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Volume 29 (2010)
- Issue 3 Pages 3_31a-
- Issue 2 Pages 72-
- Issue 1 Pages 1-
Volume 29, Issue 2
Displaying 1-6 of 6 articles from this issue
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Noriaki Kondo2010 Volume 29 Issue 2 Pages 72-77
Published: June 25, 2010
Released on J-STAGE: May 13, 2011
JOURNAL FREE ACCESSMammalian hibernation is thought as a phenomenon that animals maintain low body temperature for a long time. Therefore, an artificial induction of hibernation has often been confused with the induction of low body temperature. However, hibernation is developed through a physiological modulation that protects organisms from lethal hypothermia, diseases and stresses. Our studies have shown that myocardial Ca2+ regulation is circannually modulated for tolerating low body temperatures during the hibernation season and further identified hibernation-specific protein (HP) complex as a promising hibernation hormone that is increased and activated in the brain under control of an endogenously generated circannual rhythm. By clarifying the hormonal control of hibernation, an artificial control of hibernation will be realized.View full abstractDownload PDF (2432K) -
Hiroyuki Uchino, Tadashi Tanoue, Mikiko Tomino, Naoto Iwase, Kentaro M ...2010 Volume 29 Issue 2 Pages 78-90
Published: June 25, 2010
Released on J-STAGE: May 13, 2011
JOURNAL FREE ACCESSThere are various disease-induced brain damage, however the common pathophysiology is based on brain ischemia. So far, excessive release of excitatory amino acid, especially, massive glutamate release and intracellular increase of calcium ion leads to activate the signal transduction pathway in neurons to induce ischemic brain damage. Recently, activation of intracellular calcium-dependent enzyme, calcineurin and mitochondrial cyclophilin D play an important role to induce ischemic brain damage. This paper introduces the results of our molecular biological approaches, including the mitochondrial dysfunction and discuss about the ways of perspectives for brain protection.View full abstractDownload PDF (4498K)
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Dai Yoshizawa, Masaru Sasaki2010 Volume 29 Issue 2 Pages 91-97
Published: June 25, 2010
Released on J-STAGE: May 13, 2011
JOURNAL FREE ACCESSThere are many differences between urban city and suburban city in life style and social systems and so on. Even though industrial development and social systems consolidate and enhance a disaster management, once unexpected disaster happens, as for the urban victims, they will face to many complicated problems.
Because of densely clustered crowds and many debris and rubble from structural destruction, they can not evacuate victims from the disaster site by themselves and rescuers coming from non-affected area can not rearch the site.
Despite efficient management, medical needs in disaster area overwhelm the capasity of the emergency physicians responsibilities.
So the role of public service must be developing the more close relationship with other systems and facilities for providing more relevant measures against disasters.View full abstractDownload PDF (2745K) -
Takashi Araki, Nobuhito Morota, Hiroyuki Yokota2010 Volume 29 Issue 2 Pages 98-102
Published: June 25, 2010
Released on J-STAGE: May 13, 2011
JOURNAL FREE ACCESSJapan has been holding a nationwide discussion regarding the determination of neurological death for over two decades. Although Japan's Organ Transplantation Law has already enacted in 1997, it is still challenging to facilitate increasing the number of organ transplantation from brain-dead donors in Japan because of many controversies. Especially, removal of organs from brain dead children will be allowed after the Law is revised in July 2010, however, many issues still need to be solved. In this article, several important points are discussed from medical perspectives.View full abstractDownload PDF (2269K) -
Norio Ueda, Masatomo Hayashi, Shigeru Mori, Hajime Mikamo, Ryusuke Kat ...2010 Volume 29 Issue 2 Pages 103-106
Published: June 25, 2010
Released on J-STAGE: May 13, 2011
JOURNAL FREE ACCESS29 y.o. man was transferred to our emergency department with loss of consciousness which started several minutes after he was thrown to the ground during judo practice. On arrival, the conscious level was GCS 1/1/3, and the pupils showed no light reflex with anisocoria, right 7mm/left 4mm. Head CT showed acute subdural hematoma of 3*11 cm with a significant midline shift. We performed hematoma evacuation for external decompression immediately. After the operation, we kept him at 35 degrees Celsius as mild hypothermic treatment for 48 hours and performed barbiturate coma therapy for 7 days, monitoring intracranial pressure, O2SAT of jugular vein (SjO2), and the temperature of internal jugular vein as the brain temperature. As a result, he recovered consciousness fully on day 10, and was discharged home without any neurological abnormalities on day 54. This case showed the effectiveness of mild hypothermic treatment and barbiturate coma therapy for severe head injury.View full abstractDownload PDF (1961K)
CASE REPORT
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Atsushi Yoshitake2010 Volume 29 Issue 2 Pages 107-111
Published: June 25, 2010
Released on J-STAGE: May 13, 2011
JOURNAL FREE ACCESSA patient arrested during anesthesia was successfully managed with induced mild hypothermia and cardiopulmonary bypass (CPB). A woman, aged around 70 years, who had been diagnosed with severe aortic stenosis was scheduled to undergo aortic valve replacement. Soon after sternotomy, sudden bradycardia and low blood pressure developed, leading to ventricular fibrillation. Both CPB and systemic hypothermia were induced immediately. Low blood pressure and ventricular fibrillation continued for 10 min before CPB. The patient was cooled and maintained at target right tympanic and rectal temperatures of around 24°C during CPB. Aortic valve replacement proceeded uneventfully. She was weaned from CPB at right tympanic and rectal temperatures of 36.1 and 36.4°C, respectively. Postoperative induced hypothermia (target pulmonary artery temperature, 35°C) was applied over a period of 48 h with systemic natural cooling and ice packs around her head and neck. She was discharged to another hospital on post-operative day 19 with no neurological complications. Our experience suggests that induced hypothermia with systemic natural cooling and ice packs around the head and neck is a safe and feasible option for post-resuscitation intensive care, avoiding the need for emergency and intensive care teams.View full abstractDownload PDF (1764K)
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