Few authors have reported about electrophysiological findings including longitudinal F wave analysis in patients with Guillain-Barré syndrome during chronic stage. So we examined F waves in addition to conventional motor nerve conduction velocity (in upper extremity: elbow-wrist, in lower extremity: knee-ankle) of 6 patients with Guillain-Barré syndrome (5 males, 1 female, age: 17-54 years old) who had already had normal muscle strength. The objective nerves of this study were median, ulnar, peroneal and tibial nerves on one side respectively (24 nerves in all). Through observation of their clinical courses from acute stage, they participated in this study when muscle weakness recovered to the normal range. At the time of first examination, all of them had already returnd to their former jobs.
F waves were elicited by supramaximal stimulation at wrist or ankle. As the parameters we used minimam latency (F
min), maximam latency (F
max) and duration (F
dur). The technique to obtain F wave measurement and their normal values used in this study had been reported in detail elsewhere. In addition, we compared electrodiagnostic findings with subjective complaints. In three patients, we could conducted the serial electromyographical examinations after that.
All the patients except one had some abnormalities in conduction study. Although motor nerve conduction velocity were slow in only two nerves (both in same patient), some abnormalities more than one parameters in F wave were found in 16 nerves out of 24 nerves. Prolongation of F
max were most common (15 nerves in 4 patients). These changes in the conduction study did not show any correlation with subjective complaints such as easy fatigability or local sensation of dysesthesia. Serial electromyographical examinations revealed normalization of all the abnormal values in F wave parameters as well as motor nerve conduction velocity in two subjects, and improvement of them in one patient, who dropped out of our study 9 months later.
Theses results suggested that in some patients with Guillain-Barré syndrome, peripheral nerve function was in the middle way of recovery, even if muscle strength returned to normal. Consequently, serial electrophysiological evaluation including F wave analysis is important during chronic or recovery stage to assess its pathological condition adequately.
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