原生動物学雑誌
Online ISSN : 2189-6747
Print ISSN : 0388-3752
39 巻 , 2 号
選択された号の論文の5件中1~5を表示しています
Short Communication
  • Hiroyuki Tanabe, Shu-Yun Le
    2006 年 39 巻 2 号 p. 151-156
    発行日: 2006年
    公開日: 2018/08/03
    ジャーナル フリー

    The MS2 gene of Paramecium tetraurelia is supposed to be intimately implicated in the programmed association between sexual reproduction and life span and in the eventual setting of its maximum life span. The transcript of this gene is presumably an mRNA-like non-coding RNA, the function of which is evolutionarily conserved in its specific secondary structure. Therefore, characterizing the secondary structure of MS2 RNA would yield important insights about the molecular mechanism for the above cellular process that is shared among all of the organisms possessing limited longevity. In this study, it was found that P. tetraurelia has a close homolog of MS2 which undergoes the same regulation of expression as with MS2. We computationally analyzed the RNA secondary structures of MS2 and the homolog and detected four types of well-ordered structures that are both significantly more ordered and thermodynamically stable than anticipated at random. Our database searches revealed that these consensus structural features are conserved from other protozoan species to mammals. These results may suggest the functional importance of the distinct RNA structures in relation to the cellular program for organismal life span.

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