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Article type: Cover
2011 Volume 51 Issue 10 Pages
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Article type: Cover
2011 Volume 51 Issue 10 Pages
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Article type: Index
2011 Volume 51 Issue 10 Pages
863-
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Article type: Index
2011 Volume 51 Issue 10 Pages
863-
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Article type: Appendix
2011 Volume 51 Issue 10 Pages
864-870
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Article type: Appendix
2011 Volume 51 Issue 10 Pages
871-874
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Article type: Appendix
2011 Volume 51 Issue 10 Pages
875-
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Article type: Appendix
2011 Volume 51 Issue 10 Pages
876-
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Satoru Yoshikawa
Article type: Article
2011 Volume 51 Issue 10 Pages
877-
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Takashi Ueyama
Article type: Article
2011 Volume 51 Issue 10 Pages
879-884
Published: October 01, 2011
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Catecholamine intoxication and disturbance of coronary microcirculation, both of which may be responsible for the pathogenesis of takotsubo cardiomyopathy, could trigger the oxidation stress response in the cardiovascular system. We investigated expression and localization of inducible hemeoxygenase 1 (HO-1) and inducible cyclooxygenase 2 (COX-2), one of the oxidative stress-related factors in the heart and the aorta of immobilization stressed (IMO) rats, an animal model of takotsubo cardiomyopathy. In response to IMO, the levels of HO-1m RNA and COX-2m RNA were increased at 3h in the heart and at 1h in the aorta, respectively. The signals for HO-1m RNA were expressed in the scatted cells in the myocardium and the aortic adventitia. The signals for COX-2m RNA were expressed in the scatted cells in the myocardium and in the spindle cells in the aortic media. Blocking of α or β-adrenoceptor significantly attenuated up-regulation of HO-1m RNA levels in the heart. Blocking of α-adrenoceptor completely abolished the up-regulation of COX-2m RNA levels in the aorta, while blocking of β-adrenoceptor completely abolished the up-regulation of COX-2m RNA levels in the heart. Thus, emotional stress and surge of catecholamine up-regulate HO-1 and COX-2 in the heart and in the aorta.
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[in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
885-
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Takehiro Nozaki
Article type: Article
2011 Volume 51 Issue 10 Pages
886-895
Published: October 01, 2011
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The relationship between lifestyle-related diseases and depression has recently been a particularly noteworthy topic. When diabetes and obesity, representative lifestyle-related diseases, are comorbid with depression, the self-management ability of patients and their quality of life (QOL) are reduced, and an increased risk of various vascular complications has been well documented. Moreover, medical expenses dramatically increase, which put on immense strain on national budgets. Thus, for physicians who treat diabetes and obesity, the ability to cope with the various situations presented them while taking into consideration the psychosocial aspects associated with the diseases, including depression, is of utmost importance. In this paper, I introduce new findings concerning the relationship between diabetes, obesity and depression based on the latest overseas reviews and report the outcomes of our research.
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Tetsuaki Inamitsu
Article type: Article
2011 Volume 51 Issue 10 Pages
896-901
Published: October 01, 2011
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It is well known that depression is complicated with various life style-related diseases. In cardiovascular diseases, hypertension and coronary heart diseases (CHD) are frequently associated with depression, and depression worsens the prognosis of basal heart diseases. Depression had been considered a behavioral risk factor for life style-related diseases. But recently, functional changes in the autonomic nervous, hormonal, and immune system under depression, causes life style-related diseases. Thereafter, intervention trials to treat depression of the patients with CHD have been made. It was clarified that intervention to treat depressive patients with CHD decreased depressive symptoms, but didn't affect the prognosis of CHD. In the treatment for the cardiovascular patients with depression, heart disease and depression should not be treated separately, but should be treated from the bio-behavio-psychosocial view points, that is, holistic medical care.
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Sumiko Okura, Mikiko Okamoto, Motozumi Okamoto, Yasuhiro Yamanaka
Article type: Article
2011 Volume 51 Issue 10 Pages
902-909
Published: October 01, 2011
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Background: A medical psychologist, evaluating Baumtest (tree-drawing test) of diabetic inpatients, noted interruption of the "trunk", which is normally drawn as a single line, and its continuation with an additional line. We defined this pattern as "Intermittent trunk". To clarify the clinical usefulness of the indicator "Intermittent trunk" on Baumtest in diabetics, we examined the psychological and clinical characteristics of the diabetic inpatients. Method: Subjects were 58 diabetic inpatients (men/women=32/26; mean age at admission=66.3±10.8 years; BMI=24.9±4.6; HbA1c=9.7±2.3%). A clinical psychologist, conducting interviews for psychosocial information, examined Baumtest and questionnaires for Probrem Area In Diabetes Survey (PAID), the Dietary Distress Scale, and Self-rating Depression Scale. Results: The total scores of PAID obtained from women were significantly higher than those from men (34.0±9.2 vs. 29.1±6.0, respectively, p<0.05). The Dietary Distress Scale (26.5±5.7) and Self-rating Depression Scale (28.9±6.4) showed no differences between men and women. The total scores of PAID were significantly correlated with both the Dietary Distress Scale (r_s=0.62, p=9.880E-08) and duration of illness (r_s=0.32, p=0.00658). However, the total scores of PAID were not related to HbA1c. The subjects were divided into three groups: a group without "Intermittent trunk" (n=29), an "Intermittent trunk" group (n=15), and modified "Intermittent trunk" group (n=14). The total scores of three questionnaires (PAID, the Dietary Distress Scale, and Self-rating Depression Scale) were not high and showed no differences between the three groups. On the other hand, a Sex difference was found between the "Intermittent trunk" and modified "Intermittent trunk" groups (Yates Chi=9.323, p=0.009). The Modified "Intermittent trunk" group showed a significant decrease in both the fasting and postprandial C-peptide levels, analyzed using the Kruskal-Wallis test (fasting: H=7.494, p<0.05, postprandial; H=9.07, p<0.01). "Intermittent trunk" group also showed the same tendency toward a decrease in endogenous insulin secretion. Conclusion: In diabetic patients, the indicator "Intermittent trunk" on Baumtest, which is a non-verbal projective method, might be an aid of psycho diagnosis beyond assessment using the questionnaires of PAID, the Dietary Distress Scale, and Self-rating Depression Scale.
