The survey of the excretion concentration of various organo-chlorine pesticides in breast milk was performed on 3 districts in Wakayama prefecture. Tanabe City which is distant from Gobo. City adjoing Kawanabe-cho, was a relatively low contaminated district. The regional result is caused by the fact that the residents in Tanabe City were all housewives in non-farmer who were no contaminated by direct exposure to pesticides, and the intake of milk products and vegetables contaminated by pesticides in a food cycle was a relatively small quantity.
Since 1961 public health surveillances on the health of peoples in the rural districts in Wakayama Prefecture were carried out by M. Shirakawa, one of the authors, for a long time. For three years since 1968, health check and medical examinations were performed to the peoples in 5 towns and 3 villages: Kôyaguchi-chei (town), Katsuragi-chô, Nogami-chô, Kibi-chô, Kokawa-chô, Hanazono-mura (village), Ryajin-mura, and Kitayama-mura in Wakayama Prefecture. The results obtained were as follows: 1. After the examination of specific gravity of whole blood, hemoglobin, hematocrit, specific gravity of serum, and serum pi-otein, anemia were found in high level, especially it was evident in Tsuegayabu areas of Kôyaguchi-chô, Shinjô areas of Katsuragi-chô, Nogami-chô, Ryûjin-mura, and Kitayama-mura. Furthermore, infection rates of such intestinal parasites as ascaris, hookworm, whipworm were remarkably high. 2. Incidence rate of anemia of the peoples in Kibi-chô, Kokawa-chô, and Hanazono-mura were relatively low, and infection rates of intestinal parasites in these regions were very low. 3. The incidence rates of anemia in the vectors of the eggs of intestinal parasites in their feces were observed highly than in the rates of the vectors of eggs in the anemia. 4. As to the blood pressure, hypertension of men and women increased with ages, especially hypertension of women increased after 50 years of ages. Regional incidence of hypertension were evident in Tsuegayabu areas in Kôyaguchi-chô, Shinjô areas in Katsuragi-chô, Nogami-chô, Kibi-chô, and Ryûjin-mura and these districts are located in highland and surrounded by mountains and craggy peaks. 5. Such pesticides as EPN, NissOl, Bygit, Fussôl, Parathion, Kelsen, Elsan, BHC, Blastcidin S, and Endrin were mostly used in these districts. Intoxication by these pesticides occurred at the rate of 25.9% in Shinjo and Tsuegayabu areas, 11.6% in Nogami-chô, 16.9% in Kibi-chô, and 30.8% in Kokawa-chô.
Of the patients with cerebral stroke admitted to the Saku Central Hospital from April 1972 to October 1977, we surveyed 60 people, aged 49 and under. 1) By type of disease, cerebral hemorrhage accounted for 40%, cerebral infarction 30%, and subarachnoid hemorrhage 30%. The prevalence of cerebral hemorrhage and subarachnoideal hemorrhage in this age group was higher than those in all ages. 2) Even in this age bracket, there were many with histories of hypertension and long periods of affection. The onset was observed among many of those who had not undergone or had discontinued treatment. 3) Abnormal ECG findings were observed in 35%. 4) Patients with a cardio-thoracic ratio of 51% and over in chest X-ray findings accounted for 64% of all patients. 5) Abnomally high hematocrit, serum and total cholesterol values were noted for few cases. 6) In respect to the prognosis of life and sequela, patients with cerebral infarction in this age bracket were better than those of all ages, but no statistically significant difference was observed between patients with ceberal hemorrhage in this age bracket and those in all ages.