This research performs clinical evaluation of vascular malformation of the oral region treated by photocoagulation with an Nd:YAG laser. We report on the clinical characteristics of 70 patients who were treated for vascular malformations of the oral region from 2004 to 2012 in our hospital. The patients consisted of 23 males and 47 females, with a median age of 49.7 years. The parts in which a lesion existed were: lips 34 cases, tongue 27 cases, buccal mucosa 7 cases, gum 3 cases, mouth floor 2 cases, and soft palate 1 case.Legion size was classified into two groups: a small size of < 15mm, and a large size of 15mm ≤, and the necessity for hospitalization, in an operation and postoperative bleeding, swelling, pain, scar formation, nerve paralysis, postoperative infection, and the number of irradiation times were evaluated. Laser irradiation was performed under local anesthesia in all the cases. Critical bleeding did not occur. Postoperative swelling occurred in ten cases (16.7%) among the 60 cases with the size of < 15mm, and occurred in nine cases (64.3%) among the 14 cases with the size of 15mm ≤. Pain occurred in 11 cases but all cases of pain were slight. Scar formation occurred in three cases; all these cases were 15mm ≤ in size. Nerve paralysis occurred in two cases that occurred in the buccal mucosa fold near mandibular premolars. The good therapeutic result was obtained without any critical complications arising except in external irradiation using an Nd:YAG laser.