日本胸部疾患学会雑誌
Online ISSN : 1883-471X
Print ISSN : 0301-1542
ISSN-L : 0301-1542
17 巻, 4 号
選択された号の論文の8件中1~8を表示しています
  • 金沢 実
    1979 年 17 巻 4 号 p. 203-211
    発行日: 1979/04/25
    公開日: 2010/02/23
    ジャーナル フリー
    The annual change in ventilatory function with age was observed in sixty-three healthy subjects over a period of more than two years, during which at least three repeated observations were performed. The annual change in each parameter for every subject was determined by least-squares regression of obtained values against time.
    The mean annual change was calculated by averaging these slopes. The results were summarized as follows:
    1) The mean annual changes were decreases of 0.05 l/m/yr for VC/Ht, 0.012l/m/yr for FVC/Ht, 0.30%/yr for FEV1.0%, and 0.026l/yr for FEV1.0. The decline in these ventilatory parameters was statistically significant (p<0.05). On the other hand, changes in %VC, MVV, %MVV, and the air trapping index were not significant. A constant relationship was not found between these observed annual changes and the values expected by utilizing prediction formulae.
    2) A comparison was made between the annual changes in healthy male subjects according to age group. The decline of VC/Ht in young subjects was smaller than that observed in middle-aged and aged subjects. Greater decreases were also observed in aged subjects in FVC/Ht, FEV1.0, MVV, and %MVV.
    3). A significant difference in annual change was only detected in MVV and %MVV when non-smokers were compared with smokers.
    4) Observed variation of the ventilatory parameters was represented by the residual standard deviation (R.S.D.) of the regression line in each subject. The coefficient of variation of R.S.D. in overall subjects was
    4.08% for VC/Ht, 3.08% for FVC/Ht, 5.11% for FEV1.0%, and 4.65% for FEV1.0. That of MVV and %MVV exceeded 10%.
  • 桐沢 俊夫
    1979 年 17 巻 4 号 p. 212-221
    発行日: 1979/04/25
    公開日: 2010/02/23
    ジャーナル フリー
    Distribution of pulmonary emphysema as determined and classified by SAB was studied in comparison with clinical and functional abnormalities in 53 cases with pulmonary emphysema.
    1) The incidence and distribution of pulmonary emphysema lesions as estimated by SAB showed a tendency similar to the numerical values already reported by the postmortem findings. This indicates that a morphological diagnosis can be made antemortem.
    2) Statistical difference in the age of onset between various types of pulmonary emphysema was not seen. However, centrilobular emphysema (CE) was found in every age group including a relatively young generation. Thus, CE may develop earlier than the other two types in many cases.
    3) As for the involvement of inflammatory factors, there was a tendency for CRP to increase in the mixed type emphysema; Thus, a high incidence of infections during the clinical course may be surmised.
    4) The mixed type emphysema showed more marked decrease in FEV1%, and diffusing capacity of the lungs, and an even more marked frequency dependence of dynamic compliance than those in the other two groups; thus, it is presumed that prognosis of the mixed type is poor even in functional aspects.
    5) Referring to the data obtained from the comparative alveolo-bronchograms of the upper and lower lung fields, SAB of lower lobe alone may be enough for detecting of the presence of pulmonary emphysema.
    When the prognostic aspect is required clinically, however, radiography of upper and lower lung fields is more useful for overall diagnosis of the type of disease.
  • 桐沢 俊夫, 三上 洋, 浅沼 義英, 与沢 宏一, 岸 不尽弥, 内山 喬一, 入江 正, 本間 行彦, 川上 義和, 大崎 饒, 村尾 ...
    1979 年 17 巻 4 号 p. 222-232
    発行日: 1979/04/25
    公開日: 2010/02/23
    ジャーナル フリー
    A comparative study was carried out on the radiographic findings of the proximal and distal portion of the airways by SAB and bronchography in 49 cases with pulmonary emphysema, 4 cases with chronic bronchitis and 15 cases with chronic bronchiolitis.
    1) Pulmonary emphysema was characterized by atrophic change of the airway with concomitant narrowing of the diameter of all airways. Panlobular emphysema showed a lesser tendency for the proximal portion of airway to become narrowed compared with centrilobular and mixed type emphysema, and was characterized by uniformly dilation and irregular wall change. Thus, it was surmised that the impairment extended to the entire airway. The centrilobular type showed more marked inflammatory changes in the distal portion of the airways, indicating the involvement of infection factors.
    2) Wall irregularity was most conspicuous in the proximal portion of the airways in chronic bronchitis, followed by cylindrical dilatation. Bead-like wall irregularity was seen only in the distal portion of the airways.
    3) In chronic bronchiolitis, both proximal and distal portions of the airways showed distinct impairment in many cases. In the distal portion of the airways, inverted funnel-shaped dilatation was particulary noted, suggesting changes due to mucus plugs, and stenosis or obstruction in the lumen of the airways.
