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Six autopsy cases with multiple pulmonary granulomas caused by an hitherto unknown foreign body were reported. Underlying diseases in these cases were apoplexia cerebri, epilepsy and other brain disorders, so that the patients showed vomitting, coma or disturbed consciousness in their clinical course. 4 of 6 cases revealed clinical symptoms of boronchopneumonia.
Macroscopically, small, firm, round or irregular shaped, greyish-yellow nodules were scattered in the both lungs. In some cases, there were larger pneumonic lesions with suppuration. On histological examination, the lung nodules were granulomas with many oval foreign bodies and giant cells. These granulomas were located in the bronchioles, alveolar ducts, alveoli and septa. Surrounding areas of the granumas showed often desquamtion of the alveolar epithelial cells and exudation of blood plasma, fibrin and leucocytes in the alveoli. The alveolar septa in these areas were thickened due to cellular infiltration. At laparotomy of an additional case with duodenal ulcer, the peritoneum at the site of perforation was studded with small granulomas containing the same foreign bodies. Some of these peritoneal granulomas, however, contained also fragments of striated muscle which very probably had been ingested as foodstuff.
The foreign bodies within the pulmonary and peritoneal granulomas had various sizes and structures. The most frequent form (Type A) was oval and 50-100μ in diameter and had a translucent, refractile membrane measuring 2-5μ, Within the bodies there were many round eosinophilic granules which were 10-15μ in diameter. In some granulomas there were larger ovoid foreign bodies (Type B) with a lobulated internal structure suggesting vegetable cells. The Type C foreign bodies were consisted of polygonal meshwork in which some small oval granules were found.
Examination on histological sections and cytological smears of miso (soybean paste) showed that this foodstuff were consisted with vegetable cells which were tinctorially and structurally indentical to foreign bodies seen in the human lung and pritoneum. The structure of the predominant vegetable cells in miso were similar to that of the Type A foreign bodies in our human cases. There were also other vegetable cells corresponding to Type B and C foreign bodies.
Subcutaneous injections of cooked, destilled miso soup to the rats produced granulomatous and suppurative lesions which were similar to those seen in the human cases. This experiment indicated that the injected vegetable cells of miso soup alone can cause not only a granulomatous change, but also a marked exudative and suppurative reaction.
From these observations, it was considered that the pulmonary granulomas and surrounding pneumonic changes in our 6 cases were caused by aspiration of miso soup containing vegetable cells.

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A 50-year-old female, with chronic pyothorax occurred after pneumothorax for pulmonary tuberculosis, was admitted with remittent high fever. Leucocytosis and accelerated erythrocyte sedimentation rate were found. X-ray finding indicated a consolidation it the left phrenico-costal sinus. It was difficult to differentiate this neoplasmic shadow from pyothorax density.
Upon surgery a gray-white necrotic tumor which was grown from the chest wall was confirmed. Histologic examination demonstrated liposarcoma of round cell type. The mass was removed.
Local recurrence of the tumor appeared on the 7th month after surgery even though anti-cancer drugs were given postoperatively. Excellent response to the irradiation therapy was demonstrated.
The authors recommend for the liposarcoma of round cell type the irradiation therapy after surgical removal of the tumor rather than the chemotherapy.

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40歳の女性が約10年前に左卵巣腫瘍の摘出術を受けたが, 同年秋には正常分娩し, その後の2年間に再び子宮附属器腫瘍と右卵巣腫瘍の摘出術を2回にわたって受けたが, これらの各開腹時には転移巣を認めず, かつ, 術後全く無自覚に経過しながら, 初回の術後5年目の検診ではじめて肺の異常影を指摘され, 以来5年余の経過, すなわち術後10年7ヵ月にわたる長期の経過を示した卵巣腫瘍の肺転移例を呈示した.

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