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Tomomi Hattori, Yumiko Yoshihara, Yuki Nemoto, Tomonori Sato, Keiko Su ...
Article type: Article
2011 Volume 51 Issue 10 Pages
910-918
Published: October 01, 2011
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Background: Brachial-ankle pulse wave velocity (baPWV) is a new measure of arterial stiffness. A recent study has shown that 1700cm/sec or higher baPWV predicts total mortality in the general population. Age and blood pressure strongly correlate with the baPWV. It remains unclear, however, if psycho-behavioral factors could affect the baPWV independent of traditional risk factors. Methods: We measured baPWV, blood pressures and heart rate in 526 patients with hypertension (58.6±12.3 years, 307 male). Lipid and sugar metabolisms were examined by fasting blood. The degrees of type A behavior, statetrait anxiety and depression were measured by self-reported questionnaires. The relationship between psycho-behavioral characteristics and the baPWV was examined in the old (60yrs or older) and young (less than 60yrs) groups for both genders. Results: Age, systolic blood pressures and heart rate were independent determinants for the baPWV in all groups. In addition, the state of anxiety was an independent modulator for the baPWV in old women group (p<0.05). The odds ratio of having 1700cm/sec or higher baPWV in moderate, high, and highest state of anxiety groups was 1.80 (95% CI; 0.45-7.14), 2.20 (95% CI; 0.53-8.98), and 4.36 (95% CI; 0.94-20.30), respectively, in reference to low state of anxiety group. No other psycho-behavioral characteristics were related to the baPWV in any group. Conclusion: Our results suggest that the state of anxiety is an independent risk factor for arterial stiffness in old women with hypertension.
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Motohiro Arai, Fumiyuki Goto, Takashi Hosaka
Article type: Article
2011 Volume 51 Issue 10 Pages
919-926
Published: October 01, 2011
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Background: Vertiginous patients are more likely to have a psychological fear according to dizziness. The psychological fear may make dizziness obstinate and greatly influences prognosis, too. Moreover, previous researches reported that improvement of QOL is not enough for the patients with depression who constitutes about 10% of vertiginous patients. Method: We provide an in-hospital group with vestibular rehabilitation in our hospital. In this study, patients received SDS test at the time of admission, and SDS≧50 patients as "Depression group" was assessed of the efficacy of group rehabilitation combined with SSRI (fluvoxamine). Result and Conclusion: SF8 score improved significantly after treatment compared with baseline, but they did not reach to the average score in Japan. POMS score was significantly improved after treatment. Moreover, fluvoxamine treatment was more effective with 150mg/day than 100mg/day which was reported previously. Improvement of POMS score was necessary in the course of adqute improvement of psychological functions (MCS etc.) in the depression group.
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Shingo Ono, [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
927-934
Published: October 01, 2011
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[in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
935-
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[in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
936-
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[in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
936-937
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[in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
937-
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[in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
937-
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[in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
937-938
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[in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
938-
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2011 Volume 51 Issue 10 Pages
938-939
Published: October 01, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2011 Volume 51 Issue 10 Pages
939-
Published: October 01, 2011
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
939-
Published: October 01, 2011
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
939-
Published: October 01, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
940-
Published: October 01, 2011
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[in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
940-
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2011 Volume 51 Issue 10 Pages
940-
Published: October 01, 2011
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[in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
940-941
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2011 Volume 51 Issue 10 Pages
941-
Published: October 01, 2011
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[in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
941-
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[in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
941-
Published: October 01, 2011
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
941-942
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[in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
942-
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2011 Volume 51 Issue 10 Pages
942-
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[in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
942-943
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[in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
943-
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Article type: Article
2011 Volume 51 Issue 10 Pages
943-
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2011 Volume 51 Issue 10 Pages
943-
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
Article type: Article
2011 Volume 51 Issue 10 Pages
944-
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
944-
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[in Japanese], [in Japanese], [in Japanese]
Article type: Article
2011 Volume 51 Issue 10 Pages
944-
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Article type: Appendix
2011 Volume 51 Issue 10 Pages
945-954
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Article type: Appendix
2011 Volume 51 Issue 10 Pages
954-
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Article type: Appendix
2011 Volume 51 Issue 10 Pages
955-957
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Article type: Appendix
2011 Volume 51 Issue 10 Pages
958-959
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Article type: Appendix
2011 Volume 51 Issue 10 Pages
960-962
Published: October 01, 2011
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