    4) Comparison of chest roentgenograms and alveolo-bronchograms disclosed the following results. The more marked the morphological changes in the airways, the more reticular, linear and honeycomb shadows appeared on the chest X-ray films. Inverted funnel-shaped dilatation in the distal portion of the airways was often found in the group in which nodular shadows were seen on the chest X-ray films. This dilatation was considered to occur when the impairment of the distal portion of the airways was mild.
    5) Common abnormalities in the airways were not obtainedd between pulmonary emphysema, in particular centrilobular type, and chronic bronchiolitis. Comparing chronic bronchitis with chronic bronchiolitis, the wall irregularity of the proximal airways was remarkable in the former, while the latter was characterized by concomitant dilatation and irregularity in all airways. The alveolar pattern was easily visualized in chronic bronchitis, but not in either pulmonary emphysema or chronic bronchiolitis.
  • 富岡 真一, 笛木 隆三, 井上 〓夫, 長野 準
    1979 年 17 巻 4 号 p. 233-242
    発行日: 1979/04/25
    公開日: 2010/02/23
    ジャーナル フリー
  • 北村 諭, 石原 陽子, 小坂 樹徳, 末次 勧, 本間 れい子, 梅田 博道
    1979 年 17 巻 4 号 p. 244-249
    発行日: 1979/04/25
    公開日: 2010/02/23
    ジャーナル フリー
    Parabens, the C1-C4 alkyl esters of p-hydroxybenzoic acid, have been used since the 1930s as bacteriostatic and fungistatic agents in drugs, cosmetics, and foods. Recently, several reports of paraben-induced asthma have been published. The present investigation was conducted to explore the effect of parabens on the actions of various bronchoconstrictors.
    Male guinea pigs, weighing 250-300g, were sacrificed. Guinea pig trachea was removed, cut spirally 1.5mm in width and 2.5cm in length, suspended in bioassay glass chamber and superfused with Krebs-Henseleit solution at 37°C saturated with oxygen and carbon dioxide (95:5, v/v). Contractile responses of guinea pig tracheal tissues were detected by an isotonic transducer and displayed on a polyrecorder.
    1) The dose-response curve of acetylcholine was shifted upward by combining methylparaben and this shift became more dominant by increasing the dose of methylparaben.
    2) Acetylcholine, histamine and serotonin-induced contractile responses of tracheal tissues were potentiated dose-dependently by combination with methylparaben.
    3) Acetylcholine, serotonin, histamine and prostaglandin F-induced contractile responses of tracheal tissues were potentiated dose-dependently by combining propylparaben and reached a maximum at a dose of 2.5μg/ml.
    4) Acetylcholine, serotonin, histamine and prostaglandin F-induced contractile responses of tracheal tissues were potentiated dose-dependently by combination with ethylparaben and reached a maximum at a dose of 2.5μg/ml.
    5) The above results may suggest that such potentiating effects of parabens on the action of bronchoconstrictors could be the pathogenesis of paraben-induced asthma.
  • 血清総IgE値, IgE, IgG, IgA, IgM 抗体価と臨床経過との関連
    秋山 一男, 伊藤 幸治, 宮本 昭正, 堀内 淑彦, 信太 隆夫, 油井 泰雄, 西村 浩
    1979 年 17 巻 4 号 p. 250-258
    発行日: 1979/04/25
    公開日: 2010/02/23
    ジャーナル フリー
    The total IgE level and the specific of IgE, G, A, M class antibodies against Aspergillus fumigatus were measured in the sera of six patients with ABPA by the methods of RIST, RAST, double antibody technique and Protein A-Sepharose CL-4B particles. The results were compared with the clinical courses. The summary of the discussion and conclusion is as follows;
    1) In the active phase, the total IgE levels and the titer of specific anti-Asp. antibodies in each class in the sera of patients were higher than in the inactive phase. In the inactive phase, these levels decreased within normal ranges in some patients.
    2) These levels and titers tended to increase before the clinical findings of exacerbation appeared Therefore they could be used as indices of exacerbation beforehand.
    3) They increased from winter to late spring. Thus our data suggest that ABPA may get worse in that season.
    4) Adrenocorticosteroid hormone was effective to reduce the titer of specific anti-Asp. antibodies. The inhalation of amphotericin B was effective to treat ABPA in some patients.
  • 肺病変の組織学的検討を含めて
    高橋 清, 小林 誠, 宗田 良, 木村 郁郎, 影山 浩, 小橋 秀敏, 右橋 健, 野田 憲男
    1979 年 17 巻 4 号 p. 259-263
    発行日: 1979/04/25
    公開日: 2010/02/23
    ジャーナル フリー
    59才女性, 血痰・息切れ・血尿を主訴とし, 胸部X線上広範な微細粒状影の出現消退を繰返し, 慢性腎不全, 低色素性貧血も暫時増悪し, 15カ月の経過で急性呼吸不全により死亡した. 組織学的検討により肺胞基底膜にIgGの沈着と肺胞腔に多数の担鉄肺胞マクロファージの出現を認めた.
  • 1979 年 17 巻 4 号 p. 264-269
    発行日: 1979/04/25
    公開日: 2010/02/23
    ジャーナル フリー
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