Japanese journal of pediatric nephrology
Online ISSN : 1881-3933
Print ISSN : 0915-2245
ISSN-L : 0915-2245
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Volume 8, Issue 1
Displaying 1-18 of 18 articles from this issue
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  • Changes in peritoneal equilibration test following peritonitis in children receiving continuous peritoneal dialysis
    Akinori Nishi, Katsumaro Aida, Yusuke Amamoto, Yuhei Ito
    1995 Volume 8 Issue 1 Pages 51-55
    Published: April 30, 1995
    Released on J-STAGE: December 15, 2009
    DOIhttps://doi.org/10.3165/jjpn.8.51
    JOURNAL FREE ACCESS
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    [in Japanese]
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  • Regulation of Mn-superoxide Dismutase Expression in Glomerular Cells
    Toshimasa Yoshioka, Noriko Iwamoto, Yuri Tsunoda, Kosaku Nitta, Katsum ...
    1995 Volume 8 Issue 1 Pages 57-63
    Published: April 30, 1995
    Released on J-STAGE: December 15, 2009
    DOIhttps://doi.org/10.3165/jjpn.8.57
    JOURNAL FREE ACCESS
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     The manifestation of oxidant-mediated renal injury is determined by the dynamic balance between the pathogen, oxidant stress, and the defense mechanism, antioxidants. Although several antioxidant enzymes, such as superoxide dismutases, glutathione peroxidase, catalase have been identified, their molecular structure, regulation and reactions in kidney are less characterized.
     Glomerular expressions of Mn-superoxide dismutase (SOD) are reduced in an early phase of puromycin aminonucleoside nephrosis and ischemic renal injury in rats, as well as in human primary nephrotic syndrome at relapse. The expression is enhanced by glucocorticoid, tumor necrosis factor, interleukins, and oxidant stress. The mechanism for these changes in the glomerular enzyme expressions includes transcriptional regulation. Thus, Mn-SOD contains response elements (binding sites for the transcriptional factors) for glucocorticoid receptor, and intracellular factors responsive to serum elements, and oxidant stress. When glomerular antioxidant enzymes are enhanced by oxidant stress or by glucocorticoids, these tissues or cells confer resistance against subsequent oxidant stress.
     Since oxidants are mediators of glomerulonephritis, nephrotic syndrome, acute and chronic renal failure, and renal allograft rejection, gene regulation of antioxidant enzymes in such pathophysiological conditions is an important factor for the development and/ or progression of renal diseases.
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