Few case reports have documented patients with respiratory muscle paralysis due to spinal cord infarction or the need for ventilation. Objective：Herein, we report a case of non-invasive positive pressure ventilation (NPPV)-aided respiratory management. Patients：A 46-year-old man experienced sudden breathing difficulty, and, owing to respiratory failure, underwent tracheostomy and mechanical ventilation following tracheal intubation. The patient exhibited complete limb paralysis and was diagnosed with spinal cord infarction. Methods：Ventilator weaning was challenging, and necessitated patient transfer to our hospital. Results：Upon admission, the patient exhibited a forced vital capacity of 250 mL and required complete assistance. The ventilator settings were adjusted to a tidal volume of 20 mL/kg of the ideal body weight and positive end expiratory pressure off. One month post-admission, the patient was transferred for all day respiratory management with NPPV. One year after the onset, the patient's vital capacity improved to 1960 mL. The patient engaged in activities involving changes in body position or transfer training, gait training, and activities of daily living training with NPPV. Following training, the patient could independently propel a wheelchair and walk 40 m using a walker. The patient could also eat, brush his teeth using a self-help device, and independently wipe their face.

Conclusion：Respiratory dysfunction in this case was a ventilatory impairment resulting from respiratory muscle paralysis. Pulmonary rehabilitation for cervical spinal cord injury facilitates respiratory management with NPPV, improves respiratory condition, and reduces the amount of assistance.

Glucocorticoid-induced osteoporosis is one of the most common and serious adverse effects of glucocorticoid use. Pharmacological treatment is strongly recommended for patients at a high risk of fracture；however, it is generally avoided during pregnancy. Here, we present the rehabilitation of a pregnant patient with multiple vertebral fractures caused by glucocorticoid-induced osteoporosis. A 27-year-old woman with systemic lupus erythematosus had an unplanned pregnancy and began receiving oral glucocorticoid therapy (15 mg/day). Pharmacological treatment of osteoporosis was not recommended during pregnancy. At 31 weeks of gestation, the patient was admitted to our hospital with severe back pain. Plain X-rays showed multiple vertebral fractures. The patient was diagnosed with glucocorticoid-induced osteoporosis. She required prolonged bed rest until birth because of severe pain and high risk of additional fractures. The therapeutic strategy after delivery was shared with the Departments of Rehabilitation, Obstetrics, and Gynecology, Rheumatology, and Orthopedic Surgery. At 37 weeks of gestation, she gave birth by cesarean section, and teriparatide administration was started immediately. Six days after delivery, computed tomography showed multiple vertebral fractures from Th5 to L5, and L2-L4 bone mineral density was 0.798 g/cm2, which was 67％ of the young adult mean. She wore a corset and began a rehabilitation program. Frequent consultations were conducted with an orthopedic surgeon, and the patient carefully proceeded with getting out of bed. She gradually regained the ability to sit, stand, and walk. Sixty-three days after delivery, she could walk with a cane and was discharged from our hospital.