabbits (4). On the basis of these results, it has been assumed that a metabolic pathway of adrenaline and noradrenaline via adrenalone and noradrenalone may exist in vivo. This paper presents the results of a survey of the new metabolic pathway.
  • PHYSIOLOGICAL MEANING OF TYRAMINE AS A PRECURSOR OF ADRENALINE
    REIJI IMAIZUMI, HIROSHI YOSHIDA, HIROMITSU HIRAMATSU, KIYOSHI OMORI
    1958 年 8 巻 1 号 p. 22-30
    発行日: 1958年
    公開日: 2007/02/09
    ジャーナル フリー
    The possibility that adrenaline may arise from tyramine in adrenal gland was first postulated by Ewins and Laidlaw (1) in 1910. This was supported by the perfusion data of Nikolaeff (2) and the slice experiment of Schuler (3), Devine (4) and Holtz (5) which demonstrated the conversion of adrenaline from tyramine, but not from tyrosine, dihydroxyphenylalanine (dopa), or phenylalanine. However, since the experiment of Halle (6) in 1906, Guggenheim (7), Knoop (8), Rosenmunt and Dornsaft (9) asserted that tyrosine might be an effective precursor of adrenaline. In 1938, previous studies (10, 11) in our laboratory presented the evidence for the existence of this pathway, and later this was confirmed by the isotopic data of Udenfriend et al. (12) which established that adrenaline was formed from tyrosine, but not from tyramine in vivo. Recently the reaction of hydroxytyramine to noradrenaline has been demonstrated to be catalysed by an enzyme requiring FAD and Fe++ (13). Thus it is generally assumed at present that the following reaction sequence takes place as the main pathway to form adrenaline.
    Tyrosine→Dopa→Hydroxytyramine→Noradrenaline→Adrenaline
    More recently it has been found in our laboratory that tyramine was oxidized to hydroxytyramine in blood and liver of rabbits (14, 15). This observation suggests the possibility that tyramine might be also a precursor of adrenaline, if the same oxidation process would be demonstrated to occur in adrenal gland. In the present paper the results of a preliminary survey of this metabolic pathway are described, together with the properties of the enzyme responsible for the oxidation of tyramine to hydroxytyramine in adrenal gland.
  • HIROSHI MATSUMOTO, MUTSUO CHIHARA
    1958 年 8 巻 1 号 p. 31-47
    発行日: 1958年
    公開日: 2007/02/09
    ジャーナル フリー
  • KIRO SHIMAMOTO, KUNIO INOUE, SUSUMU OYAIZU
    1958 年 8 巻 1 号 p. 48-57
    発行日: 1958年
    公開日: 2007/02/09
    ジャーナル フリー
    It is usually accepted that the sympathetic innervation of the salivary glands in the dog is also motoric to the secretory activity as in the case of the parasympathetic innervation (1). The authors, in a preliminary report (2), showed evidence that the chief mode of the sympathetic innervation of the glands consists in the inhibitory effect on the secretory activity rather than the motoric effect in the dog, anesthetized with amytal sodium.
    The effect of the denervation of the submaxillary gland in the cat and the dog, which appears within 10 to 14 days after the extirpation of the superior cervical ganglion and causes an increased secretory response to the sympathomimetic amines, has already been observed by Bernard (3). But this denervation effect of the salivary gland was observed only with regards to the motoric activity of the amines.
    The present report deals with not only the motoric but also the inhibitory responses of the sympathetically denervated salivary glands of the dog to adrenaline and noradrenaline, as well as the motoric responses of the glands to cholinergic drugs.
  • SABURO HARA, RYOHEI NAGATA, TAKESHI SHIBUYA
    1958 年 8 巻 1 号 p. 58-62
    発行日: 1958年
    公開日: 2007/02/09
    ジャーナル フリー
  • KENGO NAKAI
    1958 年 8 巻 1 号 p. 63-69
    発行日: 1958年
    公開日: 2007/02/09
    ジャーナル フリー
    Recently, Erspamer (1) has reported that the urine of adult rabbit, guinea pig and horse contains no detectable 5-hydroxyindoleacetic acid (5-HIAA), which is found in the urine of man, dog and rat as a main metabolite of endogenous 5-hydroxytryptamine (5-HT), and he (2) has suggested that in adult herbivores the metabolic pathway for 5-HT may be different from that existing in carnivorous and omnivorous mammals.
    It may be supposed that, in herbivorous animals, oxidative deamination of 5-HT is only the first step of a more radical breakdown process, which may even involve the rupture of the indole ring.
    In the present investigation, experiments were designed, therefore, to examine the metabolic sequence of 5-HT.
  • II. ALCOHOLIC DRIVE IN MICE FOLLOWING ADMINISTRATION OF HEPATOTOXIC AGENTS
    SHOICHI IIDA
    1958 年 8 巻 1 号 p. 70-74
    発行日: 1958年
    公開日: 2007/02/09
    ジャーナル フリー
  • HARUYASU MITANI
    1958 年 8 巻 1 号 p. 75-85
    発行日: 1958年
    公開日: 2007/02/09
    ジャーナル フリー
feedback
Top