This paper deals with the results of a study undetaken to obtain information on the dropount cases from the clinical double blind comparative methods performed with six kinds of psychotropic drugs in patients with a psychosomatic disease treated in the field of internal medicine.Of 404 patients, 50 or 12.4% were considered dropouts, females accounting for 14.0% and meles for 9.9%.The causes were not clear in more than half of the dropout cases. The causes of dropouts included, side effects of drugs, no change, aggravation or improvement of symptoms, transfer and refusal of taking medicine.According to the degree of illness, the reasons for dropping out were not clear in the majority of severe cases, clear in about a half of the moderate cases, and clear in all the mild cases.With regard to diagnoses, the dropout rate was 17.5% for neurosis, 11.3% for depression, and 10.0% for psychosomatic disease.According to the results of psychological tests, the dropunt rate was relatively high in the Type IV cases of CMI evaluated by the Abe method, in the cases of MAS showing a high score but lacking in reliability or reasonableness, and in the YG personality test showing B or E types.On the other hand, an investigation was carried out to determine the effect of a beta-blocker, other than the psychotropic agents, on psychosomatic diseases such as cardiac neurosis, various types of tremor, and labile hypertension from the standpoint of anxiety and tension. Judging from the favorable responses which a beta-blocker elicited in such psychosomatic diseases, it seems that this drug finds its increasing usefulness in clinical application.
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