Objectives: To investigate the short-term effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the motor cortex on writing parameters in patients with writer's cramp. Design: Comparisons between writing performance before and after a 25-minute train of 1-Hz rTMS (1, 500 stimuli) at 95% intensity of the motor threshold. Setting: Outpatient clinic at a department of rehabilitation medicine in a university hospital in Japan. Subjects: Five healthy subjects (mean age, 28 years, 4 males) and 5 patients with writer's cramp (mean age, 27 years, 4 males). Main outcome measures: Using a simple writing pressure gauge, maximum and average writing pressure; degree of variation in writing pressure, which reflects the writer's skill in writing; and writing time, which is the amount of time required. Results: After patients received rTMS all writing parameters improved, in particular, the degree of variation decreased with significance (
p<0.01, three-way ANOVA). Conclusions: In writer's cramp suffers, low-frequency rTMS over the motor cortex can improve handwriting. The electronic pen is an easily used instrument that is helpful for analyzing writing patterns.
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