Seventy spinalized rabbits were prepared by spinal cord transection at the level of T-10 to T-11 to produce spastic paralysis. For thirty-five out of seventy rabbits, histopathological changes in the urinary tracts were then studied.
All cases in the sample showed stretch reflexes to taps on the knee and ankle between 24 to 48 hours after spinal cord transection; these reflexes graduallay increased subesequently. All cases also displayed ankle clonus and spastic paraplegia in the hind limbs after two or three weeks.
Urinary retention occurred in all the rabbits after recovery from anesthesia but automatic bladder developed the fourth and seventh days. Inflammation of the vesical wall became more and more pronounced. Hypertrophic changes in the vesical wall and muscle layer were also seen. Dilatation of the uretes were noted six weeks post-operatively.
The kidneys displayed chronic pyelonephritis and mild hydronephrosis. Histopathologic findings also suggested VUR. At six months post-operatively, amyloid deposition was noted further in some glomeruli. These findings suggest that spinal cord transection induced in order voiding disturbance, hydronephroureters and then chronic pyelonephritis.
These pathological changes in the urinary tract after experimental spinal cord transection are thought to provide a useful approach to treatment and diagnosis in clinical medicine.
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